This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as ... See more...

Aliases for RAET1E Gene

Aliases for RAET1E Gene

  • Retinoic Acid Early Transcript 1E 2 3 4 5
  • LETAL 2 3 4
  • ULBP4 2 3 4
  • Lymphocyte Effector Toxicity Activation Ligand 3 4
  • RAE-1-Like Transcript 4 3 4
  • UL16-Binding Protein 4 3 4
  • NKG2D Ligand 4 3 4
  • BA350J20.7 2 3
  • NKG2DL4 3 4
  • N2DL-4 3 4
  • RAET1E2 3
  • RAET1E 5
  • N2DL4 4
  • RL-4 3

External Ids for RAET1E Gene

Previous GeneCards Identifiers for RAET1E Gene

  • GC06M150164
  • GC06M150240
  • GC06M150297
  • GC06M150251
  • GC06M150209
  • GC06M147775

Summaries for RAET1E Gene

Entrez Gene Summary for RAET1E Gene

  • This gene belong to the RAET1 family, which consists of major histocompatibility complex (MHC) class I-related genes located in a cluster on chromosome 6q24.2-q25.3. This and RAET1G protein differ from other RAET1 proteins in that they have type I membrane-spanning sequences at their C termini rather than glycosylphosphatidylinositol anchor sequences. This protein functions as a ligand for NKG2D receptor, which is expressed on the surface of several types of immune cells, and is involved in innate and adaptive immune responses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

GeneCards Summary for RAET1E Gene

RAET1E (Retinoic Acid Early Transcript 1E) is a Protein Coding gene. Diseases associated with RAET1E include Basidiobolomycosis. Among its related pathways are Immune response Role of DAP12 receptors in NK cells and Innate Immune System. Gene Ontology (GO) annotations related to this gene include peptide antigen binding and natural killer cell lectin-like receptor binding. An important paralog of this gene is ENSG00000285991.

UniProtKB/Swiss-Prot Summary for RAET1E Gene

  • Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Gene Wiki entry for RAET1E Gene

Additional gene information for RAET1E Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAET1E Gene

Genomics for RAET1E Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAET1E Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAET1E on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAET1E

Top Transcription factor binding sites by QIAGEN in the RAET1E gene promoter:
  • AML1a
  • NRSF form 1
  • NRSF form 2
  • Pax-4a
  • STAT1
  • STAT1alpha
  • STAT1beta

Genomic Locations for RAET1E Gene

Genomic Locations for RAET1E Gene
chr6:149,864,399-149,898,353
(GRCh38/hg38)
Size:
33,955 bases
Orientation:
Minus strand
chr6:150,204,511-150,219,238
(GRCh37/hg19)
Size:
14,728 bases
Orientation:
Minus strand

Genomic View for RAET1E Gene

Genes around RAET1E on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAET1E Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAET1E Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAET1E Gene

Proteins for RAET1E Gene

  • Protein details for RAET1E Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8TD07-RAE1E_HUMAN
    Recommended name:
    Retinoic acid early transcript 1E
    Protein Accession:
    Q8TD07
    Secondary Accessions:
    • A6YF59
    • Q5VYB7
    • Q5VYB8
    • Q8TEZ2
    • Q96L41

    Protein attributes for RAET1E Gene

    Size:
    263 amino acids
    Molecular mass:
    30122 Da
    Quaternary structure:
    • Binds to KLRK1/NKG2D.
    • (Microbial infection) Contrary to other family members, does not interact with CMV glycoprotein UL16.
    Miscellaneous:
    • UL16-binding proteins (ULBPs) are unusual members of the extended MHC class I superfamily. They do not contain the alpha 3 domain and lack a transmembrane domain.

    Alternative splice isoforms for RAET1E Gene

neXtProt entry for RAET1E Gene

Post-translational modifications for RAET1E Gene

  • Glycosylation at Asn36, Asn154, and Asn212
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAET1E Gene

Domains & Families for RAET1E Gene

Gene Families for RAET1E Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for RAET1E Gene

InterPro:
Blocks:
  • MHC class I signature
ProtoNet:

Suggested Antigen Peptide Sequences for RAET1E Gene

GenScript: Design optimal peptide antigens:
  • Retinoic acid early transcript 1E (N2DL4_HUMAN)
  • Retinoic acid early transcript 1E (Q3ZAR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q8TD07

UniProtKB/Swiss-Prot:

RAE1E_HUMAN :
  • MHC class I alpha-1 like and MHC class I alpha- like regions down-regulate the cell surface expression of KLRK1.
  • Belongs to the MHC class I family.
Domain:
  • MHC class I alpha-1 like and MHC class I alpha- like regions down-regulate the cell surface expression of KLRK1.
Family:
  • Belongs to the MHC class I family.
genes like me logo Genes that share domains with RAET1E: view

Function for RAET1E Gene

Molecular function for RAET1E Gene

UniProtKB/Swiss-Prot Function:
Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity.

Phenotypes From GWAS Catalog for RAET1E Gene

Gene Ontology (GO) - Molecular Function for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18544572
GO:0046703 natural killer cell lectin-like receptor binding IPI 15240696
genes like me logo Genes that share ontologies with RAET1E: view

Phenotypes for RAET1E Gene

genes like me logo Genes that share phenotypes with RAET1E: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAET1E

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAET1E Gene

Localization for RAET1E Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAET1E Gene

Membrane. Single-pass type I membrane protein.
[Isoform 4]: Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAET1E gene
Compartment Confidence
plasma membrane 5
extracellular 5
cytosol 2
lysosome 2
cytoskeleton 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Focal adhesion sites (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IBA 21873635
GO:0005886 plasma membrane NAS,TAS --
GO:0009897 external side of plasma membrane IBA 21873635
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAET1E: view

Pathways & Interactions for RAET1E Gene

genes like me logo Genes that share pathways with RAET1E: view

Pathways by source for RAET1E Gene

Gene Ontology (GO) - Biological Process for RAET1E Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002376 immune system process IEA --
GO:0006955 immune response IBA 21873635
GO:0042267 natural killer cell mediated cytotoxicity IDA 15240696
GO:0045954 positive regulation of natural killer cell mediated cytotoxicity IDA 18544572
GO:0050776 regulation of immune response TAS --
genes like me logo Genes that share ontologies with RAET1E: view

No data available for SIGNOR curated interactions for RAET1E Gene

Drugs & Compounds for RAET1E Gene

(1) Additional Compounds for RAET1E Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAET1E: view

Transcripts for RAET1E Gene

mRNA/cDNA for RAET1E Gene

4 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAET1E

Alternative Splicing Database (ASD) splice patterns (SP) for RAET1E Gene

No ASD Table

Relevant External Links for RAET1E Gene

GeneLoc Exon Structure for
RAET1E

Expression for RAET1E Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAET1E Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAET1E Gene

This gene is overexpressed in Esophagus - Mucosa (x17.7), Vagina (x8.6), Cervix - Ectocervix (x6.6), Skin - Sun Exposed (Lower leg) (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAET1E Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAET1E

SOURCE GeneReport for Unigene cluster for RAET1E Gene:

Hs.511818

mRNA Expression by UniProt/SwissProt for RAET1E Gene:

Q8TD07-RAE1E_HUMAN
Tissue specificity: Predominantly expressed in the skin, but also expressed in testis and trachea. Up-regulated in tumor cells of different origins. Expression progressively decreased after treatment of tumor cells with retinoic acid.

Evidence on tissue expression from TISSUES for RAET1E Gene

  • Intestine(2.2)
  • Skin(2.2)
  • Liver(2.1)
  • Spleen(2.1)
  • Lymph node(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with RAET1E: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAET1E Gene

Orthologs for RAET1E Gene

This gene was present in the common ancestor of mammals.

Orthologs for RAET1E Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAET1E 30
  • 98.07 (n)
MIC 31
  • 95 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia -- 31
  • 50 (a)
OneToMany
-- 31
  • 49 (a)
OneToMany
-- 31
  • 43 (a)
OneToMany
Dog
(Canis familiaris)
Mammalia RAET1E 31
  • 38 (a)
OneToOne
Species where no ortholog for RAET1E was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for RAET1E Gene

ENSEMBL:
Gene Tree for RAET1E (if available)
TreeFam:
Gene Tree for RAET1E (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAET1E: view image

Paralogs for RAET1E Gene

(7) SIMAP similar genes for RAET1E Gene using alignment to 6 proteins:

  • N2DL4_HUMAN
  • E9PKJ6_HUMAN
  • I7EC85_HUMAN
  • I7FHP4_HUMAN
  • Q3T1D4_HUMAN
  • Q3ZAR2_HUMAN
genes like me logo Genes that share paralogs with RAET1E: view

Variants for RAET1E Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAET1E Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs2151910 - p.Tyr82Asn
rs2342767 - p.Val237Leu
rs57292884 - p.Arg194Gly
rs6925151 - p.Arg128His
rs9371533 - p.Thr142Ile

Additional dbSNP identifiers (rs#s) for RAET1E Gene

Structural Variations from Database of Genomic Variants (DGV) for RAET1E Gene

Variant ID Type Subtype PubMed ID
esv3890963 CNV loss 25118596
nsv517022 CNV gain+loss 19592680
nsv819758 CNV loss 19587683

Variation tolerance for RAET1E Gene

Residual Variation Intolerance Score: 96.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.50% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAET1E Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAET1E

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAET1E Gene

Disorders for RAET1E Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAET1E Gene - From: DISEASES

Disorder Aliases PubMed IDs
basidiobolomycosis
  • infection by basidiobolus
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAET1E

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RAET1E: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAET1E Gene

Publications for RAET1E Gene

  1. Single nucleotide polymorphism analysis of the NKG2D ligand cluster on the long arm of chromosome 6: Extensive polymorphisms and evidence of diversity between human populations. (PMID: 20219610) Antoun A … Briggs DC (Human immunology 2010) 3 23 41
  2. Polymorphisms of NKG2D ligands: diverse RAET1/ULBP genes in northeastern Thais. (PMID: 19688209) Romphruk AV … Leelayuwat C (Immunogenetics 2009) 3 23 41
  3. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. (PMID: 17470428) Cao W … He W (The Journal of biological chemistry 2007) 3 4 23
  4. Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D. (PMID: 15240696) Bacon L … Trowsdale J (Journal of immunology (Baltimore, Md. : 1950) 2004) 3 4 23
  5. ULBP4 is a novel ligand for human NKG2D. (PMID: 12732206) Chalupny NJ … Cosman D (Biochemical and biophysical research communications 2003) 3 4 23

Products for RAET1E Gene

  • Signalway ELISA kits for RAET1E

Sources for RAET1E Gene