Aliases for RAE1 Gene
External Ids for RAE1 Gene
Previous GeneCards Identifiers for RAE1 Gene
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly(A)-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAE1 Gene
RAE1 (Ribonucleic Acid Export 1) is a Protein Coding gene. Diseases associated with RAE1 include Lethal Congenital Contracture Syndrome 1 and Anterior Horn Cell Disease. Among its related pathways are Transport of the SLBP independent Mature mRNA and Cellular response to heat stress. Gene Ontology (GO) annotations related to this gene include RNA binding and microtubule binding. An important paralog of this gene is BUB3.
UniProtKB/Swiss-Prot Summary for RAE1 Gene
Plays a role in mitotic bipolar spindle formation (PubMed:17172455). Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton.