Aliases for RADIL Gene

Aliases for RADIL Gene

  • Rap Associating With DIL Domain 2 3 5
  • Ras-Associating And Dilute Domain-Containing Protein 3 4
  • Ras Association And DIL Domains 2 3
  • Rap GTPase Interactor 3
  • KIAA1849 4
  • RASIP2 3

External Ids for RADIL Gene

Previous GeneCards Identifiers for RADIL Gene

  • GC07M004804
  • GC07M004836
  • GC07M004755

Summaries for RADIL Gene

GeneCards Summary for RADIL Gene

RADIL (Rap Associating With DIL Domain) is a Protein Coding gene. An important paralog of this gene is RASIP1.

UniProtKB/Swiss-Prot Summary for RADIL Gene

  • Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.

Gene Wiki entry for RADIL Gene

Additional gene information for RADIL Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RADIL Gene

Genomics for RADIL Gene

GeneHancer (GH) Regulatory Elements for RADIL Gene

Promoters and enhancers for RADIL Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07J004881 Promoter/Enhancer 1.7 Ensembl ENCODE CraniofacialAtlas 519.8 +0.8 776 2.5 EP300 CTCF USF1 PHF8 ZIC2 ZBTB26 TARDBP REST RFX1 CHD1 RADIL RF00017-5998 RF00017-5990 RF00017-5996 RF00017-5995
GH07J004871 Enhancer 0.9 Ensembl ENCODE CraniofacialAtlas 28 +11.3 11332 2 MXI1 ZBTB7A RCOR1 MEIS2 ZBTB33 PAX5 MAX CHD2 YY1 GATA2 RADIL RF00017-5998 RPL22P16 lnc-PAPOLB-2 RF00017-5990 RF00017-5996 RF00017-5995
GH07J004774 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas 11 +107.9 107860 3.5 FOXK2 ZBTB40 ZNF217 EP300 SIN3A TCF12 POLR2G USF1 SP1 NCOR1 AP5Z1 lnc-RADIL-6 piR-44878-038 RNF216P1 RADIL RF00017-5995 RF00017-5990
GH07J004861 Promoter/Enhancer 1.1 Ensembl ENCODE CraniofacialAtlas 13 +21.9 21930 0.8 NR2C1 SPI1 POLR2A PKNOX1 PAPOLB piR-41148 RADIL RF00017-5990 RF00017-5995 RF00017-5996
GH07J004878 Enhancer 0.3 Ensembl CraniofacialAtlas 31.7 +4.0 4015 2.6 RADIL AP5Z1 RF00017-5998 RF00017-5990 RF00017-5996 RF00017-5995
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RADIL on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RADIL

Top Transcription factor binding sites by QIAGEN in the RADIL gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • C/EBPalpha
  • CUTL1
  • MAZR
  • MIF-1
  • MyoD
  • Sp1

Genomic Locations for RADIL Gene

Genomic Locations for RADIL Gene
86,662 bases
Minus strand
86,665 bases
Minus strand

Genomic View for RADIL Gene

Genes around RADIL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RADIL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RADIL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RADIL Gene

Proteins for RADIL Gene

  • Protein details for RADIL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-associating and dilute domain-containing protein
    Protein Accession:
    Secondary Accessions:
    • A4D1Z5
    • A5YM49
    • B7ZL20
    • Q0VFZ9
    • Q75LH3
    • Q9BSP5
    • Q9H0M6
    • Q9NW43
    • Q9NWC4

    Protein attributes for RADIL Gene

    1075 amino acids
    Molecular mass:
    117455 Da
    Quaternary structure:
    • Interacts with RAP1A; in a GTP-dependent manner. Does not interact with members of the Ras family (PubMed:17704304). Interacts (via PDZ domain) with KIF14; is recruited to the microtubule network restricting its interaction with activated RAP1A (PubMed:23209302).
    • Sequence=AAS07559.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA91543.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=BAB47478.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RADIL Gene

    Alternative splice isoforms for RADIL Gene


neXtProt entry for RADIL Gene

Post-translational modifications for RADIL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RADIL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RADIL Gene

Domains & Families for RADIL Gene

Gene Families for RADIL Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RADIL Gene

  • RA domain
  • Forkhead-associated (FHA)
  • PDZ/DHR/GLGF domain

Suggested Antigen Peptide Sequences for RADIL Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ50093 (B7Z2I1_HUMAN)
  • Ras-associating and dilute domain-containing protein (RADIL_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RADIL family.
  • Belongs to the RADIL family.
genes like me logo Genes that share domains with RADIL: view

Function for RADIL Gene

Molecular function for RADIL Gene

UniProtKB/Swiss-Prot Function:
Downstream effector of Rap required for cell adhesion and migration of neural crest precursors during development.

Phenotypes From GWAS Catalog for RADIL Gene

Gene Ontology (GO) - Molecular Function for RADIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with RADIL: view
genes like me logo Genes that share phenotypes with RADIL: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RADIL Gene

Localization for RADIL Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RADIL gene
Compartment Confidence
cytoskeleton 5
mitochondrion 2
nucleus 2
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RADIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005874 microtubule IDA 23209302
GO:0032991 protein-containing complex IDA 26780829
genes like me logo Genes that share ontologies with RADIL: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RADIL Gene

Pathways & Interactions for RADIL Gene

PathCards logo

SuperPathways for RADIL Gene

No Data Available

Gene Ontology (GO) - Biological Process for RADIL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007155 cell adhesion IEA --
GO:0007165 signal transduction IEA --
GO:0007275 multicellular organism development IEA --
GO:0034446 substrate adhesion-dependent cell spreading IDA 23209302
genes like me logo Genes that share ontologies with RADIL: view

No data available for Pathways by source and SIGNOR curated interactions for RADIL Gene

Drugs & Compounds for RADIL Gene

No Compound Related Data Available

Transcripts for RADIL Gene

mRNA/cDNA for RADIL Gene

16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RADIL Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14a · 14b · 14c ^ 15 ^ 16 ^
SP3: -
SP4: -
SP6: -
SP10: - -

ExUns: 17

Relevant External Links for RADIL Gene

GeneLoc Exon Structure for

Expression for RADIL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RADIL Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RADIL

SOURCE GeneReport for Unigene cluster for RADIL Gene:


Evidence on tissue expression from TISSUES for RADIL Gene

  • Nervous system(4.2)
  • Lung(4.1)
  • Heart(4)
  • Skin(4)
genes like me logo Genes that share expression patterns with RADIL: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RADIL Gene

Orthologs for RADIL Gene

This gene was present in the common ancestor of chordates.

Orthologs for RADIL Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RADIL 31 30
  • 98.73 (n)
(Canis familiaris)
Mammalia RADIL 31 30
  • 84.56 (n)
(Bos Taurus)
Mammalia RADIL 31 30
  • 82.99 (n)
(Rattus norvegicus)
Mammalia Radil 30
  • 81.16 (n)
(Mus musculus)
Mammalia Radil 17 31 30
  • 80.74 (n)
(Monodelphis domestica)
Mammalia RADIL 31
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia RADIL 31
  • 61 (a)
(Gallus gallus)
Aves RADIL 31 30
  • 68.94 (n)
(Anolis carolinensis)
Reptilia RADIL 31
  • 54 (a)
(Danio rerio)
Actinopterygii radil 31 31 30
  • 58.01 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
Species where no ortholog for RADIL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RADIL Gene

Gene Tree for RADIL (if available)
Gene Tree for RADIL (if available)
Evolutionary constrained regions (ECRs) for RADIL: view image

Paralogs for RADIL Gene

Paralogs for RADIL Gene

(5) SIMAP similar genes for RADIL Gene using alignment to 5 proteins:

  • B7Z2I1_HUMAN
  • C9J7G0_HUMAN
  • F5H6X3_HUMAN
genes like me logo Genes that share paralogs with RADIL: view

Variants for RADIL Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RADIL Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
738850 Likely Benign: not provided 4,815,317(-) G/A SYNONYMOUS_VARIANT
776199 Benign: not provided 4,799,680(-) G/A SYNONYMOUS_VARIANT
776200 Likely Benign: not provided 4,815,404(-) G/A SYNONYMOUS_VARIANT
782487 Benign: not provided 4,816,445(-) C/T SYNONYMOUS_VARIANT
rs2292498 - p.His412Asp

Additional dbSNP identifiers (rs#s) for RADIL Gene

Structural Variations from Database of Genomic Variants (DGV) for RADIL Gene

Variant ID Type Subtype PubMed ID
dgv1249e214 CNV loss 21293372
dgv6238n100 CNV loss 25217958
esv2664593 CNV deletion 23128226
esv2733904 CNV deletion 23290073
esv28123 CNV loss 19812545
esv3364985 CNV insertion 20981092
esv3571582 CNV loss 25503493
esv3611949 CNV loss 21293372
esv3611950 CNV loss 21293372
esv3611952 CNV loss 21293372
nsv1029123 CNV loss 25217958
nsv471293 CNV loss 18288195
nsv473014 CNV novel sequence insertion 20440878
nsv528748 CNV loss 19592680
nsv5626 CNV insertion 18451855
nsv605977 CNV loss 21841781
nsv605978 CNV gain 21841781
nsv605979 CNV loss 21841781
nsv605980 CNV loss 21841781
nsv8033 CNV loss 18304495
nsv823994 CNV gain 20364138
nsv950797 CNV deletion 24416366
nsv950798 CNV deletion 24416366
nsv970439 CNV duplication 23825009

Variation tolerance for RADIL Gene

Residual Variation Intolerance Score: 95.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.88; 91.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RADIL Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RADIL Gene

Disorders for RADIL Gene

Additional Disease Information for RADIL

No disorders were found for RADIL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RADIL Gene

Publications for RADIL Gene

  1. A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. (PMID: 17704304) Smolen GA … Haber DA (Genes & development 2007) 2 3 4 54
  2. KIF14 negatively regulates Rap1a-Radil signaling during breast cancer progression. (PMID: 23209302) Ahmed SM … Angers S (The Journal of cell biology 2012) 3 4 54
  3. AF6 negatively regulates Rap1-induced cell adhesion. (PMID: 16051602) Zhang Z … Bos JL (The Journal of biological chemistry 2005) 2 3 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54

Products for RADIL Gene

Sources for RADIL Gene