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The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand... See more...
Aliases for RAD54L Gene
Aliases for RAD54L Gene
External Ids for RAD54L Gene
- HGNC: 9826
- Entrez Gene: 8438
- Ensembl: ENSG00000085999
- OMIM: 603615
- UniProtKB: Q92698
Previous GeneCards Identifiers for RAD54L Gene
- GC01P046407
- GC01P045670
- GC01P046099
- GC01P046083
- GC01P046425
- GC01P046485
- GC01P046713
- GC01P044829
- GC01P046248
- GC01P046251
Summaries for RAD54L Gene
-
The protein encoded by this gene belongs to the DEAD-like helicase superfamily, and shares similarity with Saccharomyces cerevisiae Rad54, a protein known to be involved in the homologous recombination and repair of DNA. This protein has been shown to play a role in homologous recombination related repair of DNA double-strand breaks. The binding of this protein to double-strand DNA induces a DNA topological change, which is thought to facilitate homologous DNA paring, and stimulate DNA recombination. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Dec 2008]
GeneCards Summary for RAD54L Gene
RAD54L (RAD54 Like) is a Protein Coding gene. Diseases associated with RAD54L include Lymphoma, Non-Hodgkin, Familial and Breast Ductal Carcinoma. Among its related pathways are Resolution of D-loop Structures through Holliday Junction Intermediates and Integrated Breast Cancer Pathway. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and helicase activity. An important paralog of this gene is RAD54B.
UniProtKB/Swiss-Prot Summary for RAD54L Gene
-
Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
Additional gene information for RAD54L Gene
- HGNC(9826)
- Entrez Gene(8438)
- Ensembl(ENSG00000085999)
- OMIM(603615)
- UniProtKB(Q92698)
- Open Targets Platform(ENSG00000085999)
- Monarch Initiative
- Search for RAD54L at DataMed
- Search for RAD54L at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD54L Gene
Genomics for RAD54L Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAD54L Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAD54L on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAD54L
- Top Transcription factor binding sites by QIAGEN in the RAD54L gene promoter:
-
- CUTL1
- NF-1
- NF-1/L
- STAT1
- STAT1alpha
- STAT1beta
- STAT2
- STAT3
- YY1
Genomic Locations for RAD54L Gene
Genomic Locations for RAD54L Gene
- chr1:46,246,461-46,278,480
- (GRCh38/hg38)
- Size:
- 32,020 bases
- Orientation:
- Plus strand
- chr1:46,713,360-46,744,145
- (GRCh37/hg19)
- Size:
- 30,786 bases
- Orientation:
- Plus strand
Genomic View for RAD54L Gene
Genes around RAD54L on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.1 by HGNC
- 1p34.1 by Entrez Gene
- 1p34.1 by Ensembl
RAD54L Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD54L Gene
Proteins for RAD54L Gene
-
Protein details for RAD54L Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q92698-RAD54_HUMAN
- Recommended name:
- DNA repair and recombination protein RAD54-like
- Protein Accession:
- Q92698
- Q5TE31
- Q6IUY3
Protein attributes for RAD54L Gene
- Size:
- 747 amino acids
- Molecular mass:
- 84352 Da
- Quaternary structure:
-
- Interacts (via N-terminus) with RAD51.
Protein Expression for RAD54L Gene
Selected DME Specific Peptides for RAD54L Gene
- Q92698:
-
- GTIEEKI
- DEMGLGKT
- LRPHQREG
- DILSKYLPVK
- MGLGKTL
- LMWTLLRQ
- RVWRDGQK
Post-translational modifications for RAD54L Gene
Other Protein References for RAD54L Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RAD54 Antibody
-
Custom Antibody ServicesOriGene Antibodies for RAD54L
- Novus Biologicals Antibodies for RAD54L
-
Abcam antibodies for RAD54L
- Invitrogen Antibodies for RAD54L (AFLGC-RAD54L)
-
Biorbyt antibodies for RAD54L
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD54L
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD54L
- Origene Custom Protein Services for RAD54L
-
Abcam proteins for RAD54L
Domains & Families for RAD54L Gene
Gene Families for RAD54L Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAD54L Gene
- InterPro:
- Blocks:
-
- SNF2 related domain
- ProtoNet:
Suggested Antigen Peptide Sequences for RAD54L Gene
- GenScript: Design optimal peptide antigens:
-
- RAD54 homolog (RAD54_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q92698- Family:
-
- Belongs to the SNF2/RAD54 helicase family.
Function for RAD54L Gene
Molecular function for RAD54L Gene
- UniProtKB/Swiss-Prot Function:
- Involved in DNA repair and mitotic recombination. Functions in the recombinational DNA repair (RAD52) pathway. Dissociates RAD51 from nucleoprotein filaments formed on dsDNA. Could be involved in the turnover of RAD51 protein-dsDNA filaments (By similarity). May play also an essential role in telomere length maintenance and telomere capping in mammalian cells.
- UniProtKB/Swiss-Prot Induction:
- Expression increases approximately 3-fold in late G1 phase compared to other phases of the cell cycle.
- GENATLAS Biochemistry:
- yeast (S cerevisiae) RAD54 homolog,93kDa,SNF2/SW12 family,highly expressed in organs of germ cells and lymphoid development,recombinational protein associated with RAD51,involved in nucleotide excision repair of double-strand break and in meiotic recombination,RAD52 epistasis group,localized in a region of high loss of heterozygosity in breast cancer,potential tumor suppressor in parathyroid adenomas (see TSG1J) and in breast cancer with poor prognosis
Enzyme Numbers (IUBMB) for RAD54L Gene
Phenotypes From GWAS Catalog for RAD54L Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0004386 | helicase activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 16990250 |
| GO:0005524 | ATP binding | IEA | -- |
Phenotypes for RAD54L Gene
- MGI mutant phenotypes for RAD54L:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RAD54L:
Animal Models for RAD54L Gene
- MGI Knock Outs for RAD54L:
-
- Rad54l Rad54l<tm1Jhjh>
Animal Model Products
-
Taconic Biosciences Mouse Models for RAD54L
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD54L - Select products 50% OFF >
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-
OriGene CRISPR knockouts for RAD54L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD54L
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD54L
miRNA for RAD54L Gene
- miRTarBase miRNAs that target RAD54L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD54L
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Clone Products
- Applied Biological Materials (abm): Clones for RAD54L - Select products 50% OFF >
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- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210443
- MG221567
- MG221645
- MR210443
- MR210443L3
- MR210443L4
- MR221567
- MR221567L3
- MR221567L4
- MR221645
- MR221645L3
- MR221645L4
- RC220046
- RC220046L1
- RC220046L2
- RC220046L3
- RC220046L4
- RC227119
- RC227119L3
- RC227119L4
- RG220046
- RG227119
- RR209078
- RR209078L3
- RR209078L4
- MR210443L3V
- MR210443L4V
- MR221567L3V
- MR221567L4V
- MR221645L3V
- MR221645L4V
- RC220046L1V
- RC220046L2V
- RC220046L3V
- RC220046L4V
- RC227119L3V
- RC227119L4V
- RR209078L3V
- RR209078L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD54L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD54L
Cell Line Products
-
Horizon Cell Lines for RAD54L
No data available for Transcription Factor Targets and HOMER Transcription for RAD54L Gene
Localization for RAD54L Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD54L Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0032991 | protein-containing complex | IMP | 16990250 |
Pathways & Interactions for RAD54L Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Damage | ||
| 2 | Resolution of D-loop Structures through Holliday Junction Intermediates | ||
| 3 | Integrated Breast Cancer Pathway | ||
Pathways by source for RAD54L Gene
1 BioSystems pathway for RAD54L Gene
1 KEGG pathway for RAD54L Gene
1 Cell Signaling Technology pathway for RAD54L Gene
Interacting Proteins for RAD54L Gene
Selected Interacting proteins:
Q92698-RAD54_HUMAN
ENSP00000361043
for RAD54L Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RAD54L
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000724 | double-strand break repair via homologous recombination | IEA | -- |
| GO:0000733 | DNA strand renaturation | IEA | -- |
| GO:0006281 | DNA repair | TAS | 8805304 |
| GO:0006302 | double-strand break repair | IEA | -- |
| GO:0006310 | DNA recombination | TAS | 8805304 |
No data available for SIGNOR curated interactions for RAD54L Gene
Transcripts for RAD54L Gene
mRNA/cDNA for RAD54L Gene
- 3 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000371975 3078 nts (view in UCSC)
- ENST00000442598 2549 nts (view in UCSC)
- ENST00000459678 775 nts (view in UCSC)
- ENST00000463715 718 nts (view in UCSC)
- ENST00000469835 670 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD54L - Select products 50% OFF >
- * RAD54L CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAD54L
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD54L
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD54L
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD54L
- Browse OriGene Inhibitory RNA Products For RAD54L
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD54L
Clone Products
- Applied Biological Materials (abm): Clones for RAD54L - Select products 50% OFF >
- * RAD54L as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG210443
- MG221567
- MG221645
- MR210443
- MR210443L3
- MR210443L4
- MR221567
- MR221567L3
- MR221567L4
- MR221645
- MR221645L3
- MR221645L4
- RC220046
- RC220046L1
- RC220046L2
- RC220046L3
- RC220046L4
- RC227119
- RC227119L3
- RC227119L4
- RG220046
- RG227119
- RR209078
- RR209078L3
- RR209078L4
- MR210443L3V
- MR210443L4V
- MR221567L3V
- MR221567L4V
- MR221645L3V
- MR221645L4V
- RC220046L1V
- RC220046L2V
- RC220046L3V
- RC220046L4V
- RC227119L3V
- RC227119L4V
- RR209078L3V
- RR209078L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD54L
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD54L
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15a | · | 15b | ^ | 16 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for RAD54L Gene
- GeneLoc Exon Structure for
- RAD54L
Expression for RAD54L Gene
mRNA differential expression in normal tissues according to GTEx for RAD54L Gene
This gene is overexpressed in Testis (x6.9).
This gene is overexpressed in Cerebrospinal fluid (35.2), Neutrophil (15.3), Colon (7.2), and Synovial fluid (6.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD54L Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAD54L
SOURCE GeneReport for Unigene cluster for RAD54L Gene:
Hs.642042Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD54L Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- immune
- integumentary
- reproductive
- skeletal muscle
Regions:
Thorax:
- breast
General:
- blood
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for RAD54L
-
OriGene qPCR primer pairs and template standards for RAD54L
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Evidence on tissue expression from TISSUES for RAD54L Gene
Orthologs for RAD54L Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAD54L 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAD54L 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAD54L 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rad54l 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rad54l 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RAD54L 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAD54L 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RAD54L 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAD54L 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rad54l 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rad54l 30 31 |
|
OneToOne | |
| zgc56289 30 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP008748 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | okr 30 31 32 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | rad-54 30 31 |
|
OneToOne | |
| Y116A8C.13 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD54 30 31 33 |
|
OneToMany | |
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AEL297W 30 |
|
||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0A03069g 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RAD54 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os02g0762800 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU11255 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp54 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.1041 30 |
|
- Species where no ortholog for RAD54L was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAD54L Gene
- ENSEMBL:
- Gene Tree for RAD54L (if available)
- TreeFam:
- Gene Tree for RAD54L (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAD54L: view image
Paralogs for RAD54L Gene
Paralogs for RAD54L Gene
- RAD54B 5
- ERCC6 5
- ATRX 5
- CHD8 5
- CHD7 5
- CHD3 5
- CHD5 5
- CHD4 5
- ERCC6L 5
- CHD2 5
- CHD1 5
- CHD6 5
- CHD9 5
- ENSG00000285238 5
- RAD54L2 5
- SMARCA4 5
- SMARCA2 5
- SMARCAD1 5
- SMARCA5 5
- ENSG00000282034 5
- SRCAP 5
- ERCC6L2 5
- BTAF1 5
- INO80 5
- SMARCA1 5
- EP400 5
- HELLS 5
- CHD1L 5
- TTF2 5
- HLTF 5
- SHPRH 5
- ZRANB3 5
- SMARCAL1 5
- ENSG00000279765 5
(3) SIMAP similar genes for RAD54L Gene using alignment to 4 proteins:
- RAD54_HUMAN
- L8E913_HUMAN
- V9GYD3_HUMAN
- V9GYX6_HUMAN
Variants for RAD54L Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAD54L Gene
| SNP ID | Clinical significance and condition | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 801487 | Uncertain Significance: Non-Hodgkin lymphoma | 46,261,290(+) | G/C | MISSENSE_VARIANT | |
| 801488 | Likely Benign: Non-Hodgkin lymphoma | 46,261,382(+) | C/T | SYNONYMOUS_VARIANT | |
| 801489 | Uncertain Significance: Non-Hodgkin lymphoma | 46,277,816(+) | G/A | SPLICE_ACCEPTOR_VARIANT | |
| rs121908688 | Pathogenic: Colon adenocarcinoma. A colon adenocarcinoma sample | 46,250,097(+) | C/Ap.Pro63His | MISSENSE_VARIANT,FIVE_PRIME_UTR_VARIANT | |
| rs121908689 | Pathogenic: Non-Hodgkin lymphoma. A non-Hodgkin lymphoma sample | 46,272,758(+) | T/Ap.Val444Glu | MISSENSE_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2761743 | CNV | gain | 21179565 |
| esv3585930 | CNV | gain | 21293372 |
| esv3585931 | CNV | gain | 21293372 |
| nsv470711 | CNV | gain | 18288195 |
| nsv829748 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.88;
48.52% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD54L Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD54L Gene
Disorders for RAD54L Gene
(10) MalaCards diseases for RAD54L Gene - From: OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lymphoma, non-hodgkin, familial |
|
|
| breast ductal carcinoma |
|
|
| colon adenocarcinoma |
|
|
| breast cancer |
|
|
| choroid plexus cancer |
|
|
Search RAD54L in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAD54L
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAD54L Gene
Publications for RAD54L Gene
- Homologous DNA pairing by human recombination factors Rad51 and Rad54. (PMID: 12205100) Sigurdsson S … Sung P (The Journal of biological chemistry 2002) 3 4 23
- The architecture of the human Rad54-DNA complex provides evidence for protein translocation along DNA. (PMID: 11459989) Ristic D … Kanaar R (Proceedings of the National Academy of Sciences of the United States of America 2001) 3 4 23
- Characterization of the human homologue of RAD54: a gene located on chromosome 1p32 at a region of high loss of heterozygosity in breast tumors. (PMID: 9192813) Rasio D … Croce CM (Cancer research 1997) 3 4 23
- Human and mouse homologs of the Saccharomyces cerevisiae RAD54 DNA repair gene: evidence for functional conservation. (PMID: 8805304) Kanaar R … Hoeijmakers JH (Current biology : CB 1996) 2 3 4
- Comprehensive screen of genetic variation in DNA repair pathway genes and postmenopausal breast cancer risk. (PMID: 20496165) Monsees GM … Han J (Breast cancer research and treatment 2011) 3 41
ExternalLinks
Products for RAD54L Gene
- Custom Antibody ServicesOriGene Antibodies for RAD54L
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD54L
- Origene Custom Protein Services for RAD54L
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD54L
- Browse OriGene Inhibitory RNA Products For RAD54L
- OriGene qPCR primer pairs for RAD54L
- OriGene qPCR primer pairs and template standards for RAD54L
- OriGene CRISPR knockouts for RAD54L
- MG210443
- MG221567
- MG221645
- MR210443
- MR210443L3
- MR210443L4
- MR221567
- MR221567L3
- MR221567L4
- MR221645
- MR221645L3
- MR221645L4
- RC220046
- RC220046L1
- RC220046L2
- RC220046L3
- RC220046L4
- RC227119
- RC227119L3
- RC227119L4
- RG220046
- RG227119
- RR209078
- RR209078L3
- RR209078L4
- MR210443L3V
- MR210443L4V
- MR221567L3V
- MR221567L4V
- MR221645L3V
- MR221645L4V
- RC220046L1V
- RC220046L2V
- RC220046L3V
- RC220046L4V
- RC227119L3V
- RC227119L4V
- RR209078L3V
- RR209078L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RAD54L
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- Novus Biologicals proteins and lysates for RAD54L
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- Taconic Biosciences Mouse Models for RAD54L
- Find your next knockout model in the Taconic Knockout Repository
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- Invitrogen Antibodies for RAD54L (AFLGC-RAD54L)
- VectorBuilder Custom and pre-made DNA vectors for RAD54L (ie. gene expression, shRNA knockdown, CRISPR)
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- antibodies-online: Show 36 available RAD54L Antibodies ranked by validation data
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- antibodies-online: Show 5 available RAD54L Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for RAD54L
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- Horizon Cell Lines for RAD54L
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD54L
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD54L
- Biorbyt antibodies for RAD54L
Sources for RAD54L Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
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- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
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- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB