The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombinatio... See more...

Aliases for RAD52 Gene

Aliases for RAD52 Gene

  • RAD52 Homolog, DNA Repair Protein 2 3 5
  • DNA Repair Protein RAD52 Homolog 3 4
  • Rhabdomyosarcoma Antigen MU-RMS-40.23 3
  • RAD52 (S. Cerevisiae) Homolog 2
  • RAD52 Homolog (S. Cerevisiae) 2
  • Recombination Protein RAD52 3

External Ids for RAD52 Gene

Previous GeneCards Identifiers for RAD52 Gene

  • GC12M000841
  • GC12M000891
  • GC12M001021

Summaries for RAD52 Gene

Entrez Gene Summary for RAD52 Gene

  • The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

GeneCards Summary for RAD52 Gene

RAD52 (RAD52 Homolog, DNA Repair Protein) is a Protein Coding gene. Diseases associated with RAD52 include Werner Syndrome and Rothmund-Thomson Syndrome, Type 2. Among its related pathways are Metabolism of proteins and miRNAs involved in DNA damage response. Gene Ontology (GO) annotations related to this gene include identical protein binding and recombinase activity.

UniProtKB/Swiss-Prot Summary for RAD52 Gene

  • Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase.

Gene Wiki entry for RAD52 Gene

Additional gene information for RAD52 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD52 Gene

Genomics for RAD52 Gene

GeneHancer (GH) Regulatory Elements for RAD52 Gene

Promoters and enhancers for RAD52 Gene