The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and st... See more...

Aliases for RAD51 Gene

Aliases for RAD51 Gene

  • RAD51 Recombinase 2 3 5
  • BRCA1/BRCA2-Containing Complex, Subunit 5 2 3
  • DNA Repair Protein RAD51 Homolog 1 3 4
  • RAD51 Homolog A 3 4
  • HRAD51 3 4
  • RAD51A 3 4
  • RECA 3 4
  • RAD51 Homolog (RecA Homolog, E. Coli) (S. Cerevisiae) 2
  • RAD51 (S. Cerevisiae) Homolog (E Coli RecA Homolog) 2
  • RAD51 Homolog (S. Cerevisiae) 2
  • RecA, E. Coli, Homolog Of 3
  • Recombination Protein A 3
  • RecA-Like Protein 3
  • HsT16930 3
  • HsRad51 3
  • HsRAD51 4
  • BRCC5 3
  • FANCR 3
  • MRMV2 3

External Ids for RAD51 Gene

Previous HGNC Symbols for RAD51 Gene

  • RAD51A
  • RECA

Previous GeneCards Identifiers for RAD51 Gene

  • GC15P036354
  • GC15P033883
  • GC15P038566
  • GC15P038703
  • GC15P038774
  • GC15P040987
  • GC15P017834

Summaries for RAD51 Gene

Entrez Gene Summary for RAD51 Gene

  • The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]

GeneCards Summary for RAD51 Gene

RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include Fanconi Anemia, Complementation Group R and Mirror Movements 2. Among its related pathways are Meiosis and DNA Damage Response. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is DMC1.

UniProtKB/Swiss-Prot Summary for RAD51 Gene

  • Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).

Tocris Summary for RAD51 Gene

  • The syntheses of RNA (transcription), DNA and proteins (translation) are fundamental processes necessary for all life. Transcription begins by uncoiling a section of DNA that will be used as the template and is initiated by RNA polymerase binding to a promoter sequence.

Gene Wiki entry for RAD51 Gene

Additional gene information for RAD51 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD51 Gene

Genomics for RAD51 Gene

GeneHancer (GH) Regulatory Elements for RAD51 Gene

Promoters and enhancers for RAD51 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAD51 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAD51 gene promoter:
  • C/EBPbeta
  • Elk-1
  • Meis-1
  • Meis-1a
  • Meis-1b
  • p53
  • TBP
  • TGIF

Genomic Locations for RAD51 Gene

Genomic Locations for RAD51 Gene
chr15:40,694,774-40,732,340
(GRCh38/hg38)
Size:
37,567 bases
Orientation:
Plus strand
chr15:40,986,972-41,024,356
(GRCh37/hg19)
Size:
37,385 bases
Orientation:
Plus strand

Genomic View for RAD51 Gene

Genes around RAD51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD51 Gene

Proteins for RAD51 Gene

  • Protein details for RAD51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q06609-RAD51_HUMAN
    Recommended name:
    DNA repair protein RAD51 homolog 1
    Protein Accession:
    Q06609
    Secondary Accessions:
    • B0FXP0
    • B2R8T6
    • Q6FHX9
    • Q6ZNA8
    • Q9BV60

    Protein attributes for RAD51 Gene

    Size:
    339 amino acids
    Molecular mass:
    36966 Da
    Quaternary structure:
    • Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). Interacts with FBH1 (PubMed:23393192). Interacts with POLN (PubMed:19995904). Interacts with RFWD3 (PubMed:28575658). Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (PubMed:23401855).

    Three dimensional structures from OCA and Proteopedia for RAD51 Gene

    Alternative splice isoforms for RAD51 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD51 Gene

Post-translational modifications for RAD51 Gene

  • Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination (PubMed:28575658).
  • Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
  • Ubiquitination at Lys58, Lys64, and Lys156
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RAD51

No data available for DME Specific Peptides for RAD51 Gene

Domains & Families for RAD51 Gene

Gene Families for RAD51 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAD51 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ78599 (Q6ZNA8_HUMAN)
  • RAD51 homolog A (RAD51_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q06609

UniProtKB/Swiss-Prot:

RAD51_HUMAN :
  • The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
  • Belongs to the RecA family. RAD51 subfamily.
Domain:
  • The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
Family:
  • Belongs to the RecA family. RAD51 subfamily.
genes like me logo Genes that share domains with RAD51: view

Function for RAD51 Gene

Molecular function for RAD51 Gene

UniProtKB/Swiss-Prot Function:
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
UniProtKB/Swiss-Prot Induction:
Stress-induced increase in the mitochondrial levels is seen.
GENATLAS Biochemistry:
yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor prognosis,uncommonly associated with parathyroid tumorigenesis

Phenotypes From GWAS Catalog for RAD51 Gene

Gene Ontology (GO) - Molecular Function for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000150 recombinase activity IBA 21873635
GO:0000166 nucleotide binding IEA --
GO:0003677 DNA binding IEA --
GO:0003682 chromatin binding IDA 23401855
GO:0003690 double-stranded DNA binding IBA,IMP 26681308
genes like me logo Genes that share ontologies with RAD51: view
genes like me logo Genes that share phenotypes with RAD51: view

Human Phenotype Ontology for RAD51 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for RAD51 Gene

MGI Knock Outs for RAD51:

Animal Model Products

CRISPR Products

miRNA for RAD51 Gene

miRTarBase miRNAs that target RAD51

Clone Products

  • Addgene plasmids for RAD51

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAD51 Gene

Localization for RAD51 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD51 Gene

Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). {ECO:0000269 PubMed:20154705, ECO:0000269 PubMed:23401855, ECO:0000269 PubMed:23509288, ECO:0000269 PubMed:23754376}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD51 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
cytoskeleton 3
plasma membrane 1
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (4)
  • Cytosol (3)
  • Mitochondria (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000228 nuclear chromosome IDA 23754376
GO:0000784 nuclear chromosome, telomeric region IDA 21076401
GO:0000785 chromatin IDA 25585578
GO:0000790 nuclear chromatin IDA 26323318
GO:0000793 condensed chromosome ISS --
genes like me logo Genes that share ontologies with RAD51: view

Pathways & Interactions for RAD51 Gene

genes like me logo Genes that share pathways with RAD51: view

Pathways by source for RAD51 Gene

5 Qiagen pathways for RAD51 Gene
  • ATM Pathway
  • BRCA1 Pathway
  • DNA Repair Mechanisms
  • Fanconi's Anaemia Pathway
  • Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for RAD51 Gene
1 GeneTex pathway for RAD51 Gene

SIGNOR curated interactions for RAD51 Gene

Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RAD51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000722 telomere maintenance via recombination ISS 21076401
GO:0000724 double-strand break repair via homologous recombination IDA,TAS 12427746
GO:0000730 DNA recombinase assembly IMP 26681308
GO:0001932 regulation of protein phosphorylation IMP --
GO:0006259 DNA metabolic process IEA --
genes like me logo Genes that share ontologies with RAD51: view

Drugs & Compounds for RAD51 Gene

(47) Drugs for RAD51 Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Rucaparib Approved, Investigational Pharma PARP inhibitor, PARP Inhibitors, Other 48
Adenosine 5'-[γ-thio]triphosphate Experimental Pharma Target, Target, Target 0
dATP Experimental Pharma Full agonist, Agonist, Target, Target 0
Phosphoaminophosphonic Acid-Adenylate Ester Experimental Pharma Target 0
Tetrafluoroaluminate Ion Experimental Pharma Target 0

(24) Additional Compounds for RAD51 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(2) ApexBio Compounds for RAD51 Gene

Compound Action Cas Number
RI-1 RAD51 inhibitor,cell-permeable 415713-60-9
RI-2 Optimized reversible RAD51 inhibitor 1417162-36-7
genes like me logo Genes that share compounds with RAD51: view

Transcripts for RAD51 Gene

CRISPR Products

Clone Products

  • Addgene plasmids for RAD51

Alternative Splicing Database (ASD) splice patterns (SP) for RAD51 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b
SP1: - - -
SP2: - - -
SP3: - - - -
SP4: -
SP5:

Relevant External Links for RAD51 Gene

GeneLoc Exon Structure for
RAD51
ECgene alternative splicing isoforms for
RAD51

Expression for RAD51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAD51 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD51 Gene

This gene is overexpressed in Testis (x9.7).

Protein differential expression in normal tissues from HIPED for RAD51 Gene

This gene is overexpressed in Fetal Brain (17.3), Testis (15.4), Adrenal (13.8), and Blymphocyte (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD51 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAD51 Gene:

RAD51

SOURCE GeneReport for Unigene cluster for RAD51 Gene:

Hs.631709

mRNA Expression by UniProt/SwissProt for RAD51 Gene:

Q06609-RAD51_HUMAN
Tissue specificity: Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.

Evidence on tissue expression from TISSUES for RAD51 Gene

  • Nervous system(4.4)
  • Blood(2)
  • Intestine(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD51 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
Regions:
Head and neck:
  • brain
  • cerebellum
  • head
Thorax:
  • breast
Limb:
  • hand
  • upper limb
genes like me logo Genes that share expression patterns with RAD51: view

No data available for Protein tissue co-expression partners for RAD51 Gene

Orthologs for RAD51 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD51 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAD51 33 32
  • 99.8 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAD51 33 32
  • 94.2 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAD51 33 32
  • 93.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rad51 32
  • 91.45 (n)
mouse
(Mus musculus)
Mammalia Rad51 17 33 32
  • 91.05 (n)
oppossum
(Monodelphis domestica)
Mammalia RAD51 33
  • 86 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAD51 33
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAD51A 33
  • 85 (a)
OneToOne
RAD51 32
  • 81.51 (n)
lizard
(Anolis carolinensis)
Reptilia RAD51 33
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rad51 32
  • 79.27 (n)
African clawed frog
(Xenopus laevis)
Amphibia rad51-prov 32
zebrafish
(Danio rerio)
Actinopterygii rad51 33 32
  • 77.31 (n)
OneToOne
wufb38e12 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3942 32
fruit fly
(Drosophila melanogaster)
Insecta Rad51 34
  • 68 (a)
spn-A 33 32
  • 65.11 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP013412 32
  • 67.27 (n)
worm
(Caenorhabditis elegans)
Secernentea rad-51 33 34 32
  • 58.19 (n)
OneToOne
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E20241g 32
  • 64.56 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ACR226W 32
  • 63.71 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD51 35 33 32
  • 60.2 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RAD51 32
  • 66.05 (n)
rice
(Oryza sativa)
Liliopsida Os12g0497300 32
  • 66.46 (n)
Os.19630 32
wheat
(Triticum aestivum)
Liliopsida Ta.7197 32
corn
(Zea mays)
Liliopsida Zm.631 32
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes rhp51 32
  • 66.27 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3685 33
  • 66 (a)
OneToOne
Cin.7666 32
bread mold
(Neurospora crassa)
Ascomycetes NCU02741 32
  • 65.29 (n)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.7666 32
Species where no ortholog for RAD51 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAD51 Gene

ENSEMBL:
Gene Tree for RAD51 (if available)
TreeFam:
Gene Tree for RAD51 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAD51: view image

Paralogs for RAD51 Gene

Paralogs for RAD51 Gene

(20) SIMAP similar genes for RAD51 Gene using alignment to 6 proteins:

  • RAD51_HUMAN
  • E9PI54_HUMAN
  • E9PJ30_HUMAN
  • E9PNT5_HUMAN
  • H0YD61_HUMAN
  • Q9NZG9_HUMAN
genes like me logo Genes that share paralogs with RAD51: view

Variants for RAD51 Gene

Sequence variations from dbSNP and Humsavar for RAD51 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1057519413 pathogenic, Fanconi anemia, complementation group R, Inborn genetic diseases, Fanconi anemia, complementation group R (FANCR) [MIM:617244] 40,729,955(+) G/A coding_sequence_variant, intron_variant, missense_variant
rs121917739 pathogenic, Familial cancer of breast, Breast cancer (BC) [MIM:114480] 40,718,818(+) G/A coding_sequence_variant, missense_variant
rs1555429623 pathogenic, Mirror movements 2 40,729,609(+) G/A coding_sequence_variant, missense_variant
rs1555429629 likely-pathogenic, Fanconi anemia, complementation group R 40,729,632(+) G/A coding_sequence_variant, missense_variant
rs1801320 risk-factor, Breast cancer, susceptibility to, in BRCA1 and BRCA2 carriers 40,695,330(+) G/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RAD51 Gene

Variant ID Type Subtype PubMed ID
esv2478123 CNV deletion 19546169
esv2760026 CNV loss 17122850
esv3636229 CNV loss 21293372
esv3636230 CNV loss 21293372
nsv527234 CNV loss 19592680
nsv529030 CNV loss 19592680
nsv832984 CNV loss 17160897

Variation tolerance for RAD51 Gene

Residual Variation Intolerance Score: 39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.88; 18.35% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAD51 Gene

Human Gene Mutation Database (HGMD)
RAD51
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD51

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51 Gene

Disorders for RAD51 Gene

MalaCards: The human disease database

(26) MalaCards diseases for RAD51 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
fanconi anemia, complementation group r
  • fancr
mirror movements 2
  • mrmv2
breast cancer
  • breast cancer, familial