Aliases for RAD51 Gene
Aliases for RAD51 Gene
External Ids for RAD51 Gene
- HGNC: 9817
- Entrez Gene: 5888
- Ensembl: ENSG00000051180
- OMIM: 179617
- UniProtKB: Q06609
Previous HGNC Symbols for RAD51 Gene
- RAD51A
- RECA
Previous GeneCards Identifiers for RAD51 Gene
- GC15P036354
- GC15P033883
- GC15P038566
- GC15P038703
- GC15P038774
- GC15P040987
- GC15P017834
Summaries for RAD51 Gene
-
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for RAD51 Gene
RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include Fanconi Anemia, Complementation Group R and Mirror Movements 2. Among its related pathways are Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) and Homologous DNA Pairing and Strand Exchange. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding.
UniProtKB/Swiss-Prot for RAD51 Gene
-
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
-
The syntheses of RNA (transcription), DNA and proteins (translation) are fundamental processes necessary for all life. Transcription begins by uncoiling a section of DNA that will be used as the template and is initiated by RNA polymerase binding to a promoter sequence.
Additional gene information for RAD51 Gene
- Monarch Initiative
- Search for RAD51 at DataMed
- Search for RAD51 at HumanCyc
No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD51 Gene
Genomics for RAD51 Gene
GeneHancer (GH) Regulatory Elements for RAD51 Gene
Promoters and enhancers for RAD51 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RAD51 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Locations for RAD51 Gene
Genomic Locations for RAD51 Gene
- chr15:40,694,774-40,732,339
- (GRCh38/hg38)
- Size:
- 37,566 bases
- Orientation:
- Plus strand
- chr15:40,986,972-41,024,356
- (GRCh37/hg19)
Genomic View for RAD51 Gene
Genes around RAD51 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by Ensembl
- 15q15.1 by Entrez Gene
- 15q15.1 by HGNC
RAD51 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD51 Gene
Proteins for RAD51 Gene
-
Protein details for RAD51 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06609-RAD51_HUMAN
- Recommended name:
- DNA repair protein RAD51 homolog 1
- Protein Accession:
- Q06609
- B0FXP0
- B2R8T6
- Q6FHX9
- Q6ZNA8
- Q9BV60
Protein attributes for RAD51 Gene
- Size:
- 339 amino acids
- Molecular mass:
- 36966 Da
- Quaternary structure:
-
- Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). Interacts with FBXO18/FBH1 (PubMed:23393192). Interacts with POLN (PubMed:19995904). Interacts with RFWD3 (PubMed:28575658).
Three dimensional structures from OCA and Proteopedia for RAD51 Gene
Protein Expression for RAD51 Gene
Post-translational modifications for RAD51 Gene
- Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
- Ubiquitinated by the SCF(FBXO18) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination (PubMed:28575658).
- Ubiquitination at Lys58 and Lys156
Other Protein References for RAD51 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Cell Signaling Technology (CST) Antibodies for RAD51 (RAD51)
-
Custom Antibody ServicesOriGene Antibodies for RAD51
- Novus Biologicals Antibodies for RAD51
-
Abcam antibodies for RAD51
-
Cloud-Clone Corp. Antibodies for RAD51
- Invitrogen Antibodies for RAD51
- antibodies-online: Search results for 225 available RAD51 Antibodies ranked by validation data
- Compare Top RAD51 Antibodies
-
Recommended
- 2 IHC (p) Antibodies (anti-rat)
- 3 IP Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 46 WB Antibodies (anti-rat)
- 1 IF Antibody (anti-human)
- 3 IP Antibodies (anti-human)
- 5 IHC Antibodies (anti-human)
- 8 IHC (p) Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 161 WB Antibodies (anti-human)
- 2 IHC Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 87 WB Antibodies (anti-mouse)
- GeneTex RAD51 antibody for RAD51
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD51
- Sino Biological Antibodies for RAD51
Protein Products
-
OriGene Purified Proteins for RAD51
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD51
- Origene Custom Protein Services for RAD51
-
Cloud-Clone Corp. Proteins for RAD51
- Search GeneTex for Proteins for RAD51
-
Abcam proteins for RAD51
Assay Products
-
Cloud-Clone Corp. Assay Kits for RAD51
No data available for DME Specific Peptides for RAD51 Gene
Domains & Families for RAD51 Gene
Gene Families for RAD51 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for RAD51 Gene
Suggested Antigen Peptide Sequences for RAD51 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q06609UniProtKB/Swiss-Prot:
RAD51_HUMAN :- The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
- Belongs to the RecA family. RAD51 subfamily.
- Domain:
-
- The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
- Family:
-
- Belongs to the RecA family. RAD51 subfamily.
Function for RAD51 Gene
Molecular function for RAD51 Gene
- GENATLAS Biochemistry:
- yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor prognosis,uncommonly associated with parathyroid tumorigenesis
- UniProtKB/Swiss-Prot Function:
- Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
- UniProtKB/Swiss-Prot Induction:
- Stress-induced increase in the mitochondrial levels is seen.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000150 | recombinase activity | IBA | -- |
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0000400 | four-way junction DNA binding | IBA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IEA | -- |
Phenotypes for RAD51 Gene
- MGI mutant phenotypes for RAD51:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RAD51:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability in esophageal squamous lineage
- Decreased NF-kappaB reporter expression
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased homologous recombination repair frequency
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Decreased infection with West Nile virus (WNV)
- Decreased West Nile virus (WNV) infection
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased cell number
- Decreased viability of wild-type and TP53 knockout cells
- Synthetic lethal with cisplatin
- Decreased viability
- Decreased viability with cisplatin
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAD51
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RAD51 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD51 gene
- Search ViGene Biosciences for RAD51
CRISPR Products
-
OriGene CRISPR knockouts for RAD51
- genomics-online: gRNA clones - Search results for 79 available RAD51 gene related products
- Overview of 79 available RAD51 gene related products
- Applied Biological Materials CRISPR for RAD51
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD51
- GenScript: Design CRISPR guide RNA sequences for RAD51
miRNA for RAD51 Gene
- miRTarBase miRNAs that target RAD51
-
- hsa-mir-197-3p (MIRT003819)
- hsa-mir-96-5p (MIRT006780)
- hsa-mir-193b-3p (MIRT016582)
- hsa-mir-124-3p (MIRT023031)
- hsa-mir-215-5p (MIRT024626)
- hsa-mir-192-5p (MIRT026888)
- hsa-mir-103a-3p (MIRT027144)
- hsa-mir-92a-1-5p (MIRT038926)
- hsa-mir-23b-3p (MIRT046358)
- hsa-mir-155-5p (MIRT054639)
- hsa-mir-107 (MIRT438264)
- hsa-mir-221-3p (MIRT438601)
- hsa-mir-3149 (MIRT453413)
- hsa-mir-4775 (MIRT453414)
- hsa-mir-4735-5p (MIRT453415)
- hsa-mir-6872-3p (MIRT453416)
- hsa-mir-590-3p (MIRT453417)
- hsa-mir-6780a-5p (MIRT521437)
- hsa-mir-6779-5p (MIRT521438)
- hsa-mir-3689c (MIRT521439)
- hsa-mir-3689b-3p (MIRT521440)
- hsa-mir-3689a-3p (MIRT521441)
- hsa-mir-30b-3p (MIRT521442)
- hsa-mir-1273h-5p (MIRT521443)
- hsa-mir-921 (MIRT521444)
- hsa-mir-142-3p (MIRT521445)
- hsa-mir-6073 (MIRT521446)
- hsa-mir-6799-5p (MIRT521447)
- hsa-mir-6883-5p (MIRT521448)
- hsa-mir-6785-5p (MIRT521449)
- hsa-mir-4728-5p (MIRT521450)
- hsa-mir-149-3p (MIRT521451)
- hsa-mir-7106-5p (MIRT521452)
- hsa-mir-6851-5p (MIRT521453)
- hsa-mir-3689d (MIRT521454)
- hsa-mir-571 (MIRT521455)
- hsa-mir-219a-1-3p (MIRT521456)
- hsa-mir-7854-3p (MIRT521457)
- hsa-mir-493-3p (MIRT521458)
- hsa-mir-3192-5p (MIRT521459)
- hsa-mir-3174 (MIRT521460)
- hsa-mir-7851-3p (MIRT521461)
- hsa-mir-490-3p (MIRT521462)
- hsa-mir-384 (MIRT609808)
- hsa-mir-3685 (MIRT609809)
- hsa-mir-7975 (MIRT609810)
- hsa-mir-5571-3p (MIRT609811)
- hsa-mir-4321 (MIRT609812)
- hsa-mir-575 (MIRT609813)
- hsa-mir-4676-5p (MIRT609814)
- hsa-mir-6858-3p (MIRT609815)
- hsa-mir-4279 (MIRT622521)
- hsa-mir-1976 (MIRT622522)
- hsa-mir-3653-5p (MIRT622523)
- hsa-mir-6747-3p (MIRT622524)
- hsa-mir-6727-3p (MIRT622525)
- hsa-mir-4722-3p (MIRT622526)
- hsa-mir-770-5p (MIRT622527)
- hsa-mir-4712-5p (MIRT622528)
- hsa-mir-6877-3p (MIRT622529)
- hsa-mir-6819-3p (MIRT622530)
- hsa-mir-328-3p (MIRT635121)
- hsa-mir-514b-5p (MIRT635122)
- hsa-mir-513c-5p (MIRT635123)
- hsa-mir-378a-5p (MIRT635124)
- hsa-mir-874-5p (MIRT635125)
- hsa-mir-4454 (MIRT635126)
- hsa-mir-6821-3p (MIRT635127)
- hsa-mir-6790-3p (MIRT635128)
- hsa-mir-372-5p (MIRT635129)
- hsa-mir-371a-5p (MIRT635130)
- hsa-mir-616-5p (MIRT635131)
- hsa-mir-373-5p (MIRT635132)
- hsa-mir-371b-5p (MIRT635133)
- hsa-mir-1224-3p (MIRT635134)
- hsa-mir-764 (MIRT635135)
- hsa-mir-6813-3p (MIRT635136)
- hsa-mir-6847-3p (MIRT638373)
- hsa-mir-4267 (MIRT638374)
- hsa-mir-548s (MIRT639203)
- hsa-mir-6864-3p (MIRT639204)
- hsa-mir-3672 (MIRT639205)
- hsa-mir-4684-5p (MIRT639206)
- hsa-mir-3926 (MIRT639207)
- hsa-mir-769-5p (MIRT639208)
- hsa-mir-4786-5p (MIRT639209)
- hsa-mir-3190-5p (MIRT639210)
- hsa-mir-6849-3p (MIRT639211)
- hsa-mir-3675-3p (MIRT639212)
- hsa-mir-6771-3p (MIRT639213)
- hsa-mir-212-5p (MIRT654495)
- hsa-mir-3934-5p (MIRT654496)
- hsa-mir-3925-3p (MIRT674232)
- hsa-mir-766-3p (MIRT674233)
- hsa-mir-498 (MIRT676531)
- hsa-mir-4726-3p (MIRT676532)
- hsa-mir-6764-5p (MIRT676533)
- hsa-mir-1915-3p (MIRT676534)
- hsa-mir-6840-3p (MIRT676535)
- hsa-mir-6514-3p (MIRT690919)
- hsa-mir-6771-5p (MIRT690920)
- hsa-mir-7977 (MIRT690921)
- hsa-mir-891a-3p (MIRT690922)
- hsa-mir-550a-5p (MIRT690923)
- hsa-mir-550a-3-5p (MIRT690924)
- hsa-mir-1271-3p (MIRT690925)
- hsa-mir-4294 (MIRT690926)
- hsa-mir-564 (MIRT690927)
- hsa-mir-6811-3p (MIRT690928)
- hsa-mir-214-5p (MIRT690929)
- hsa-mir-6746-5p (MIRT690930)
- hsa-mir-5690 (MIRT690931)
- hsa-mir-6767-3p (MIRT690932)
- mmu-mir-193b-3p (MIRT733667)
- hsa-mir-34a-5p (MIRT733962)
- hsa-mir-122-3p (MIRT736080)
- hsa-mir-25-3p (MIRT739366)
- hsa-mir-32-5p (MIRT741259)
- hsa-mir-363-3p (MIRT741811)
- hsa-mir-367-3p (MIRT742127)
- hsa-mir-377-5p (MIRT742711)
- hsa-mir-4325 (MIRT744083)
- hsa-mir-4537 (MIRT746103)
- hsa-mir-4710 (MIRT747420)
- hsa-mir-4792 (MIRT748922)
- hsa-mir-508-5p (MIRT749620)
- hsa-mir-6086 (MIRT751864)
- hsa-mir-7703 (MIRT759718)
- hsa-mir-7847-3p (MIRT759865)
- hsa-mir-7855-5p (MIRT759956)
- hsa-mir-92a-3p (MIRT760629)
- hsa-mir-92b-3p (MIRT760657)
- hsa-mir-1207-5p (MIRT761267)
- hsa-mir-1228-3p (MIRT761435)
- hsa-mir-1301-5p (MIRT762398)
- hsa-mir-1909-3p (MIRT763248)
- hsa-mir-3160-3p (MIRT765139)
- hsa-mir-4487 (MIRT769677)
- hsa-mir-455-3p (MIRT770403)
- hsa-mir-4763-3p (MIRT772024)
- hsa-mir-558 (MIRT774849)
- hsa-mir-6499-3p (MIRT776348)
- hsa-mir-6502-5p (MIRT776562)
- hsa-mir-6516-5p (MIRT777197)
- hsa-mir-6722-3p (MIRT777837)
- hsa-mir-6808-5p (MIRT779698)
- hsa-mir-6893-5p (MIRT781231)
- hsa-mir-940 (MIRT782925)
miRNA Products
- Search ViGene Biosciences for RAD51
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RAD51
- Browse OriGene Inhibitory RNA Products For RAD51
- genomics-online: shRNA clones - Search results for 79 available RAD51 gene related products
- Overview of 79 available RAD51 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD51 gene
Clone Products
-
OriGene ORF clones in human for RAD51
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD51
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RAD51
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD51
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RAD51
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
-
Cloud-CloneCorp. cDNA clones for RAD51
- Browse primers at Cloud-Clone Corp.
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RAD51 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RAD51 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD51 gene
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Transcription Factor Targets and HOMER Transcription for RAD51 Gene
Localization for RAD51 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD51 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage. DNA damage induces an increase in nuclear levels. Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment. Accumulated at sites of DNA damage in a SPIDR-dependent manner. {ECO:0000269 PubMed:20154705, ECO:0000269 PubMed:23754376, ECO:0000269 PubMed:26681308}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 4 |
| extracellular | 2 |
| plasma membrane | 1 |
- Nucleoli (4)
- Cytosol (3)
- Mitochondria (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 23754376 |
| GO:0000784 | nuclear chromosome, telomeric region | IDA,IEA | 21076401 |
| GO:0000785 | chromatin | IDA | 25585578 |
| GO:0000790 | nuclear chromatin | IDA | 26323318 |
| GO:0000793 | condensed chromosome | ISS,IEA | -- |
Pathways & Interactions for RAD51 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Homologous DNA Pairing and Strand Exchange | ||
| 4 | ATM Pathway |
.47
|
|
| 5 | BRCA1 Pathway | ||
Pathways by source for RAD51 Gene
1 GeneTex pathway for RAD51 Gene
1 Cell Signaling Technology pathway for RAD51 Gene
7 BioSystems pathways for RAD51 Gene
4 KEGG pathways for RAD51 Gene
1 GeneGo (Thomson Reuters) pathway for RAD51 Gene
5 Qiagen pathways for RAD51 Gene
Interacting Proteins for RAD51 Gene
Selected Interacting proteins:
ENSP00000372088
Q06609-RAD51_HUMAN
for RAD51 Gene via
STRING
MINT
UniProtKB
IID
SIGNOR curated interactions for RAD51 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000722 | telomere maintenance via recombination | IEA,ISS | 21076401 |
| GO:0000724 | double-strand break repair via homologous recombination | TAS,IDA | 12427746 |
| GO:0000730 | DNA recombinase assembly | IMP | 26681308 |
| GO:0000731 | DNA synthesis involved in DNA repair | TAS | -- |
| GO:0000732 | strand displacement | TAS | -- |
Drugs & Compounds for RAD51 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rucaparib | Approved, Investigational | Pharma | PARP inhibitor, PARP Inhibitors, Other | 23 | ||
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| amuvatinib | Investigational | Pharma | Target, inhibitor | Kinase Inhibitors, c-MET/hepatocyte growth factor receptor (HGFR) pathway inhibitors | 0 | |
| Poly(ADP-ribose) Polymerase Inhibitors | Pharma | 389 | ||||
| RI-1 | Pharma | RAD51 inhibitor,cell-permeable | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for RAD51 Gene
Transcripts for RAD51 Gene
mRNA/cDNA for RAD51 Gene
- (11) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (118) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RAD51 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RAD51
- genomics-online: gRNA clones - Search results for 79 available RAD51 gene related products
- Overview of 79 available RAD51 gene related products
- Applied Biological Materials CRISPR for RAD51
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD51
- GenScript: Design CRISPR guide RNA sequences for RAD51
miRNA Products
- Search ViGene Biosciences for RAD51
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RAD51
- Browse OriGene Inhibitory RNA Products For RAD51
- genomics-online: shRNA clones - Search results for 79 available RAD51 gene related products
- Overview of 79 available RAD51 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD51 gene
Clone Products
-
OriGene ORF clones in human for RAD51
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD51
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for RAD51
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD51
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for RAD51
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
-
Cloud-CloneCorp. cDNA clones for RAD51
- Browse primers at Cloud-Clone Corp.
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: |
Expression for RAD51 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- XX Germ Cells Ovigerous Cord
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
- Oviduct
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
mRNA differential expression in normal tissues according to GTEx for RAD51 Gene
This gene is overexpressed in Testis (x9.7).
This gene is overexpressed in Fetal Brain (17.3), Testis (15.4), Adrenal (13.8), and Blymphocyte (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD51 Gene
NURSA nuclear receptor signaling pathways regulating expression of RAD51 Gene:
RAD51SOURCE GeneReport for Unigene cluster for RAD51 Gene:
Hs.631709mRNA Expression by UniProt/SwissProt for RAD51 Gene:
Q06609-RAD51_HUMAN
Tissue specificity:
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
Evidence on tissue expression from TISSUES for RAD51 Gene
- Nervous system(4.4)
- Intestine(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD51 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- head
Thorax:
- breast
Limb:
- hand
- upper limb
Primer Products
-
OriGene qPCR primer pairs for RAD51
-
OriGene qPCR primer pairs and template standards for RAD51
No data available for Protein tissue co-expression partners for RAD51 Gene
Orthologs for RAD51 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RAD51 33 34 |
|
||
| dog (Canis familiaris) |
Mammalia | RAD51 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RAD51 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rad51 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Rad51 33 16 34 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | RAD51 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | RAD51 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RAD51A 34 |
|
OneToOne | |
| RAD51 33 |
|
||||
| lizard (Anolis carolinensis) |
Reptilia | RAD51 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rad51 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rad51-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rad51 33 34 |
|
||
| wufb38e12 33 |
|
||||
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3942 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | Rad51 35 |
|
|
|
| spn-A 33 34 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013412 33 |
|
||
| worm (Caenorhabditis elegans) |
Secernentea | rad-51 35 33 34 |
|
||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20241g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACR226W 33 |
|
||
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD51 33 34 36 |
|
||
| thale cress (Arabidopsis thaliana) |
eudicotyledons | RAD51 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os12g0497300 33 |
|
||
| Os.19630 33 |
|
||||
| wheat (Triticum aestivum) |
Liliopsida | Ta.7197 33 |
|
||
| corn (Zea mays) |
Liliopsida | Zm.631 33 |
|
||
| fission yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp51 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3685 34 |
|
OneToOne | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU02741 33 |
|
||
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.7666 33 |
|
- Species where no ortholog for RAD51 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Paralogs for RAD51 Gene
(20) SIMAP similar genes for RAD51 Gene using alignment to 6 proteins:
No data available for Paralogs for RAD51 Gene
Variants for RAD51 Gene
| SNP ID | Clin | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057519413 | pathogenic, Fanconi anemia, complementation group R, anemia, complementation group R (FANCR) [MIM:617244] | 40,729,955(+) | G/A | coding_sequence_variant, intron_variant, missense_variant | |
| rs121917739 | pathogenic, Familial cancer of breast, Breast cancer (BC) [MIM:114480] | 40,718,818(+) | G/A | coding_sequence_variant, missense_variant | |
| rs1801320 | risk-factor, Breast cancer, susceptibility to, in BRCA1 and BRCA2 carriers | 40,695,330(+) | G/C | 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant | |
| rs199925463 | pathogenic, Mirror movements 2 | 40,729,620(+) | C/A/T | coding_sequence_variant, stop_gained, synonymous_variant | |
| rs34091239 | pathogenic, Mirror movements 2 | 40,729,928(+) | AAAAAA/AAAAA/AAAAAAA | coding_sequence_variant, frameshift, intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv832984 | CNV | loss | 17160897 |
| nsv529030 | CNV | loss | 19592680 |
| nsv527234 | CNV | loss | 19592680 |
| esv3636230 | CNV | loss | 21293372 |
| esv3636229 | CNV | loss | 21293372 |
| esv2760026 | CNV | loss | 17122850 |
| esv2478123 | CNV | deletion | 19546169 |
Residual Variation Intolerance Score:
39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD51 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51 Gene
Disorders for RAD51 Gene
(24) MalaCards diseases for RAD51 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group r |
|
|
| mirror movements 2 |
|
|
| breast cancer |
|
|
| mirror movements 1 |
|
|
| fanconi anemia, complementation group a |
|
Search RAD51 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RAD51_HUMAN- Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:10807537, ECO:0000269 PubMed:25539919}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.
- Fanconi anemia, complementation group R (FANCR) [MIM:617244]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:26253028, ECO:0000269 PubMed:26681308}. Note=The disease is caused by mutations affecting the gene represented in this entry.
- Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:22305526}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RAD51
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RAD51 Gene
Publications for RAD51 Gene
- A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PMID: 11535547) Wang WW … Struewing JP (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001) 3 4 22 44 58
- A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. (PMID: 26253028) Wang AT … Smogorzewska A (Molecular cell 2015) 2 3 4 58
- Physical interaction of RECQ5 helicase with RAD51 facilitates its anti-recombinase activity. (PMID: 20348101) Schwendener S … Janscak P (The Journal of biological chemistry 2010) 3 4 22 58
- Genetic variants of BLM interact with RAD51 to increase breast cancer susceptibility. (PMID: 18974064) Ding SL … Shen CY (Carcinogenesis 2009) 3 22 44 58
- Do BRCA1 modifiers also affect the risk of breast cancer in non-carriers? (PMID: 19071013) Jakubowska A … IHCC-Breast Cancer Study Group (European journal of cancer (Oxford, England : 1990) 2009) 3 22 44 58
Products for RAD51 Gene
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- Custom Antibody ServicesOriGene Antibodies for RAD51
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- Browse Primary Antibodies
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- Cloud-Clone Corp. Antibodies for RAD51
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- Cloud-Clone Corp. disease models service
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- Invitrogen Antibodies for RAD51
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- ApexBio compounds for RAD51
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAD51
- VectorBuilder custom plasmid, inducible vectors for RAD51
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD51
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 225 available RAD51 Antibodies ranked by validation data
- Compare Top RAD51 Antibodies
- Recommended
- 87 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 3 IHC (p) Antibodies (anti-mouse)
- 3 IP Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 161 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
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- 5 IHC Antibodies (anti-human)
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- antibodies-online: Search results for 6 available RAD51 Elisa Kits ranked by validation data
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- antibodies-online: Search results for 13 available RAD51 Proteins ranked by validation data
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- GeneTex RAD51 antibody for RAD51
- Search GeneTex for Proteins for RAD51
- ViGene Biosciences adenoviral particle packaged cDNA for RAD51 gene
- ViGene Biosciences lentiviral particle packaged cDNA for RAD51 gene
- ViGene Biosciences ready-to-package AAV shRNAs for RAD51 gene
- Search ViGene Biosciences for RAD51
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- genomics-online: cdna clones - Search results for 79 available RAD51 gene related products
- Overview of 79 available RAD51 gene related products
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- Overview of 79 available RAD51 gene related products
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- Overview of 79 available RAD51 gene related products
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- Overview of 79 available RAD51 gene related products