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The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and st... See more...
Aliases for RAD51 Gene
Aliases for RAD51 Gene
External Ids for RAD51 Gene
- HGNC: 9817
- NCBI Entrez Gene: 5888
- Ensembl: ENSG00000051180
- OMIM®: 179617
- UniProtKB/Swiss-Prot: Q06609
Previous HGNC Symbols for RAD51 Gene
- RAD51A
- RECA
Previous GeneCards Identifiers for RAD51 Gene
- GC15P036354
- GC15P033883
- GC15P038566
- GC15P038703
- GC15P038774
- GC15P040987
- GC15P017834
Summaries for RAD51 Gene
-
The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
GeneCards Summary for RAD51 Gene
RAD51 (RAD51 Recombinase) is a Protein Coding gene. Diseases associated with RAD51 include Fanconi Anemia, Complementation Group R and Mirror Movements 2. Among its related pathways are Cell Cycle, Mitotic and ATM Pathway. Gene Ontology (GO) annotations related to this gene include identical protein binding and protein C-terminus binding. An important paralog of this gene is DMC1.
UniProtKB/Swiss-Prot Summary for RAD51 Gene
-
Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
-
The syntheses of RNA (transcription), DNA and proteins (translation) are fundamental processes necessary for all life. Transcription begins by uncoiling a section of DNA that will be used as the template and is initiated by RNA polymerase binding to a promoter sequence.
Additional gene information for RAD51 Gene
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD51 Gene
Genomics for RAD51 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAD51 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAD51 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAD51
- Top Transcription factor binding sites by QIAGEN in the RAD51 gene promoter:
-
- C/EBPbeta
- Elk-1
- Meis-1
- Meis-1a
- Meis-1b
- p53
- TBP
- TGIF
Genomic Locations for RAD51 Gene
Latest Assembly
- chr15:40,694,774-40,732,340
- (GRCh38/hg38)
- Size:
- 37,567 bases
- Orientation:
- Plus strand
Previous Assembly
- chr15:40,987,372-41,024,538
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 37,167 bases
- Orientation:
- Plus strand
Genomic View for RAD51 Gene
Genes around RAD51 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 15q15.1 by HGNC
- 15q15.1 by Entrez Gene
- 15q15.1 by Ensembl
RAD51 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD51 Gene
Proteins for RAD51 Gene
-
Protein details for RAD51 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q06609-RAD51_HUMAN
- Recommended name:
- DNA repair protein RAD51 homolog 1
- Protein Accession:
- Q06609
- B0FXP0
- B2R8T6
- Q6FHX9
- Q6ZNA8
- Q9BV60
Protein attributes for RAD51 Gene
- Size:
- 339 amino acids
- Molecular mass:
- 36966 Da
- Quaternary structure:
-
- Forms linear homooligomers, giving rise to a RAD51 nucleoprotein filament, which is essential for strand-pairing reactions during DNA recombination. Interacts with BRCA1 and either directly or indirectly with p53. Interacts with XRCC3, RAD54L and RAD54B. Interacts with the BCDX2 subcomplex RAD51C:RAD51B. Interacts directly with PALB2 which may serve as a scaffold for a HR complex containing PALB2, BRCA2, RAD51C, RAD51 and XRCC3. Interacts with RAD51AP1 and RAD51AP2. Interacts with CHEK1, and this may require prior phosphorylation of CHEK1. Interacts with the MND1-PSMC3IP heterodimer. Found in a complex, at least composed of BLM, RAD51 and SPIDR; the complex formation is mediated by SPIDR. Interacts with SPIDR; the interaction is direct and recruits RAD51 to DNA damage sites. Interacts with FIGNL1 (via N-terminal one-half region); the interaction is direct. Interacts with RAD51AP1 (via C-terminal region); the interaction is direct. Interacts with NABP2, RPA1, PALB2 and RAD51. Interacts with SWI5/C9orf119, and at lower level with SFR1/MEIR5. Interacts with hyperphosphorylated RPA2; this interaction is necessary for efficient recruitment to chromatin in response to DNA damage. Interacts with SWSAP1; involved in homologous recombination repair. Interacts with PARPBP, BRCA2 and RECQL5; these interactions interfere with the formation of the RAD51-DNA homologous recombination structure. Interacts with POLQ; POLQ acts as an inhibitor of homology-recombination repair (HR) pathway by limiting RAD51 accumulation at resected ends (PubMed:25642963). Interacts with FBH1 (PubMed:23393192). Interacts with POLN (PubMed:19995904). Interacts with RFWD3 (PubMed:28575658). Interacts with the MCM8-MCM9 complex; the interaction recruits RAD51 to DNA damage sites (PubMed:23401855). Component of a multiprotein complex with MEIOB and SPATA22. Interacts with the complex BRME1:HSF2BP:BRCA2 (By similarity).
- Miscellaneous:
-
- [Isoform 3]: Mutagenesis of Arg-264 to Ala inhibits nuclear localization. Mutagenesis of Lys-264 to Gln inhibits nuclear localization. Deletion of 254-Arg-Lys-255 inhibits nuclear localization.
Three dimensional structures from OCA and Proteopedia for RAD51 Gene
Protein Expression for RAD51 Gene
Post-translational modifications for RAD51 Gene
- Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination (PubMed:28575658).
- Phosphorylated. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylation by ABL1 inhibits function.
-
Ubiquitination at Lys58, Lys64, and Lys156
- NX_Q06609 (NX_Q06609-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RAD51 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences RAD51 / RECA Monoclonal Antibody (LS-B2597) and RAD51 / RECA Monoclonal Antibody (LS-B4787)
- G Biosciences Immunotag™ RAD51 Antibody
- GeneTex Anti-Rad51 antibody [N1C2] and Anti-Rad51 antibody [14B4]
- NSJ Bioreagents RAD51 Antibody (Mouse Monoclonal)
-
Custom Antibody ServicesOriGene Antibodies for RAD51
- Novus Biologicals Antibodies for RAD51
-
Abcam antibodies for RAD51
- Invitrogen Antibodies for RAD51 (AFLGC-Rad51)
- antibodies-online: Show 163 available RAD51 Antibodies ranked by validation data
- Compare Top RAD51 Antibodies
-
Recommended
- 168 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 11 IHC Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 4 IP Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 40 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 4 IP Antibodies (anti-rat)
- 2 IHC (p) Antibodies (anti-rat)
- 94 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 5 IHC (p) Antibodies (anti-mouse)
- 4 IHC Antibodies (anti-mouse)
- 4 IP Antibodies (anti-mouse)
-
Boster Bio Antibodies for RAD51
-
Custom Antibody ServicesProSci Antibodies for RAD51
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD51
- Sino Biological Antibodies for RAD51
Protein products for research
- RayBiotech Recombinant Human RAD51
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD51
- Origene Custom Protein Services for RAD51
-
Abcam proteins for RAD51
Assay products for research
- antibodies-online: Show 4 available RAD51 Elisa Kits ranked by validation data
- Compare Top RAD51 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RAD51 Gene
Domains & Families for RAD51 Gene
Gene Families for RAD51 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for RAD51 Gene
- InterPro:
- Blocks:
-
- Helix-hairpin-helix DNA-binding, class 1
- Rad51, C-terminal
Suggested Antigen Peptide Sequences for RAD51 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ78599 (Q6ZNA8_HUMAN)
- RAD51 homolog A (RAD51_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q06609UniProtKB/Swiss-Prot:
RAD51_HUMAN :- The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
- Belongs to the RecA family. RAD51 subfamily.
- Domain:
-
- The nuclear localization may reside in the C-terminus (between 259 and 339 AA).
- Family:
-
- Belongs to the RecA family. RAD51 subfamily.
Function for RAD51 Gene
Molecular function for RAD51 Gene
- UniProtKB/Swiss-Prot Function:
- Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).
- UniProtKB/Swiss-Prot Induction:
- Stress-induced increase in the mitochondrial levels is seen.
- GENATLAS Biochemistry:
- yeast (S cerevisiae) RAD51 homolog A,colocalizing with RPA heterotrimeric ssDNA binding protein,complexing with phosphorylated BRCA1,BRCA2 and RAD52 for DNA repair of double strand breaks through homologous recombination,also involved in immunoglobulin switch recombination,not mutated ,deleted in breast cancer with poor prognosis,uncommonly associated with parathyroid tumorigenesis
Phenotypes From GWAS Catalog for RAD51 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000150 | recombinase activity | IBA | 21873635 |
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IDA | 23401855 |
| GO:0003690 | double-stranded DNA binding | IBA,IMP | 26681308 |
Phenotypes for RAD51 Gene
- MGI mutant phenotypes for RAD51:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RAD51:
-
- Decreased viability
- shRNA abundance <= 25%
- Reduced mammosphere formation
- no effect
- Increased viability with MLN4924 (a NAE inhibitor)
- Inconclusive
- Decreased shRNA abundance
- Increased cell death HMECs cells
- Decreased viability in ovarian lineage
- Negative genetic interaction between KRASG13D/+ and KRAS+/-
- Decreased West Nile virus (WNV) infection
- Decreased homologous recombination repair frequency
- Synthetic lethal with vaccinia virus (VACV) infection
- Synthetic lethal with cisplatin
- Decreased cell number
- Decreased infection with West Nile virus (WNV)
- Decreased viability of wild-type and TP53 knockout cells, decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Increased cell death in HCT116 cells
- Decreased viability with cisplatin
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RAD51 - Starting at $85 >
- * RAD51 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RAD51
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD51
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD51
miRNA for RAD51 Gene
- miRTarBase miRNAs that target RAD51
-
- hsa-miR-197-3p (MIRT003819)
- hsa-miR-96-5p (MIRT006780)
- hsa-miR-193b-3p (MIRT016582)
- hsa-miR-124-3p (MIRT023031)
- hsa-miR-215-5p (MIRT024626)
- hsa-miR-192-5p (MIRT026888)
- hsa-miR-103a-3p (MIRT027144)
- hsa-miR-92a-1-5p (MIRT038926)
- hsa-miR-23b-3p (MIRT046358)
- hsa-miR-155-5p (MIRT054639)
- hsa-miR-107 (MIRT438264)
- hsa-miR-221-3p (MIRT438601)
- hsa-miR-3149 (MIRT453413)
- hsa-miR-4775 (MIRT453414)
- hsa-miR-4735-5p (MIRT453415)
- hsa-miR-6872-3p (MIRT453416)
- hsa-miR-590-3p (MIRT453417)
- hsa-miR-6780a-5p (MIRT521437)
- hsa-miR-6779-5p (MIRT521438)
- hsa-miR-3689c (MIRT521439)
- hsa-miR-3689b-3p (MIRT521440)
- hsa-miR-3689a-3p (MIRT521441)
- hsa-miR-30b-3p (MIRT521442)
- hsa-miR-1273h-5p (MIRT521443)
- hsa-miR-921 (MIRT521444)
- hsa-miR-142-3p (MIRT521445)
- hsa-miR-6073 (MIRT521446)
- hsa-miR-6799-5p (MIRT521447)
- hsa-miR-6883-5p (MIRT521448)
- hsa-miR-6785-5p (MIRT521449)
- hsa-miR-4728-5p (MIRT521450)
- hsa-miR-149-3p (MIRT521451)
- hsa-miR-7106-5p (MIRT521452)
- hsa-miR-6851-5p (MIRT521453)
- hsa-miR-3689d (MIRT521454)
- hsa-miR-571 (MIRT521455)
- hsa-miR-219a-1-3p (MIRT521456)
- hsa-miR-7854-3p (MIRT521457)
- hsa-miR-493-3p (MIRT521458)
- hsa-miR-3192-5p (MIRT521459)
- hsa-miR-3174 (MIRT521460)
- hsa-miR-7851-3p (MIRT521461)
- hsa-miR-490-3p (MIRT521462)
- hsa-miR-384 (MIRT609808)
- hsa-miR-3685 (MIRT609809)
- hsa-miR-7975 (MIRT609810)
- hsa-miR-5571-3p (MIRT609811)
- hsa-miR-4321 (MIRT609812)
- hsa-miR-575 (MIRT609813)
- hsa-miR-4676-5p (MIRT609814)
- hsa-miR-6858-3p (MIRT609815)
- hsa-miR-4279 (MIRT622521)
- hsa-miR-1976 (MIRT622522)
- hsa-miR-3653-5p (MIRT622523)
- hsa-miR-6747-3p (MIRT622524)
- hsa-miR-6727-3p (MIRT622525)
- hsa-miR-4722-3p (MIRT622526)
- hsa-miR-770-5p (MIRT622527)
- hsa-miR-4712-5p (MIRT622528)
- hsa-miR-6877-3p (MIRT622529)
- hsa-miR-6819-3p (MIRT622530)
- hsa-miR-328-3p (MIRT635121)
- hsa-miR-514b-5p (MIRT635122)
- hsa-miR-513c-5p (MIRT635123)
- hsa-miR-378a-5p (MIRT635124)
- hsa-miR-874-5p (MIRT635125)
- hsa-miR-4454 (MIRT635126)
- hsa-miR-6821-3p (MIRT635127)
- hsa-miR-6790-3p (MIRT635128)
- hsa-miR-372-5p (MIRT635129)
- hsa-miR-371a-5p (MIRT635130)
- hsa-miR-616-5p (MIRT635131)
- hsa-miR-373-5p (MIRT635132)
- hsa-miR-371b-5p (MIRT635133)
- hsa-miR-1224-3p (MIRT635134)
- hsa-miR-764 (MIRT635135)
- hsa-miR-6813-3p (MIRT635136)
- hsa-miR-6847-3p (MIRT638373)
- hsa-miR-4267 (MIRT638374)
- hsa-miR-548s (MIRT639203)
- hsa-miR-6864-3p (MIRT639204)
- hsa-miR-3672 (MIRT639205)
- hsa-miR-4684-5p (MIRT639206)
- hsa-miR-3926 (MIRT639207)
- hsa-miR-769-5p (MIRT639208)
- hsa-miR-4786-5p (MIRT639209)
- hsa-miR-3190-5p (MIRT639210)
- hsa-miR-6849-3p (MIRT639211)
- hsa-miR-3675-3p (MIRT639212)
- hsa-miR-6771-3p (MIRT639213)
- hsa-miR-212-5p (MIRT654495)
- hsa-miR-3934-5p (MIRT654496)
- hsa-miR-3925-3p (MIRT674232)
- hsa-miR-766-3p (MIRT674233)
- hsa-miR-498 (MIRT676531)
- hsa-miR-4726-3p (MIRT676532)
- hsa-miR-6764-5p (MIRT676533)
- hsa-miR-1915-3p (MIRT676534)
- hsa-miR-6840-3p (MIRT676535)
- hsa-miR-6514-3p (MIRT690919)
- hsa-miR-6771-5p (MIRT690920)
- hsa-miR-7977 (MIRT690921)
- hsa-miR-891a-3p (MIRT690922)
- hsa-miR-550a-5p (MIRT690923)
- hsa-miR-550a-3-5p (MIRT690924)
- hsa-miR-1271-3p (MIRT690925)
- hsa-miR-4294 (MIRT690926)
- hsa-miR-564 (MIRT690927)
- hsa-miR-6811-3p (MIRT690928)
- hsa-miR-214-5p (MIRT690929)
- hsa-miR-6746-5p (MIRT690930)
- hsa-miR-5690 (MIRT690931)
- hsa-miR-6767-3p (MIRT690932)
- mmu-miR-193b-3p (MIRT733667)
- hsa-miR-34a-5p (MIRT733962)
- hsa-miR-122-3p (MIRT736080)
- hsa-miR-25-3p (MIRT739366)
- hsa-miR-32-5p (MIRT741259)
- hsa-miR-363-3p (MIRT741811)
- hsa-miR-367-3p (MIRT742127)
- hsa-miR-377-5p (MIRT742711)
- hsa-miR-4325 (MIRT744083)
- hsa-miR-4537 (MIRT746103)
- hsa-miR-4710 (MIRT747420)
- hsa-miR-4792 (MIRT748922)
- hsa-miR-508-5p (MIRT749620)
- hsa-miR-6086 (MIRT751864)
- hsa-miR-7703 (MIRT759718)
- hsa-miR-7847-3p (MIRT759865)
- hsa-miR-7855-5p (MIRT759956)
- hsa-miR-92a-3p (MIRT760629)
- hsa-miR-92b-3p (MIRT760657)
- hsa-miR-1207-5p (MIRT761267)
- hsa-miR-1228-3p (MIRT761435)
- hsa-miR-1301-5p (MIRT762398)
- hsa-miR-1909-3p (MIRT763248)
- hsa-miR-3160-3p (MIRT765139)
- hsa-miR-4487 (MIRT769677)
- hsa-miR-455-3p (MIRT770403)
- hsa-miR-4763-3p (MIRT772024)
- hsa-miR-558 (MIRT774849)
- hsa-miR-6499-3p (MIRT776348)
- hsa-miR-6502-5p (MIRT776562)
- hsa-miR-6516-5p (MIRT777197)
- hsa-miR-6722-3p (MIRT777837)
- hsa-miR-6808-5p (MIRT779698)
- hsa-miR-6893-5p (MIRT781231)
- hsa-miR-940 (MIRT782925)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD51
- Browse OriGene Inhibitory RNA Products For RAD51
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD51
Clone products for research
- Applied Biological Materials (abm): Clones for RAD51 - Starting at $45 >
- * RAD51 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205059
- MR205059
- MR205059L3
- MR205059L4
- RC200692
- RC200692L1
- RC200692L2
- RC200692L3
- RC200692L4
- RC218333
- RC218333L1
- RC218333L2
- RC218333L3
- RC218333L4
- RC228212
- RC228212L3
- RC228212L4
- RC228272
- RC228272L3
- RC228272L4
- RG200692
- RG218333
- RG228212
- RG228272
- RR210445
- RR210445L3
- RR210445L4
- MR205059L3V
- MR205059L4V
- RC200692L1V
- RC200692L2V
- RC200692L3V
- RC200692L4V
- RC218333L1V
- RC218333L2V
- RC218333L3V
- RC218333L4V
- RC228212L3V
- RC228212L4V
- RC228272L3V
- RC228272L4V
- RR210445L3V
- RR210445L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD51
- Addgene plasmids for RAD51
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD51
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for RAD51 Gene
Localization for RAD51 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD51 Gene
- Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Mitochondrion matrix. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Colocalizes with RAD51AP1 and RPA2 to multiple nuclear foci upon induction of DNA damage (PubMed:20154705). DNA damage induces an increase in nuclear levels (PubMed:20154705). Together with FIGNL1, redistributed in discrete nuclear DNA damage-induced foci after ionizing radiation (IR) or camptothecin (CPT) treatment (PubMed:23754376). Accumulated at sites of DNA damage in a SPIDR-dependent manner (PubMed:23509288). Recruited at sites of DNA damage in a MCM9-MCM8-dependent manner (PubMed:23401855). {ECO:0000269 PubMed:20154705, ECO:0000269 PubMed:23401855, ECO:0000269 PubMed:23509288, ECO:0000269 PubMed:23754376}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytoskeleton | 4 |
| cytosol | 4 |
| plasma membrane | 2 |
| extracellular | 2 |
| endoplasmic reticulum | 2 |
| golgi apparatus | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
- Cytosol (3)
- Nucleoli rim (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000228 | nuclear chromosome | IDA | 23754376 |
| GO:0000781 | chromosome, telomeric region | IDA | 21076401 |
| GO:0000785 | chromatin | IDA | 25585578 |
| GO:0000793 | condensed chromosome | ISS | -- |
| GO:0000794 | condensed nuclear chromosome | IBA,ISS | -- |
Pathways & Interactions for RAD51 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Resolution of D-loop Structures through Holliday Junction Intermediates | ||
| 2 | DNA Double-Strand Break Repair |
.53
|
|
| 3 | Homologous DNA Pairing and Strand Exchange | ||
| 4 | ATM Pathway |
ATM Pathway
.45
|
|
| 5 | BRCA1 Pathway |
Fanconi's Anaemia Pathway
.01
|
BRCA1 Pathway
-
|
Pathways by source for RAD51 Gene
7 BioSystems pathways for RAD51 Gene
14 Reactome pathways for RAD51 Gene
4 KEGG pathways for RAD51 Gene
1 GeneGo (Thomson Reuters) pathway for RAD51 Gene
- DNA damage_Role of Brca1 and Brca2 in DNA repair
5 Qiagen pathways for RAD51 Gene
- ATM Pathway
- BRCA1 Pathway
- DNA Repair Mechanisms
- Fanconi's Anaemia Pathway
- Molecular Mechanisms of Cancer
1 Cell Signaling Technology pathway for RAD51 Gene
1 GeneTex pathway for RAD51 Gene
Interacting Proteins for RAD51 Gene
Selected Interacting proteins:
Q06609-RAD51_HUMAN
ENSP00000372088
for RAD51 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RAD51
SIGNOR curated interactions for RAD51 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000722 | telomere maintenance via recombination | ISS | 21076401 |
| GO:0000724 | double-strand break repair via homologous recombination | TAS | 12427746 |
| GO:0000730 | DNA recombinase assembly | IMP | 26681308 |
| GO:0001932 | regulation of protein phosphorylation | IEA | -- |
| GO:0006259 | DNA metabolic process | IEA | -- |
Drugs & Compounds for RAD51 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Rucaparib | Approved, Investigational | Pharma | PARP inhibitor, PARP Inhibitors, Other | 64 | ||
| Adenosine 5'-[gamma-thio]triphosphate | Experimental | Pharma | Target, Target, Target | 0 | ||
| dATP | Experimental | Pharma | Target, Target | 0 | ||
| Phosphoaminophosphonic Acid-Adenylate Ester | Experimental | Pharma | Target | 0 | ||
| Tetrafluoroaluminate Ion | Experimental | Pharma | Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(2) ApexBio Compounds for RAD51 Gene
Transcripts for RAD51 Gene
mRNA/cDNA for RAD51 Gene
- 4 REFSEQ mRNAs :
- 13 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000267868 2436 nts (view in UCSC)
- ENST00000382643 1588 nts (view in UCSC)
- ENST00000423169 1611 nts (view in UCSC)
- ENST00000525066 1545 nts (view in UCSC)
- ENST00000526763 665 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for RAD51 - Starting at $85 >
- * RAD51 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for RAD51
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD51
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD51
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD51
- Browse OriGene Inhibitory RNA Products For RAD51
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD51
Clone products for research
- Applied Biological Materials (abm): Clones for RAD51 - Starting at $45 >
- * RAD51 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
-
- MG205059
- MR205059
- MR205059L3
- MR205059L4
- RC200692
- RC200692L1
- RC200692L2
- RC200692L3
- RC200692L4
- RC218333
- RC218333L1
- RC218333L2
- RC218333L3
- RC218333L4
- RC228212
- RC228212L3
- RC228212L4
- RC228272
- RC228272L3
- RC228272L4
- RG200692
- RG218333
- RG228212
- RG228272
- RR210445
- RR210445L3
- RR210445L4
- MR205059L3V
- MR205059L4V
- RC200692L1V
- RC200692L2V
- RC200692L3V
- RC200692L4V
- RC218333L1V
- RC218333L2V
- RC218333L3V
- RC218333L4V
- RC228212L3V
- RC228212L4V
- RC228272L3V
- RC228272L4V
- RR210445L3V
- RR210445L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD51
- Addgene plasmids for RAD51
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD51
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10a | · | 10b | ^ | 11 | ^ | 12a | · | 12b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | |||||||||||||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||||||||||||||||
| SP5: |
Relevant External Links for RAD51 Gene
- GeneLoc Exon Structure for
- RAD51
Expression for RAD51 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Gonad (Reproductive System)
- Primordial Germ Cells Primitive Gonad
- XX Germ Cells Ovigerous Cord
-
Ovary (Reproductive System)
- XX Germ Cells Ovigerous Cord
- Oviduct
-
Blood (Hematopoietic System)
- Hematopoietic Stem Cells Hematopoietic Bone Marrow
- Hematopoietic Bone Marrow
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Testis (Reproductive System)
- Leydig Cells Testis Interstitium
mRNA differential expression in normal tissues according to GTEx for RAD51 Gene
This gene is overexpressed in Testis (x9.7).
This gene is overexpressed in Fetal Brain (17.3), Testis (15.4), Adrenal (13.8), and Blymphocyte (8.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD51 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAD51
SOURCE GeneReport for Unigene cluster for RAD51 Gene:
Hs.631709mRNA Expression by UniProt/SwissProt for RAD51 Gene:
Q06609-RAD51_HUMAN
Tissue specificity:
Highly expressed in testis and thymus, followed by small intestine, placenta, colon, pancreas and ovary. Weakly expressed in breast.
Evidence on tissue expression from TISSUES for RAD51 Gene
- Nervous system(4.5)
- Skin(2.7)
- Intestine(2.6)
- Blood(2.5)
- Lymph node(2.4)
- Lung(2.3)
- Bone marrow(2.2)
- Liver(2.2)
- Heart(2.1)
- Stomach(2.1)
- Kidney(2.1)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD51 Gene
Germ Layers:
- ectoderm
- mesoderm
Systems:
- integumentary
- nervous
- reproductive
- skeletal muscle
Regions:
Head and neck:
- brain
- cerebellum
- head
Thorax:
- breast
Limb:
- hand
- upper limb
Primer products for research
-
OriGene qPCR primer pairs for RAD51
-
OriGene qPCR primer pairs and template standards for RAD51
Gene Expression Assays for research
No data available for Protein tissue co-expression partners for RAD51 Gene
Orthologs for RAD51 Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAD51 29 30 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAD51 29 30 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAD51 29 30 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rad51 29 |
|
||
| Mouse (Mus musculus) |
Mammalia | Rad51 29 16 30 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RAD51 30 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAD51 30 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RAD51A 30 |
|
OneToOne | |
| RAD51 29 |
|
||||
| Lizard (Anolis carolinensis) |
Reptilia | RAD51 30 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rad51 29 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | rad51-prov 29 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rad51 29 30 |
|
OneToOne | |
| wufb38e12 29 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3942 29 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rad51 31 |
|
|
|
| spn-A 29 30 |
|
OneToOne | |||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP013412 29 |
|
||
| Worm (Caenorhabditis elegans) |
Secernentea | rad-51 29 30 31 |
|
OneToOne | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E20241g 29 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACR226W 29 |
|
||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD51 29 30 32 |
|
OneToOne | |
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RAD51 29 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os12g0497300 29 |
|
||
| Os.19630 29 |
|
||||
| Wheat (Triticum aestivum) |
Liliopsida | Ta.7197 29 |
|
||
| Corn (Zea mays) |
Liliopsida | Zm.631 29 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp51 29 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3685 30 |
|
OneToOne | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU02741 29 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.7666 29 |
|
- Species where no ortholog for RAD51 was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
Evolution for RAD51 Gene
- ENSEMBL:
- Gene Tree for RAD51 (if available)
- TreeFam:
- Gene Tree for RAD51 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAD51: view image
- Alliance of Genome Resources:
- Additional Orthologs for RAD51
Paralogs for RAD51 Gene
(20) SIMAP similar genes for RAD51 Gene using alignment to 6 proteins:
- RAD51_HUMAN
- E9PI54_HUMAN
- E9PJ30_HUMAN
- E9PNT5_HUMAN
- H0YD61_HUMAN
- Q9NZG9_HUMAN
Variants for RAD51 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAD51 Gene
| SNP ID | Clinical significance and condition | Chr 15 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 916731 | Pathogenic: Fanconi anemia, complementation group R; not provided | 40,709,072(+) |
A/C NM_002875.5(RAD51):c.391A>C (p.Thr131Pro) |
MISSENSE | |
| rs105751941 | Fanconi anemia, complementation group R (FANCR) [MIM:617244] |
p.Ala293Thr |
|||
| rs1057519413 | Pathogenic: Fanconi anemia, complementation group R; Inborn genetic diseases; not provided | 40,729,955(+) |
G/A NM_002875.5(RAD51):c.877G>A (p.Ala293Thr) |
MISSENSE_VARIANT,INTRON | |
| rs121917739 | Conflicting Interpretations: Mirror movements 2; Familial cancer of breast; not provided. Breast cancer (BC) [MIM:114480] | 40,718,818(+) |
G/Ap.Arg150Gln NM_002875.5(RAD51):c.449G>A (p.Arg150Gln) |
MISSENSE | |
| rs139810756 | Likely Benign: not provided | 40,731,103(+) |
C/T NM_002875.5(RAD51):c.945C>T (p.Tyr315=) |
NONSENSE,SYNONYMOUS |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2478123 | CNV | deletion | 19546169 |
| esv2760026 | CNV | loss | 17122850 |
| esv3636229 | CNV | loss | 21293372 |
| esv3636230 | CNV | loss | 21293372 |
| nsv527234 | CNV | loss | 19592680 |
| nsv529030 | CNV | loss | 19592680 |
| nsv832984 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
39.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.88;
18.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD51 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD51 Gene
Disorders for RAD51 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fanconi anemia, complementation group r |
|
|
| mirror movements 2 |
|
|
| breast cancer |
|
|
| mirror movements 1 |
|
|
| fanconi anemia, complementation group a |
|
Search RAD51 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RAD51_HUMAN- Breast cancer (BC) [MIM:114480]: A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case. {ECO:0000269 PubMed:10807537, ECO:0000269 PubMed:25539919}. Note=Disease susceptibility is associated with variants affecting the gene represented in this entry.
- Mirror movements 2 (MRMV2) [MIM:614508]: A disorder characterized by contralateral involuntary movements that mirror voluntary ones. While mirror movements are occasionally found in young children, persistence beyond the age of 10 is abnormal. Mirror movements occur more commonly in the upper extremities. {ECO:0000269 PubMed:22305526}. Note=The disease is caused by variants affecting the gene represented in this entry.
- Fanconi anemia, complementation group R (FANCR) [MIM:617244]: A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair. {ECO:0000269 PubMed:26253028, ECO:0000269 PubMed:26681308}. Note=The disease is caused by variants affecting the gene represented in this entry.
Additional Disease Information for RAD51
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for Genatlas for RAD51 Gene
Publications for RAD51 Gene
- A single nucleotide polymorphism in the 5' untranslated region of RAD51 and risk of cancer among BRCA1/2 mutation carriers. (PMID: 11535547) Wang WW … Struewing JP (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2001) 3 4 22 40
- Identification of Rad51 alteration in patients with bilateral breast cancer. (PMID: 10807537) Kato M … Miki Y (Journal of human genetics 2000) 3 4 22 72
- A novel Fanconi anaemia subtype associated with a dominant-negative mutation in RAD51. (PMID: 26681308) Ameziane N … Dorsman JC (Nature communications 2015) 3 4 72
- A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination. (PMID: 26253028) Wang AT … Smogorzewska A (Molecular cell 2015) 2 3 4
- RAD51 haploinsufficiency causes congenital mirror movements in humans. (PMID: 22305526) Depienne C … Roze E (American journal of human genetics 2012) 3 4 72
ExternalLinks
Products for RAD51 Gene
- Custom Antibody ServicesOriGene Antibodies for RAD51
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD51
- Origene Custom Protein Services for RAD51
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD51
- Browse OriGene Inhibitory RNA Products For RAD51
- OriGene qPCR primer pairs for RAD51
- OriGene qPCR primer pairs and template standards for RAD51
- OriGene CRISPR knockouts for RAD51
- MG205059
- MR205059
- MR205059L3
- MR205059L4
- RC200692
- RC200692L1
- RC200692L2
- RC200692L3
- RC200692L4
- RC218333
- RC218333L1
- RC218333L2
- RC218333L3
- RC218333L4
- RC228212
- RC228212L3
- RC228212L4
- RC228272
- RC228272L3
- RC228272L4
- RG200692
- RG218333
- RG228212
- RG228272
- RR210445
- RR210445L3
- RR210445L4
- MR205059L3V
- MR205059L4V
- RC200692L1V
- RC200692L2V
- RC200692L3V
- RC200692L4V
- RC218333L1V
- RC218333L2V
- RC218333L3V
- RC218333L4V
- RC228212L3V
- RC228212L4V
- RC228272L3V
- RC228272L4V
- RR210445L3V
- RR210445L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RAD51
- Sino Biological