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The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and ... See more...
Aliases for RAD23B Gene
Aliases for RAD23B Gene
External Ids for RAD23B Gene
- HGNC: 9813
- Entrez Gene: 5887
- Ensembl: ENSG00000119318
- OMIM: 600062
- UniProtKB: P54727
Previous GeneCards Identifiers for RAD23B Gene
- GC09P100840
- GC09P101777
- GC09P103503
- GC09P105425
- GC09P107125
- GC09P109085
- GC09P110045
- GC09P079647
Summaries for RAD23B Gene
-
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in the nucleotide excision repair (NER). This protein was found to be a component of the protein complex that specifically complements the NER defect of xeroderma pigmentosum group C (XP-c) cell extracts in vitro. This protein was also shown to interact with, and elevate the nucleotide excision activity of 3-methyladenine-DNA glycosylase (MPG), which suggested a role in DNA damage recognition in base excision repair. This protein contains an N-terminal ubiquitin-like domain, which was reported to interact with 26S proteasome, and thus this protein may be involved in the ubiquitin mediated proteolytic pathway in cells. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Sep 2011]
GeneCards Summary for RAD23B Gene
RAD23B (RAD23 Homolog B, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23B include Xeroderma Pigmentosum, Complementation Group C and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Calnexin/calreticulin cycle and Transport to the Golgi and subsequent modification. Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is RAD23A.
UniProtKB/Swiss-Prot Summary for RAD23B Gene
-
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
-
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.
-
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
Additional gene information for RAD23B Gene
- HGNC(9813)
- Entrez Gene(5887)
- Ensembl(ENSG00000119318)
- OMIM(600062)
- UniProtKB(P54727)
- Open Targets Platform(ENSG00000119318)
- Monarch Initiative
- Search for RAD23B at DataMed
- Search for RAD23B at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD23B Gene
Genomics for RAD23B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAD23B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAD23B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAD23B
- Top Transcription factor binding sites by QIAGEN in the RAD23B gene promoter:
-
- AML1a
- Bach1
- c-Myb
- CBF-B
- CBF-C
- CP1A
- CP1C
- HOXA5
- p53
- Pax-3
Genomic Locations for RAD23B Gene
Genomic Locations for RAD23B Gene
- chr9:107,283,137-107,332,194
- (GRCh38/hg38)
- Size:
- 49,058 bases
- Orientation:
- Plus strand
- chr9:110,045,418-110,094,475
- (GRCh37/hg19)
- Size:
- 49,058 bases
- Orientation:
- Plus strand
Genomic View for RAD23B Gene
Genes around RAD23B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q31.2 by HGNC
- 9q31.2 by Entrez Gene
- 9q31.2 by Ensembl
RAD23B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD23B Gene
Proteins for RAD23B Gene
-
Protein details for RAD23B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P54727-RD23B_HUMAN
- Recommended name:
- UV excision repair protein RAD23 homolog B
- Protein Accession:
- P54727
- B3KWK8
- G5E9P0
- Q7Z5K8
- Q8WUB0
Protein attributes for RAD23B Gene
- Size:
- 409 amino acids
- Molecular mass:
- 43171 Da
- Quaternary structure:
-
- Component of the XPC complex composed of XPC, RAD23B and CETN2. Interacts with NGLY1 and PSMC1. Interacts with ATXN3 (PubMed:30455355). Interacts with PSMD4 and PSMC5. Interacts with AMFR. Interacts with VCP; the interaction is indirect and mediated by NGLY1 (By similarity).
- Miscellaneous:
-
- [Isoform 2]: Highly expressed in the testis and in ejaculated spermatozoa.
Protein Expression for RAD23B Gene
Post-translational modifications for RAD23B Gene
Other Protein References for RAD23B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RAD23B Antibody
- BioLegend Rad23B Antibody
-
Custom Antibody ServicesOriGene Antibodies for RAD23B
- Novus Biologicals Antibodies for RAD23B
-
Abcam antibodies for RAD23B
- Invitrogen Antibodies for RAD23B (AFLGC-Rad23b)
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD23B
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD23B
- Origene Custom Protein Services for RAD23B
-
Signalway Proteins for RAD23B
-
Abcam proteins for RAD23B
Assay Products
- antibodies-online: Show 8 available RAD23B Elisa Kits ranked by validation data
- Compare Top RAD23B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RAD23B Gene
Domains & Families for RAD23B Gene
Gene Families for RAD23B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RAD23B Gene
- InterPro:
- Blocks:
-
- Ubiquitin domain
- Ubiquitin-associated domain
- Heat shock chaperonin-binding
- ProtoNet:
Suggested Antigen Peptide Sequences for RAD23B Gene
- GenScript: Design optimal peptide antigens:
-
- RAD23 homolog B (S. cerevisiae) (Q5W0S3_HUMAN)
- XP-C repair-complementing complex 58 kDa protein (RD23B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P54727UniProtKB/Swiss-Prot:
RD23B_HUMAN :- The ubiquitin-like domain mediates interaction with ATXN3.
- Belongs to the RAD23 family.
- Domain:
-
- The ubiquitin-like domain mediates interaction with ATXN3.
- Family:
-
- Belongs to the RAD23 family.
Function for RAD23B Gene
Molecular function for RAD23B Gene
- UniProtKB/Swiss-Prot Function:
- Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome.
- UniProtKB/Swiss-Prot Function:
- Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with CETN2 appears to stabilize XPC. May protect XPC from proteasomal degradation.
- UniProtKB/Swiss-Prot Function:
- The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5'-to-3' direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair. In vitro, the XPC:RAD23B dimer is sufficient to initiate NER; it preferentially binds to cisplatin and UV-damaged double-stranded DNA and also binds to a variety of chemically and structurally diverse DNA adducts. XPC:RAD23B contacts DNA both 5' and 3' of a cisplatin lesion with a preference for the 5' side. XPC:RAD23B induces a bend in DNA upon binding. XPC:RAD23B stimulates the activity of DNA glycosylases TDG and SMUG1.
- GENATLAS Biochemistry:
- yeast (S cerevisiae) RAD23 homolog B,ubiquitin conjugating enzyme E3B,58kDa,forming a tight complex with XPC
Phenotypes From GWAS Catalog for RAD23B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0003684 | damaged DNA binding | IEA | -- |
| GO:0003697 | single-stranded DNA binding | TAS | 8168482 |
| GO:0005515 | protein binding | IPI | 10488153 |
| GO:0031593 | polyubiquitin modification-dependent protein binding | IBA,IDA | 19435460 |
Phenotypes for RAD23B Gene
- MGI mutant phenotypes for RAD23B:
-
inferred from 1 alleles
- immune system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for RAD23B:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Increased cell death HMECs cells
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased vaccinia virus (VACV) infection
- shRNA abundance <= 50%
- Decreased viability ratio
- Negative genetic interaction between BLM-/- and BLM+/+
- Synthetic lethal with Ras
- Reduced mammosphere formation
- Increased ionizing radiation sensitivity
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased viability in colon lineage
- Synthetic lethal with vaccinia virus (VACV) infection
- Decreased viability with paclitaxel
- Decreased Sindbis virus (SINV) infection
- Decreased viability (cell death)
- Increased HDAC inhibitor resistance
Animal Models for RAD23B Gene
- MGI Knock Outs for RAD23B:
-
- Rad23b Rad23b<tm1Gvh>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD23B - Select products 50% OFF >
- * RAD23B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAD23B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD23B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD23B
miRNA for RAD23B Gene
- miRTarBase miRNAs that target RAD23B
-
- hsa-miR-373-3p (MIRT000056)
- hsa-miR-30a-5p (MIRT005172)
- hsa-miR-155-5p (MIRT021032)
- hsa-miR-1301-3p (MIRT035963)
- hsa-miR-106b-5p (MIRT044281)
- hsa-miR-197-3p (MIRT048119)
- hsa-miR-106a-5p (MIRT048344)
- hsa-miR-92a-3p (MIRT048988)
- hsa-miR-494-3p (MIRT054721)
- hsa-miR-15a-5p (MIRT106733)
- hsa-miR-16-5p (MIRT106734)
- hsa-miR-15b-5p (MIRT106735)
- hsa-miR-195-5p (MIRT106736)
- hsa-miR-424-5p (MIRT106737)
- hsa-miR-497-5p (MIRT106738)
- hsa-miR-6838-5p (MIRT106743)
- hsa-miR-30c-5p (MIRT106744)
- hsa-miR-30d-5p (MIRT106745)
- hsa-miR-30b-5p (MIRT106746)
- hsa-miR-30e-5p (MIRT106747)
- hsa-let-7a-2-3p (MIRT173647)
- hsa-miR-96-3p (MIRT173648)
- hsa-let-7g-3p (MIRT173649)
- hsa-miR-371a-5p (MIRT173650)
- hsa-miR-372-5p (MIRT173651)
- hsa-miR-373-5p (MIRT173652)
- hsa-miR-616-5p (MIRT173655)
- hsa-miR-1182 (MIRT173657)
- hsa-miR-3154 (MIRT173660)
- hsa-miR-371b-5p (MIRT173662)
- hsa-miR-573 (MIRT226860)
- hsa-miR-595 (MIRT226861)
- hsa-miR-3611 (MIRT226864)
- hsa-miR-3616-5p (MIRT226865)
- hsa-miR-4795-5p (MIRT226868)
- hsa-miR-7978 (MIRT226869)
- hsa-miR-361-5p (MIRT226898)
- hsa-miR-2052 (MIRT226900)
- hsa-miR-2115-3p (MIRT226901)
- hsa-miR-3074-3p (MIRT226903)
- hsa-miR-4328 (MIRT226904)
- hsa-miR-3144-3p (MIRT364274)
- hsa-miR-485-5p (MIRT439829)
- hsa-miR-3650 (MIRT488682)
- hsa-miR-493-5p (MIRT534780)
- hsa-let-7c-3p (MIRT534781)
- hsa-miR-514b-5p (MIRT534782)
- hsa-miR-513c-5p (MIRT534783)
- hsa-miR-342-3p (MIRT534784)
- hsa-miR-4762-5p (MIRT534785)
- hsa-miR-6793-3p (MIRT541113)
- hsa-miR-510-3p (MIRT554949)
- hsa-miR-524-5p (MIRT554950)
- hsa-miR-520d-5p (MIRT554951)
- hsa-miR-127-5p (MIRT566125)
- hsa-miR-7843-3p (MIRT566126)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD23B
- Browse OriGene Inhibitory RNA Products For RAD23B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD23B
Clone Products
- Applied Biological Materials (abm): Clones for RAD23B - Select products 50% OFF >
- * RAD23B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RAD23B
- Addgene plasmids for RAD23B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD23B
Cell Line Products
-
Horizon Cell Lines for RAD23B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD23B Gene
Localization for RAD23B Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD23B Gene
- Nucleus. Cytoplasm. Note=The intracellular distribution is cell cycle dependent. Localized to the nucleus and the cytoplasm during G1 phase. Nuclear levels decrease during S-phase. upon entering mitosis, relocalizes in the cytoplasm without association with chromatin.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000502 | proteasome complex | IEA | -- |
| GO:0005634 | nucleus | TAS | 8168482 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0005829 | cytosol | TAS | -- |
Pathways & Interactions for RAD23B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Transcription-Coupled Nucleotide Excision Repair (TC-NER) | ||
| 2 | Nucleotide excision repair |
Nucleotide Excision Repair Pathway
.39
|
|
| 3 | Metabolism of proteins | ||
| 4 | DNA Damage | ||
| 5 | Protein processing in endoplasmic reticulum | ||
Pathways by source for RAD23B Gene
11 Reactome pathways for RAD23B Gene
2 KEGG pathways for RAD23B Gene
2 Qiagen pathways for RAD23B Gene
- DNA Repair Mechanisms
- Nucleotide Excision Repair Pathway
1 Cell Signaling Technology pathway for RAD23B Gene
Interacting Proteins for RAD23B Gene
Selected Interacting proteins:
P54727-RD23B_HUMAN
ENSP00000350708
for RAD23B Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for RAD23B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000715 | nucleotide-excision repair, DNA damage recognition | IDA,TAS | -- |
| GO:0000717 | nucleotide-excision repair, DNA duplex unwinding | TAS | -- |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006289 | nucleotide-excision repair | TAS,IDA | 8168482 |
| GO:0006294 | nucleotide-excision repair, preincision complex assembly | TAS | -- |
Transcripts for RAD23B Gene
mRNA/cDNA for RAD23B Gene
- 3 REFSEQ mRNAs :
- 21 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000358015 4114 nts (view in UCSC)
- ENST00000416373 3835 nts (view in UCSC)
- ENST00000419616 716 nts (view in UCSC)
- ENST00000442587 456 nts (view in UCSC)
- ENST00000457811 811 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD23B - Select products 50% OFF >
- * RAD23B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAD23B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD23B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD23B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD23B
- Browse OriGene Inhibitory RNA Products For RAD23B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD23B
Clone Products
- Applied Biological Materials (abm): Clones for RAD23B - Select products 50% OFF >
- * RAD23B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RAD23B
- Addgene plasmids for RAD23B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD23B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12a | · | 12b | · | 12c | ^ | 13 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||||||||||||||||||
| SP2: | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | |||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | |||||||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | - | - |
Relevant External Links for RAD23B Gene
- GeneLoc Exon Structure for
- RAD23B
Expression for RAD23B Gene
This gene is overexpressed in Lymph node (9.6) and Bone marrow stromal cell (6.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD23B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAD23B
SOURCE GeneReport for Unigene cluster for RAD23B Gene:
Hs.521640Evidence on tissue expression from TISSUES for RAD23B Gene
- Liver(4.6)
- Lung(4.5)
- Nervous system(4.3)
- Skin(3.6)
- Muscle(2.8)
- Intestine(2.7)
- Kidney(2.6)
- Heart(2.6)
- Spleen(2.4)
- Blood(2.4)
- Lymph node(2.3)
- Thyroid gland(2.3)
- Stomach(2.2)
- Bone marrow(2.2)
- Adrenal gland(2.2)
- Pancreas(2.1)
Primer Products
-
OriGene qPCR primer pairs for RAD23B
-
OriGene qPCR primer pairs and template standards for RAD23B
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD23B Gene
Orthologs for RAD23B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAD23B 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Cow (Bos Taurus) |
Mammalia | RAD23B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAD23B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rad23b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rad23b 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | RAD23B 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | RAD23B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAD23B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rad23b 30 |
|
||
| Str.10080 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | MGC53561 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rad23b 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.1739 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rad23 30 31 32 |
|
ManyToMany | |
| CG10694 31 |
|
ManyToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | rad-23 30 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | RAD23 30 31 33 |
|
OneToMany | |
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0E22133g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_AFR358W 30 |
|
||
| Thale Cress (Arabidopsis thaliana) |
eudicotyledons | RAD23D 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os08g0430200 30 |
|
||
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rhp23 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU07542 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.1944 31 |
|
OneToMany |
- Species where no ortholog for RAD23B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAD23B Gene
- ENSEMBL:
- Gene Tree for RAD23B (if available)
- TreeFam:
- Gene Tree for RAD23B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAD23B: view image
Paralogs for RAD23B Gene
(2) SIMAP similar genes for RAD23B Gene using alignment to 5 proteins:
- RD23B_HUMAN
- H0Y579_HUMAN
- L8EA19_HUMAN
- Q5W0S4_HUMAN
- Q5W0S5_HUMAN
Pseudogenes.org Pseudogenes for RAD23B Gene
Variants for RAD23B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAD23B Gene
| SNP ID | Clinical significance and condition | Chr 09 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1805329 | - | p.Ala249Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2669320 | CNV | deletion | 23128226 |
| esv2738896 | CNV | deletion | 23290073 |
| esv2738897 | CNV | deletion | 23290073 |
| esv3621396 | CNV | loss | 21293372 |
| nsv508560 | CNV | deletion | 20534489 |
| nsv519266 | CNV | gain | 19592680 |
| nsv831682 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
32.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.39;
81.74% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD23B Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD23B Gene
Disorders for RAD23B Gene
Search RAD23B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAD23B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAD23B Gene
Publications for RAD23B Gene
- Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PMID: 16712842) Chen L … Madura K (FEBS letters 2006) 3 4 23
- Nucleotide excision repair gene polymorphisms and risk of advanced colorectal adenoma: XPC polymorphisms modify smoking-related risk. (PMID: 16492920) Huang WY … Hayes RB (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2006) 3 23 41
- Solution structure and backbone dynamics of the XPC-binding domain of the human DNA repair protein hHR23B. (PMID: 15885096) Kim B … Choi BS (The FEBS journal 2005) 3 4 23
- A complex between peptide:N-glycanase and two proteasome-linked proteins suggests a mechanism for the degradation of misfolded glycoproteins. (PMID: 15358861) Katiyar S … Lennarz WJ (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 23
- Structure of the ubiquitin-interacting motif of S5a bound to the ubiquitin-like domain of HR23B. (PMID: 14585839) Fujiwara K … Shirakawa M (The Journal of biological chemistry 2004) 3 4 23
ExternalLinks
Products for RAD23B Gene
- Custom Antibody ServicesOriGene Antibodies for RAD23B
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD23B
- Origene Custom Protein Services for RAD23B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD23B
- Browse OriGene Inhibitory RNA Products For RAD23B
- OriGene qPCR primer pairs for RAD23B
- OriGene qPCR primer pairs and template standards for RAD23B
- OriGene CRISPR knockouts for RAD23B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RAD23B
- Sino Biological Human cDNA Clone for RAD23B
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RAD23B
- Novus Biologicals proteins and lysates for RAD23B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RAD23B
- Abcam proteins for RAD23B
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for RAD23B (AFLGC-Rad23b)
- VectorBuilder Custom and pre-made DNA vectors for RAD23B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RAD23B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RAD23B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RAD23B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RAD23B
- Addgene plasmids for RAD23B
- antibodies-online: Show 46 available RAD23B Antibodies ranked by validation data
- Compare Top RAD23B Antibodies
- antibodies-online: Show 8 available RAD23B Elisa Kits ranked by validation data
- Compare Top RAD23B Elisa Kits
- Quality Products:
- antibodies-online: Show 8 available RAD23B Proteins ranked by validation data
- Compare Top RAD23B Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for RAD23B
- Search Santa Cruz Biotechnology (SCBT) for RAD23B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RAD23B
- Horizon Cell Lines for RAD23B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD23B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD23B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RAD23B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD23B
Sources for RAD23B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB