Aliases for RAD23A Gene
External Ids for RAD23A Gene
Previous GeneCards Identifiers for RAD23A Gene
The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]
GeneCards Summary for RAD23A Gene
RAD23A (RAD23 Homolog A, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23A include Xeroderma Pigmentosum, Complementation Group C and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Metabolism of proteins and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is RAD23B.
UniProtKB/Swiss-Prot Summary for RAD23A Gene
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
(Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.