The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucl... See more...

Aliases for RAD23A Gene

Aliases for RAD23A Gene

  • RAD23 Homolog A, Nucleotide Excision Repair Protein 2 3 5
  • HHR23A 2 3 4
  • UV Excision Repair Protein RAD23 Homolog A 3 4
  • RAD23, Yeast Homolog, A 2 3
  • HR23A 3 4
  • RAD23 (S. Cerevisiae) Homolog A 2
  • RAD23 Homolog A (S. Cerevisiae) 2
  • MGC111083 2
  • RAD23A 5

External Ids for RAD23A Gene

Previous GeneCards Identifiers for RAD23A Gene

  • GC19P013188
  • GC19M013321
  • GC19P012901
  • GC19P012917
  • GC19P013056
  • GC19P012628
  • GC19P012946

Summaries for RAD23A Gene

Entrez Gene Summary for RAD23A Gene

  • The protein encoded by this gene is one of two human homologs of Saccharomyces cerevisiae Rad23, a protein involved in nucleotide excision repair. Proteins in this family have a modular domain structure consisting of an ubiquitin-like domain (UbL), ubiquitin-associated domain 1 (UbA1), XPC-binding domain and UbA2. The protein encoded by this gene plays an important role in nucleotide excision repair and also in delivery of polyubiquitinated proteins to the proteasome. Alternative splicing results in multiple transcript variants encoding multiple isoforms. [provided by RefSeq, Jun 2012]

GeneCards Summary for RAD23A Gene

RAD23A (RAD23 Homolog A, Nucleotide Excision Repair Protein) is a Protein Coding gene. Diseases associated with RAD23A include Xeroderma Pigmentosum, Complementation Group C and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Metabolism of proteins and Transcription-Coupled Nucleotide Excision Repair (TC-NER). Gene Ontology (GO) annotations related to this gene include single-stranded DNA binding and polyubiquitin modification-dependent protein binding. An important paralog of this gene is RAD23B.

UniProtKB/Swiss-Prot Summary for RAD23A Gene

  • Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
  • Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
  • (Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.

Gene Wiki entry for RAD23A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD23A Gene

Genomics for RAD23A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAD23A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAD23A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAD23A

Top Transcription factor binding sites by QIAGEN in the RAD23A gene promoter:
  • ATF-2
  • c-Jun
  • CUTL1
  • NF-kappaB1
  • Nkx2-5
  • p53

Genomic Locations for RAD23A Gene

Genomic Locations for RAD23A Gene
chr19:12,945,814-12,953,643
(GRCh38/hg38)
Size:
7,830 bases
Orientation:
Plus strand
chr19:13,056,654-13,064,456
(GRCh37/hg19)
Size:
7,803 bases
Orientation:
Plus strand

Genomic View for RAD23A Gene

Genes around RAD23A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAD23A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAD23A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAD23A Gene

Proteins for RAD23A Gene

  • Protein details for RAD23A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P54725-RD23A_HUMAN
    Recommended name:
    UV excision repair protein RAD23 homolog A
    Protein Accession:
    P54725
    Secondary Accessions:
    • K7ESE3
    • Q59EU8
    • Q5M7Z1

    Protein attributes for RAD23A Gene

    Size:
    363 amino acids
    Molecular mass:
    39609 Da
    Quaternary structure:
    • Interacts with XPC; the interaction is suggesting the existence of a functional equivalent variant XPC complex. Interacts with PSMD4 and PSMC5. Interacts with ATXN3 (PubMed:30455355). Interacts with UBQLN2.
    • (Microbial infection) Interacts with HIV-1 Vpr.
    SequenceCaution:
    • Sequence=BAD92950.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=BX448989; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAD23A Gene

    Alternative splice isoforms for RAD23A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAD23A Gene

Post-translational modifications for RAD23A Gene

  • Ubiquitination at Lys8, Lys16, Lys26, Lys53, Lys78, Lys80, and Lys122
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAD23A Gene

Domains & Families for RAD23A Gene

Gene Families for RAD23A Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RAD23A Gene

InterPro:
Blocks:
  • Ubiquitin domain
  • Ubiquitin-associated domain
  • Heat shock chaperonin-binding
ProtoNet:

Suggested Antigen Peptide Sequences for RAD23A Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51789, highly similar to UV excision repair protein RAD23 homolog A (B4DDJ7_HUMAN)
  • RAD23 homolog A (S. cerevisiae) (Q5M7Z1_HUMAN)
  • UV excision repair protein RAD23 homolog A (RD23A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P54725

UniProtKB/Swiss-Prot:

RD23A_HUMAN :
  • The ubiquitin-like domain mediates interaction with ATXN3.
  • Belongs to the RAD23 family.
Domain:
  • The ubiquitin-like domain mediates interaction with ATXN3.
  • The ubiquitin-like (UBL) and the UBA (ubiquitin-associated) domains interact intramolecularly in a highly dynamic manner, as each UBA domain competes for an overlapping UBL domain surface. Binding of ubiquitin or proteasome subunit PSMD4 disrupt the UBL-UBA domain interactions and drive RAD23A in to an open conformation.
Family:
  • Belongs to the RAD23 family.
genes like me logo Genes that share domains with RAD23A: view

Function for RAD23A Gene

Molecular function for RAD23A Gene

UniProtKB/Swiss-Prot Function:
Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to 'Lys-48'-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to 'Lys-63'-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome.
UniProtKB/Swiss-Prot Function:
Involved in nucleotide excision repair and is thought to be functional equivalent for RAD23B in global genome nucleotide excision repair (GG-NER) by association with XPC. In vitro, the XPC:RAD23A dimer has NER activity. Can stabilize XPC.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Involved in Vpr-dependent replication of HIV-1 in non-proliferating cells and primary macrophages. Required for the association of HIV-1 Vpr with the host proteasome.
GENATLAS Biochemistry:
yeast (S cerevisiae) RAD23 homolog A,ubiquitin conjugating enzyme E3A,involved in the degradation of short-lived and abnormal proteins

Phenotypes From GWAS Catalog for RAD23A Gene

Gene Ontology (GO) - Molecular Function for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003684 damaged DNA binding IEA --
GO:0003697 single-stranded DNA binding TAS 8168482
GO:0005515 protein binding IEA,IPI 10488153
GO:0019900 kinase binding IPI 26296656
GO:0031593 polyubiquitin modification-dependent protein binding IBA,IDA 12643283
genes like me logo Genes that share ontologies with RAD23A: view
genes like me logo Genes that share phenotypes with RAD23A: view

Animal Models for RAD23A Gene

MGI Knock Outs for RAD23A:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD23A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD23A Gene

Localization for RAD23A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAD23A Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAD23A gene
Compartment Confidence
nucleus 5
cytosol 5
cytoskeleton 4
mitochondrion 2
plasma membrane 1
extracellular 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (4)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000502 proteasome complex IEA --
GO:0005634 nucleus IEA,IDA 26296656
GO:0005654 nucleoplasm IDA,TAS --
GO:0005737 cytoplasm IDA 26296656
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with RAD23A: view

Pathways & Interactions for RAD23A Gene

genes like me logo Genes that share pathways with RAD23A: view

Pathways by source for RAD23A Gene

Gene Ontology (GO) - Biological Process for RAD23A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006289 nucleotide-excision repair IEA,IDA 9372924
GO:0006974 cellular response to DNA damage stimulus IEA --
GO:0016032 viral process IEA --
GO:0016579 protein deubiquitination TAS --
genes like me logo Genes that share ontologies with RAD23A: view

No data available for SIGNOR curated interactions for RAD23A Gene

Drugs & Compounds for RAD23A Gene

(1) Drugs for RAD23A Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with RAD23A: view

Transcripts for RAD23A Gene

mRNA/cDNA for RAD23A Gene

3 REFSEQ mRNAs :
13 NCBI additional mRNA sequence :
11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD23A

Alternative Splicing Database (ASD) splice patterns (SP) for RAD23A Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c · 10d
SP1: -
SP2: -
SP3: - -
SP4: - - -
SP5: -
SP6: - - - - -
SP7: - - -
SP8: - - - -
SP9:
SP10: - -

Relevant External Links for RAD23A Gene

GeneLoc Exon Structure for
RAD23A

Expression for RAD23A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAD23A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAD23A Gene

This gene is overexpressed in Muscle - Skeletal (x8.2).

Protein differential expression in normal tissues from HIPED for RAD23A Gene

This gene is overexpressed in Lavage (9.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD23A Gene



Protein tissue co-expression partners for RAD23A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAD23A

SOURCE GeneReport for Unigene cluster for RAD23A Gene:

Hs.643267

Evidence on tissue expression from TISSUES for RAD23A Gene

  • Nervous system(4.9)
  • Liver(4.6)
  • Pancreas(4.3)
  • Muscle(4.1)
  • Lung(3.7)
  • Skin(3.3)
  • Eye(3.2)
  • Kidney(3)
  • Heart(3)
  • Intestine(2.9)
  • Blood(2.8)
  • Lymph node(2)
  • Stomach(2)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RAD23A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD23A Gene

Orthologs for RAD23A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAD23A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAD23A 30 31
  • 97.51 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RAD23A 30 31
  • 93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RAD23A 30 31
  • 92.91 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rad23a 30 17 31
  • 89.23 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rad23a 30
  • 88.04 (n)
Oppossum
(Monodelphis domestica)
Mammalia RAD23A 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RAD23A 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RAD23A 31
  • 86 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 80 (a)
OneToMany
-- 31
  • 57 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii rad23aa 30 31
  • 67.42 (n)
OneToOne
zgc65951 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rad23 31 32
  • 37 (a)
ManyToMany
CG10694 31
  • 33 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea rad-23 31
  • 36 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RAD23 31
  • 30 (a)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RAD23B 30
  • 48.62 (n)
Rice
(Oryza sativa)
Liliopsida Os02g0179300 30
  • 50.15 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.1944 31
  • 44 (a)
OneToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2042 30
Species where no ortholog for RAD23A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RAD23A Gene

ENSEMBL:
Gene Tree for RAD23A (if available)
TreeFam:
Gene Tree for RAD23A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAD23A: view image

Paralogs for RAD23A Gene

Paralogs for RAD23A Gene

(8) SIMAP similar genes for RAD23A Gene using alignment to 7 proteins:

  • RD23A_HUMAN
  • B4DDJ7_HUMAN
  • K7ELU6_HUMAN
  • K7ELW1_HUMAN
  • K7ENJ0_HUMAN
  • K7EQ16_HUMAN
  • Q5M7Z1_HUMAN
genes like me logo Genes that share paralogs with RAD23A: view

Variants for RAD23A Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAD23A Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs11558955 - p.Thr131Ala
rs4987202 - p.Thr200Met
rs4987203 - p.Arg179Gln

Additional dbSNP identifiers (rs#s) for RAD23A Gene

Structural Variations from Database of Genomic Variants (DGV) for RAD23A Gene

Variant ID Type Subtype PubMed ID
nsv1160589 CNV duplication 26073780
nsv833754 CNV loss 17160897
nsv953977 CNV deletion 24416366

Variation tolerance for RAD23A Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.93; 59.54% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAD23A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAD23A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD23A Gene

Disorders for RAD23A Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAD23A Gene - From: DISEASES, Novoseek, and GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAD23A

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RAD23A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAD23A Gene

Publications for RAD23A Gene

  1. Components of the ubiquitin-proteasome pathway compete for surfaces on Rad23 family proteins. (PMID: 18234089) Goh AM … Howley PM (BMC biochemistry 2008) 3 4 23
  2. Evidence for distinct functions for human DNA repair factors hHR23A and hHR23B. (PMID: 16712842) Chen L … Madura K (FEBS letters 2006) 3 4 23
  3. Binding of polyubiquitin chains to ubiquitin-associated (UBA) domains of HHR23A. (PMID: 15321727) Raasi S … Pickart CM (Journal of molecular biology 2004) 3 4 23
  4. DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a. (PMID: 14557549) Walters KJ … Howley PM (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23
  5. Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B. (PMID: 10915768) Wang G … Nukina N (Human molecular genetics 2000) 3 4 23

Products for RAD23A Gene

Sources for RAD23A Gene