Aliases for RAD21 Gene
Aliases for RAD21 Gene
External Ids for RAD21 Gene
- HGNC: 9811
- Entrez Gene: 5885
- Ensembl: ENSG00000164754
- OMIM: 606462
- UniProtKB: O60216
Previous GeneCards Identifiers for RAD21 Gene
- GC08M117919
- GC08M117526
- GC08M117814
- GC08M117927
- GC08M113184
- GC08M117858
Summaries for RAD21 Gene
-
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAD21 Gene
RAD21 (RAD21 Cohesin Complex Component) is a Protein Coding gene. Diseases associated with RAD21 include Cornelia De Lange Syndrome 4 and Cornelia De Lange Syndrome. Among its related pathways are SUMOylation and Mitotic Telophase/Cytokinesis. An important paralog of this gene is RAD21L1.
UniProtKB/Swiss-Prot for RAD21 Gene
-
Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
Additional gene information for RAD21 Gene
- Monarch Initiative
- Search for RAD21 at DataMed
- Search for RAD21 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAD21 Gene
Genomics for RAD21 Gene
GeneHancer (GH) Regulatory Elements for RAD21 Gene
Promoters and enhancers for RAD21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data dump
GeneHancers around RAD21 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RAD21 gene promoter:
Regulatory Element Products
Genomic Locations for RAD21 Gene
Genomic Locations for RAD21 Gene
- chr8:116,845,934-116,874,866
- (GRCh38/hg38)
- Size:
- 28,933 bases
- Orientation:
- Minus strand
- chr8:117,858,173-117,887,105
- (GRCh37/hg19)
Genomic View for RAD21 Gene
Genes around RAD21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 8q24.11 by Ensembl
- 8q24.11 by Entrez Gene
- 8q24.11 by HGNC
RAD21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD21 Gene
Proteins for RAD21 Gene
-
Protein details for RAD21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60216-RAD21_HUMAN
- Recommended name:
- Double-strand-break repair protein rad21 homolog
- Protein Accession:
- O60216
- A8K0E0
- Q15001
- Q99568
Protein attributes for RAD21 Gene
- Size:
- 631 amino acids
- Molecular mass:
- 71690 Da
- Quaternary structure:
-
- Cohesin complexes are composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domain, RAD21 which link them, and one STAG protein (STAG1, STAG2 or STAG3), which interacts with RAD21 (PubMed:11590136, PubMed:19696148). Found in a complex with SMC1A, SMC3, CDCA5, PDS5A/SCC-112 and PDS5B/APRIN (PubMed:15837422). Interacts with PDS5B and WAPL; the interaction is direct (PubMed:19696148). Interacts with SMC1A and SMC3 (By similarity). Interacts with DDX11 (PubMed:17105772).
- SequenceCaution:
-
- Sequence=BAA07554.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for RAD21 Gene
Post-translational modifications for RAD21 Gene
- Cleaved by separase/ESPL1 at the onset of anaphase. Cleaved by caspase-3 and caspase-7 at the beginning of apoptosis. The cleavage by ESPL1 and caspase-3 take place at different sites.
- Phosphorylated; becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK.
- Ubiquitination at isoforms=72, isoforms=86, Lys364, isoforms=371, isoforms=387, Lys573, and Lys605
- Modification sites at PhosphoSitePlus
Other Protein References for RAD21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RAD21
- Novus Biologicals Antibodies for RAD21
-
Abcam antibodies for RAD21
- Invitrogen Antibodies for RAD21
- antibodies-online: Search results for 85 available RAD21 Antibodies ranked by validation data
- Compare Top RAD21 Antibodies
-
Recommended
- 1 IHC Antibody (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 20 WB Antibodies (anti-rat)
- 1 IP Antibody (anti-mouse)
- 1 IHC Antibody (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 46 WB Antibodies (anti-mouse)
- 1 IHC Antibody (anti-human)
- 2 IHC (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 65 WB Antibodies (anti-human)
- GeneTex RAD21 antibody for RAD21
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD21
Protein Products
-
OriGene Purified Proteins for RAD21
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD21
- Origene Custom Protein Services for RAD21
- Search GeneTex for Proteins for RAD21
-
Abcam proteins for RAD21
Assay Products
No data available for DME Specific Peptides for RAD21 Gene
Domains & Families for RAD21 Gene
Gene Families for RAD21 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
Protein Domains for RAD21 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for RAD21 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O60216UniProtKB/Swiss-Prot:
RAD21_HUMAN :- The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.
- Belongs to the rad21 family.
- Domain:
-
- The C-terminal part associates with the head of SMC1A, while the N-terminal part binds to the head of SMC3.
- Family:
-
- Belongs to the rad21 family.
Function for RAD21 Gene
Molecular function for RAD21 Gene
- GENATLAS Biochemistry:
- yeast (S pombe),RAD21 homolog,highly expressed in testis,thymus,involved in nucleotide excision repair of ionizing radiation induced DNA double-strand break
- UniProtKB/Swiss-Prot Function:
- Cleavable component of the cohesin complex, involved in chromosome cohesion during cell cycle, in DNA repair, and in apoptosis. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At metaphase-anaphase transition, this protein is cleaved by separase/ESPL1 and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Also plays a role in apoptosis, via its cleavage by caspase-3/CASP3 or caspase-7/CASP7 during early steps of apoptosis: the C-terminal 64 kDa cleavage product may act as a nuclear signal to initiate cytoplasmic events involved in the apoptotic pathway.
Phenotypes From GWAS Catalog for RAD21 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003682 | chromatin binding | IBA | -- |
| GO:0005515 | protein binding | IPI | 12672959 |
| GO:0032403 | protein complex binding | IEA | -- |
Phenotypes for RAD21 Gene
- MGI mutant phenotypes for RAD21:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for RAD21:
-
- Increased viability
- Increased vaccinia virus (VACV) infection
- Lamellipodia cells
- Dynamic nuclei (hole, folded or small irregular)
- Increased transferrin (TF) endocytosis
- Negative genetic interaction between PTEN-/- and PTEN+/+
- Decreased viability after Maraba virus infection
- Effect on mitosis
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Synthetic lethal with vaccinia virus (VACV) infection
- Increased cell death in breast cancer cell lines (MCF10A, MDA-MB-435)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability of wild-type and TP53 knockout cells
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Decreased TP53 protein expression ratio (wild-type / TP53 knockout cells)
- Decreased HIV-1 infection
- Increased ID2::GFP protein expression
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAD21
-
-
ViGene Biosciences lentiviral particle packaged cDNA for RAD21 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD21 gene
- Search ViGene Biosciences for RAD21
CRISPR Products
-
OriGene CRISPR knockouts for RAD21
- genomics-online: gRNA clones - Search results for 105 available RAD21 gene related products
- Overview of 105 available RAD21 gene related products
- Applied Biological Materials CRISPR for RAD21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD21
- GenScript: Design CRISPR guide RNA sequences for RAD21
miRNA for RAD21 Gene
- miRTarBase miRNAs that target RAD21
-
- hsa-mir-215-5p (MIRT024779)
- hsa-mir-192-5p (MIRT026196)
- hsa-mir-191-5p (MIRT045808)
- hsa-let-7a-5p (MIRT052491)
- hsa-mir-143-5p (MIRT469620)
- hsa-mir-3944-5p (MIRT469621)
- hsa-mir-4683 (MIRT469622)
- hsa-mir-6124 (MIRT469623)
- hsa-mir-3148 (MIRT469624)
- hsa-mir-107 (MIRT469625)
- hsa-mir-103a-3p (MIRT469626)
- hsa-mir-574-5p (MIRT469627)
- hsa-mir-875-3p (MIRT469628)
- hsa-mir-665 (MIRT469629)
- hsa-mir-4433a-3p (MIRT469630)
- hsa-mir-383-3p (MIRT469631)
- hsa-mir-6715a-3p (MIRT469632)
- hsa-mir-648 (MIRT469633)
- hsa-mir-4433b-3p (MIRT469634)
- hsa-mir-6888-5p (MIRT469635)
- hsa-mir-383-5p (MIRT469636)
- hsa-mir-122-5p (MIRT469637)
- hsa-mir-4428 (MIRT513723)
- hsa-mir-92b-3p (MIRT726796)
- hsa-mir-32-5p (MIRT726797)
- hsa-mir-92a-3p (MIRT726798)
- hsa-mir-17-5p (MIRT734736)
miRNA Products
- Search ViGene Biosciences for RAD21
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RAD21
- Browse OriGene Inhibitory RNA Products For RAD21
- genomics-online: shRNA clones - Search results for 105 available RAD21 gene related products
- Overview of 105 available RAD21 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD21 gene
Clone Products
- Sino Biological Human cDNA Clone for RAD21
- VectorBuilder custom plasmid, inducible vectors for RAD21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD21
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAD21
- Applied Biological Materials Clones for RAD21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for RAD21 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for RAD21 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD21 gene
No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for RAD21 Gene
Localization for RAD21 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD21 Gene
- Nucleus. Chromosome. Chromosome, centromere. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, it is cleaved by separase/ESPL1, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. Once cleaved by caspase-3, the C-terminal 64 kDa cleavage product translocates to the cytoplasm, where it may trigger apoptosis. {ECO:0000269 PubMed:11073952}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| cytoskeleton | 2 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000775 | chromosome, centromeric region | TAS | -- |
| GO:0000785 | chromatin | IEA | -- |
| GO:0000794 | condensed nuclear chromosome | IEA | -- |
| GO:0000798 | nuclear cohesin complex | IBA | -- |
| GO:0005634 | nucleus | IEA | -- |
Pathways & Interactions for RAD21 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Cell Cycle, Mitotic |
.83
|
.60
|
| 2 | Mitotic Metaphase and Anaphase |
.94
|
|
| 3 | SUMOylation |
.95
|
|
| 4 | Mitotic Telophase/Cytokinesis | ||
| 5 | CDK-mediated phosphorylation and removal of Cdc6 |
.78
|
|
Pathways by source for RAD21 Gene
19 Reactome pathways for RAD21 Gene
1 KEGG pathway for RAD21 Gene
1 GeneGo (Thomson Reuters) pathway for RAD21 Gene
2 Cell Signaling Technology pathways for RAD21 Gene
Interacting Proteins for RAD21 Gene
Selected Interacting proteins:
ENSP00000297338
O60216-RAD21_HUMAN
for RAD21 Gene via
STRING
MINT
IID
UniProtKB
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006302 | double-strand break repair | TAS | 8812457 |
| GO:0006310 | DNA recombination | TAS | 8812457 |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 19468298 |
| GO:0006366 | transcription by RNA polymerase II | IEA | -- |
Transcripts for RAD21 Gene
mRNA/cDNA for RAD21 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (8) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for RAD21 Gene
CRISPR Products
-
OriGene CRISPR knockouts for RAD21
- genomics-online: gRNA clones - Search results for 105 available RAD21 gene related products
- Overview of 105 available RAD21 gene related products
- Applied Biological Materials CRISPR for RAD21
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD21
- GenScript: Design CRISPR guide RNA sequences for RAD21
miRNA Products
- Search ViGene Biosciences for RAD21
Inhibitory RNA Products
- Origene RNAi, sirna, and shrna products in human, mouse, rat for RAD21
- Browse OriGene Inhibitory RNA Products For RAD21
- genomics-online: shRNA clones - Search results for 105 available RAD21 gene related products
- Overview of 105 available RAD21 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for RAD21 gene
Clone Products
- Sino Biological Human cDNA Clone for RAD21
- VectorBuilder custom plasmid, inducible vectors for RAD21
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAD21
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAD21
- Applied Biological Materials Clones for RAD21
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
| SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP9: |
| ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | - | ||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: | |||||||||
| SP9: |
Expression for RAD21 Gene
This gene is overexpressed in Peripheral blood mononuclear cells (14.2), Blymphocyte (11.3), and Tlymphocyte (6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAD21 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RAD21 Gene:
RAD21SOURCE GeneReport for Unigene cluster for RAD21 Gene:
Hs.81848Evidence on tissue expression from TISSUES for RAD21 Gene
- Nervous system(5)
- Liver(4.5)
- Bone marrow(4.4)
- Kidney(3)
- Intestine(2.9)
- Blood(2.3)
- Lung(2.3)
- Eye(2.2)
- Heart(2)
- Spleen(2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD21 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- reproductive
- respiratory
- skeletal muscle
- skeleton
- urinary
Regions:
Head and neck:
- brain
- chin
- cranial nerve
- ear
- eye
- eyelid
- face
- forehead
- head
- inner ear
- jaw
- larynx
- lip
- mandible
- maxilla
- middle ear
- mouth
- neck
- nose
- outer ear
- pharynx
- scalp
- skull
- tooth
- vocal cord
Thorax:
- breast
- chest wall
- clavicle
- diaphragm
- esophagus
- heart
- lung
- rib
- rib cage
- scapula
- sternum
Abdomen:
- abdominal wall
- intestine
- kidney
- large intestine
- liver
- small intestine
- stomach
Pelvis:
- pelvis
- penis
- testicle
- ureter
- urethra
- urinary bladder
- uterus
- vulva
Limb:
- ankle
- arm
- digit
- elbow
- femur
- fibula
- finger
- foot
- forearm
- hand
- hip
- humerus
- knee
- lower limb
- radius
- shin
- shoulder
- thigh
- tibia
- toe
- ulna
- upper limb
- wrist
General:
- blood
- blood vessel
- coagulation system
- hair
- peripheral nervous system
- skin
- spinal column
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for RAD21
-
OriGene qPCR primer pairs and template standards for RAD21
- genomics-online: primer clones - Search results for 105 available RAD21 gene related products
- Overview of 105 available RAD21 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for RAD21 Gene
Orthologs for RAD21 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RAD21 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | RAD21 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RAD21 33 34 |
|
||
| cow (Bos Taurus) |
Mammalia | RAD21 33 34 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rad21 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Rad21 33 16 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | RAD21 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | RAD21 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RAD21 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rad21 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.6046 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rad21a 34 34 |
|
OneToMany | |
| rad21b 33 34 |
|
||||
| rad21 33 |
|
||||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004560 33 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | vtd 33 34 |
|
||
| Rad21 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | coh-1 35 34 |
|
||
| scc-1 35 34 |
|
||||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToMany | |
| sea squirt (Ciona intestinalis) |
Ascidiacea | Cin.2469 33 |
|
- Species where no ortholog for RAD21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Paralogs for RAD21 Gene
(2) SIMAP similar genes for RAD21 Gene using alignment to 8 proteins:
Pseudogenes.org Pseudogenes for RAD21 Gene
Variants for RAD21 Gene
Polymorphic Variants from UniProtKB/Swiss-Prot for RAD21 Gene
- RAD21_HUMAN-O60216
- Some radiosensitive cancer patients seem to have Arg-481 instead of the conserved Gly-481. It may be that this mutation could contribute to radiosensitivity.
| SNP ID | Clin | Chr 08 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs138040512 | uncertain-significance, Cornelia de Lange syndrome 4 | 116,850,621(-) | T/C | coding_sequence_variant, synonymous_variant | |
| rs202233096 | likely-benign, Cornelia de Lange syndrome 4 | 116,854,341(-) | C/T | coding_sequence_variant, synonymous_variant | |
| rs34653007 | benign, Cornelia de Lange syndrome 4 | 116,856,674(-) | G/A | coding_sequence_variant, synonymous_variant | |
| rs373026310 | uncertain-significance, Cornelia de Lange syndrome 4 | 116,850,662(-) | C/G | coding_sequence_variant, missense_variant | |
| rs387907212 | pathogenic, Cornelia de Lange syndrome 4, Cornelia de Lange syndrome 4 (CDLS4) [MIM:614701] | 116,854,279(-) | G/C | coding_sequence_variant, missense_variant |
Residual Variation Intolerance Score:
8.31% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.82;
34.21% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD21 Gene
SNP Genotyping and Copy Number Assay Products
Disorders for RAD21 Gene
(7) MalaCards diseases for RAD21 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| cornelia de lange syndrome 4 |
|
|
| cornelia de lange syndrome |
|
|
| cornelia de lange syndrome 1 |
|
|
| tl antigen |
|
|
| trichorhinophalangeal syndrome, type ii |
|
|
Search RAD21 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
RAD21_HUMAN- Cornelia de Lange syndrome 4 (CDLS4) [MIM:614701]: A form of Cornelia de Lange syndrome, a clinically heterogeneous developmental disorder associated with malformations affecting multiple systems. It is characterized by facial dysmorphisms, abnormal hands and feet, growth delay, cognitive retardation, hirsutism, gastroesophageal dysfunction and cardiac, ophthalmologic and genitourinary anomalies. {ECO:0000269 PubMed:22633399}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for RAD21
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for RAD21 Gene
Publications for RAD21 Gene
- Human chromatid cohesin component hRad21 is phosphorylated in M phase and associated with metaphase centromeres. (PMID: 11073952) Hoque MT … Ishikawa F (The Journal of biological chemistry 2001) 3 4 22 58
- Novel DNA sequence variants in the hHR21 DNA repair gene in radiosensitive cancer patients. (PMID: 11483345) Severin DM … McKay M (International journal of radiation oncology, biology, physics 2001) 3 4 22 58
- Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. (PMID: 11509732) Hauf S … Peters JM (Science (New York, N.Y.) 2001) 3 4 22 58
- Sequence conservation of the rad21 Schizosaccharomyces pombe DNA double-strand break repair gene in human and mouse. (PMID: 8812457) McKay MJ … Hoeijmakers JH (Genomics 1996) 2 3 4 58
- RAD21 mutations cause a human cohesinopathy. (PMID: 22633399) Deardorff MA … Kaiser FJ (American journal of human genetics 2012) 3 4 58
Products for RAD21 Gene
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- Mammalian expression: PiggyBac
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- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
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- genomics-online: cdna clones - Search results for 105 available RAD21 gene related products
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- Overview of 105 available RAD21 gene related products
Sources for RAD21 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
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- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
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- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
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