Free for academic non-profit institutions. Other users need a Commercial license
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells. [provided by RefSeq, Jul 2008]
RAD21 (RAD21 Cohesin Complex Component) is a Protein Coding gene. Diseases associated with RAD21 include Cornelia De Lange Syndrome 4 With Or Without Midline Brain Defects and Mungan Syndrome. Among its related pathways are Cell cycle_Spindle assembly and chromosome separation and Meiosis. An important paralog of this gene is RAD21L1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003682 | chromatin binding | IBA | 21873635 |
GO:0005515 | protein binding | IEA,IPI | 12672959 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000775 | chromosome, centromeric region | TAS | -- |
GO:0000785 | chromatin | IEA | -- |
GO:0000794 | condensed nuclear chromosome | IEA | -- |
GO:0000798 | nuclear cohesin complex | IBA | 21873635 |
GO:0000922 | spindle pole | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Cell Cycle, Mitotic |
.83
|
.60
|
2 | Mitotic Metaphase and Anaphase |
.94
|
|
3 | SUMOylation |
.95
|
|
4 | Mitotic Telophase/Cytokinesis | ||
5 | Regulation of activated PAK-2p34 by proteasome mediated degradation |
.78
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006281 | DNA repair | IEA | -- |
GO:0006302 | double-strand break repair | TAS,IBA | 21873635 |
GO:0006310 | DNA recombination | TAS | 8812457 |
GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 19468298 |
GO:0006915 | apoptotic process | IEA | -- |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | · | 14c | ^ | 15a | · | 15b | ^ |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||||
SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | - | |||||||||||||||||||||||||||||||
SP5: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
SP7: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
SP8: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
SP9: |
ExUns: | 16a | · | 16b | ^ | 17a | · | 17b | · | 17c |
---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||
SP2: | |||||||||
SP3: | |||||||||
SP4: | - | ||||||||
SP5: | |||||||||
SP6: | |||||||||
SP7: | |||||||||
SP8: | |||||||||
SP9: |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RAD21 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RAD21 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RAD21 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RAD21 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rad21 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Rad21 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RAD21 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RAD21 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAD21 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rad21 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.6046 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rad21a 31 31 |
|
OneToMany | |
rad21b 30 31 |
|
OneToMany | |||
rad21 30 |
|
||||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP004560 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | vtd 30 31 |
|
OneToMany | |
Rad21 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | scc-1 31 32 |
|
ManyToMany | |
coh-1 31 32 |
|
ManyToMany | |||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany | |
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.2469 30 |
|
SNP ID | Clinical significance and condition | Chr 08 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
668613 | Benign: not provided | 116,858,136(-) | A/G | INTRON_VARIANT | |
669106 | Benign: not provided | 116,849,277(-) | T/C | INTRON_VARIANT | |
669108 | Benign: not provided | 116,847,913(-) | T/C | INTRON_VARIANT | |
670486 | Benign: not provided | 116,866,452(-) | C/T | INTRON_VARIANT | |
675063 | Benign: not provided | 116,857,221(-) | A/G | INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
cornelia de lange syndrome 4 with or without midline brain defects |
|
|
mungan syndrome |
|
|
cornelia de lange syndrome |
|
|
cornelia de lange syndrome 1 |
|
|
tl antigen |
|
|