Aliases for RAD18 Gene
External Ids for RAD18 Gene
Previous GeneCards Identifiers for RAD18 Gene
The protein encoded by this gene is highly similar to S. cerevisiae DNA damage repair protein Rad18. Yeast Rad18 functions through its interaction with Rad6, which is an ubiquitin-conjugating enzyme required for post-replication repair of damaged DNA. Similar to its yeast counterpart, this protein is able to interact with the human homolog of yeast Rad6 protein through a conserved ring-finger motif. Mutation of this motif results in defective replication of UV-damaged DNA and hypersensitivity to multiple mutagens. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAD18 Gene
RAD18 (RAD18 E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with RAD18 include Xeroderma Pigmentosum, Variant Type and Congenital Hypoplastic Anemia. Among its related pathways are DNA Damage and Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template. Gene Ontology (GO) annotations related to this gene include ligase activity and damaged DNA binding.
UniProtKB/Swiss-Prot Summary for RAD18 Gene
E3 ubiquitin-protein ligase involved in postreplication repair of UV-damaged DNA. Postreplication repair functions in gap-filling of a daughter strand on replication of damaged DNA. Associates to the E2 ubiquitin conjugating enzyme UBE2B to form the UBE2B-RAD18 ubiquitin ligase complex involved in mono-ubiquitination of DNA-associated PCNA on 'Lys-164'. Has ssDNA binding activity.