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This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced tran... See more...
Aliases for RAD1 Gene
Aliases for RAD1 Gene
External Ids for RAD1 Gene
- HGNC: 9806
- Entrez Gene: 5810
- Ensembl: ENSG00000113456
- OMIM: 603153
- UniProtKB: O60671
Previous GeneCards Identifiers for RAD1 Gene
- GC05M034941
- GC05M035934
- GC05M034953
- GC05M034944
- GC05M034854
Summaries for RAD1 Gene
-
This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]
GeneCards Summary for RAD1 Gene
RAD1 (RAD1 Checkpoint DNA Exonuclease) is a Protein Coding gene. Diseases associated with RAD1 include Alpha-Thalassemia/Mental Retardation Syndrome, X-Linked and Restless Legs Syndrome. Among its related pathways are Homologous DNA Pairing and Strand Exchange and E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include damaged DNA binding and exodeoxyribonuclease III activity.
UniProtKB/Swiss-Prot Summary for RAD1 Gene
-
Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).
Additional gene information for RAD1 Gene
- HGNC(9806)
- Entrez Gene(5810)
- Ensembl(ENSG00000113456)
- OMIM(603153)
- UniProtKB(O60671)
- Open Targets Platform(ENSG00000113456)
- Search for RAD1 at DataMed
- Search for RAD1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAD1 Gene
Genomics for RAD1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAD1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH05J034914 | Promoter/Enhancer | 2.1 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.7 | +3.3 | 3299 | 4.8 | SP1 HNRNPL CREB1 GATAD2A PRDM10 REST ZNF629 TFE3 ZNF512 LEF1 | BRIX1 RAD1 lnc-AGXT2-1 DNAJC21 TTC23L RF00017-4570 | |
| GH05J034918 | Promoter | 0.6 | Ensembl | 600.7 | +0.7 | 688 | 0.2 | OSR2 PRDM4 ZNF362 ZNF121 | RAD1 DNAJC21 BRIX1 RF00017-4570 | |
| GH05J035022 | Enhancer | 0.6 | ENCODE | 4.7 | -104.6 | -104578 | 1.3 | SP1 SCRT1 ZC3H11A HNF4A RXRA MAX ZNF781 ZNF518A HNF4G EGR1 | AGXT2 RAD1 piR-61580-505 RF01061-135 DNAJC21 | |
| GH05J034922 | Enhancer | 1.1 | Ensembl ENCODE | 0.4 | -5.0 | -5012 | 2.8 | CREB1 ZNF629 LEF1 ZNF692 BACH1 JUND DDX20 PRDM1 MTA2 MTA1 | DNAJC21 BRIX1 ENSG00000215158 RF00017-4571 RAD1 RF00017-4570 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAD1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAD1
- Top Transcription factor binding sites by QIAGEN in the RAD1 gene promoter:
-
- GATA-1
- GR
- GR-alpha
Genomic Locations for RAD1 Gene
Genomic Locations for RAD1 Gene
- chr5:34,905,260-34,918,989
- (GRCh38/hg38)
- Size:
- 13,730 bases
- Orientation:
- Minus strand
- chr5:34,905,365-34,919,094
- (GRCh37/hg19)
- Size:
- 13,730 bases
- Orientation:
- Minus strand
Genomic View for RAD1 Gene
Genes around RAD1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 5p13.2 by HGNC
- 5p13.2 by Entrez Gene
- 5p13.2 by Ensembl
RAD1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAD1 Gene
Proteins for RAD1 Gene
-
Protein details for RAD1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O60671-RAD1_HUMAN
- Recommended name:
- Cell cycle checkpoint protein RAD1
- Protein Accession:
- O60671
- O75572
- O95304
- Q1W161
- Q5KSM0
- Q5KSM1
- Q9UEP1
Protein attributes for RAD1 Gene
- Size:
- 282 amino acids
- Molecular mass:
- 31827 Da
- Quaternary structure:
-
- Component of the toroidal 9-1-1 (RAD9-RAD1-HUS1) complex, composed of RAD9A, RAD1 and HUS1 (PubMed:10846170, PubMed:10884395). The 9-1-1 complex associates with LIG1, POLB, FEN1, RAD17, HDAC1, RPA1 and RPA2 (PubMed:10846170, PubMed:10884395, PubMed:15314187, PubMed:15556996, PubMed:15871698, PubMed:15897895, PubMed:16216273). The 9-1-1 complex associates with the RAD17-RFC complex (PubMed:12578958). RAD1 interacts with POLB, FEN1, HUS1, HUS1B, RAD9A and RAD9B (PubMed:10359610, PubMed:10777662, PubMed:11944979, PubMed:14500360, PubMed:14611806, PubMed:15314187, PubMed:15556996, PubMed:16216273). Interacts with DNAJC7 (PubMed:11573955).
- SequenceCaution:
-
- Sequence=AAC35550.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=AAC35550.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=CAA06249.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; Sequence=CAA06249.1; Type=Frameshift; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Three dimensional structures from OCA and Proteopedia for RAD1 Gene
Protein Expression for RAD1 Gene
Post-translational modifications for RAD1 Gene
Other Protein References for RAD1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-RAD1 monoclonal antibody, clone 5237
- Creative Biolabs Mouse Anti-RAD1 Recombinant Antibody (1A12) and Mouse Anti-RAD1 Recombinant Antibody (4126)
-
Custom Antibody ServicesOriGene Antibodies for RAD1
- Novus Biologicals Antibodies for RAD1
-
Abcam antibodies for RAD1
- Invitrogen Antibodies for RAD1 (AFLGC-RAD1)
-
Biorbyt antibodies for RAD1
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAD1
- Sino Biological Antibodies for RAD1
Protein Products
- Creative Biomart Recombinant Human RAD1 Homolog (S. pombe), His-tagged
- Search Origene for MassSpec and Protein Over-expression Lysates for RAD1
- Origene Custom Protein Services for RAD1
- ProSpec Recombinant Proteins for RAD1
-
Signalway Proteins for RAD1
-
Abcam proteins for RAD1
No data available for DME Specific Peptides for RAD1 Gene
Domains & Families for RAD1 Gene
Gene Families for RAD1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Enzymes
- Predicted intracellular proteins
Protein Domains for RAD1 Gene
- InterPro:
- Blocks:
-
- Rad1 repair protein signature
- Repair protein Rad1/Rec1 family signature
- ProtoNet:
Suggested Antigen Peptide Sequences for RAD1 Gene
- GenScript: Design optimal peptide antigens:
-
- Rad1-like DNA damage checkpoint protein (RAD1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O60671- Family:
-
- Belongs to the rad1 family.
Function for RAD1 Gene
Molecular function for RAD1 Gene
- UniProtKB/Swiss-Prot Function:
- Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). Isoform 1 possesses 3'->5' double stranded DNA exonuclease activity (PubMed:9660799).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.; EC=3.1.11.2; Evidence={ECO:0000269|PubMed:9660799};.
- GENATLAS Biochemistry:
- cell cycle G2 checkpoint control gene,also involved in DNA repair,homologous to RAD17,S pombe Rad1,S.cerevisiae,with two alternatively spliced isoforms (large RAD1-b and short RAD1-c),ubiquitously expressed,may be involved in lung carcinoma
Enzyme Numbers (IUBMB) for RAD1 Gene
Phenotypes From GWAS Catalog for RAD1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003684 | damaged DNA binding | TAS | 9872989 |
| GO:0004518 | nuclease activity | IEA | -- |
| GO:0004527 | exonuclease activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 10359610 |
| GO:0008408 | 3'-5' exonuclease activity | IDA | 9660799 |
Phenotypes for RAD1 Gene
- MGI mutant phenotypes for RAD1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for RAD1:
-
- no effect
- Decreased viability
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability ratio
- Upregulation of Wnt/beta-catenin pathway after WNT3A stimulation
- Increased epidermal growth factor (EGF) endocytosis, decreased endosome-nucleus distance (endosomes clustered in the perinuclear region)
Animal Models for RAD1 Gene
- MGI Knock Outs for RAD1:
-
- Rad1 Rad1<tm1b(KOMP)Wtsi>
Animal Model Products
-
Taconic Biosciences Mouse Models for RAD1
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD1 - Select products 50% OFF >
- * RAD1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD1
miRNA for RAD1 Gene
- miRTarBase miRNAs that target RAD1
-
- hsa-miR-155-5p (MIRT020681)
- hsa-miR-215-5p (MIRT024409)
- hsa-miR-192-5p (MIRT026379)
- hsa-miR-943 (MIRT036556)
- mmu-miR-804 (MIRT592131)
- mmu-miR-1195 (MIRT592132)
- mmu-miR-3089-5p (MIRT592133)
- mmu-miR-665-3p (MIRT592134)
- mmu-miR-3082-5p (MIRT592135)
- mmu-miR-706 (MIRT592136)
- mmu-miR-10b-5p (MIRT592137)
- mmu-miR-10a-5p (MIRT592138)
- mmu-miR-339-5p (MIRT592139)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD1
- Browse OriGene Inhibitory RNA Products For RAD1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD1
Clone Products
- Applied Biological Materials (abm): Clones for RAD1 - Select products 50% OFF >
- * RAD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203788
- MR203788
- MR203788L3
- MR203788L4
- MR228926
- MR228965
- RC201576
- RC201576L1
- RC201576L2
- RC201576L3
- RC201576L4
- RC216420
- RC216420L1
- RC216420L2
- RC216420L3
- RC216420L4
- RG201576
- RG216420
- RR207223
- RR207223L3
- RR207223L4
- MR203788L3V
- MR203788L4V
- RC201576L1V
- RC201576L2V
- RC201576L3V
- RC201576L4V
- RC216420L1V
- RC216420L2V
- RC216420L3V
- RC216420L4V
- RR207223L3V
- RR207223L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD1
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAD1 Gene
Localization for RAD1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAD1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| cytosol | 2 |
| plasma membrane | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| peroxisome | 0 |
- Nucleoplasm (3)
- Vesicles (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA,IC | 9660799 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005694 | chromosome | IDA | 9716408 |
| GO:0030896 | checkpoint clamp complex | IBA | 21873635 |
| GO:0042025 | host cell nucleus | IEA | -- |
Pathways & Interactions for RAD1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | DNA Double-Strand Break Repair |
.53
|
|
| 2 | Homologous DNA Pairing and Strand Exchange |
.01
|
|
| 3 | Regulation of TP53 Activity | ||
| 4 | Chks in Checkpoint Regulation |
Chks in Checkpoint Regulation
.58
|
DNA Repair Mechanisms
.31
|
| 5 | Cell Cycle Checkpoints |
.84
|
|
Pathways by source for RAD1 Gene
4 BioSystems pathways for RAD1 Gene
19 Reactome pathways for RAD1 Gene
1 KEGG pathway for RAD1 Gene
3 Qiagen pathways for RAD1 Gene
- Chks in Checkpoint Regulation
- DNA Damage Induced 14-3-3Sigma Signaling
- DNA Repair Mechanisms
Interacting Proteins for RAD1 Gene
Selected Interacting proteins:
O60671-RAD1_HUMAN
ENSP00000371469
for RAD1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RAD1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000077 | DNA damage checkpoint | IEA,IMP | 21659603 |
| GO:0006260 | DNA replication | TAS | -- |
| GO:0006281 | DNA repair | TAS,IBA | 21873635 |
| GO:0006974 | cellular response to DNA damage stimulus | TAS | 9872989 |
| GO:0021762 | substantia nigra development | HEP | 22926577 |
Drugs & Compounds for RAD1 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human RAD1 Homolog (S. pombe), His-tagged
Transcripts for RAD1 Gene
mRNA/cDNA for RAD1 Gene
- 4 REFSEQ mRNAs :
- 19 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000325577 1153 nts (view in UCSC)
- ENST00000341754 2341 nts (view in UCSC)
- ENST00000382038 4512 nts (view in UCSC)
- ENST00000506311 574 nts (view in UCSC)
- ENST00000511456 664 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAD1 - Select products 50% OFF >
- * RAD1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAD1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAD1
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAD1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAD1
- Browse OriGene Inhibitory RNA Products For RAD1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAD1
Clone Products
- Applied Biological Materials (abm): Clones for RAD1 - Select products 50% OFF >
- * RAD1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG203788
- MR203788
- MR203788L3
- MR203788L4
- MR228926
- MR228965
- RC201576
- RC201576L1
- RC201576L2
- RC201576L3
- RC201576L4
- RC216420
- RC216420L1
- RC216420L2
- RC216420L3
- RC216420L4
- RG201576
- RG216420
- RR207223
- RR207223L3
- RR207223L4
- MR203788L3V
- MR203788L4V
- RC201576L1V
- RC201576L2V
- RC201576L3V
- RC201576L4V
- RC216420L1V
- RC216420L2V
- RC216420L3V
- RC216420L4V
- RR207223L3V
- RR207223L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAD1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAD1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||||||||||||||||
| SP2: | |||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||
| SP5: |
Relevant External Links for RAD1 Gene
- GeneLoc Exon Structure for
- RAD1
Expression for RAD1 Gene
This gene is overexpressed in Blymphocyte (15.2), Lymph node (12.7), Salivary gland (8.1), Adrenal (7.9), and CD8 Tcells (7.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAD1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAD1
SOURCE GeneReport for Unigene cluster for RAD1 Gene:
Hs.38114mRNA Expression by UniProt/SwissProt for RAD1 Gene:
O60671-RAD1_HUMAN
Tissue specificity:
Expressed in testis, uterus, bladder, spleen, ovaries, lung, brain and muscle (at protein level).
Evidence on tissue expression from TISSUES for RAD1 Gene
- Bone marrow(4.4)
- Blood(2.3)
- Skin(2.1)
- Lymph node(2.1)
Primer Products
-
OriGene qPCR primer pairs for RAD1
-
OriGene qPCR primer pairs and template standards for RAD1
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAD1 Gene
Orthologs for RAD1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAD1 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAD1 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAD1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RAD1 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAD1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rad1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rad1 30 |
|
||
| Chicken (Gallus gallus) |
Aves | RAD1 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAD1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rad1 30 |
|
||
| Str.15014 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Rad1 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rad1 30 31 |
|
OneToOne | |
| zgc77779 30 |
|
||||
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.2152 30 |
|
||
| African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP002255 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rad1 30 31 |
|
OneToOne | |
| Worm (Caenorhabditis elegans) |
Secernentea | mrt-2 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.9754 31 |
|
OneToOne | |
| Fission Yeast (Schizosaccharomyces pombe) |
Schizosaccharomycetes | rad1 30 |
|
||
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU00942 30 |
|
||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.4289 30 |
|
- Species where no ortholog for RAD1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAD1 Gene
- ENSEMBL:
- Gene Tree for RAD1 (if available)
- TreeFam:
- Gene Tree for RAD1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAD1: view image
Paralogs for RAD1 Gene
Pseudogenes.org Pseudogenes for RAD1 Gene
No data available for Paralogs for RAD1 Gene
Variants for RAD1 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv5629n100 | CNV | gain | 25217958 |
| esv3604679 | CNV | gain | 21293372 |
| esv3604690 | CNV | gain | 21293372 |
| nsv597809 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
34.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
4.36;
63.35% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAD1 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RAD1
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAD1 Gene
Disorders for RAD1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| alpha-thalassemia/mental retardation syndrome, x-linked |
|
|
| restless legs syndrome |
|
|
Search RAD1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAD1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAD1 Gene
Publications for RAD1 Gene
- A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. (PMID: 9828137) Bluyssen HA … de Klein A (Genomics 1998) 2 3 4 23
- Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. (PMID: 9716408) Freire R … Jackson SP (Genes & development 1998) 2 3 4 23
- Interaction and colocalization of Rad9/Rad1/Hus1 checkpoint complex with replication protein A in human cells. (PMID: 15897895) Wu X … Zou Y (Oncogene 2005) 3 4 23
- The human Rad9/Rad1/Hus1 damage sensor clamp interacts with DNA polymerase beta and increases its DNA substrate utilisation efficiency: implications for DNA repair. (PMID: 15314187) Toueille M … Hübscher U (Nucleic acids research 2004) 3 4 23
- Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. (PMID: 14500360) Hopkins KM … Lieberman HB (Cancer research 2003) 3 4 23
ExternalLinks
Products for RAD1 Gene
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- antibodies-online: Show 67 available RAD1 Antibodies ranked by validation data
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- antibodies-online: Show 9 available RAD1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for RAD1
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- Biorbyt antibodies for RAD1
- Signalway Proteins for RAD1
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