Aliases for RACK1 Gene

Aliases for RACK1 Gene

  • Receptor For Activated C Kinase 1 2 3 5
  • Guanine Nucleotide Binding Protein (G Protein), Beta Polypeptide 2-Like 1 2 3
  • Guanine Nucleotide-Binding Protein Subunit Beta-Like Protein 12.3 3 4
  • Guanine Nucleotide-Binding Protein Subunit Beta-2-Like 1 3 4
  • Cell Proliferation-Inducing Gene 21 Protein 3 4
  • Receptor Of Activated Protein C Kinase 1 3 4
  • Small Ribosomal Subunit Protein RACK1 3 4
  • Human Lung Cancer Oncogene 7 Protein 3 4
  • Gnb2-Rs1 2 3
  • GNB2L1 3 4
  • H12.3 2 3
  • HLC-7 3 4
  • Protein Homologous To Chicken B Complex Protein, Guanine Nucleotide Binding 3
  • Guanine Nucleotide Binding Protein Beta Polypeptide 2-Like 1 3
  • Receptor Of Activated Protein Kinase C 1 3
  • Receptor For Activated C Kinase 4
  • Proliferation-Inducing Gene 21 3
  • Lung Cancer Oncogene 7 3
  • PIG21 3
  • RACK1 5

External Ids for RACK1 Gene

Previous HGNC Symbols for RACK1 Gene

  • GNB2L1

Previous GeneCards Identifiers for RACK1 Gene

  • GC05M181252
  • GC05M181253
  • GC05M181266
  • GC05M181286
  • GC05M181237
  • GC05M181238
  • GC05M181244
  • GC05M181310

Summaries for RACK1 Gene

GeneCards Summary for RACK1 Gene

RACK1 (Receptor For Activated C Kinase 1) is a Protein Coding gene. Diseases associated with RACK1 include Wells Syndrome and Lung Cancer. Among its related pathways are Androgen receptor signaling pathway and Signaling by GPCR.

UniProtKB/Swiss-Prot Summary for RACK1 Gene

  • Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).
  • (Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells.
  • (Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs.
  • (Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs.
  • (Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses.

Gene Wiki entry for RACK1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RACK1 Gene

Genomics for RACK1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RACK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RACK1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RACK1

Genomic Locations for RACK1 Gene

Latest Assembly
chr5:181,236,897-181,248,096
(GRCh38/hg38)
Size:
11,200 bases
Orientation:
Minus strand

Previous Assembly
chr5:180,663,897-180,670,906
(GRCh37/hg19 by Entrez Gene)
Size:
7,010 bases
Orientation:
Minus strand

chr5:180,663,909-180,675,096
(GRCh37/hg19 by Ensembl)
Size:
11,188 bases
Orientation:
Minus strand

Genomic View for RACK1 Gene

Genes around RACK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RACK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RACK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RACK1 Gene

Proteins for RACK1 Gene

  • Protein details for RACK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P63244-RACK1_HUMAN
    Recommended name:
    Receptor of activated protein C kinase 1
    Protein Accession:
    P63244
    Secondary Accessions:
    • B3KTJ0
    • D3DWS0
    • P25388
    • P99049
    • Q53HU2
    • Q5J8M6
    • Q5VLR4
    • Q6FH47

    Protein attributes for RACK1 Gene

    Size:
    317 amino acids
    Molecular mass:
    35077 Da
    Quaternary structure:
    • Monomer; also forms homodimers and homooligomers (PubMed:20529362, PubMed:15140893). Interacts with CPNE3 (PubMed:20010870). May interact with ABCB4 (PubMed:19674157). Component of the small (40S) ribosomal subunit (By similarity). Interacts with the 80S ribosome (PubMed:23636399). Binds SLC9A3R1. Forms a ternary complex with TRIM63 and PRKCE. Interacts with HABP4, KRT1 and OTUB1. Interacts with SRC (via SH2 domain); the interaction is enhanced by tyrosine phosphorylation of RACK1. Recruited in a circadian manner into a nuclear complex which also includes BMAL1 and PRKCA. Interacts with AR. Interacts with IGF1R but not with INSR. Interacts with ADAM12. Interacts with CLEC1B (via N-terminal region) and with HIF1A; the interaction promotes their degradation. Interacts with RHOA; this enhances RHOA activation and promotes cell migration. Interacts with CHRM2; the interaction regulates CHRM2 internalization. Interacts with TRPM6 (via kinase domain). Interacts with PTK2/FAK1; required for PTK2/FAK1 phosphorylation and dephosphorylation. Interacts with FLT1. Interacts with TBXA2R isoform 2. Interacts with HRAS. Interacts with LARP4B. Interacts with LARP4 (PubMed:21098120). Interacts with PKD2L1.
    • (Microbial infection) Interacts with Y.pseudotuberculosis yopK.
    • (Microbial infection) Interacts with Y.pseudotuberculosis yopK. Interacts with a number of viral proteins including Epstein-Barr virus BZLF1 and HIV-1 Nef; interaction with Nef increases Nef phosphorylation by PKC.
    SequenceCaution:
    • Sequence=AAO21313.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAR24619.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RACK1 Gene

neXtProt entry for RACK1 Gene

Post-translational modifications for RACK1 Gene

  • Phosphorylated on Tyr-228 and/or Tyr-246 by SRC. This is required for binding to SRC.
  • (Microbial infection) Phosphorylated by vaccinia virus B1 kinase on serine and threonine residues; this phosphorylation remodels the ribosome properties, favoring the viral mRNA translation.
  • Ubiquitination at Lys12, Lys38, Lys44, Lys106, Lys130, Lys139, Lys172, Lys175, Lys183, Lys185, Lys212, Lys257, Lys264, and Lys271
  • Modification sites at PhosphoSitePlus

Antibodies for research

  • Abcam antibodies for RACK1
  • Santa Cruz Biotechnology (SCBT) Antibodies for RACK1

No data available for DME Specific Peptides for RACK1 Gene

Domains & Families for RACK1 Gene

Gene Families for RACK1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Ribosomal proteins

Suggested Antigen Peptide Sequences for RACK1 Gene

GenScript: Design optimal peptide antigens:
  • Receptor of activated protein kinase C 1 (GBLP_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P63244

UniProtKB/Swiss-Prot:

RACK1_HUMAN :
  • The 7 WD repeats mediate protein-protein interactions with binding partners.
  • Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
Domain:
  • The 7 WD repeats mediate protein-protein interactions with binding partners.
Family:
  • Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily.
genes like me logo Genes that share domains with RACK1: view

Function for RACK1 Gene

Molecular function for RACK1 Gene

UniProtKB/Swiss-Prot Function:
Scaffolding protein involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression (PubMed:23636399). Involved in the initiation of the ribosome quality control (RQC), a pathway that takes place when a ribosome has stalled during translation, by promoting ubiquitination of a subset of 40S ribosomal subunits (PubMed:28132843). Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand-independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-dependent translocation of ADAM12 to the cell membrane. Promotes the ubiquitination and proteasome-mediated degradation of proteins such as CLEC1B and HIF1A. Required for VANGL2 membrane localization, inhibits Wnt signaling, and regulates cellular polarization and oriented cell division during gastrulation. Required for PTK2/FAK1 phosphorylation and dephosphorylation. Regulates internalization of the muscarinic receptor CHRM2. Promotes apoptosis by increasing oligomerization of BAX and disrupting the interaction of BAX with the anti-apoptotic factor BCL2L. Inhibits TRPM6 channel activity. Regulates cell surface expression of some GPCRs such as TBXA2R. Plays a role in regulation of FLT1-mediated cell migration. Involved in the transport of ABCB4 from the Golgi to the apical bile canalicular membrane (PubMed:19674157). Promotes migration of breast carcinoma cells by binding to and activating RHOA (PubMed:20499158).
UniProtKB/Swiss-Prot Function:
(Microbial infection) Binds to Y.pseudotuberculosis yopK which leads to inhibition of phagocytosis and survival of bacteria following infection of host cells.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Enhances phosphorylation of HIV-1 Nef by PKCs.
UniProtKB/Swiss-Prot Function:
(Microbial infection) In case of poxvirus infection, remodels the ribosomes so that they become optimal for the viral mRNAs (containing poly-A leaders) translation but not for host mRNAs.
UniProtKB/Swiss-Prot Function:
(Microbial infection) Contributes to the cap-independent internal ribosome entry site (IRES)-mediated translation by some RNA viruses.

Phenotypes From GWAS Catalog for RACK1 Gene

Gene Ontology (GO) - Molecular Function for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005080 protein kinase C binding IBA,IDA 11279199
GO:0005102 signaling receptor binding NAS 12809483
GO:0005515 protein binding IEA,IPI 10849009
GO:0008200 ion channel inhibitor activity ISS --
genes like me logo Genes that share ontologies with RACK1: view
genes like me logo Genes that share phenotypes with RACK1: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RACK1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RACK1 Gene

Localization for RACK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RACK1 Gene

Cell membrane. Peripheral membrane protein. Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Perikaryon. Cell projection, dendrite. Cell projection, phagocytic cup. Note=Recruited to the plasma membrane through interaction with KRT1 which binds to membrane-bound ITGB1 (PubMed:17956333). Also associated with the membrane in oncogene-transformed cells (PubMed:11884618). PKC activation induces translocation from the perinuclear region to the cell periphery (PubMed:11279199). In the brain, detected mainly in cell bodies and dendrites with little expression in axonal fibers or nuclei (By similarity). Localized to phagocytic cups following infection by Y.pestis (PubMed:21347310). {ECO:0000250 UniProtKB:P68040, ECO:0000269 PubMed:11279199, ECO:0000269 PubMed:11884618, ECO:0000269 PubMed:17956333, ECO:0000269 PubMed:21347310}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RACK1 gene
Compartment Confidence
plasma membrane 5
nucleus 5
cytosol 5
extracellular 4
mitochondrion 4
cytoskeleton 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA,IDA 21347310
GO:0005634 nucleus IBA,IDA 10849009
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 10849009
GO:0005739 mitochondrion IMP 19767770
genes like me logo Genes that share ontologies with RACK1: view

Pathways & Interactions for RACK1 Gene

genes like me logo Genes that share pathways with RACK1: view

Pathways by source for RACK1 Gene

3 GeneGo (Thomson Reuters) pathways for RACK1 Gene
  • Immune response_Role of integrins in NK cells cytotoxicity
  • Regulation of CFTR activity (norm and CF)
  • wtCFTR and deltaF508 traffic / Membrane expression (norm and CF)
2 Qiagen pathways for RACK1 Gene
  • Activation of PKC through GPCR
  • Molecular Mechanisms of Cancer
3 Cell Signaling Technology pathways for RACK1 Gene

SIGNOR curated interactions for RACK1 Gene

Activates:
Inactivates:
Is activated by:

Gene Ontology (GO) - Biological Process for RACK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001934 positive regulation of protein phosphorylation IBA,IDA 11312657
GO:0006417 regulation of translation IEA --
GO:0006915 apoptotic process IEA --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 19767770
GO:0007049 cell cycle IEA --
genes like me logo Genes that share ontologies with RACK1: view

Drugs & Compounds for RACK1 Gene

(10) Drugs for RACK1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Copper Approved, Investigational Pharma Target 271

(9) Additional Compounds for RACK1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RACK1: view

Transcripts for RACK1 Gene

mRNA/cDNA for RACK1 Gene

1 REFSEQ mRNAs :
26 NCBI additional mRNA sequence :
35 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RACK1

Alternative Splicing Database (ASD) splice patterns (SP) for RACK1 Gene

No ASD Table

Relevant External Links for RACK1 Gene

GeneLoc Exon Structure for
RACK1

Expression for RACK1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RACK1

mRNA Expression by UniProt/SwissProt for RACK1 Gene:

P63244-RACK1_HUMAN
Tissue specificity: In the liver, expressed at higher levels in activated hepatic stellate cells than in hepatocytes or Kupffer cells. Up-regulated in hepatocellular carcinomas and in the adjacent non-tumor liver tissue.

Evidence on tissue expression from TISSUES for RACK1 Gene

  • Nervous system(5)
  • Lung(5)
  • Skin(5)
  • Liver(5)
  • Kidney(5)
  • Blood(5)
  • Eye(4.9)
  • Pancreas(4.9)
  • Intestine(4.9)
  • Muscle(4.9)
  • Bone(4.7)
  • Stomach(4.7)
  • Heart(4.3)
  • Lymph node(3.5)
  • Spleen(3.4)
  • Bone marrow(3.4)
  • Thyroid gland(3.3)
  • Adrenal gland(3.2)
  • Gall bladder(2.8)

Primer products for research

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RACK1 Gene

Orthologs for RACK1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RACK1 Gene

Organism Taxonomy Gene Similarity Type Details
Oppossum
(Monodelphis domestica)
Mammalia GNB2L1 31
  • 100 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia GNB2L1 31
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia GNB2L1 30 31
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia GNB2L1 30 31
  • 92.22 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Gnb2l1 30
  • 90.96 (n)
Mouse
(Mus musculus)
Mammalia Gnb2l1 30 31
  • 90.85 (n)
OneToOne
Rack1 17
Dog
(Canis familiaris)
Mammalia GNB2L1 30 31
  • 90.12 (n)
OneToOne
Chicken
(Gallus gallus)
Aves GNB2L1 30 31
  • 85.38 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia GNB2L1 31
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia gnb2l1 30
  • 80.97 (n)
Str.6701 30
African clawed frog
(Xenopus laevis)
Amphibia gnb2l1-prov 30
Zebrafish
(Danio rerio)
Actinopterygii gnb2l1 30 31
  • 83.81 (n)
OneToOne
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1296 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rack1 30 31
  • 72.51 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010173 30
  • 70.09 (n)
Worm
(Caenorhabditis elegans)
Secernentea rack-1 30 31
  • 68.05 (n)
OneToOne
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_AFR199C 30
  • 59.07 (n)
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0E12277g 30
  • 55.74 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes ASC1 30 31 33
  • 54.83 (n)
OneToMany
Thale Cress
(Arabidopsis thaliana)
eudicotyledons RACK1C_AT 30
  • 61.97 (n)
Rice
(Oryza sativa)
Liliopsida Os05g0552300 30
  • 64.83 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.4423 31
  • 73 (a)
OneToOne
Bread mold
(Neurospora crassa)
Ascomycetes NCU05810 30
  • 68.7 (n)
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cpc2 30
  • 63.47 (n)
Species where no ortholog for RACK1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RACK1 Gene

ENSEMBL:
Gene Tree for RACK1 (if available)
TreeFam:
Gene Tree for RACK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RACK1: view image

Paralogs for RACK1 Gene

Pseudogenes.org Pseudogenes for RACK1 Gene

genes like me logo Genes that share paralogs with RACK1: view

No data available for Paralogs for RACK1 Gene

Variants for RACK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RACK1 Gene

SNP ID Clinical significance and condition Chr 05 pos Variation AA Info Type
rs59085681 Benign: not provided 181,242,275(-) C/T
NM_006098.5(RACK1):c.180G>A (p.Arg60=)
SYNONYMOUS
rs61751567 Benign: not provided 181,241,646(-) G/A
NM_006098.5(RACK1):c.282-7C>T
INTRON

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RACK1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RACK1 Gene

Variant ID Type Subtype PubMed ID
dgv1155e214 CNV gain 21293372
dgv1156e214 CNV loss 21293372
nsv1028730 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781
nsv830567 CNV loss 17160897

Variation tolerance for RACK1 Gene

Residual Variation Intolerance Score: 28.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.48; 28.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RACK1 Gene

Human Gene Mutation Database (HGMD)
RACK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RACK1

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RACK1 Gene

Disorders for RACK1 Gene

MalaCards: The human disease database

(5) MalaCards diseases for RACK1 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
wells syndrome
  • bullous cellulitis with eosinophilia
lung cancer
  • lung cancer, susceptibility to
gastrointestinal stromal tumor
  • gist
alzheimer disease
  • ad
noonan syndrome 1
  • ns1
- elite association - COSMIC cancer census association via MalaCards
Search RACK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RACK1

genes like me logo Genes that share disorders with RACK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RACK1 Gene

Publications for RACK1 Gene

  1. Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4. (PMID: 19674157) Ikebuchi Y … Suzuki H (Hepatology research : the official journal of the Japan Society of Hepatology 2009) 3 4 23
  2. Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for insulin-like growth factor I-mediated regulation of focal adhesion kinase. (PMID: 19423701) Kiely PA … O'Connor R (The Journal of biological chemistry 2009) 3 4 23
  3. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. (PMID: 18621736) Bourd-Boittin K … Théret N (The Journal of biological chemistry 2008) 3 4 23
  4. RACK1 competes with HSP90 for binding to HIF-1alpha and is required for O(2)-independent and HSP90 inhibitor-induced degradation of HIF-1alpha. (PMID: 17244529) Liu YV … Semenza GL (Molecular cell 2007) 3 4 23
  5. Receptor for activated C kinase 1 (RACK1) and Src regulate the tyrosine phosphorylation and function of the androgen receptor. (PMID: 17108144) Kraus S … Weber MJ (Cancer research 2006) 3 4 23

Products for RACK1 Gene

Sources for RACK1 Gene