Aliases for RACGAP1 Gene
External Ids for RACGAP1 Gene
Previous GeneCards Identifiers for RACGAP1 Gene
This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]
GeneCards Summary for RACGAP1 Gene
RACGAP1 (Rac GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RACGAP1 include Uterine Carcinosarcoma and Cataract 36. Among its related pathways are Signaling by GPCR and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding.
UniProtKB/Swiss-Prot Summary for RACGAP1 Gene
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.