This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have... See more...

Aliases for RACGAP1 Gene

Aliases for RACGAP1 Gene

  • Rac GTPase Activating Protein 1 2 3 5
  • MgcRacGAP 2 3 4
  • Rac GTPase-Activating Protein 1 3 4
  • Male Germ Cell RacGap 3 4
  • Protein CYK4 Homolog 3 4
  • HsCYK-4 3 4
  • CYK4 3 4
  • MGCRACGAP 4
  • KIAA1478 4
  • RACGAP1 5
  • ID-GAP 3

External Ids for RACGAP1 Gene

Previous GeneCards Identifiers for RACGAP1 Gene

  • GC12M050677
  • GC12M050438
  • GC12M050099
  • GC12M048669
  • GC12M050370

Summaries for RACGAP1 Gene

Entrez Gene Summary for RACGAP1 Gene

  • This gene encodes a GTPase-activating protein (GAP) that is a compoment of the centralspindlin complex. This protein binds activated forms of Rho GTPases and stimulates GTP hydrolysis, which results in negative regulation of Rho-mediated signals. This protein plays a regulatory role in cytokinesis, cell growth, and differentiation. Alternatively spliced transcript variants have been found for this gene. There is a pseudogene for this gene on chromosome 12. [provided by RefSeq, Feb 2016]

GeneCards Summary for RACGAP1 Gene

RACGAP1 (Rac GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RACGAP1 include Uterine Carcinosarcoma and Cataract 36. Among its related pathways are Signaling by GPCR and Regulation of CDC42 activity. Gene Ontology (GO) annotations related to this gene include protein kinase binding and microtubule binding.

UniProtKB/Swiss-Prot Summary for RACGAP1 Gene

  • Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.

Gene Wiki entry for RACGAP1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RACGAP1 Gene

Genomics for RACGAP1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RACGAP1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J050024 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 610.3 +8.1 8105 2.6 BRCA1 SP1 CREB1 GATAD2A ATF7 PRDM10 ZNF629 ZNF512 SIX5 IKZF1 RACGAP1 BCDIN3D SMARCD1 LMBR1L KMT2D PRPF40B ASIC1 AQP6 AQP5 AQP2
GH12J050032 Promoter/Enhancer 0.9 Ensembl ENCODE 607.4 +0.1 105 1.4 KDM1A NR2C1 EGR1 SPI1 ZNF384 SIN3A REST ZBTB33 TBP EGR2 RACGAP1 SMARCD1 ASIC1 AQP6 AQP5 AQP2 LIMA1 piR-43107-069
GH12J050057 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.2 -24.4 -24364 2.5 CTCF PRDM10 ZNF629 ZNF692 ZNF143 ZIC2 ZSCAN4 POLR2A PATZ1 REST ASIC1 KMT2D LIMA1 SMARCD1 LMBR1L ATF1 BCDIN3D CERS5 LOC101927267 SPATS2
GH12J049983 Enhancer 1.1 FANTOM5 ENCODE CraniofacialAtlas 10.1 +48.9 48906 1.7 IKZF1 ZNF692 ZNF7 JUND PHF21A ZIC2 HDAC1 ZNF600 TCF12 NRF1 CERS5 RACGAP1 LOC102723963 piR-53190 AQP6
GH12J050066 Enhancer 1 FANTOM5 Ensembl ENCODE 10.8 -33.3 -33296 1.4 ZBTB33 TEAD4 KDM1A ZNF692 RFX1 ZIC2 CEBPB FOS ZBTB17 NR2F2 CERS5 AQP6 AQP5 RACGAP1 AQP2 ASIC1 SMARCD1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RACGAP1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RACGAP1

Top Transcription factor binding sites by QIAGEN in the RACGAP1 gene promoter:
  • AP-4
  • FOXD3
  • FOXO1
  • FOXO1a
  • FOXO4
  • GATA-1
  • SRY
  • STAT3
  • TBP

Genomic Locations for RACGAP1 Gene

Genomic Locations for RACGAP1 Gene
chr12:49,976,923-50,033,206
(GRCh38/hg38)
Size:
56,284 bases
Orientation:
Minus strand
chr12:50,370,706-50,426,919
(GRCh37/hg19)
Size:
56,214 bases
Orientation:
Minus strand

Genomic View for RACGAP1 Gene

Genes around RACGAP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RACGAP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RACGAP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RACGAP1 Gene

Proteins for RACGAP1 Gene

  • Protein details for RACGAP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0H5-RGAP1_HUMAN
    Recommended name:
    Rac GTPase-activating protein 1
    Protein Accession:
    Q9H0H5
    Secondary Accessions:
    • Q6PJ26
    • Q9NWN2
    • Q9P250
    • Q9P2W2

    Protein attributes for RACGAP1 Gene

    Size:
    632 amino acids
    Molecular mass:
    71027 Da
    Quaternary structure:
    • Heterotetramer of two molecules each of RACGAP1 and KIF23. Found in the centralspindlin complex. Associates with alpha-, beta- and gamma-tubulin and microtubules. Interacts via its Rho-GAP domain with RND2. Associates with AURKB during M phase. Interacts via its Rho-GAP domain and basic region with PRC1. The interaction with PRC1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology. Interacts with SLC26A8 via its N-terminus. Interacts with RAB11FIP3. Interacts with ECT2; the interaction is direct, occurs at anaphase and during cytokinesis in a microtubule-dependent manner, is enhanced by phosphorylation by PLK1 and phosphorylation at Ser-164 plays a major role in mediating binding (PubMed:25068414). Interacts with KIF23; the interaction is direct.
    SequenceCaution:
    • Sequence=AAH24144.1; Type=Frameshift; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RACGAP1 Gene

neXtProt entry for RACGAP1 Gene

Post-translational modifications for RACGAP1 Gene

  • Phosphorylated at multiple sites in the midbody during cytokinesis (PubMed:12689593). Phosphorylation by AURKB on Ser-387 at the midbody is, at least in part, responsible for exerting its latent GAP activity towards RhoA (PubMed:12689593). Phosphorylation on multiple serine residues by PLK1 enhances its association with ECT2 and is critical for cleavage furrow formation (PubMed:19468302, PubMed:19468300). Phosphorylation on Ser-164 plays a major role in mediating interaction with ECT2 (PubMed:25068414). Phosphorylation on Ser-157 does not appear to contribute to binding to ECT2 (PubMed:25068414).
  • Ubiquitination at Lys173, Lys248, Lys292, Lys430, Lys490, and Lys587
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Abcam antibodies for RACGAP1

No data available for DME Specific Peptides for RACGAP1 Gene

Domains & Families for RACGAP1 Gene

Gene Families for RACGAP1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RACGAP1 Gene

InterPro:
Blocks:
  • RhoGAP domain
ProtoNet:

Suggested Antigen Peptide Sequences for RACGAP1 Gene

GenScript: Design optimal peptide antigens:
  • Male germ cell RacGap (RGAP1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0H5

UniProtKB/Swiss-Prot:

RGAP1_HUMAN :
  • The coiled coil region is indispensible for localization to the midbody during cytokinesis.
Domain:
  • The coiled coil region is indispensible for localization to the midbody during cytokinesis.
  • The phorbol-ester/DAG-type zinc finger domain mediates interaction with membranes enriched in phosphatidylinositol 3,4,5-trisphosphate and is required during mitotic cytokinesis for normal attachment of the midbody to the cell membrane.
genes like me logo Genes that share domains with RACGAP1: view

Function for RACGAP1 Gene

Molecular function for RACGAP1 Gene

UniProtKB/Swiss-Prot Function:
Component of the centralspindlin complex that serves as a microtubule-dependent and Rho-mediated signaling required for the myosin contractile ring formation during the cell cycle cytokinesis. Required for proper attachment of the midbody to the cell membrane during cytokinesis. Plays key roles in controlling cell growth and differentiation of hematopoietic cells through mechanisms other than regulating Rac GTPase activity. Also involved in the regulation of growth-related processes in adipocytes and myoblasts. May be involved in regulating spermatogenesis and in the RACGAP1 pathway in neuronal proliferation. Shows strong GAP (GTPase activation) activity towards CDC42 and RAC1 and less towards RHOA. Essential for the early stages of embryogenesis. May play a role in regulating cortical activity through RHOA during cytokinesis. May participate in the regulation of sulfate transport in male germ cells.
UniProtKB/Swiss-Prot Induction:
Expression is down-regulated during macrophage differention of HL-60 cells.

Phenotypes From GWAS Catalog for RACGAP1 Gene

Gene Ontology (GO) - Molecular Function for RACGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005096 GTPase activator activity IMP 15642749
GO:0005515 protein binding IPI 11278976
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 23235882
GO:0008017 microtubule binding IDA 11782313
GO:0008289 lipid binding IEA --
genes like me logo Genes that share ontologies with RACGAP1: view
genes like me logo Genes that share phenotypes with RACGAP1: view

Animal Model Products

CRISPR Products

miRNA for RACGAP1 Gene

miRTarBase miRNAs that target RACGAP1

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RACGAP1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RACGAP1 Gene

Localization for RACGAP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RACGAP1 Gene

Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Cytoplasmic vesicle, secretory vesicle, acrosome. Cleavage furrow. Midbody, Midbody ring. Cell membrane. Peripheral membrane protein. Cytoplasmic side. Note=Colocalizes with RND2 in Golgi-derived proacrosomal vesicles and the acrosome (By similarity). During interphase, localized to the nucleus and cytoplasm along with microtubules, in anaphase, is redistributed to the central spindle and, in telophase and cytokinesis, to the midbody ring, also called Flemming body. Colocalizes with RHOA at the myosin contractile ring during cytokinesis. Colocalizes with ECT2 to the mitotic spindles during anaphase/metaphase, the cleavage furrow during telophase and at the midbody at the end of cytokinesis. Colocalizes with Cdc42 to spindle microtubules from prometaphase to telophase. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RACGAP1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
nucleus 5
cytosol 5
extracellular 4
mitochondrion 1
endoplasmic reticulum 1
endosome 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RACGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001669 acrosomal vesicle IEA --
GO:0005634 nucleus IEA,IDA 11085985
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005819 spindle IEA --
genes like me logo Genes that share ontologies with RACGAP1: view

Pathways & Interactions for RACGAP1 Gene

genes like me logo Genes that share pathways with RACGAP1: view

Pathways by source for RACGAP1 Gene

2 GeneGo (Thomson Reuters) pathways for RACGAP1 Gene
  • G-protein signaling_Rac2 regulation pathway
  • G-protein signaling_Regulation of RAC1 activity
1 Qiagen pathway for RACGAP1 Gene
  • Rac1 Pathway

SIGNOR curated interactions for RACGAP1 Gene

Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for RACGAP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IMP 16236794
GO:0000915 actomyosin contractile ring assembly IMP 16129829
GO:0006811 ion transport IEA --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0007018 microtubule-based movement TAS --
genes like me logo Genes that share ontologies with RACGAP1: view

Drugs & Compounds for RACGAP1 Gene

(3) Additional Compounds for RACGAP1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Diglycerides Group B
  • 1-Myristoyl-2-eicosadienoyl-sn-glycerol
  • DAG(14:0/20:2)
  • DAG(14:0/20:2N6)
  • DAG(14:0/20:2W6)
  • DAG(34:2)
Diglycerides Group C
  • 1-(9Z-Octadecenoyl)-2-hexadecanoyl-sn-glycerol
  • 1-O-Oleoyl-2-O-palmitoyl-sn-glycerol
  • DG (18:1(9Z)/16:0/0:0)
  • DG(18:1/16:0)
  • Diglyceride
Diglycerides Group D
  • 1,2-Di-(4Z,7Z,10Z,13Z,16Z,19Z-docosahexaenoyl)-sn-glycerol
  • 1,2-Didocosahexaenoyl-sn-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6N3/22:6N3)
  • DAG(22:6OMEGA3/22:6OMEGA3)
genes like me logo Genes that share compounds with RACGAP1: view

Transcripts for RACGAP1 Gene

mRNA/cDNA for RACGAP1 Gene

12 REFSEQ mRNAs :
19 NCBI additional mRNA sequence :
28 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RACGAP1

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RACGAP1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^
SP1: - - - - -
SP2: - - -
SP3: - - - -
SP4: - - - -
SP5: - - - - -
SP6: -
SP7: - - - -
SP8: - - - -
SP9: - - - -
SP10: - - -
SP11: - - - - - -
SP12: - - - -
SP13: - - -
SP14: - - -
SP15: - - - -
SP16: - - - -
SP17: - - -
SP18: -
SP19: - - - - - - - -

ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:

Relevant External Links for RACGAP1 Gene

GeneLoc Exon Structure for
RACGAP1

Expression for RACGAP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RACGAP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RACGAP1 Gene

This gene is overexpressed in Testis (x4.1).

Protein differential expression in normal tissues from HIPED for RACGAP1 Gene

This gene is overexpressed in Spinal cord (23.6), Lung (17.2), Testis (12.3), and Esophagus (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RACGAP1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RACGAP1

SOURCE GeneReport for Unigene cluster for RACGAP1 Gene:

Hs.505469

mRNA Expression by UniProt/SwissProt for RACGAP1 Gene:

Q9H0H5-RGAP1_HUMAN
Tissue specificity: Highly expressed in testis, thymus and placenta. Expressed at lower levels in spleen and peripheral blood lymphocytes. In testis, expression is restricted to germ cells with the highest levels of expression found in spermatocytes. Expression is regulated in a cell cycle-dependent manner and peaks during G2/M phase.

Evidence on tissue expression from TISSUES for RACGAP1 Gene

  • Nervous system(3.9)
  • Skin(2.5)
  • Blood(2.3)
  • Intestine(2.2)
  • Lymph node(2.1)
  • Kidney(2)
genes like me logo Genes that share expression patterns with RACGAP1: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RACGAP1 Gene

Orthologs for RACGAP1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RACGAP1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RACGAP1 30 31
  • 99.63 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RACGAP1 30 31
  • 92.93 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RACGAP1 30 31
  • 91.46 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RACGAP1 31
  • 89 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RACGAP1 31
  • 88 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Racgap1 30
  • 84.43 (n)
Mouse
(Mus musculus)
Mammalia Racgap1 30 17 31
  • 84.26 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RACGAP1 30 31
  • 74.87 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RACGAP1 31
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia racgap1 30
  • 70.75 (n)
Str.360 30
African clawed frog
(Xenopus laevis)
Amphibia MGC53048 30
Zebrafish
(Danio rerio)
Actinopterygii racgap1 30 31
  • 66.51 (n)
OneToOne
wufb92c08 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12503 30
Fruit Fly
(Drosophila melanogaster)
Insecta tum 30 31
  • 48.06 (n)
OneToMany
RacGAP84C 31 32
  • 36 (a)
OneToMany
RacGAP50C 32
  • 33 (a)
RhoGAP16F 31
  • 15 (a)
OneToMany
RhoGAP18B 31
  • 9 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008912 30
  • 45.47 (n)
Worm
(Caenorhabditis elegans)
Secernentea cyk-4 31 32
  • 21 (a)
OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes BEM2 31
  • 5 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8791 31
  • 44 (a)
OneToOne
Species where no ortholog for RACGAP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RACGAP1 Gene

ENSEMBL:
Gene Tree for RACGAP1 (if available)
TreeFam:
Gene Tree for RACGAP1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RACGAP1: view image

Paralogs for RACGAP1 Gene

(3) SIMAP similar genes for RACGAP1 Gene using alignment to 22 proteins:

  • RGAP1_HUMAN
  • F8VQF5_HUMAN
  • F8VQZ5_HUMAN
  • F8VRD2_HUMAN
  • F8VRL2_HUMAN
  • F8VS54_HUMAN
  • F8VUW9_HUMAN
  • F8VV37_HUMAN
  • F8VV39_HUMAN
  • F8VV47_HUMAN
  • F8VVE5_HUMAN
  • F8VVY0_HUMAN
  • F8VWX0_HUMAN
  • F8VWY4_HUMAN
  • F8VXH1_HUMAN
  • F8VYH6_HUMAN
  • F8VZ41_HUMAN
  • F8VZ66_HUMAN
  • F8W0L1_HUMAN
  • F8W1E5_HUMAN
  • F8W1T4_HUMAN
  • H0YIK5_HUMAN

Pseudogenes.org Pseudogenes for RACGAP1 Gene

genes like me logo Genes that share paralogs with RACGAP1: view

No data available for Paralogs for RACGAP1 Gene

Variants for RACGAP1 Gene

Additional dbSNP identifiers (rs#s) for RACGAP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for RACGAP1 Gene

Variant ID Type Subtype PubMed ID
esv1010880 CNV insertion 20482838
esv1766563 CNV insertion 17803354
esv3307517 CNV mobile element insertion 20981092
esv3326667 CNV insertion 20981092
esv3580271 CNV loss 25503493
nsv522972 CNV gain 19592680
nsv558835 CNV gain 21841781
nsv558837 CNV loss 21841781
nsv832407 CNV loss 17160897

Variation tolerance for RACGAP1 Gene

Residual Variation Intolerance Score: 49.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RACGAP1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RACGAP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RACGAP1 Gene

Disorders for RACGAP1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RACGAP1 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
uterine carcinosarcoma
  • mixed mullerian sarcoma of uterus
cataract 36
  • ctrct36
uterine body mixed cancer
  • malignant mixed tumor of corpus uteri
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RACGAP1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RACGAP1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RACGAP1 Gene

Publications for RACGAP1 Gene

  1. MgcRacGAP, a new human GTPase-activating protein for Rac and Cdc42 similar to Drosophila rotundRacGAP gene product, is expressed in male germ cells. (PMID: 9497316) Touré A … Gacon G (The Journal of biological chemistry 1998) 2 3 4 23
  2. Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation. (PMID: 19468300) Wolfe BA … Glotzer M (PLoS biology 2009) 3 4 23
  3. Plk1 self-organization and priming phosphorylation of HsCYK-4 at the spindle midzone regulate the onset of division in human cells. (PMID: 19468302) Burkard ME … Jallepalli PV (PLoS biology 2009) 3 4 23
  4. MgcRacGAP controls the assembly of the contractile ring and the initiation of cytokinesis. (PMID: 16129829) Zhao WM … Fang G (Proceedings of the National Academy of Sciences of the United States of America 2005) 3 4 23
  5. Human mitotic spindle-associated protein PRC1 inhibits MgcRacGAP activity toward Cdc42 during the metaphase. (PMID: 14744859) Ban R … Tanaka H (The Journal of biological chemistry 2004) 3 4 23

Products for RACGAP1 Gene

Sources for RACGAP1 Gene