Aliases for RAC3 Gene
External Ids for RAC3 Gene
Previous GeneCards Identifiers for RAC3 Gene
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
GeneCards Summary for RAC3 Gene
RAC3 (Rac Family Small GTPase 3) is a Protein Coding gene. Diseases associated with RAC3 include Neurodevelopmental Disorder With Structural Brain Anomalies And Dysmorphic Facies and Deafness, Autosomal Recessive 104. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and calcium-dependent protein binding. An important paralog of this gene is RAC1.
UniProtKB/Swiss-Prot Summary for RAC3 Gene
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner.
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.