Aliases for RAC2 Gene
External Ids for RAC2 Gene
Previous GeneCards Identifiers for RAC2 Gene
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]
GeneCards Summary for RAC2 Gene
RAC2 (Rac Family Small GTPase 2) is a Protein Coding gene. Diseases associated with RAC2 include Neutrophil Immunodeficiency Syndrome and Lymphopenia. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and NGF Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAC1.
UniProtKB/Swiss-Prot Summary for RAC2 Gene
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase.
Small G proteins (small GTPases) are homologous to Galpha proteins and are often referred to as the Ras proto-oncogene superfamily. Small GTPases regulate a wide variety of processes in the cell, including growth, differentiation, movement and lipid vesicle transport.