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Aliases for RABIF Gene

Aliases for RABIF Gene

  • RAB Interacting Factor 2 3 5
  • Rab-Interacting Factor 3 4
  • RASGRF3 3 4
  • MSS4 3 4
  • Ras-Specific Guanine-Releasing Factor 3 3
  • Guanine Nucleotide Exchange Factor MSS4 3
  • Mammalian Suppressor Of SEC4 3
  • RASGFR3 3

External Ids for RABIF Gene

Previous HGNC Symbols for RABIF Gene

  • RASGRF3

Previous GeneCards Identifiers for RABIF Gene

  • GC01M200532
  • GC01M198278
  • GC01M199314
  • GC01M200136
  • GC01M199579
  • GC01M201114
  • GC01M174013

Summaries for RABIF Gene

Entrez Gene Summary for RABIF Gene

  • This gene encodes a member of the SCE4/YPT1/RAB family of small GTP-binding proteins that are involved in the regulation of intracellular vesicular transport. This protein stimulates GTP-GDP exchange in SEC4, and to a lesser extent in YPT1 and RAB3A, and may play a general role in vesicular transport. [provided by RefSeq, Oct 2011]

GeneCards Summary for RABIF Gene

RABIF (RAB Interacting Factor) is a Protein Coding gene. Among its related pathways are Retinoblastoma (RB) in Cancer. Gene Ontology (GO) annotations related to this gene include guanyl-nucleotide exchange factor activity.

UniProtKB/Swiss-Prot for RABIF Gene

  • Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.

Gene Wiki entry for RABIF Gene

Additional gene information for RABIF Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RABIF Gene

Genomics for RABIF Gene

GeneHancer (GH) Regulatory Elements for RABIF Gene

Promoters and enhancers for RABIF Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J202887 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 422 2.1 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B E2F8 RABIF ZC3H11A KLHL12 PIR34155
GH01J202856 Promoter/Enhancer 1.7 Ensembl ENCODE 12.1 +29.7 29717 5.7 CLOCK FOXA2 ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZBTB7B YY1 FOS KDM5B LOC730222 ADIPOR1 RABIF PCAT6 LOC148709 MGAT4EP
GH01J202862 Enhancer 0.7 ENCODE 12.1 +26.0 26032 1.5 SOX13 CTCF TFAP4 FOXA2 SAP130 ARID4B CEBPG RAD21 ETS1 ZNF205 LOC730222 LOC148709 RABIF KDM5B PCAT6 PIR34155
GH01J202835 Enhancer 0.7 ENCODE 11.4 +52.6 52565 3 PKNOX1 KLF1 DDX20 MAX SIN3A ZBTB7B RFX5 CTBP1 GATA3 POLR2A KDM5B PCAT6 RABIF CYB5R1 CHIT1 MGAT4EP LOC730222
GH01J203150 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 5.7 -263.9 -263876 6.1 PKNOX1 KLF17 SIN3A FEZF1 GLIS2 ZSCAN5C ZFP91 FOS EGR2 CEBPB ENSG00000224671 ADORA1 RABIF FMOD MYBPH
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RABIF on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RABIF gene promoter:
  • POU2F1
  • POU2F1a
  • ZID
  • CHOP-10
  • C/EBPalpha
  • AML1a
  • FOXD3
  • HNF-3beta
  • E2F

Genomic Locations for RABIF Gene

Genomic Locations for RABIF Gene
chr1:202,878,282-202,889,257
(GRCh38/hg38)
Size:
10,976 bases
Orientation:
Minus strand
chr1:202,848,085-202,858,263
(GRCh37/hg19)
Size:
10,179 bases
Orientation:
Minus strand

Genomic View for RABIF Gene

Genes around RABIF on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RABIF Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RABIF Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RABIF Gene

Proteins for RABIF Gene

  • Protein details for RABIF Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P47224-MSS4_HUMAN
    Recommended name:
    Guanine nucleotide exchange factor MSS4
    Protein Accession:
    P47224
    Secondary Accessions:
    • B2R4P4
    • Q92992

    Protein attributes for RABIF Gene

    Size:
    123 amino acids
    Molecular mass:
    13839 Da
    Quaternary structure:
    • Interacts with RAB8A.

    Three dimensional structures from OCA and Proteopedia for RABIF Gene

neXtProt entry for RABIF Gene

Post-translational modifications for RABIF Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RABIF Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RABIF Gene

Domains & Families for RABIF Gene

Gene Families for RABIF Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RABIF Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for RABIF Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P47224

UniProtKB/Swiss-Prot:

MSS4_HUMAN :
  • Belongs to the DSS4/MSS4 family.
Family:
  • Belongs to the DSS4/MSS4 family.
genes like me logo Genes that share domains with RABIF: view

Function for RABIF Gene

Molecular function for RABIF Gene

UniProtKB/Swiss-Prot Function:
Guanine-nucleotide-releasing protein that acts on members of the SEC4/YPT1/RAB subfamily. Stimulates GDP release from both YPT1 and RAB3A, but is less active on these proteins than on the SEC4 protein. Might play a general role in vesicular transport.
GENATLAS Biochemistry:
guanine nucleotide releasing (exchange) factor,14kDa,specific for Sec4/Ypt/RAB family,RAS superfamily,of GTP binding proteins,involved in the regulation of intracellular vesicular transport,expressed in pancreatic cancer

Gene Ontology (GO) - Molecular Function for RABIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005085 guanyl-nucleotide exchange factor activity NAS 7619808
GO:0005515 protein binding IPI 16541104
GO:0008270 zinc ion binding IDA 7619808
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with RABIF: view
genes like me logo Genes that share phenotypes with RABIF: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RABIF Gene

Localization for RABIF Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RABIF gene
Compartment Confidence
cytosol 4
cytoskeleton 3
extracellular 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (2)
  • Microtubules (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RABIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IBA --
GO:0016020 membrane IBA --
genes like me logo Genes that share ontologies with RABIF: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for RABIF Gene

Pathways & Interactions for RABIF Gene

genes like me logo Genes that share pathways with RABIF: view

Pathways by source for RABIF Gene

1 BioSystems pathway for RABIF Gene

Gene Ontology (GO) - Biological Process for RABIF Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006892 post-Golgi vesicle-mediated transport IBA --
GO:0007264 small GTPase mediated signal transduction IEA --
GO:0015031 protein transport IEA --
GO:0061025 membrane fusion TAS 9441742
GO:0065009 regulation of molecular function IEA --
genes like me logo Genes that share ontologies with RABIF: view

No data available for SIGNOR curated interactions for RABIF Gene

Drugs & Compounds for RABIF Gene

No Compound Related Data Available

Transcripts for RABIF Gene

mRNA/cDNA for RABIF Gene

(1) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(103) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RABIF Gene

RAB interacting factor:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RABIF Gene

No ASD Table

Relevant External Links for RABIF Gene

GeneLoc Exon Structure for
RABIF
ECgene alternative splicing isoforms for
RABIF

Expression for RABIF Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RABIF Gene

Protein differential expression in normal tissues from HIPED for RABIF Gene

This gene is overexpressed in Bone (18.8) and Cervix (8.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RABIF Gene



Protein tissue co-expression partners for RABIF Gene

NURSA nuclear receptor signaling pathways regulating expression of RABIF Gene:

RABIF

SOURCE GeneReport for Unigene cluster for RABIF Gene:

Hs.90875

mRNA Expression by UniProt/SwissProt for RABIF Gene:

P47224-MSS4_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RABIF Gene

  • Nervous system(4.5)
  • Spleen(4.1)
genes like me logo Genes that share expression patterns with RABIF: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RABIF Gene

Orthologs for RABIF Gene

This gene was present in the common ancestor of animals.

Orthologs for RABIF Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RABIF 34 33
  • 99.73 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RABIF 34 33
  • 93.22 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rabif 16 34 33
  • 91.87 (n)
rat
(Rattus norvegicus)
Mammalia Rabif 33
  • 89.43 (n)
cow
(Bos Taurus)
Mammalia RABIF 34 33
  • 83.47 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RABIF 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves RABIF 34 33
  • 73.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RABIF 34
  • 73 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rabif 33
  • 67.54 (n)
zebrafish
(Danio rerio)
Actinopterygii rabif 34 33
  • 69.91 (n)
OneToOne
wufc54e04 33
fruit fly
(Drosophila melanogaster)
Insecta CG7787 34 33
  • 54.09 (n)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008798 33
  • 48.41 (n)
worm
(Caenorhabditis elegans)
Secernentea ZK970.8 34
  • 27 (a)
OneToMany
mdt-9 34
  • 26 (a)
OneToMany
Species where no ortholog for RABIF was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RABIF Gene

ENSEMBL:
Gene Tree for RABIF (if available)
TreeFam:
Gene Tree for RABIF (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RABIF: view image

Paralogs for RABIF Gene

No data available for Paralogs for RABIF Gene

Variants for RABIF Gene

Sequence variations from dbSNP and Humsavar for RABIF Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000252518 -- 202,889,157(-) C/A 5_prime_UTR_variant
rs1000437732 -- 202,883,760(-) T/C intron_variant
rs1000615324 -- 202,880,930(-) G/A/C 3_prime_UTR_variant
rs1001017950 -- 202,888,116(-) C/A intron_variant
rs1001277277 -- 202,877,780(-) TTCTT/TT downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RABIF Gene

Variant ID Type Subtype PubMed ID
nsv832359 CNV loss 17160897

Variation tolerance for RABIF Gene

Residual Variation Intolerance Score: 67.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.47; 10.24% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RABIF Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RABIF

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RABIF Gene

Disorders for RABIF Gene

Additional Disease Information for RABIF

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RABIF Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RABIF Gene

Publications for RABIF Gene

  1. Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer. (PMID: 9441742) Müller-Pillasch F … Gress TM (Genomics 1997) 2 3 4 22 58
  2. Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. (PMID: 7619808) Yu H … Schreiber SL (Biochemistry 1995) 2 3 4 22 58
  3. Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface. (PMID: 7651540) Yu H … Schreiber SL (Nature 1995) 3 4 22 58
  4. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret GB … Chakravarti A (European journal of human genetics : EJHG 2009) 3 44 58
  5. Nucleotide exchange via local protein unfolding--structure of Rab8 in complex with MSS4. (PMID: 16541104) Itzen A … Rak A (The EMBO journal 2006) 3 4 58

Products for RABIF Gene

Sources for RABIF Gene

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