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RABGAP1 (RAB GTPase Activating Protein 1) is a Protein Coding gene. Diseases associated with RABGAP1 include Warburg Micro Syndrome and Warburg Micro Syndrome 1. Among its related pathways are TBC/RABGAPs and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and Rab GTPase binding. An important paralog of this gene is RABGAP1L.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004930 | G protein-coupled receptor activity | IEA | -- |
GO:0005096 | GTPase activator activity | IEA,IDA | 17562788 |
GO:0005515 | protein binding | IPI | 20562859 |
GO:0015631 | tubulin binding | TAS | 10202141 |
GO:0017137 | Rab GTPase binding | IPI | 17562788 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005737 | cytoplasm | IEA | -- |
GO:0005813 | centrosome | TAS | 10202141 |
GO:0005815 | microtubule organizing center | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005856 | cytoskeleton | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | TBC/RABGAPs | ||
3 | Peptide ligand-binding receptors |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007165 | signal transduction | IEA | -- |
GO:0007186 | G protein-coupled receptor signaling pathway | IEA | -- |
GO:0043087 | regulation of GTPase activity | IDA | 17562788 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RABGAP1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | RABGAP1 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RABGAP1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RABGAP1 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rabgap1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rabgap1 30 |
|
||
Chicken (Gallus gallus) |
Aves | RABGAP1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RABGAP1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rabgap1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | RABGAP1 31 |
|
OneToOne | |
LOC559632 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | GapcenA 30 |
|
||
CG7112 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP007332 30 |
|
||
Worm (Caenorhabditis elegans) |
Secernentea | tbc-11 30 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | GYP5 33 |
|
|
|
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2659860 | CNV | deletion | 23128226 |
esv3621686 | CNV | loss | 21293372 |
nsv1110060 | CNV | deletion | 24896259 |
nsv517807 | CNV | loss | 19592680 |
nsv831717 | CNV | gain | 17160897 |
nsv972805 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
warburg micro syndrome |
|
|
warburg micro syndrome 1 |
|
|
charcot-marie-tooth disease, type 4h |
|
|
martsolf syndrome |
|
|