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Aliases for RAB9B Gene

Aliases for RAB9B Gene

  • RAB9B, Member RAS Oncogene Family 2 3 5
  • Rab-9L 3 4
  • RAB9L 3 4
  • Ras-Associated Protein RAB9-Like 3
  • Ras-Related Protein Rab-9B 3
  • Ras-Associated Protein 9B 3
  • Rab-9-Like Protein 4

External Ids for RAB9B Gene

Previous GeneCards Identifiers for RAB9B Gene

  • GC0XM098381
  • GC0XM099989
  • GC0XM101064
  • GC0XM101849
  • GC0XM102883
  • GC0XM102966
  • GC0XM103077
  • GC0XM092733

Summaries for RAB9B Gene

Entrez Gene Summary for RAB9B Gene

  • This gene encodes a member of a subfamily of RAS small guanosine triphosphate (GTP)-binding proteins that regulate membrane trafficking. The encoded protein may be involved in endosome-to-Golgi transport. [provided by RefSeq, Jan 2010]

GeneCards Summary for RAB9B Gene

RAB9B (RAB9B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB9A.

UniProtKB/Swiss-Prot for RAB9B Gene

  • Involved in the transport of proteins between the endosomes and the trans Golgi network.

Additional gene information for RAB9B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB9B Gene

Genomics for RAB9B Gene

GeneHancer (GH) Regulatory Elements for RAB9B Gene

Promoters and enhancers for RAB9B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI103831 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 550.8 +0.3 325 1.5 CTCF MEIS2 MXI1 LEF1 ZNF777 SIN3A ZNF335 E2F1 ZFHX2 GATA3 RAB9B ENSG00000235946 PLP1
GH0XI103828 Promoter/Enhancer 0.7 EPDnew ENCODE 550.8 +3.6 3574 1.2 RAB9B PLP1
GH0XI103917 Promoter/Enhancer 1.3 Ensembl ENCODE 4.4 -86.8 -86811 2.8 PKNOX1 SIN3A ZNF335 GLIS2 SCRT2 BCLAF1 EGR2 SMARCA5 SP3 ZNF654 LOC100128594 TMSB15B H2BFM ENSG00000235946 SLC25A53 FAM199X RAB9B
GH0XI103845 Enhancer 0.6 ENCODE 0.4 -13.0 -13034 0 CTCF ZNF654 ZNF362 RB1 TRIM22 REST RAD21 CBX8 ZNF366 IKZF1 RNA5SP511 RAB9B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB9B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB9B gene promoter:

Genomic Locations for RAB9B Gene

Genomic Locations for RAB9B Gene
9,961 bases
Minus strand

Genomic View for RAB9B Gene

Genes around RAB9B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB9B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB9B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB9B Gene

Proteins for RAB9B Gene

  • Protein details for RAB9B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-9B
    Protein Accession:
    Secondary Accessions:
    • B2R8M0
    • Q52LX2

    Protein attributes for RAB9B Gene

    201 amino acids
    Molecular mass:
    22719 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with SGSM1; the GDP-bound form has much lower affinity for SGSM1 (PubMed:22637480). The GTP-bound form but not the GDP-bound form interacts with HPS4 and the BLOC-3 complex (heterodimer of HPS1 and HPS4) but does not interact with HPS1 alone (PubMed:20048159).

    Three dimensional structures from OCA and Proteopedia for RAB9B Gene

neXtProt entry for RAB9B Gene

Post-translational modifications for RAB9B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB9B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB9B Gene

Domains & Families for RAB9B Gene

Gene Families for RAB9B Gene

Protein Domains for RAB9B Gene

Suggested Antigen Peptide Sequences for RAB9B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB9B: view

Function for RAB9B Gene

Molecular function for RAB9B Gene

UniProtKB/Swiss-Prot Function:
Involved in the transport of proteins between the endosomes and the trans Golgi network.

Gene Ontology (GO) - Molecular Function for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 19490898
GO:0005525 GTP binding IEA --
GO:0019003 GDP binding IDA 20937701
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with RAB9B: view
genes like me logo Genes that share phenotypes with RAB9B: view

Clone Products

  • Addgene plasmids for RAB9B

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB9B Gene

Localization for RAB9B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB9B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB9B gene
Compartment Confidence
plasma membrane 4
cytosol 4
extracellular 2
mitochondrion 1
peroxisome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with RAB9B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB9B Gene

Pathways & Interactions for RAB9B Gene

genes like me logo Genes that share pathways with RAB9B: view

Pathways by source for RAB9B Gene

1 Qiagen pathway for RAB9B Gene

Gene Ontology (GO) - Biological Process for RAB9B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB9B: view

No data available for SIGNOR curated interactions for RAB9B Gene

Drugs & Compounds for RAB9B Gene

No Compound Related Data Available

Transcripts for RAB9B Gene

mRNA/cDNA for RAB9B Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(76) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB9B Gene

RAB9B, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB9B

Alternative Splicing Database (ASD) splice patterns (SP) for RAB9B Gene

No ASD Table

Relevant External Links for RAB9B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB9B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB9B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB9B Gene

This gene is overexpressed in Brain (24.6), Frontal cortex (8.1), Fetal testis (7.9), and Fetal heart (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB9B Gene

Protein tissue co-expression partners for RAB9B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB9B Gene:


SOURCE GeneReport for Unigene cluster for RAB9B Gene:


mRNA Expression by UniProt/SwissProt for RAB9B Gene:

Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RAB9B Gene

  • Nervous system(4.6)
genes like me logo Genes that share expression patterns with RAB9B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB9B Gene

Orthologs for RAB9B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB9B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB9B 33 34
  • 99.83 (n)
(Ornithorhynchus anatinus)
Mammalia RAB9B 34
  • 95 (a)
(Monodelphis domestica)
Mammalia RAB9B 34
  • 95 (a)
(Canis familiaris)
Mammalia RAB9B 33 34
  • 94.03 (n)
(Bos Taurus)
Mammalia RAB9B 34 33
  • 94.03 (n)
(Mus musculus)
Mammalia Rab9b 33 16 34
  • 92.04 (n)
(Rattus norvegicus)
Mammalia Rab9b 33
  • 91.54 (n)
(Gallus gallus)
Aves RAB9B 33 34
  • 80.76 (n)
(Anolis carolinensis)
Reptilia RAB9B 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab9b 33
  • 74.46 (n)
(Danio rerio)
Actinopterygii rab9b 34 33
  • 68.82 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1580 33
fruit fly
(Drosophila melanogaster)
Insecta Rab7 35
  • 57 (a)
Rab9 33 34
  • 56.63 (n)
CG9994 35
  • 54 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009846 33
  • 53.87 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT7 34
  • 46 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
Species where no ortholog for RAB9B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB9B Gene

Gene Tree for RAB9B (if available)
Gene Tree for RAB9B (if available)

Paralogs for RAB9B Gene

Paralogs for RAB9B Gene Pseudogenes for RAB9B Gene

genes like me logo Genes that share paralogs with RAB9B: view

Variants for RAB9B Gene

Sequence variations from dbSNP and Humsavar for RAB9B Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1000323304 -- 103,828,370(-) A/C intron_variant
rs1000328400 -- 103,831,463(-) T/C intron_variant
rs1000605455 -- 103,826,799(-) T/C intron_variant
rs1000675261 -- 103,828,861(-) C/T intron_variant
rs1000933929 -- 103,829,053(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB9B Gene

Variant ID Type Subtype PubMed ID
esv2758880 CNV gain 17122850

Variation tolerance for RAB9B Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.27; 5.94% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB9B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB9B Gene

Disorders for RAB9B Gene

Additional Disease Information for RAB9B

No disorders were found for RAB9B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB9B Gene

Publications for RAB9B Gene

  1. cDNA cloning of a new member of the Ras superfamily, RAB9-like, on the human chromosome Xq22.1-q22.3 region. (PMID: 11043518) Seki N … Saito T (Journal of human genetics 2000) 2 3 4 58
  2. RUTBC2 protein, a Rab9A effector and GTPase-activating protein for Rab36. (PMID: 22637480) Nottingham RM … Pfeffer SR (The Journal of biological chemistry 2012) 3 4 58
  3. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  4. Assembly of the biogenesis of lysosome-related organelles complex-3 (BLOC-3) and its interaction with Rab9. (PMID: 20048159) Kloer DP … Bonifacino JS (The Journal of biological chemistry 2010) 3 4 58
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58

Products for RAB9B Gene

  • Addgene plasmids for RAB9B

Sources for RAB9B Gene

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