Free for academic non-profit institutions. Other users need a Commercial license
RAB9A (RAB9A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB9A include Simpson-Golabi-Behmel Syndrome, Type 2. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB9B.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | TAS,IDA | 15263003 |
GO:0005515 | protein binding | IPI | 15471887 |
GO:0005525 | GTP binding | IDA | 15263003 |
GO:0019003 | GDP binding | IDA | 15263003 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IEA | -- |
GO:0005764 | lysosome | IDA | 15078902 |
GO:0005768 | endosome | IEA | -- |
GO:0005770 | late endosome | IBA,IDA | 15078902 |
GO:0005783 | endoplasmic reticulum | IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Metabolism of proteins | ||
3 | Delta508-CFTR traffic / ER-to-Golgi in CF |
wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
.33
|
Transport Clathrin-coated vesicle cycle
.32
|
4 | Cytoskeletal Signaling | ||
5 | Measles |
.35
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0032482 | Rab protein signal transduction | IBA | -- |
GO:0032880 | regulation of protein localization | IMP | 18787122 |
GO:0042147 | retrograde transport, endosome to Golgi | IBA | 21873635 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Guanosine diphosphate | Experimental | Pharma | Target | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RAB9A 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | RAB9A 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
Dog (Canis familiaris) |
Mammalia | RAB9A 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rab9a 30 |
|
||
Cow (Bos Taurus) |
Mammalia | RAB9A 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rab9 30 17 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RAB9A 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAB9A 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab9a 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.17219 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rab9a 30 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | CG9994 32 |
|
|
|
Rab7 32 |
|
|
|||
Rab9 31 |
|
OneToMany | |||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YPT7 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv2224e212 | CNV | loss | 25503493 |
dgv2225e212 | CNV | gain | 25503493 |
esv3576776 | CNV | gain | 25503493 |
nsv528634 | CNV | gain | 19592680 |
Disorder | Aliases | PubMed IDs |
---|---|---|
simpson-golabi-behmel syndrome, type 2 |
|
|