Aliases for RAB5B Gene
External Ids for RAB5B Gene
- HGNC: 9784
- Entrez Gene: 5869
- Ensembl: ENSG00000111540
- OMIM: 179514
- UniProtKB: P61020
Previous GeneCards Identifiers for RAB5B Gene
- GC12M056195
- GC12P056944
- GC12P056084
- GC12P054654
- GC12P056368
- GC12P053407
Summaries for RAB5B Gene
GeneCards Summary for RAB5B Gene
RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and SMAD Signaling Network. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.
UniProtKB/Swiss-Prot for RAB5B Gene
-
Protein transport. Probably involved in vesicular traffic (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB5B Gene
Genomics for RAB5B Gene
GeneHancer (GH) Regulatory Elements for RAB5B Gene
Promoters and enhancers for RAB5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAB5B on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the RAB5B gene promoter:
-
- Sp1
- C/EBPbeta
Regulatory Element Products
Genomic Locations for RAB5B Gene
Genomic Locations for RAB5B Gene
- chr12:55,973,913-55,996,683
- (GRCh38/hg38)
- Size:
- 22,771 bases
- Orientation:
- Plus strand
- chr12:56,367,697-56,388,490
- (GRCh37/hg19)
- Size:
- 20,794 bases
- Orientation:
- Plus strand
Genomic View for RAB5B Gene
Genes around RAB5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by Entrez Gene
- 12q13 by HGNC
- 12q13.2 by Ensembl
RAB5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAB5B Gene
Proteins for RAB5B Gene
-
Protein details for RAB5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61020-RAB5B_HUMAN
- Recommended name:
- Ras-related protein Rab-5B
- Protein Accession:
- P61020
- A8K982
- B4DKD7
- P35239
- P35277
- Q6PIK9
- Q86TH0
- Q8IXL2
Protein attributes for RAB5B Gene
- Size:
- 215 amino acids
- Molecular mass:
- 23707 Da
- Quaternary structure:
-
- Binds EEA1. Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs.
- SequenceCaution:
-
- Sequence=AAH40143.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RAB5B Gene
Post-translational modifications for RAB5B Gene
Other Protein References for RAB5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for RAB5B
- Novus Biologicals Antibodies for RAB5B
-
Abcam antibodies for RAB5B
- Invitrogen Antibodies for RAB5B
- GeneTex RAB5B Antibody for RAB5B
-
Boster Bio Antibodies for RAB5B
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAB5B
Protein Products
-
OriGene Purified Proteins for RAB5B
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB5B
- Origene Custom Protein Services for RAB5B
- Novus Biologicals proteins for RAB5B
- ProSpec Recombinant Proteins for RAB5B
- antibodies-online: Search results for 10 available RAB5B Proteins ranked by validation data
- Compare Top RAB5B Proteins
-
Quality Products:
- Search GeneTex for Proteins for RAB5B
-
Abcam proteins for RAB5B
Assay Products
- antibodies-online: Search results for 1 available RAB5B Elisa Kits ranked by validation data
- Compare Top RAB5B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RAB5B Gene
Domains & Families for RAB5B Gene
Gene Families for RAB5B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAB5B Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for RAB5B Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
P61020- Family:
-
- Belongs to the small GTPase superfamily. Rab family.
Function for RAB5B Gene
Molecular function for RAB5B Gene
- UniProtKB/Swiss-Prot Function:
- Protein transport. Probably involved in vesicular traffic (By similarity).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
- GENATLAS Biochemistry:
- RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle
Phenotypes From GWAS Catalog for RAB5B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003924 | GTPase activity | IDA,IEA | 17562788 |
| GO:0005515 | protein binding | IPI | 10491193 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0019003 | GDP binding | IDA | 20937701 |
| GO:0030742 | GTP-dependent protein binding | IDA | 10491193 |
Phenotypes for RAB5B Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for RAB5B
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAB5B
-
CRISPR Products
-
OriGene CRISPR knockouts for RAB5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
- genomics-online: gRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- Applied Biological Materials CRISPR for RAB5B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
- GenScript: Design CRISPR guide RNA sequences for RAB5B
miRNA for RAB5B Gene
- miRTarBase miRNAs that target RAB5B
-
- hsa-mir-335-5p (MIRT016752)
- hsa-mir-340-5p (MIRT019535)
- hsa-mir-130b-3p (MIRT020119)
- hsa-mir-96-5p (MIRT027918)
- hsa-mir-93-5p (MIRT027977)
- hsa-mir-22-3p (MIRT030657)
- hsa-mir-19b-3p (MIRT031098)
- hsa-mir-760 (MIRT036762)
- hsa-mir-877-3p (MIRT036953)
- hsa-mir-615-3p (MIRT040223)
- hsa-mir-23b-3p (MIRT046305)
- hsa-mir-183-5p (MIRT047065)
- hsa-mir-17-5p (MIRT050969)
- hsa-let-7c-5p (MIRT051791)
- hsa-mir-19a-3p (MIRT065885)
- hsa-mir-20a-5p (MIRT065886)
- hsa-mir-106a-5p (MIRT065887)
- hsa-mir-130a-3p (MIRT065888)
- hsa-mir-106b-5p (MIRT065889)
- hsa-mir-301a-3p (MIRT065890)
- hsa-mir-20b-5p (MIRT065891)
- hsa-mir-519c-3p (MIRT065892)
- hsa-mir-526b-3p (MIRT065893)
- hsa-mir-519b-3p (MIRT065894)
- hsa-mir-519d-3p (MIRT065895)
- hsa-mir-519a-3p (MIRT065896)
- hsa-mir-509-5p (MIRT065897)
- hsa-mir-454-3p (MIRT065898)
- hsa-mir-301b-3p (MIRT065899)
- hsa-mir-509-3-5p (MIRT065900)
- hsa-mir-1205 (MIRT065901)
- hsa-mir-1909-3p (MIRT065902)
- hsa-mir-4295 (MIRT065903)
- hsa-mir-3666 (MIRT065904)
- hsa-mir-4418 (MIRT065905)
- hsa-mir-548av-3p (MIRT065906)
- hsa-mir-6722-3p (MIRT065907)
- hsa-mir-8076 (MIRT065910)
- hsa-mir-620 (MIRT065911)
- hsa-mir-1270 (MIRT065912)
- hsa-mir-3117-3p (MIRT065913)
- hsa-mir-3169 (MIRT065914)
- hsa-mir-4252 (MIRT065915)
- hsa-mir-4759 (MIRT065920)
- hsa-mir-6869-5p (MIRT065921)
- hsa-mir-8083 (MIRT065922)
- hsa-mir-4505 (MIRT113399)
- hsa-mir-4731-5p (MIRT113400)
- hsa-mir-5787 (MIRT113401)
- hsa-mir-6842-3p (MIRT113402)
- hsa-mir-154-5p (MIRT135426)
- hsa-mir-4802-5p (MIRT135456)
- hsa-mir-7160-5p (MIRT135471)
- hsa-mir-374a-5p (MIRT135474)
- hsa-mir-3609 (MIRT135491)
- hsa-mir-548ah-5p (MIRT135494)
- hsa-mir-185-3p (MIRT135516)
- hsa-mir-3924 (MIRT135530)
- hsa-mir-4656 (MIRT135536)
- hsa-mir-3150a-5p (MIRT273795)
- hsa-mir-3150b-5p (MIRT273797)
- hsa-mir-4476 (MIRT405440)
- hsa-mir-4536-5p (MIRT405441)
- hsa-mir-5197-3p (MIRT405442)
- hsa-mir-6134 (MIRT405443)
- hsa-mir-6873-5p (MIRT405446)
- hsa-mir-6876-5p (MIRT405447)
- hsa-mir-8065 (MIRT405448)
- hsa-mir-9500 (MIRT405449)
- hsa-mir-214-3p (MIRT437673)
- hsa-mir-6878-5p (MIRT469673)
- hsa-mir-6133 (MIRT469674)
- hsa-mir-6130 (MIRT469675)
- hsa-mir-6129 (MIRT469676)
- hsa-mir-6127 (MIRT469677)
- hsa-mir-4510 (MIRT469678)
- hsa-mir-4419a (MIRT469679)
- hsa-mir-4693-3p (MIRT469680)
- hsa-mir-6760-5p (MIRT469681)
- hsa-mir-5586-3p (MIRT469682)
- hsa-mir-6856-5p (MIRT469683)
- hsa-mir-6758-5p (MIRT469684)
- hsa-mir-605-3p (MIRT469685)
- hsa-mir-1295b-3p (MIRT469686)
- hsa-mir-4747-3p (MIRT469687)
- hsa-mir-6511a-5p (MIRT469688)
- hsa-mir-1910-3p (MIRT469689)
- hsa-mir-3714 (MIRT469690)
- hsa-mir-4283 (MIRT469691)
- hsa-mir-4489 (MIRT469692)
- hsa-mir-4430 (MIRT469693)
- hsa-mir-3652 (MIRT469694)
- hsa-mir-6836-5p (MIRT469695)
- hsa-mir-6132 (MIRT469696)
- hsa-mir-4275 (MIRT469697)
- hsa-mir-181c-3p (MIRT469698)
- hsa-mir-4796-3p (MIRT469699)
- hsa-mir-1277-5p (MIRT510884)
- hsa-mir-190a-3p (MIRT510885)
- hsa-mir-5192 (MIRT510886)
- hsa-mir-4644 (MIRT510887)
- hsa-mir-4306 (MIRT510888)
- hsa-mir-185-5p (MIRT510889)
- hsa-mir-6514-5p (MIRT510890)
- hsa-mir-5011-5p (MIRT510891)
- hsa-mir-4683 (MIRT554982)
- hsa-mir-6800-3p (MIRT554983)
- hsa-mir-212-3p (MIRT554984)
- hsa-mir-132-3p (MIRT554985)
- hsa-mir-4520-2-3p (MIRT654507)
- hsa-mir-3152-5p (MIRT654508)
- hsa-mir-4774-3p (MIRT654509)
- hsa-mir-6514-3p (MIRT654510)
- hsa-mir-6894-3p (MIRT654511)
- hsa-mir-6749-3p (MIRT654512)
- hsa-mir-211-5p (MIRT654513)
- hsa-mir-204-5p (MIRT654514)
- hsa-mir-4685-3p (MIRT654515)
- hsa-mir-4287 (MIRT654516)
- hsa-mir-483-3p (MIRT654517)
- hsa-mir-8080 (MIRT654518)
- hsa-mir-182-5p (MIRT738072)
- hsa-mir-31-5p (MIRT740502)
- hsa-mir-4443 (MIRT744591)
- hsa-mir-4453 (MIRT744713)
- hsa-mir-4538 (MIRT746130)
- hsa-mir-5579-3p (MIRT750917)
- hsa-mir-571 (MIRT751405)
- hsa-mir-6507-5p (MIRT752964)
- hsa-mir-6515-5p (MIRT753297)
- hsa-mir-6809-5p (MIRT756634)
- hsa-mir-6826-5p (MIRT757038)
- hsa-mir-6894-5p (MIRT758789)
- hsa-mir-7154-3p (MIRT759239)
- hsa-mir-765 (MIRT759584)
- hsa-mir-766-5p (MIRT759657)
- hsa-mir-1273h-5p (MIRT762069)
- hsa-mir-1293 (MIRT762331)
- hsa-mir-149-3p (MIRT762814)
- hsa-mir-30b-3p (MIRT764607)
- hsa-mir-30c-1-3p (MIRT764669)
- hsa-mir-30c-2-3p (MIRT764714)
- hsa-mir-3122 (MIRT764814)
- hsa-mir-3165 (MIRT765191)
- hsa-mir-340-3p (MIRT765734)
- hsa-mir-363-5p (MIRT766233)
- hsa-mir-3650 (MIRT766258)
- hsa-mir-3689a-3p (MIRT766835)
- hsa-mir-3689b-3p (MIRT766923)
- hsa-mir-3689c (MIRT767011)
- hsa-mir-383-3p (MIRT767561)
- hsa-mir-3913-5p (MIRT767618)
- hsa-mir-4293 (MIRT768442)
- hsa-mir-4459 (MIRT769327)
- hsa-mir-4483 (MIRT769598)
- hsa-mir-450a-1-3p (MIRT769853)
- hsa-mir-4684-5p (MIRT771018)
- hsa-mir-4728-5p (MIRT771730)
- hsa-mir-4761-5p (MIRT772002)
- hsa-mir-548c-3p (MIRT774336)
- hsa-mir-5589-5p (MIRT774815)
- hsa-mir-609 (MIRT775774)
- hsa-mir-6513-5p (MIRT777004)
- hsa-mir-6745 (MIRT778201)
- hsa-mir-6748-5p (MIRT778329)
- hsa-mir-6756-5p (MIRT778404)
- hsa-mir-6766-5p (MIRT778559)
- hsa-mir-6769a-5p (MIRT778584)
- hsa-mir-6769b-5p (MIRT778594)
- hsa-mir-6771-3p (MIRT778649)
- hsa-mir-6772-5p (MIRT778700)
- hsa-mir-6776-5p (MIRT778759)
- hsa-mir-6779-5p (MIRT778913)
- hsa-mir-6780a-5p (MIRT779003)
- hsa-mir-6785-5p (MIRT779140)
- hsa-mir-6788-5p (MIRT779246)
- hsa-mir-6799-5p (MIRT779439)
- hsa-mir-6827-3p (MIRT779932)
- hsa-mir-6849-3p (MIRT780331)
- hsa-mir-6883-5p (MIRT780936)
- hsa-mir-7977 (MIRT782284)
- hsa-mir-887-5p (MIRT782564)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
- genomics-online: shRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
Clone Products
- Sino Biological Human cDNA Clone for RAB5B
- VectorBuilder custom plasmid, inducible vectors for RAB5B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB5B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
- Applied Biological Materials Clones for RAB5B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for RAB5B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB5B Gene
Localization for RAB5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAB5B Gene
- Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endosome | 5 |
| plasma membrane | 3 |
| mitochondrion | 3 |
| cytosol | 3 |
| lysosome | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | -- |
| GO:0005768 | endosome | IEA,IDA | 10491193 |
| GO:0005769 | early endosome | IBA | -- |
| GO:0005886 | plasma membrane | IBA,TAS | -- |
| GO:0012505 | endomembrane system | IBA | -- |
Pathways & Interactions for RAB5B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Vesicle-mediated transport | ||
| 3 | Metabolism of proteins | ||
| 4 | Amoebiasis | ||
| 5 | Endocytosis | ||
Pathways by source for RAB5B Gene
11 Reactome pathways for RAB5B Gene
6 KEGG pathways for RAB5B Gene
3 Qiagen pathways for RAB5B Gene
Interacting Proteins for RAB5B Gene
Selected Interacting proteins:
ENSP00000353444
P61020-RAB5B_HUMAN
for RAB5B Gene via
STRING
UniProtKB
IID
GPS-Prot Interaction Network for RAB5B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | -- |
| GO:0007032 | endosome organization | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0019882 | antigen processing and presentation | IMP | 19717423 |
| GO:0030100 | regulation of endocytosis | IBA | -- |
Transcripts for RAB5B Gene
mRNA/cDNA for RAB5B Gene
- (5) REFSEQ mRNAs :
- (15) Additional mRNA sequences :
- (451) Selected AceView cDNA sequences:
- (11) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000553116 3322 bps (uc001siv.4)
- ENST00000360299 5340 bps (uc001siw.3)
- ENST00000549505 3148 bps (uc058pfh.1)
- ENST00000546810 589 bps (uc058pfi.1)
- ENST00000548068 596 bps (uc058pfj.1)
Unigene Clusters for RAB5B Gene
- RAB5B, member RAS oncogene family:
- Representative Sequences:
CRISPR Products
-
OriGene CRISPR knockouts for RAB5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
- genomics-online: gRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- Applied Biological Materials CRISPR for RAB5B
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
- GenScript: Design CRISPR guide RNA sequences for RAB5B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
- genomics-online: shRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
Clone Products
- Sino Biological Human cDNA Clone for RAB5B
- VectorBuilder custom plasmid, inducible vectors for RAB5B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB5B
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
- Applied Biological Materials Clones for RAB5B
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | - |
Expression for RAB5B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Nasal epithelium (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB5B Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of RAB5B Gene:
RAB5BSOURCE GeneReport for Unigene cluster for RAB5B Gene:
Hs.157659Evidence on tissue expression from TISSUES for RAB5B Gene
- Nervous system(4.9)
- Skin(4.7)
- Eye(4.2)
- Kidney(2.4)
- Muscle(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for RAB5B
-
OriGene qPCR primer pairs for RAB5B
- genomics-online: primer clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB5B Gene
Orthologs for RAB5B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | RAB5B 34 33 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | RAB5B 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | RAB5B 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Rab5b 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Rab5b 33 |
|
||
| chicken (Gallus gallus) |
Aves | RAB5B 34 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | RAB5B 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | rab5b 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3907 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | rab5b 34 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | Rab5 34 35 |
|
OneToMany | |
| chrw 35 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | rab-5 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS21 34 33 |
|
ManyToMany | |
| YPT53 34 |
|
ManyToMany | |||
| K. lactis yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13728g 33 |
|
||
| A. gosspyii yeast (Ashbya gossypii) |
Saccharomycetes | AGOS_ACL084C 33 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7710 33 |
|
||
| rice (Oryza sativa) |
Liliopsida | Os.11076 33 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.11163 34 |
|
OneToMany | |
| bread mold (Neurospora crassa) |
Ascomycetes | NCU06410 33 |
|
- Species where no ortholog for RAB5B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for RAB5B Gene
- ENSEMBL:
- Gene Tree for RAB5B (if available)
- TreeFam:
- Gene Tree for RAB5B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAB5B: view image
Paralogs for RAB5B Gene
Paralogs for RAB5B Gene
(106) SIMAP similar genes for RAB5B Gene using alignment to 6 proteins:
- RAB5B_HUMAN
- F8VPW9_HUMAN
- F8VUA5_HUMAN
- F8VVZ0_HUMAN
- F8VWZ7_HUMAN
- Q6FI54_HUMAN
- RAB5C
- RAB5A
- rab1b
- DKFZp686J06205
- RAB6B
- RAB11A
- RAB22A
- RAB11B
- RAB39B
- RAB6A
- RAB30
- RAB6A
- RAB15
- RAB24
- RAB31
- DKFZp686J07132
- RAB25
- DKFZp313C1541
- RAB21
- RAB1C
- RAB19
- RAB17
- RAB2B
- RAB7A
- RAB8B
- RAB37
- RAB7B
- RAB35
- RAB4B
- RAB41
- RAB2A
- RASEF
- RAB4A
- RAB8A
- RAB6C
- RAB3D
- RAB1B
- RAB43
- RIT2
- RAB23
- RAB14
- RAB13
- RAB3A
- RAB3C
- NRAS
- RAB3B
- KRAS
- RAB10
- RAB26
- RAB33B
- RAB44
- RAB1A
- RHOH
- HRAS
- RAB7L1
- c-bas/has
- RALA
- DKFZp547A0616
- RAB38
- RAP1B
- RHOF
- RAP2A
- RRAS
- RIT1
- RERG
- RAB33A
- RABL2B
- RANP1
- RALB
- RAB34
- RAB27A
- RAP2B
- RAP1A
- RABL2A
- RAB12
- ARL8B
- RAB39A
- LOC51277
- DIRAS1
- RRAS2
- RAB18
- RAP2C
- RAB9A
- TC4
- RAN
- RHEB
- RAB36
- IFT27
- RHEBL1
- RHOC
- RHOA
- RASD2
- RAB27B
- RAC2
- RAB28
- RAB9B
- RHOD
- RAC1
- RAB32
- DIRAS2
- RAB40C
- RND2
- RHOV
- RAB40A
- RAB40B
- RHOQ
Variants for RAB5B Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002373 | -- | 55,973,570(+) | C/T | upstream_transcript_variant | |
| rs1000461817 | -- | 55,992,792(+) | G/A | 3_prime_UTR_variant | |
| rs1000568856 | -- | 55,972,446(+) | T/C/G | upstream_transcript_variant | |
| rs1000630792 | -- | 55,978,738(+) | G/A | intron_variant | |
| rs1000638422 | -- | 55,991,646(+) | C/T | intron_variant |
Residual Variation Intolerance Score:
60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.09;
22.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAB5B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RAB5B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB5B Gene
Disorders for RAB5B Gene
Additional Disease Information for RAB5B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for RAB5B Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB5B Gene
Publications for RAB5B Gene
- Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PMID: 1541686) Wilson DB … Wilson MP (The Journal of clinical investigation 1992) 2 3 4 22 58
- Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J … Stenmark H (European journal of biochemistry 1999) 3 4 22 58
- Common variants in FOXP1 are associated with generalized vitiligo. (PMID: 20526340) Jin Y … Spritz RA (Nature genetics 2010) 3 44 58
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H … Polychronakos C (Diabetes 2008) 3 44 58
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 58
Products for RAB5B Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for RAB5B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RAB5B
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB5B
- Origene Custom Protein Services for RAB5B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- OriGene qPCR primer pairs and template standards for RAB5B
- OriGene qPCR primer pairs for RAB5B
- OriGene CRISPR knockouts for RAB5B
- OriGene ORF clones in human for RAB5B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RAB5B
- GenScript: Next-day shipping of latest version cDNA ORF clones for RAB5B in any vector
- GenScript Custom Purified and Recombinant Proteins Services for RAB5B
- GenScript Custom Assay Services for RAB5B
- GenScript Custom overexpressing Cell Line Services for RAB5B
- GenScript: Design CRISPR guide RNA sequences for RAB5B
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for RAB5B
- Sino Biological Human cDNA Clone for RAB5B
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RAB5B
- Novus Biologicals proteins for RAB5B
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RAB5B
- Abcam proteins for RAB5B
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for RAB5B
- Taconic Biosciences Mouse Models for RAB5B
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RAB5B
- Cyagen custom Knockout/knockin (KOKI) mouse models for RAB5B
- VectorBuilder custom plasmid, inducible vectors for RAB5B
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for RAB5B
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for RAB5B
- antibodies-online: Search results for 37 available RAB5B Antibodies ranked by validation data
- Compare Top RAB5B Antibodies
- antibodies-online: Search results for 1 available RAB5B Elisa Kits ranked by validation data
- Compare Top RAB5B Elisa Kits
- Quality Products:
- antibodies-online: Search results for 10 available RAB5B Proteins ranked by validation data
- Compare Top RAB5B Proteins
- Quality Products:
- GeneTex RAB5B Antibody for RAB5B
- Search GeneTex for Proteins for RAB5B
- Santa Cruz Biotechnology (SCBT) Antibodies for RAB5B
- Search Santa Cruz Biotechnology (SCBT) for RAB5B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
- Horizon Cell Lines for RAB5B
- genomics-online: cdna clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- orf clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- genomics-online: gRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- genomics-online: primer clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- genomics-online: shRNA clones - Search results for 114 available RAB5B gene related products
- Overview of 114 available RAB5B gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
- GeneCopoeia miRNA 3'UTR Target clone products for RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
- Boster Bio Antibodies for RAB5B
- Browse Boster Bio ELISA Kits
Sources for RAB5B Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153)