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RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5B include Parkinson Disease, Late-Onset. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IDA | 17562788 |
GO:0005515 | protein binding | IPI | 10491193 |
GO:0005525 | GTP binding | IEA | -- |
GO:0019003 | GDP binding | IDA | 20937701 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005622 | intracellular | IDA | -- |
GO:0005768 | endosome | IBA,IDA | 10491193 |
GO:0005769 | early endosome | IBA | 21873635 |
GO:0005886 | plasma membrane | TAS | -- |
GO:0012505 | endomembrane system | IBA | 21873635 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Innate Immune System |
.61
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2 | Vesicle-mediated transport | ||
3 | Metabolism of proteins | ||
4 | Amoebiasis | ||
5 | Endocytosis |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0006897 | endocytosis | IBA | 21873635 |
GO:0007032 | endosome organization | IEA | -- |
GO:0015031 | protein transport | IEA | -- |
GO:0019882 | antigen processing and presentation | IMP | 19717423 |
ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | |||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||||
SP4: | |||||||||||||||||||||||||||||
SP5: | - | ||||||||||||||||||||||||||||
SP6: | |||||||||||||||||||||||||||||
SP7: | - | - |
This gene was present in the common ancestor of eukaryotes.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rab5b 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rab5b 30 |
|
||
Chicken (Gallus gallus) |
Aves | RAB5B 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAB5B 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab5b 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.3907 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | rab5b 31 |
|
OneToOne | |
Fruit Fly (Drosophila melanogaster) |
Insecta | Rab5 31 32 |
|
OneToMany | |
chrw 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | rab-5 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS21 30 31 |
|
ManyToMany | |
YPT53 31 |
|
ManyToMany | |||
K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13728g 30 |
|
||
A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACL084C 30 |
|
||
Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7710 30 |
|
||
Rice (Oryza sativa) |
Liliopsida | Os.11076 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11163 31 |
|
OneToMany | |
Bread mold (Neurospora crassa) |
Ascomycetes | NCU06410 30 |
|
Disorder | Aliases | PubMed IDs |
---|---|---|
parkinson disease, late-onset |
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