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Aliases for RAB5B Gene
Aliases for RAB5B Gene
External Ids for RAB5B Gene
- HGNC: 9784
- Entrez Gene: 5869
- Ensembl: ENSG00000111540
- OMIM: 179514
- UniProtKB: P61020
Previous GeneCards Identifiers for RAB5B Gene
- GC12M056195
- GC12P056944
- GC12P056084
- GC12P054654
- GC12P056368
- GC12P053407
Summaries for RAB5B Gene
GeneCards Summary for RAB5B Gene
RAB5B (RAB5B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB5B include Parkinson Disease, Late-Onset. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB5C.
UniProtKB/Swiss-Prot Summary for RAB5B Gene
-
Protein transport. Probably involved in vesicular traffic (By similarity).
Additional gene information for RAB5B Gene
- HGNC(9784)
- Entrez Gene(5869)
- Ensembl(ENSG00000111540)
- OMIM(179514)
- UniProtKB(P61020)
- Open Targets Platform(ENSG00000111540)
- Search for RAB5B at DataMed
- Search for RAB5B at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB5B Gene
Genomics for RAB5B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAB5B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAB5B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB5B
- Top Transcription factor binding sites by QIAGEN in the RAB5B gene promoter:
-
- C/EBPbeta
- Sp1
Genomic Locations for RAB5B Gene
Genomic Locations for RAB5B Gene
- chr12:55,973,913-55,996,683
- (GRCh38/hg38)
- Size:
- 22,771 bases
- Orientation:
- Plus strand
- chr12:56,367,697-56,388,490
- (GRCh37/hg19)
- Size:
- 20,794 bases
- Orientation:
- Plus strand
Genomic View for RAB5B Gene
Genes around RAB5B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.2 by HGNC
- 12q13.2 by Entrez Gene
- 12q13.2 by Ensembl
RAB5B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAB5B Gene
Proteins for RAB5B Gene
-
Protein details for RAB5B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P61020-RAB5B_HUMAN
- Recommended name:
- Ras-related protein Rab-5B
- Protein Accession:
- P61020
- A8K982
- B4DKD7
- P35239
- P35277
- Q6PIK9
- Q86TH0
- Q8IXL2
Protein attributes for RAB5B Gene
- Size:
- 215 amino acids
- Molecular mass:
- 23707 Da
- Quaternary structure:
-
- Binds EEA1 (PubMed:10491193). Interacts with RIN2 and RIN3, which probably regulate its pathway, possibly by acting as GEFs (PubMed:11733506). Interacts with GDI1, GDI2, CHML and CHM; phosphorylation at Ser-84 disrupts this interaction (PubMed:29125462).
- SequenceCaution:
-
- Sequence=AAH40143.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Protein Expression for RAB5B Gene
Post-translational modifications for RAB5B Gene
- Phosphorylation of Ser-84 in the switch II region by LRRK2 prevents the association of RAB regulatory proteins, including CHM, CHML and RAB GDP dissociation inhibitors GDI1 and GDI2.
-
Ubiquitination at Lys134
- NX_P61020 (NX_P61020-1)
- Modification sites at PhosphoSitePlus
Other Protein References for RAB5B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ RAB5B Antibody
-
Custom Antibody ServicesOriGene Antibodies for RAB5B
- Novus Biologicals Antibodies for RAB5B
-
Abcam antibodies for RAB5B
- Invitrogen Antibodies for RAB5B (AFLGC-RAB5B)
-
Boster Bio Antibodies for RAB5B
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAB5B
- Sino Biological Antibodies for RAB5B
Protein Products
-
OriGene Purified Proteins for RAB5B
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB5B
- Origene Custom Protein Services for RAB5B
- Novus Biologicals proteins for RAB5B
- ProSpec Recombinant Proteins for RAB5B
- antibodies-online: Show 8 available RAB5B Proteins ranked by validation data
- Compare Top RAB5B Proteins
-
Quality Products:
-
Signalway Proteins for RAB5B
-
Abcam proteins for RAB5B
Assay Products
- antibodies-online: Show 1 available RAB5B Elisa Kits ranked by validation data
- Compare Top RAB5B Elisa Kits
-
Quality Products:
-
Signalway ELISA kits for RAB5B
No data available for DME Specific Peptides for RAB5B Gene
Domains & Families for RAB5B Gene
Gene Families for RAB5B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for RAB5B Gene
- InterPro:
- Blocks:
-
- GTP-binding nuclear protein Ran
- Ras small GTPase, Ras type
- Ras small GTPase, Rho type
- ProtoNet:
Suggested Antigen Peptide Sequences for RAB5B Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ60627, highly similar to Ras-related protein Rab-5B (B4DKD7_HUMAN)
- RAB5B protein (Q6FI54_HUMAN)
- Ras-related protein Rab-5B (RAB5B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P61020- Family:
-
- Belongs to the small GTPase superfamily. Rab family.
Function for RAB5B Gene
Molecular function for RAB5B Gene
- UniProtKB/Swiss-Prot Function:
- Protein transport. Probably involved in vesicular traffic (By similarity).
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP.
- GENATLAS Biochemistry:
- RAB5B,Ras oncogene superfamily member,involved in endocytosis,expressed in skeletal muscle
Phenotypes From GWAS Catalog for RAB5B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA,IDA | 17562788 |
| GO:0005515 | protein binding | IPI | 10491193 |
| GO:0005525 | GTP binding | IEA | -- |
| GO:0019003 | GDP binding | IDA | 20937701 |
Phenotypes for RAB5B Gene
- MGI mutant phenotypes for RAB5B:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for RAB5B:
Animal Model Products
-
Taconic Biosciences Mouse Models for RAB5B
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAB5B - Select products 50% OFF >
- * RAB5B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAB5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
miRNA for RAB5B Gene
- miRTarBase miRNAs that target RAB5B
-
- mmu-miR-7b-5p (MIRT009240)
- mmu-miR-324-3p (MIRT010896)
- hsa-miR-335-5p (MIRT016752)
- hsa-miR-340-5p (MIRT019535)
- hsa-miR-130b-3p (MIRT020119)
- hsa-miR-96-5p (MIRT027918)
- hsa-miR-93-5p (MIRT027977)
- hsa-miR-22-3p (MIRT030657)
- hsa-miR-19b-3p (MIRT031098)
- hsa-miR-760 (MIRT036762)
- hsa-miR-877-3p (MIRT036953)
- hsa-miR-615-3p (MIRT040223)
- hsa-miR-23b-3p (MIRT046305)
- hsa-miR-183-5p (MIRT047065)
- hsa-miR-17-5p (MIRT050969)
- hsa-let-7c-5p (MIRT051791)
- hsa-miR-19a-3p (MIRT065885)
- hsa-miR-20a-5p (MIRT065886)
- hsa-miR-106a-5p (MIRT065887)
- hsa-miR-130a-3p (MIRT065888)
- hsa-miR-106b-5p (MIRT065889)
- hsa-miR-301a-3p (MIRT065890)
- hsa-miR-20b-5p (MIRT065891)
- hsa-miR-519c-3p (MIRT065892)
- hsa-miR-526b-3p (MIRT065893)
- hsa-miR-519b-3p (MIRT065894)
- hsa-miR-519d-3p (MIRT065895)
- hsa-miR-519a-3p (MIRT065896)
- hsa-miR-509-5p (MIRT065897)
- hsa-miR-454-3p (MIRT065898)
- hsa-miR-301b-3p (MIRT065899)
- hsa-miR-509-3-5p (MIRT065900)
- hsa-miR-1205 (MIRT065901)
- hsa-miR-1909-3p (MIRT065902)
- hsa-miR-4295 (MIRT065903)
- hsa-miR-3666 (MIRT065904)
- hsa-miR-4418 (MIRT065905)
- hsa-miR-548av-3p (MIRT065906)
- hsa-miR-6722-3p (MIRT065907)
- hsa-miR-8076 (MIRT065910)
- hsa-miR-620 (MIRT065911)
- hsa-miR-1270 (MIRT065912)
- hsa-miR-3117-3p (MIRT065913)
- hsa-miR-3169 (MIRT065914)
- hsa-miR-4252 (MIRT065915)
- hsa-miR-4759 (MIRT065920)
- hsa-miR-6869-5p (MIRT065921)
- hsa-miR-8083 (MIRT065922)
- hsa-miR-4505 (MIRT113399)
- hsa-miR-4731-5p (MIRT113400)
- hsa-miR-5787 (MIRT113401)
- hsa-miR-6842-3p (MIRT113402)
- hsa-miR-154-5p (MIRT135426)
- hsa-miR-4802-5p (MIRT135456)
- hsa-miR-7160-5p (MIRT135471)
- hsa-miR-374a-5p (MIRT135474)
- hsa-miR-3609 (MIRT135491)
- hsa-miR-548ah-5p (MIRT135494)
- hsa-miR-185-3p (MIRT135516)
- hsa-miR-3924 (MIRT135530)
- hsa-miR-4656 (MIRT135536)
- hsa-miR-3150a-5p (MIRT273795)
- hsa-miR-3150b-5p (MIRT273797)
- hsa-miR-4476 (MIRT405440)
- hsa-miR-4536-5p (MIRT405441)
- hsa-miR-5197-3p (MIRT405442)
- hsa-miR-6134 (MIRT405443)
- hsa-miR-6873-5p (MIRT405446)
- hsa-miR-6876-5p (MIRT405447)
- hsa-miR-8065 (MIRT405448)
- hsa-miR-9500 (MIRT405449)
- hsa-miR-214-3p (MIRT437673)
- hsa-miR-6878-5p (MIRT469673)
- hsa-miR-6133 (MIRT469674)
- hsa-miR-6130 (MIRT469675)
- hsa-miR-6129 (MIRT469676)
- hsa-miR-6127 (MIRT469677)
- hsa-miR-4510 (MIRT469678)
- hsa-miR-4419a (MIRT469679)
- hsa-miR-4693-3p (MIRT469680)
- hsa-miR-6760-5p (MIRT469681)
- hsa-miR-5586-3p (MIRT469682)
- hsa-miR-6856-5p (MIRT469683)
- hsa-miR-6758-5p (MIRT469684)
- hsa-miR-605-3p (MIRT469685)
- hsa-miR-1295b-3p (MIRT469686)
- hsa-miR-4747-3p (MIRT469687)
- hsa-miR-6511a-5p (MIRT469688)
- hsa-miR-1910-3p (MIRT469689)
- hsa-miR-3714 (MIRT469690)
- hsa-miR-4283 (MIRT469691)
- hsa-miR-4489 (MIRT469692)
- hsa-miR-4430 (MIRT469693)
- hsa-miR-3652 (MIRT469694)
- hsa-miR-6836-5p (MIRT469695)
- hsa-miR-6132 (MIRT469696)
- hsa-miR-4275 (MIRT469697)
- hsa-miR-181c-3p (MIRT469698)
- hsa-miR-4796-3p (MIRT469699)
- hsa-miR-1277-5p (MIRT510884)
- hsa-miR-190a-3p (MIRT510885)
- hsa-miR-5192 (MIRT510886)
- hsa-miR-4644 (MIRT510887)
- hsa-miR-4306 (MIRT510888)
- hsa-miR-185-5p (MIRT510889)
- hsa-miR-6514-5p (MIRT510890)
- hsa-miR-5011-5p (MIRT510891)
- hsa-miR-4683 (MIRT554982)
- hsa-miR-6800-3p (MIRT554983)
- hsa-miR-212-3p (MIRT554984)
- hsa-miR-132-3p (MIRT554985)
- mmu-miR-882 (MIRT581479)
- mmu-miR-185-5p (MIRT581480)
- mmu-miR-3473a (MIRT581481)
- hsa-miR-4520-2-3p (MIRT654507)
- hsa-miR-3152-5p (MIRT654508)
- hsa-miR-4774-3p (MIRT654509)
- hsa-miR-6514-3p (MIRT654510)
- hsa-miR-6894-3p (MIRT654511)
- hsa-miR-6749-3p (MIRT654512)
- hsa-miR-211-5p (MIRT654513)
- hsa-miR-204-5p (MIRT654514)
- hsa-miR-4685-3p (MIRT654515)
- hsa-miR-4287 (MIRT654516)
- hsa-miR-483-3p (MIRT654517)
- hsa-miR-8080 (MIRT654518)
- hsa-miR-182-5p (MIRT738072)
- hsa-miR-31-5p (MIRT740502)
- hsa-miR-4443 (MIRT744591)
- hsa-miR-4453 (MIRT744713)
- hsa-miR-4538 (MIRT746130)
- hsa-miR-5579-3p (MIRT750917)
- hsa-miR-571 (MIRT751405)
- hsa-miR-6507-5p (MIRT752964)
- hsa-miR-6515-5p (MIRT753297)
- hsa-miR-6809-5p (MIRT756634)
- hsa-miR-6826-5p (MIRT757038)
- hsa-miR-6894-5p (MIRT758789)
- hsa-miR-7154-3p (MIRT759239)
- hsa-miR-765 (MIRT759584)
- hsa-miR-766-5p (MIRT759657)
- hsa-miR-1273h-5p (MIRT762069)
- hsa-miR-1293 (MIRT762331)
- hsa-miR-149-3p (MIRT762814)
- hsa-miR-30b-3p (MIRT764607)
- hsa-miR-30c-1-3p (MIRT764669)
- hsa-miR-30c-2-3p (MIRT764714)
- hsa-miR-3122 (MIRT764814)
- hsa-miR-3165 (MIRT765191)
- hsa-miR-340-3p (MIRT765734)
- hsa-miR-363-5p (MIRT766233)
- hsa-miR-3650 (MIRT766258)
- hsa-miR-3689a-3p (MIRT766835)
- hsa-miR-3689b-3p (MIRT766923)
- hsa-miR-3689c (MIRT767011)
- hsa-miR-383-3p (MIRT767561)
- hsa-miR-3913-5p (MIRT767618)
- hsa-miR-4293 (MIRT768442)
- hsa-miR-4459 (MIRT769327)
- hsa-miR-4483 (MIRT769598)
- hsa-miR-450a-1-3p (MIRT769853)
- hsa-miR-4684-5p (MIRT771018)
- hsa-miR-4728-5p (MIRT771730)
- hsa-miR-4761-5p (MIRT772002)
- hsa-miR-548c-3p (MIRT774336)
- hsa-miR-5589-5p (MIRT774815)
- hsa-miR-609 (MIRT775774)
- hsa-miR-6513-5p (MIRT777004)
- hsa-miR-6745 (MIRT778201)
- hsa-miR-6748-5p (MIRT778329)
- hsa-miR-6756-5p (MIRT778404)
- hsa-miR-6766-5p (MIRT778559)
- hsa-miR-6769a-5p (MIRT778584)
- hsa-miR-6769b-5p (MIRT778594)
- hsa-miR-6771-3p (MIRT778649)
- hsa-miR-6772-5p (MIRT778700)
- hsa-miR-6776-5p (MIRT778759)
- hsa-miR-6779-5p (MIRT778913)
- hsa-miR-6780a-5p (MIRT779003)
- hsa-miR-6785-5p (MIRT779140)
- hsa-miR-6788-5p (MIRT779246)
- hsa-miR-6799-5p (MIRT779439)
- hsa-miR-6827-3p (MIRT779932)
- hsa-miR-6849-3p (MIRT780331)
- hsa-miR-6883-5p (MIRT780936)
- hsa-miR-7977 (MIRT782284)
- hsa-miR-887-5p (MIRT782564)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
Clone Products
- Applied Biological Materials (abm): Clones for RAB5B - Select products 50% OFF >
- * RAB5B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RAB5B
- Addgene plasmids for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
Cell Line Products
-
Horizon Cell Lines for RAB5B
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB5B Gene
Localization for RAB5B Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAB5B Gene
- Cell membrane. Lipid-anchor. Cytoplasmic side. Early endosome membrane. Lipid-anchor. Melanosome. Note=Enriched in stage I melanosomes.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| endosome | 5 |
| plasma membrane | 4 |
| mitochondrion | 3 |
| cytosol | 3 |
| cytoskeleton | 2 |
| lysosome | 2 |
| golgi apparatus | 2 |
| nucleus | 1 |
| endoplasmic reticulum | 1 |
- Vesicles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005622 | intracellular | IDA | -- |
| GO:0005768 | endosome | IBA,IDA | 10491193 |
| GO:0005769 | early endosome | IBA | 21873635 |
| GO:0005886 | plasma membrane | TAS | -- |
| GO:0012505 | endomembrane system | IBA | 21873635 |
Pathways & Interactions for RAB5B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Innate Immune System |
.61
|
|
| 2 | Vesicle-mediated transport | ||
| 3 | Metabolism of proteins | ||
| 4 | Amoebiasis | ||
| 5 | Endocytosis | ||
Pathways by source for RAB5B Gene
1 Sino Biological pathway for RAB5B Gene
11 Reactome pathways for RAB5B Gene
7 KEGG pathways for RAB5B Gene
3 Qiagen pathways for RAB5B Gene
- Epithelial Tight Junctions
- Remodeling of Adherens Junctions
- SMAD Signaling Network
Interacting Proteins for RAB5B Gene
Selected Interacting proteins:
P61020-RAB5B_HUMAN
ENSP00000353444
for RAB5B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RAB5B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006886 | intracellular protein transport | IBA | 21873635 |
| GO:0006897 | endocytosis | IBA | 21873635 |
| GO:0007032 | endosome organization | IEA | -- |
| GO:0015031 | protein transport | IEA | -- |
| GO:0019882 | antigen processing and presentation | IMP | 19717423 |
Transcripts for RAB5B Gene
mRNA/cDNA for RAB5B Gene
- 3 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 11 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000360299 5273 nts (view in UCSC)
- ENST00000448789 1530 nts (view in UCSC)
- ENST00000546810 589 nts (view in UCSC)
- ENST00000548068 596 nts (view in UCSC)
- ENST00000549034 558 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAB5B - Select products 50% OFF >
- * RAB5B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAB5B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
Clone Products
- Applied Biological Materials (abm): Clones for RAB5B - Select products 50% OFF >
- * RAB5B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for RAB5B
- Addgene plasmids for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | · | 9c | · | 9d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - | ||||||||||||||||||||||||||||
| SP6: | |||||||||||||||||||||||||||||
| SP7: | - | - |
Relevant External Links for RAB5B Gene
- GeneLoc Exon Structure for
- RAB5B
Expression for RAB5B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Prostate (Endocrine System)
-
Thyroid (Endocrine System)
-
Gall Bladder (Hepatobiliary System)
-
Lung (Respiratory System)
-
Testis (Reproductive System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
-
Ovary (Reproductive System)
This gene is overexpressed in Nasal epithelium (10.9).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB5B Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB5B
SOURCE GeneReport for Unigene cluster for RAB5B Gene:
Hs.157659Evidence on tissue expression from TISSUES for RAB5B Gene
- Nervous system(5)
- Skin(4.8)
- Eye(4.3)
- Kidney(2.8)
- Muscle(2.7)
- Heart(2.4)
- Liver(2.4)
- Adrenal gland(2.3)
- Intestine(2.2)
- Spleen(2.2)
- Lymph node(2.2)
- Lung(2.1)
- Blood(2.1)
- Thyroid gland(2.1)
- Pancreas(2)
Primer Products
-
OriGene qPCR primer pairs for RAB5B
-
OriGene qPCR primer pairs and template standards for RAB5B
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB5B Gene
Orthologs for RAB5B Gene
This gene was present in the common ancestor of eukaryotes.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAB5B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rab5b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rab5b 30 |
|
||
| Chicken (Gallus gallus) |
Aves | RAB5B 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | RAB5B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab5b 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.3907 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | rab5b 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | Rab5 31 32 |
|
OneToMany | |
| chrw 32 |
|
|
|||
| Worm (Caenorhabditis elegans) |
Secernentea | rab-5 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | VPS21 30 31 |
|
ManyToMany | |
| YPT53 31 |
|
ManyToMany | |||
| K. Lactis Yeast (Kluyveromyces lactis) |
Saccharomycetes | KLLA0C13728g 30 |
|
||
| A. gosspyii yeast (Eremothecium gossypii) |
Saccharomycetes | AGOS_ACL084C 30 |
|
||
| Alicante grape (Vitis vinifera) |
eudicotyledons | Vvi.7710 30 |
|
||
| Rice (Oryza sativa) |
Liliopsida | Os.11076 30 |
|
||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.11163 31 |
|
OneToMany | |
| Bread mold (Neurospora crassa) |
Ascomycetes | NCU06410 30 |
|
- Species where no ortholog for RAB5B was found in the sources mined by GeneCards:
-
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAB5B Gene
- ENSEMBL:
- Gene Tree for RAB5B (if available)
- TreeFam:
- Gene Tree for RAB5B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAB5B: view image
Paralogs for RAB5B Gene
Paralogs for RAB5B Gene
- RAB5C 5
- RAB5A 5
- ENSG00000267261 5
- RAB22A 5
- RAB31 5
- RAB1A 5
- RAB17 5
- RAB24 5
- RAB11A 5
- RAB11B 5
- RAB21 5
- RAB26 5
- RAB18 5
- RAB6A 5
- RAB1B 5
- RAB6B 5
- RAB4B-EGLN2 5
- RAB4B 5
- RAB14 5
- RAB25 5
- RAB6D 5
- RAB2B 5
- RAB6C 5
- RAB41 5
- RAB2A 5
- RAB8A 5
- RAB8B 5
- RAB4A 5
- RAB3D 5
- RAB37 5
- RAB35 5
- RAB30 5
- RAB13 5
- ENSG00000285641 5
- RAB10 5
- RAB43 5
- RAB33B 5
- RAB3C 5
- RAB12 5
- RAB33A 5
- RAB19 5
- RAB15 5
- RAB40B 5
- RAB3B 5
- RAB40C 5
- RAB27B 5
- RAB3A 5
- RAB7A 5
- RAB39A 5
- RAB36 5
- RASEF 5
- RAB27A 5
- RABL2A 5
- RABL2B 5
- RAB7B 5
- RAB39B 5
- RAB40AL 5
- RAB40A 5
- RAB20 5
- RAB9A 5
- IFT27 5
- RAB44 5
- RAB28 5
- RAB42 5
- RAB38 5
- RAB9B 5
- RAB32 5
- RAB29 5
- RAB23 5
- RAB34 5
- DNAJC27 5
(106) SIMAP similar genes for RAB5B Gene using alignment to 6 proteins:
- RAB5B_HUMAN
- F8VPW9_HUMAN
- F8VUA5_HUMAN
- F8VVZ0_HUMAN
- F8VWZ7_HUMAN
- Q6FI54_HUMAN
- RAB5C
- RAB5A
- rab1b
- DKFZp686J06205
- RAB6B
- RAB11A
- RAB22A
- RAB11B
- RAB39B
- RAB6A
- RAB30
- RAB6A'
- RAB15
- RAB24
- RAB31
- DKFZp686J07132
- RAB25
- DKFZp313C1541
- RAB21
- RAB1C
- RAB19
- RAB17
- RAB2B
- RAB7A
- RAB8B
- RAB37
- RAB7B
- RAB35
- RAB4B
- RAB41
- RAB2A
- RASEF
- RAB4A
- RAB8A
- RAB6C
- RAB3D
- RAB1B
- RAB43
- RIT2
- RAB23
- RAB14
- RAB13
- RAB3A
- RAB3C
- NRAS
- RAB3B
- KRAS
- RAB10
- RAB26
- RAB33B
- RAB44
- RAB1A
- RHOH
- HRAS
- RAB7L1
- c-bas/has
- RALA
- DKFZp547A0616
- RAB38
- RAP1B
- RHOF
- RAP2A
- RRAS
- RIT1
- RERG
- RAB33A
- RABL2B
- RANP1
- RALB
- RAB34
- RAB27A
- RAP2B
- RAP1A
- RABL2A
- RAB12
- ARL8B
- RAB39A
- LOC51277
- DIRAS1
- RRAS2
- RAB18
- RAP2C
- RAB9A
- TC4
- RAN
- RHEB
- RAB36
- IFT27
- RHEBL1
- RHOC
- RHOA
- RASD2
- RAB27B
- RAC2
- RAB28
- RAB9B
- RHOD
- RAC1
- RAB32
- DIRAS2
- RAB40C
- RND2
- RHOV
- RAB40A
- RAB40B
- RHOQ
Variants for RAB5B Gene
Residual Variation Intolerance Score:
60.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.09;
22.26% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAB5B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RAB5B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB5B Gene
Disorders for RAB5B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| parkinson disease, late-onset |
|
|
Search RAB5B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAB5B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAB5B Gene
Publications for RAB5B Gene
- Identification and subcellular localization of human rab5b, a new member of the ras-related superfamily of GTPases. (PMID: 1541686) Wilson DB … Wilson MP (The Journal of clinical investigation 1992) 2 3 4 23
- Direct interaction of EEA1 with Rab5b. (PMID: 10491193) Callaghan J … Stenmark H (European journal of biochemistry 1999) 3 4 23
- Common variants in FOXP1 are associated with generalized vitiligo. (PMID: 20526340) Jin Y … Spritz RA (Nature genetics 2010) 3 41
- A novel susceptibility locus for type 1 diabetes on Chr12q13 identified by a genome-wide association study. (PMID: 18198356) Hakonarson H … Polychronakos C (Diabetes 2008) 3 41
- Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4
ExternalLinks
Products for RAB5B Gene
- Custom Antibody ServicesOriGene Antibodies for RAB5B
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for RAB5B
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB5B
- Origene Custom Protein Services for RAB5B
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB5B
- Browse OriGene Inhibitory RNA Products For RAB5B
- OriGene qPCR primer pairs for RAB5B
- OriGene qPCR primer pairs and template standards for RAB5B
- OriGene CRISPR knockouts for RAB5B
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For RAB5B
- Sino Biological Human cDNA Clone for RAB5B
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for RAB5B
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for RAB5B
- Novus Biologicals proteins for RAB5B
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for RAB5B
- Abcam proteins for RAB5B
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- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- ProSpec Recombinant Proteins for RAB5B
- Taconic Biosciences Mouse Models for RAB5B
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for RAB5B (AFLGC-RAB5B)
- VectorBuilder Custom and pre-made DNA vectors for RAB5B (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for RAB5B (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for RAB5B (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for RAB5B CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for RAB5B
- Addgene plasmids for RAB5B
- antibodies-online: Show 37 available RAB5B Antibodies ranked by validation data
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- antibodies-online: Show 1 available RAB5B Elisa Kits ranked by validation data
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- Quality Products:
- antibodies-online: Show 8 available RAB5B Proteins ranked by validation data
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- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for RAB5B
- Search Santa Cruz Biotechnology (SCBT) for RAB5B siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for RAB5B
- Horizon Cell Lines for RAB5B
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB5B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB5B
- Search GeneCopoeia for miRNA 3'UTR Target clone products for RAB5B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB5B
- Boster Bio Antibodies for RAB5B
- Browse Boster Bio ELISA Kits
Sources for RAB5B Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB