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Aliases for RAB4B Gene

Aliases for RAB4B Gene

  • RAB4B, Member RAS Oncogene Family 2 3 5
  • Ras-Related GTP-Binding Protein 4b 2
  • Small GTP Binding Protein RAB4B 2

External Ids for RAB4B Gene

Previous GeneCards Identifiers for RAB4B Gene

  • GC19P041923
  • GC19P041675
  • GC19P045960
  • GC19P045974
  • GC19P045977
  • GC19P045979
  • GC19P041284
  • GC19P037717

Summaries for RAB4B Gene

Entrez Gene Summary for RAB4B Gene

  • RAB proteins, such as RAB4B, are members of the RAS superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB4B Gene

RAB4B (RAB4B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB4B-EGLN2.

UniProtKB/Swiss-Prot for RAB4B Gene

  • Protein transport. Probably involved in vesicular traffic (By similarity).

Additional gene information for RAB4B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB4B Gene

Genomics for RAB4B Gene

GeneHancer (GH) Regulatory Elements for RAB4B Gene

Promoters and enhancers for RAB4B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I040776 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 550.8 -0.3 -273 3.3 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 IRF4 RAB4B RAB4B-EGLN2 HNRNPUL1 SNRPA CCDC97 PSMC4 FBL C19orf54 MIA CYP2F2P
GH19I040747 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 -25.5 -25455 9.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 ZNF213 E2F8 ZNF416 SNRPA C19orf54 HNRNPUL1 ENSG00000269843 CCDC97 COQ8B ZNF780A FBL AKT2 ZNF780B
GH19I040662 Enhancer 1.3 Ensembl ENCODE 17.3 -114.5 -114469 2.8 HDGF PKNOX1 CLOCK MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 PIR47829 SNRPA HNRNPUL1 FBL ENSG00000269843 AKT2 CCDC97 ZNF780A ITPKC RAB4B
GH19I040612 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 10.7 -163.7 -163733 4 HDGF PKNOX1 ARNT SIN3A ZBTB7B E2F8 ZNF207 ZNF143 FOS ZNF263 SNRPA ENSG00000269843 HNRNPUL1 PSMC4 SERTAD3 CCDC97 FBL SHKBP1 ITPKC AKT2
GH19I040665 Enhancer 1.2 Ensembl ENCODE 11.1 -111.7 -111730 1.7 ATF1 ARNT SIN3A TCF12 GATA2 FOS ATF7 YY2 NCOA1 REST C19orf54 RNU6-195P ZNF546 CYP2G1P RAB4B RAB4B-EGLN2 SNRPA EGLN2 ZNF780B COQ8B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB4B gene promoter:

Genomic Locations for RAB4B Gene

Genomic Locations for RAB4B Gene
18,729 bases
Plus strand

Genomic View for RAB4B Gene

Genes around RAB4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB4B Gene

Proteins for RAB4B Gene

  • Protein details for RAB4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-4B
    Protein Accession:
    Secondary Accessions:
    • P22750
    • Q7Z514
    • Q9HBR6

    Protein attributes for RAB4B Gene

    213 amino acids
    Molecular mass:
    23587 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB4B Gene

    Alternative splice isoforms for RAB4B Gene


neXtProt entry for RAB4B Gene

Post-translational modifications for RAB4B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB4B Gene

No data available for DME Specific Peptides for RAB4B Gene

Domains & Families for RAB4B Gene

Gene Families for RAB4B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB4B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB4B: view

Function for RAB4B Gene

Molecular function for RAB4B Gene

UniProtKB/Swiss-Prot Function:
Protein transport. Probably involved in vesicular traffic (By similarity).

Phenotypes From GWAS Catalog for RAB4B Gene

Gene Ontology (GO) - Molecular Function for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB4B: view
genes like me logo Genes that share phenotypes with RAB4B: view

Animal Model Products

miRNA for RAB4B Gene

miRTarBase miRNAs that target RAB4B

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB4B Gene

Localization for RAB4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB4B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB4B gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 3
mitochondrion 2
extracellular 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0030667 secretory granule membrane TAS --
GO:0032593 insulin-responsive compartment IDA 19590752
GO:0048471 perinuclear region of cytoplasm IDA 19590752
genes like me logo Genes that share ontologies with RAB4B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB4B Gene

Pathways & Interactions for RAB4B Gene

genes like me logo Genes that share pathways with RAB4B: view

Gene Ontology (GO) - Biological Process for RAB4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
GO:0043312 neutrophil degranulation TAS --
GO:0046323 glucose import IMP 19590752
genes like me logo Genes that share ontologies with RAB4B: view

No data available for SIGNOR curated interactions for RAB4B Gene

Drugs & Compounds for RAB4B Gene

No Compound Related Data Available

Transcripts for RAB4B Gene

Unigene Clusters for RAB4B Gene

RAB4B, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Alternative Splicing Database (ASD) splice patterns (SP) for RAB4B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9
SP1: - - -
SP2: -
SP3: - -

Relevant External Links for RAB4B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB4B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB4B Gene

This gene is overexpressed in Whole Blood (x4.5).

Protein differential expression in normal tissues from HIPED for RAB4B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (17.8) and Brain (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB4B Gene

Protein tissue co-expression partners for RAB4B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB4B Gene:


SOURCE GeneReport for Unigene cluster for RAB4B Gene:


Evidence on tissue expression from TISSUES for RAB4B Gene

  • Nervous system(4.9)
  • Lung(2.7)
  • Spleen(2)
genes like me logo Genes that share expression patterns with RAB4B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB4B Gene

Orthologs for RAB4B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB4B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB4B 34
  • 100 (a)
(Canis familiaris)
Mammalia RAB4B 33 34
  • 94.37 (n)
(Bos Taurus)
Mammalia RAB4B 33
  • 92.8 (n)
-- 34
  • 77 (a)
(Rattus norvegicus)
Mammalia Rab4b 33
  • 91.86 (n)
(Mus musculus)
Mammalia Rab4b 33 16 34
  • 91.55 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 91 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 92 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab4b 33
  • 72.61 (n)
(Danio rerio)
Actinopterygii rab4b 33 34
  • 79.03 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004204 33
  • 71.12 (n)
fruit fly
(Drosophila melanogaster)
Insecta Rab4 35 33 34
  • 67.93 (n)
Rab-RP4 35
  • 45 (a)
(Caenorhabditis elegans)
Secernentea F11A5.4 35
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 69 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.13157 33
Species where no ortholog for RAB4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB4B Gene

Gene Tree for RAB4B (if available)
Gene Tree for RAB4B (if available)

Paralogs for RAB4B Gene

genes like me logo Genes that share paralogs with RAB4B: view

Variants for RAB4B Gene

Sequence variations from dbSNP and Humsavar for RAB4B Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000126726 -- 40,795,782(+) A/T intron_variant
rs1000215381 -- 40,785,366(+) C/G intron_variant
rs1000315692 -- 40,791,205(+) G/A intron_variant
rs1000327350 -- 40,790,981(+) G/T intron_variant
rs1000500606 -- 40,795,993(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB4B Gene

Variant ID Type Subtype PubMed ID
esv26234 CNV loss 19812545
esv2758762 CNV gain+loss 17122850
nsv833832 CNV loss 17160897

Variation tolerance for RAB4B Gene

Residual Variation Intolerance Score: 31.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB4B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB4B Gene

Disorders for RAB4B Gene

Additional Disease Information for RAB4B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB4B Gene

Publications for RAB4B Gene

  1. A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. (PMID: 22080838) Cho MH … COPDGene Investigators (Human molecular genetics 2012) 3 44 58
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RAB4B Gene

  • Addgene plasmids for RAB4B
  • Addgene plasmids for RAB4B

Sources for RAB4B Gene

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