Aliases for RAB4A Gene
External Ids for RAB4A Gene
Previous HGNC Symbols for RAB4A Gene
Previous GeneCards Identifiers for RAB4A Gene
This gene is a member of the largest group in the Ras superfamily of small GTPases, which regulate membrane trafficking. The encoded protein is associated with early endosomes and is involved in their sorting and recycling. The protein also plays a role in regulating the recycling of receptors from endosomes to the plasma membrane. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
GeneCards Summary for RAB4A Gene
RAB4A (RAB4A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB4A include Pontocerebellar Hypoplasia, Type 2E and Charcot-Marie-Tooth Disease, Type 4D. Among its related pathways are Metabolism of proteins and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and protein transporter activity. An important paralog of this gene is RAB4B.
UniProtKB/Swiss-Prot Summary for RAB4A Gene
Protein transport. Plays a role in vesicular traffic. Mediates VEGFR2 endosomal trafficking to enhance VEGFR2 signaling.