Free for academic non-profit institutions. Other users need a Commercial license

Aliases for RAB44 Gene

Aliases for RAB44 Gene

  • RAB44, Member RAS Oncogene Family 2 3 5
  • RASD Family, Member 3 2 3
  • Ras-Related Protein Rab-44 3
  • RAS-Like, Family 13 3
  • DJ431A14.3 3
  • RASL13 3
  • RASD3 3

External Ids for RAB44 Gene

Previous HGNC Symbols for RAB44 Gene

  • RASD3
  • RASL13

Previous GeneCards Identifiers for RAB44 Gene

  • GC06U900627
  • GC06P036799
  • GC06P036665
  • GC06P036778
  • GC06P037311
  • GC06P036978
  • GC06P037015
  • GC06P037795
  • GC06P038418
  • GC06P039008
  • GC06P039596
  • GC06P040156
  • GC06P041235

Summaries for RAB44 Gene

GeneCards Summary for RAB44 Gene

RAB44 (RAB44, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include calcium ion binding and GTPase activity. An important paralog of this gene is RASEF.

Additional gene information for RAB44 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB44 Gene

Genomics for RAB44 Gene

GeneHancer (GH) Regulatory Elements for RAB44 Gene

Promoters and enhancers for RAB44 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J036697 Enhancer 1 Ensembl ENCODE dbSUPER 657.8 +0.8 824 2.5 SCRT1 BCOR CEBPB MAX ZMYM3 GABPA SKIL POLR2A SCRT2 ADNP RAB44 GPR166P
GH06J036592 Promoter/Enhancer 3.2 UCNEbase EPDnew FANTOM5 Ensembl ENCODE dbSUPER 24.1 -100.4 -100391 10.7 CLOCK MLX ZFP64 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 E2F8 SRSF3 C6orf89 CMTR1 KCTD20 BRPF3 MAPK14 CDKN1A LAP3P2 RAB44 STK38
GH06J036884 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 13.1 +189.5 189531 4.9 CLOCK DMAP1 YY1 SLC30A9 E2F8 ZNF143 ZNF263 SP3 NFYC MEF2D C6orf89 PPIL1 CMTR1 SRSF3 FGD2 CDKN1A RAB44 MTCH1 BRPF3 TBC1D22B
GH06J036751 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 17.9 +57.2 57198 6.3 HDGF PKNOX1 RB1 ZFP64 KLF17 IRF4 ZNF335 ZNF143 ATF7 FOS CPNE5 RAB44 RNU1-88P CDKN1A ENSG00000251864 LAP3P2 MTCH1 FGD2 C6orf89 TBC1D22B
GH06J035918 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 13 -777.2 -777157 4.9 HDGF FOXA2 SMAD1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SRPK1 FKBP5 CDKN1A RAB44 SLC26A8 TEAD3 GC06M038959
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB44 on UCSC Golden Path with GeneCards custom track

Genomic Locations for RAB44 Gene

Genomic Locations for RAB44 Gene
chr6:36,697,810-36,733,183
(GRCh38/hg38)
Size:
35,374 bases
Orientation:
Plus strand
chr6:36,683,256-36,699,870
(GRCh37/hg19)
Size:
16,615 bases
Orientation:
Plus strand

Genomic View for RAB44 Gene

Genes around RAB44 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB44 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB44 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB44 Gene

Proteins for RAB44 Gene

  • Protein details for RAB44 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z6P3-RAB44_HUMAN
    Recommended name:
    Ras-related protein Rab-44
    Protein Accession:
    Q7Z6P3

    Protein attributes for RAB44 Gene

    Size:
    723 amino acids
    Molecular mass:
    77638 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAD92808.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for RAB44 Gene

Post-translational modifications for RAB44 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB44 Gene

No data available for DME Specific Peptides for RAB44 Gene

Domains & Families for RAB44 Gene

Gene Families for RAB44 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB44 Gene

Suggested Antigen Peptide Sequences for RAB44 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z6P3

UniProtKB/Swiss-Prot:

RAB44_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB44: view

Function for RAB44 Gene

Phenotypes From GWAS Catalog for RAB44 Gene

Gene Ontology (GO) - Molecular Function for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005509 calcium ion binding IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB44: view
genes like me logo Genes that share phenotypes with RAB44: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB44 Gene

Localization for RAB44 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB44 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB44 gene
Compartment Confidence
plasma membrane 4
lysosome 4
golgi apparatus 1
endosome 1

Gene Ontology (GO) - Cellular Components for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0012505 endomembrane system IBA --
GO:0035577 azurophil granule membrane TAS --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with RAB44: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB44 Gene

Pathways & Interactions for RAB44 Gene

genes like me logo Genes that share pathways with RAB44: view

Interacting Proteins for RAB44 Gene

Gene Ontology (GO) - Biological Process for RAB44 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0032482 Rab protein signal transduction IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB44: view

No data available for SIGNOR curated interactions for RAB44 Gene

Drugs & Compounds for RAB44 Gene

No Compound Related Data Available

Transcripts for RAB44 Gene

mRNA/cDNA for RAB44 Gene

(9) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB44 Gene

RAB44, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB44 Gene

No ASD Table

Relevant External Links for RAB44 Gene

GeneLoc Exon Structure for
RAB44
ECgene alternative splicing isoforms for
RAB44

Expression for RAB44 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB44 Gene

mRNA differential expression in normal tissues according to GTEx for RAB44 Gene

This gene is overexpressed in Whole Blood (x17.1).

Protein differential expression in normal tissues from HIPED for RAB44 Gene

This gene is overexpressed in Lavage (33.0), Cerebrospinal fluid (12.6), Monocytes (12.2), and Peripheral blood mononuclear cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAB44 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB44 Gene:

RAB44

SOURCE GeneReport for Unigene cluster for RAB44 Gene:

Hs.485258
genes like me logo Genes that share expression patterns with RAB44: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB44 Gene

Orthologs for RAB44 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB44 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB44 34 33
  • 99.22 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB44 34 33
  • 81.3 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB44 34 33
  • 80.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab44 33
  • 71.48 (n)
mouse
(Mus musculus)
Mammalia Rab44 16 34 33
  • 68.54 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia RAB44 34
  • 42 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB44 34
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB44 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB44 34
  • 53 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii rab44 34
  • 9 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea 4R79.2 34
  • 26 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT52 34
  • 30 (a)
ManyToMany
YPT10 34
  • 27 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 30 (a)
ManyToMany
Species where no ortholog for RAB44 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB44 Gene

ENSEMBL:
Gene Tree for RAB44 (if available)
TreeFam:
Gene Tree for RAB44 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB44: view image

Paralogs for RAB44 Gene

Variants for RAB44 Gene

Sequence variations from dbSNP and Humsavar for RAB44 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000041053 -- 36,699,512(+) G/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000098835 -- 36,705,086(+) A/C/T intron_variant
rs1000158524 -- 36,719,246(+) G/A intron_variant
rs1000212932 -- 36,704,865(+) A/G intron_variant
rs1000285436 -- 36,711,208(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB44 Gene

Variant ID Type Subtype PubMed ID
dgv1001e201 CNV deletion 23290073
dgv1002e201 CNV deletion 23290073
dgv3301n106 CNV deletion 24896259
esv2731922 CNV deletion 23290073
esv2731927 CNV deletion 23290073
esv3343209 CNV duplication 20981092
esv3571013 CNV loss 25503493
esv3608711 CNV loss 21293372
nsv1015689 CNV gain 25217958
nsv1074923 CNV deletion 25765185
nsv1121346 CNV deletion 24896259
nsv524053 CNV loss 19592680
nsv819609 CNV loss 19587683

Additional Variant Information for RAB44 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB44

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for RAB44 Gene

Disorders for RAB44 Gene

Additional Disease Information for RAB44

No disorders were found for RAB44 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB44 Gene

Publications for RAB44 Gene

  1. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
  2. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome AS … Carapito C (Proteomics 2015) 4 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for RAB44 Gene

Sources for RAB44 Gene

Content
Loading form....