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Aliases for RAB41 Gene

Aliases for RAB41 Gene

  • RAB41, Member RAS Oncogene Family 2 3 5
  • RAB41, Member RAS Homolog Family 2

External Ids for RAB41 Gene

Previous GeneCards Identifiers for RAB41 Gene

  • GC00U991172
  • GC0XP068369
  • GC0XP069285
  • GC0XP069418
  • GC0XP069502
  • GC0XP063322

Summaries for RAB41 Gene

Entrez Gene Summary for RAB41 Gene

  • This gene encodes a small GTP-binding protein that belongs to the largest family within the Ras superfamily. These proteins function as regulators of membrane trafficking. They cycle between inactive GDP-bound and activated GTP-bound states, which is controlled by GTP hydrolysis-activating proteins (GAPs). This family member can be activated by the GAP protein RN-Tre, and it is localized to the Golgi complex. [provided by RefSeq, May 2010]

GeneCards Summary for RAB41 Gene

RAB41 (RAB41, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB6B.

UniProtKB/Swiss-Prot for RAB41 Gene

  • Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

Additional gene information for RAB41 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB41 Gene

Genomics for RAB41 Gene

GeneHancer (GH) Regulatory Elements for RAB41 Gene

Promoters and enhancers for RAB41 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XI070282 Promoter 0.5 EPDnew 550.8 +0.8 763 0.1 RAB41 KIF4A
GH0XI071181 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.8 +901.5 901480 3.5 PKNOX1 FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 POLR2B TAF1 NONO MED12 OGT LOC100420758 ENSG00000229601 P2RY4 ARR3 RPS26P11 RTL5
GH0XI070268 Promoter 0.5 EPDnew 0.4 -13.1 -13076 0.1 ARR3 RAB41
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB41 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB41 gene promoter:

Genomic Locations for RAB41 Gene

Genomic Locations for RAB41 Gene
4,410 bases
Plus strand

Genomic View for RAB41 Gene

Genes around RAB41 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB41 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB41 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB41 Gene

Proteins for RAB41 Gene

  • Protein details for RAB41 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-41
    Protein Accession:
    Secondary Accessions:
    • Q17RQ0

    Protein attributes for RAB41 Gene

    222 amino acids
    Molecular mass:
    25038 Da
    Quaternary structure:
    No Data Available
    • Sequence=CAI41489.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for RAB41 Gene


neXtProt entry for RAB41 Gene

Post-translational modifications for RAB41 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB41 Gene

No data available for DME Specific Peptides for RAB41 Gene

Domains & Families for RAB41 Gene

Gene Families for RAB41 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB41 Gene

Suggested Antigen Peptide Sequences for RAB41 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB41: view

Function for RAB41 Gene

Molecular function for RAB41 Gene

UniProtKB/Swiss-Prot Function:
Required for normal Golgi ribbon organization and ER-to-Golgi trafficking.

Gene Ontology (GO) - Molecular Function for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB41: view
genes like me logo Genes that share phenotypes with RAB41: view

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB41 Gene

Localization for RAB41 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB41 Gene

Cytoplasm. Note=punctate localization concentrated in ruffled regions at the cell periphery.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB41 gene
Compartment Confidence
cytosol 4
golgi apparatus 4
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005794 Golgi apparatus IBA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB41: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB41 Gene

Pathways & Interactions for RAB41 Gene

genes like me logo Genes that share pathways with RAB41: view

Gene Ontology (GO) - Biological Process for RAB41 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER IBA --
GO:0006891 intra-Golgi vesicle-mediated transport IBA --
GO:0042147 retrograde transport, endosome to Golgi IBA --
genes like me logo Genes that share ontologies with RAB41: view

No data available for SIGNOR curated interactions for RAB41 Gene

Drugs & Compounds for RAB41 Gene

No Compound Related Data Available

Transcripts for RAB41 Gene

mRNA/cDNA for RAB41 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB41 Gene

RAB41, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB41 Gene

No ASD Table

Relevant External Links for RAB41 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB41 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB41 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB41 Gene

This gene is overexpressed in Testis (x5.2).

Protein differential expression in normal tissues from HIPED for RAB41 Gene

This gene is overexpressed in Brain (57.8) and Urine (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB41 Gene

Protein tissue co-expression partners for RAB41 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB41 Gene:


SOURCE GeneReport for Unigene cluster for RAB41 Gene:


mRNA Expression by UniProt/SwissProt for RAB41 Gene:

Tissue specificity: Widely expressed in brain, testis, lung, heart, ovary, colon, kidney, uterus and spleen but not in liver.
genes like me logo Genes that share expression patterns with RAB41: view

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB41 Gene

Orthologs for RAB41 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB41 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB41 33 34
  • 99.25 (n)
(Danio rerio)
Actinopterygii zgc:63637 34
  • 62 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab6 34
  • 64 (a)
(Caenorhabditis elegans)
Secernentea rab-6.2 34
  • 62 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT6 34
  • 51 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10389 34
  • 64 (a)
Species where no ortholog for RAB41 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for RAB41 Gene

Gene Tree for RAB41 (if available)
Gene Tree for RAB41 (if available)

Paralogs for RAB41 Gene

Variants for RAB41 Gene

Sequence variations from dbSNP and Humsavar for RAB41 Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs140505250 likely-benign, Anophthalmia - microphthalmia 70,280,804(+) C/G/T upstream_transcript_variant
rs1000410161 -- 70,282,104(+) C/T 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001006356 -- 70,284,456(+) C/T 3_prime_UTR_variant, intron_variant
rs1001267125 -- 70,281,398(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001340197 -- 70,283,554(+) G/A coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB41 Gene

Variant ID Type Subtype PubMed ID
esv1584074 OTHER inversion 17803354
nsv525258 CNV gain 19592680

Variation tolerance for RAB41 Gene

Residual Variation Intolerance Score: 55.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.29; 6.42% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB41 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB41 Gene

Disorders for RAB41 Gene

Additional Disease Information for RAB41

No disorders were found for RAB41 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB41 Gene

Publications for RAB41 Gene

  1. Rab41 is a novel regulator of Golgi apparatus organization that is needed for ER-to-Golgi trafficking and cell growth. (PMID: 23936529) Liu S … Storrie B (PloS one 2013) 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal JB … Seabra MC (Journal of molecular biology 2001) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M … Rocchi P (Molecular & cellular proteomics : MCP 2014) 3 58

Products for RAB41 Gene

Sources for RAB41 Gene

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