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Aliases for RAB40B Gene

Aliases for RAB40B Gene

  • RAB40B, Member RAS Oncogene Family 2 3 5
  • SOCS Box-Containing Protein RAR 3 4
  • Protein Rar 3 4
  • SEC4L 3 4
  • GTP-Binding Protein Homologous To Saccharomyces Cerevisiae SEC4 3
  • Ras-Related Protein Rab-40B 3
  • RAR 3

External Ids for RAB40B Gene

Previous GeneCards Identifiers for RAB40B Gene

  • GC17M079683
  • GC17M083584
  • GC17M081144
  • GC17M081293
  • GC17M078208
  • GC17M080614
  • GC17M076014

Summaries for RAB40B Gene

Entrez Gene Summary for RAB40B Gene

  • The protein encoded by this gene has similarity to a yeast protein which suggests a role of the gene product in regulating secretory vesicles. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB40B Gene

RAB40B (RAB40B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB40AL.

UniProtKB/Swiss-Prot for RAB40B Gene

  • May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Additional gene information for RAB40B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB40B Gene

Genomics for RAB40B Gene

GeneHancer (GH) Regulatory Elements for RAB40B Gene

Promoters and enhancers for RAB40B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I082696 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 581.6 +0.6 612 2.4 PKNOX1 CLOCK FOXA2 ARID4B SIN3A ZNF2 ZNF143 FOS SP3 CEBPZ RAB40B TBCD OGFOD3 ALYREF FOXK2 ENSG00000260563 LOC105371942 NARF-IT1 CSNK1D ENSG00000262652
GH17I082686 Enhancer 0.8 ENCODE dbSUPER 65.4 +11.4 11359 1.7 FOXA2 BACH1 DACH1 SIN3A ZC3H11A REST ATF2 YY1 SP1 JUND RAB40B DUS1L ENSG00000260563 OGFOD3 HEXDC ENSG00000262652 ARL2BPP9 ENSG00000262663 NARF-IT1 ENSG00000265678
GH17I082703 Enhancer 0.9 ENCODE dbSUPER 34.7 -5.7 -5650 1 SOX13 SAP130 ARID4B MAX RAD21 RARA SCRT2 NR2F6 MAFK SCRT1 LOC105376791 RAB40B
GH17I082688 Enhancer 0.5 dbSUPER 62.3 +7.3 7328 5.7 ZFHX2 RFX1 POLR2A CHD4 ZNF524 MNT ZBTB26 RAB40B GC17M082673
GH17I082707 Enhancer 1.2 Ensembl ENCODE dbSUPER 21.5 -9.9 -9861 2.1 PKNOX1 SIN3A FEZF1 GLIS2 EGR1 ZNF366 ATF7 FOS IKZF2 EGR2 LOC101929552 RAB40B FN3KRP TBCD LOC105376791
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB40B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB40B gene promoter:

Genomic Locations for RAB40B Gene

Genomic Locations for RAB40B Gene
43,770 bases
Minus strand

Genomic View for RAB40B Gene

Genes around RAB40B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB40B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB40B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB40B Gene

Proteins for RAB40B Gene

  • Protein details for RAB40B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-40B
    Protein Accession:
    Secondary Accessions:
    • Q8WVG3

    Protein attributes for RAB40B Gene

    278 amino acids
    Molecular mass:
    30956 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB40B Gene

Post-translational modifications for RAB40B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB40B Gene

Domains & Families for RAB40B Gene

Gene Families for RAB40B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB40B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the small GTPase superfamily. Rab family.
  • The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB40B: view

Function for RAB40B Gene

Molecular function for RAB40B Gene

UniProtKB/Swiss-Prot Function:
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

Gene Ontology (GO) - Molecular Function for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB40B: view
genes like me logo Genes that share phenotypes with RAB40B: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB40B Gene

Localization for RAB40B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB40B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB40B gene
Compartment Confidence
nucleus 5
plasma membrane 3
cytosol 3
endosome 3
extracellular 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005635 nuclear envelope IDA 22042847
GO:0005768 endosome IBA --
GO:0005886 plasma membrane IBA --
GO:0008021 synaptic vesicle IBA --
genes like me logo Genes that share ontologies with RAB40B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB40B Gene

Pathways & Interactions for RAB40B Gene

genes like me logo Genes that share pathways with RAB40B: view

Pathways by source for RAB40B Gene

UniProtKB/Swiss-Prot Q12829-RB40B_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for RAB40B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006904 NOT vesicle docking involved in exocytosis IBA --
GO:0009306 NOT protein secretion IBA --
GO:0016567 protein ubiquitination IEA --
GO:0017157 NOT regulation of exocytosis IBA --
GO:0035556 intracellular signal transduction IEA --
genes like me logo Genes that share ontologies with RAB40B: view

No data available for SIGNOR curated interactions for RAB40B Gene

Drugs & Compounds for RAB40B Gene

No Compound Related Data Available

Transcripts for RAB40B Gene

Unigene Clusters for RAB40B Gene

RAB40B, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB40B Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for RAB40B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB40B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB40B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB40B Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x4.5) and Brain - Nucleus accumbens (basal ganglia) (x4.2).

Protein differential expression in normal tissues from HIPED for RAB40B Gene

This gene is overexpressed in Plasma (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for RAB40B Gene

Protein tissue co-expression partners for RAB40B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB40B Gene:


SOURCE GeneReport for Unigene cluster for RAB40B Gene:


Evidence on tissue expression from TISSUES for RAB40B Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with RAB40B: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB40B Gene

Orthologs for RAB40B Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB40B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB40B 33 34
  • 99.76 (n)
(Bos Taurus)
Mammalia RAB40B 33 34
  • 88.37 (n)
(Mus musculus)
Mammalia Rab40b 33 16 34
  • 87.41 (n)
(Rattus norvegicus)
Mammalia Rab40b 33
  • 86.81 (n)
(Canis familiaris)
Mammalia -- 34
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 5 (a)
(Gallus gallus)
Aves RAB40B 33 34
  • 78.9 (n)
(Anolis carolinensis)
Reptilia -- 34
  • 81 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab40b 33
  • 80.58 (n)
Str.14347 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.23887 33
(Danio rerio)
Actinopterygii rab40b 33 34
  • 74.22 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.595 33
fruit fly
(Drosophila melanogaster)
Insecta CG1900 35
  • 60 (a)
Rab40 34
  • 59 (a)
Species where no ortholog for RAB40B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB40B Gene

Gene Tree for RAB40B (if available)
Gene Tree for RAB40B (if available)

Paralogs for RAB40B Gene

Variants for RAB40B Gene

Sequence variations from dbSNP and Humsavar for RAB40B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000048318 -- 82,687,361(-) A/G genic_upstream_transcript_variant, intron_variant
rs1000079105 -- 82,687,009(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000153592 -- 82,664,033(-) G/A intron_variant
rs1000207602 -- 82,673,076(-) C/T genic_upstream_transcript_variant, intron_variant
rs1000334606 -- 82,669,177(-) A/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB40B Gene

Variant ID Type Subtype PubMed ID
dgv1832e59 CNV duplication 20981092
dgv5805n54 CNV loss 21841781
esv1007821 CNV deletion 20482838
esv1288593 CNV deletion 17803354
esv1330810 CNV insertion 17803354
esv1371613 CNV deletion 17803354
esv1463213 CNV deletion 17803354
esv1565279 CNV insertion 17803354
esv1664800 CNV insertion 17803354
esv1683901 CNV deletion 17803354
esv1706997 CNV deletion 17803354
esv21913 CNV gain+loss 19812545
esv2506580 CNV insertion 19546169
esv2716514 CNV deletion 23290073
esv2716515 CNV deletion 23290073
esv2716516 CNV deletion 23290073
esv2716517 CNV deletion 23290073
esv2716519 CNV deletion 23290073
esv2716520 CNV deletion 23290073
esv2716521 CNV deletion 23290073
esv2762577 CNV gain+loss 21179565
esv3380492 CNV duplication 20981092
esv3434025 CNV duplication 20981092
esv3554909 CNV deletion 23714750
esv3641436 CNV loss 21293372
esv3641437 CNV loss 21293372
esv5414 CNV loss 18987735
nsv1061637 CNV loss 25217958
nsv1062980 CNV gain 25217958
nsv1065226 CNV loss 25217958
nsv1067362 CNV gain 25217958
nsv1067553 CNV loss 25217958
nsv1111152 CNV tandem duplication 24896259
nsv1119460 CNV insertion 24896259
nsv1125644 CNV tandem duplication 24896259
nsv1133238 CNV tandem duplication 24896259
nsv1138588 CNV deletion 24896259
nsv1154011 CNV insertion 26484159
nsv428351 CNV gain 18775914
nsv509680 CNV insertion 20534489
nsv576208 CNV loss 21841781
nsv576209 CNV gain 21841781
nsv820798 CNV duplication 20802225
nsv833575 CNV loss 17160897
nsv952395 CNV deletion 24416366
nsv954911 CNV deletion 24416366

Variation tolerance for RAB40B Gene

Residual Variation Intolerance Score: 19.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB40B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB40B Gene

Disorders for RAB40B Gene

Additional Disease Information for RAB40B

No disorders were found for RAB40B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB40B Gene

Publications for RAB40B Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Evolution of the Rab family of small GTP-binding proteins. (PMID: 11697911) Pereira-Leal JB … Seabra MC (Journal of molecular biology 2001) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The role and regulation of Rab40b-Tks5 complex during invadopodia formation and cancer cell invasion. (PMID: 27789576) Jacob A … Prekeris R (Journal of cell science 2016) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for RAB40B Gene

Sources for RAB40B Gene

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