Aliases for RAB3IP Gene
External Ids for RAB3IP Gene
Previous GeneCards Identifiers for RAB3IP Gene
GeneCards Summary for RAB3IP Gene
RAB3IP (RAB3A Interacting Protein) is a Protein Coding gene. Diseases associated with RAB3IP include Nephronophthisis 15 and Bardet-Biedl Syndrome 3. Among its related pathways are Vesicle-mediated transport and Organelle biogenesis and maintenance. Gene Ontology (GO) annotations related to this gene include Rab guanyl-nucleotide exchange factor activity. An important paralog of this gene is RAB3IL1.
UniProtKB/Swiss-Prot Summary for RAB3IP Gene
Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B (PubMed:12221131, PubMed:26824392). Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:12221131, PubMed:26824392). Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5 (PubMed:20937701, PubMed:26824392). Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface (PubMed:12221131). Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (PubMed:20890297).