RAB37 Gene (Protein Coding)

RAB37, Member RAS Oncogene Family

GC17P074671
GIFtS:
39
Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006] See more...

Aliases for RAB37 Gene

Aliases for RAB37 Gene

  • RAB37, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-37 3 4
  • RAB37, Member Of RAS Oncogene Family 3
  • RAB37 5

External Ids for RAB37 Gene

Previous GeneCards Identifiers for RAB37 Gene

  • GC17P073131
  • GC17P073264
  • GC17P073263
  • GC17P070178
  • GC17P072666
  • GC17P068076

Summaries for RAB37 Gene

Entrez Gene Summary for RAB37 Gene

  • Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB37 Gene

RAB37 (RAB37, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB37 include Griscelli Syndrome. Among its related pathways are Innate Immune System and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB26.

Gene Wiki entry for RAB37 Gene

Additional gene information for RAB37 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB37 Gene

Genomics for RAB37 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for RAB37 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB37 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB37

Top Transcription factor binding sites by QIAGEN in the RAB37 gene promoter:
  • CBF(2)
  • CBF-A
  • CBF-B
  • CBF-C
  • CP1A
  • GATA-3
  • HNF-4alpha1
  • NF-kappaB1
  • NF-Y
  • STAT5B

Genomic Locations for RAB37 Gene

Latest Assembly
chr17:74,670,578-74,747,335
(GRCh38/hg38)
Size:
76,758 bases
Orientation:
Plus strand

Previous Assembly
chr17:72,667,270-72,743,474
(GRCh37/hg19 by Entrez Gene)
Size:
76,205 bases
Orientation:
Plus strand

chr17:72,666,717-72,743,474
(GRCh37/hg19 by Ensembl)
Size:
76,758 bases
Orientation:
Plus strand

Genomic View for RAB37 Gene

Genes around RAB37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB37 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RAB37 Gene

Proteins for RAB37 Gene

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  • Protein details for RAB37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96AX2-RAB37_HUMAN
    Recommended name:
    Ras-related protein Rab-37
    Protein Accession:
    Q96AX2
    Secondary Accessions:
    • A8MXF5
    • A8MYT0
    • Q8IWA7

    Protein attributes for RAB37 Gene

    Size:
    223 amino acids
    Molecular mass:
    24815 Da
    Quaternary structure:
    • Interacts with RIMS1.

    Alternative splice isoforms for RAB37 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB37 Gene

Protein Expression for RAB37 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RAB37 Gene

  • Ubiquitination at Lys115 and Lys189
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB37 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB37 Gene

Domains & Families for RAB37 Gene

Gene Families for RAB37 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB37 Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
ProtoNet:

Suggested Antigen Peptide Sequences for RAB37 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ45130 fis, clone BRAWH3037428, highly similar to Homo sapiens RAB37, member RAS oncogene family (RAB37), transcript variant 3, mRNA (A8MSP2_HUMAN)
  • cDNA FLJ30284 fis, clone BRACE2002812, highly similar to Homo sapiens RAB37, member RAS oncogene family (RAB37), transcript variant 3, mRNA (A8MUU7_HUMAN)
  • cDNA FLJ55151, highly similar to Ras-related protein Rab-37 (A8MXF5_HUMAN)
  • cDNA FLJ58966, highly similar to Ras-related protein Rab-37 (A8MYT0_HUMAN)
  • cDNA FLJ61124, highly similar to Ras-related protein Rab-37 (B7Z3L0_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q96AX2

UniProtKB/Swiss-Prot:

RAB37_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB37: view

Function for RAB37 Gene

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  1. Animal Models for research
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  4. Inhibitory RNAs for research
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  6. Cell Lines for research

Phenotypes From GWAS Catalog for RAB37 Gene

Gene Ontology (GO) - Molecular Function for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB37: view
genes like me logo Genes that share phenotypes with RAB37: view

Animal Models for research

  • Taconic Biosciences Mouse Models for RAB37

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB37

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB37 Gene

Localization for RAB37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB37 Gene

Cytoplasmic vesicle. Note=Secretory granules. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB37 gene
Compartment Confidence
plasma membrane 4
endosome 4
lysosome 4
golgi apparatus 4
cytosol 3
nucleus 2
extracellular 1
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005794 Golgi apparatus IBA 21873635
GO:0005886 plasma membrane TAS --
GO:0031410 cytoplasmic vesicle IEA --
genes like me logo Genes that share ontologies with RAB37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB37 Gene

Pathways & Interactions for RAB37 Gene

genes like me logo Genes that share pathways with RAB37: view

Gene Ontology (GO) - Biological Process for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015031 protein transport IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB37: view

No data available for SIGNOR curated interactions for RAB37 Gene

Drugs & Compounds for RAB37 Gene

Products:

  1. Drug products for research
No Compound Related Data Available

Transcripts for RAB37 Gene

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mRNA/cDNA for RAB37 Gene

6 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
16 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB37

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: -
SP9: -
SP10: - -

Relevant External Links for RAB37 Gene

GeneLoc Exon Structure for
RAB37

Expression for RAB37 Gene

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  1. Primer products for research
  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB37 Gene

mRNA expression in normal human tissues for RAB37 Gene
mRNA expression by BioGPS for RAB37 GenemRNA expression by GTEx for RAB37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB37 Gene

This gene is overexpressed in Brain - Cerebellum (x11.0), Brain - Cerebellar Hemisphere (x10.7), and Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for RAB37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.3), Platelet (14.0), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB37 Gene



Protein tissue co-expression partners for RAB37 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB37

SOURCE GeneReport for Unigene cluster for RAB37 Gene:

Hs.351413

Evidence on tissue expression from TISSUES for RAB37 Gene

  • Nervous system(4.7)
  • Blood(4.4)
genes like me logo Genes that share expression patterns with RAB37: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB37 Gene

Orthologs for RAB37 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB37 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia RAB37 30 31
  • 96.71 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia RAB37 30 31
  • 89.64 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Rab37 30 17 31
  • 88.94 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC100364984 30
  • 88.89 (n)
Oppossum
(Monodelphis domestica)
 Mammalia RAB37 31
  • 79 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia RAB37 31
  • 79 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia RAB37 31
  • 75 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves RAB37 31
  • 64 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia RAB37 31
  • 69 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia rab37 30
  • 70.33 (n)
Str.14110 30
Zebrafish
(Danio rerio)
 Actinopterygii zgc:112183 30
  • 72.22 (n)
RAB37 31
  • 68 (a)
 OneToOne
Fruit Fly
(Drosophila melanogaster)
 Insecta Rab26 31
  • 31 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea rab-37 30 31
  • 57.8 (n)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 52 (a)
 OneToMany
Species where no ortholog for RAB37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RAB37 Gene

ENSEMBL:
Gene Tree for RAB37 (if available)
TreeFam:
Gene Tree for RAB37 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB37: view image

Paralogs for RAB37 Gene

Paralogs for RAB37 Gene

(107) SIMAP similar genes for RAB37 Gene using alignment to 7 proteins:

  • RAB37_HUMAN
  • A8MSP2_HUMAN
  • A8MTC6_HUMAN
  • A8MUU7_HUMAN
  • A8MZI4_HUMAN
  • B7Z3L0_HUMAN
  • L8EBG4_HUMAN
genes like me logo Genes that share paralogs with RAB37: view

Variants for RAB37 Gene

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Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB37 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs34215331 - p.Ala188Pro

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAB37 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAB37 Gene

Variant ID Type Subtype PubMed ID
dgv1815e59 CNV duplication 20981092
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2574609 CNV insertion 19546169
esv2716232 CNV deletion 23290073
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv3310549 CNV novel sequence insertion 20981092
esv3398562 CNV duplication 20981092
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
esv4044 CNV loss 18987735
esv8799 CNV loss 19470904
nsv1116238 CNV deletion 24896259
nsv1124759 CNV duplication 24896259
nsv2140 CNV deletion 18451855
nsv517569 CNV gain+loss 19592680

Variation tolerance for RAB37 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB37

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB37 Gene

Disorders for RAB37 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB37 Gene - From: COP

Disorder Aliases PubMed IDs
griscelli syndrome
  • chediak-higashi-like syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAB37 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB37

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with RAB37: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB37 Gene

Publications for RAB37 Gene

  1. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S … Nakamura Y (Oncology reports 2009) 3 23
  2. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik JS … Ridker PM (Circulation. Cardiovascular genetics 2009) 3 41
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4

ExternalLinks

View latest publications for RAB37 gene in Mastermind

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Sources for RAB37 Gene