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Aliases for RAB37 Gene

Aliases for RAB37 Gene

  • RAB37, Member RAS Oncogene Family 2 3 5
  • RAB37, Member Of RAS Oncogene Family 3
  • Ras-Related Protein Rab-37 3

External Ids for RAB37 Gene

Previous GeneCards Identifiers for RAB37 Gene

  • GC17P073131
  • GC17P073264
  • GC17P073263
  • GC17P070178
  • GC17P072666
  • GC17P068076

Summaries for RAB37 Gene

Entrez Gene Summary for RAB37 Gene

  • Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB37 Gene

RAB37 (RAB37, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Innate Immune System. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB26.

Gene Wiki entry for RAB37 Gene

Additional gene information for RAB37 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB37 Gene

Genomics for RAB37 Gene

GeneHancer (GH) Regulatory Elements for RAB37 Gene

Promoters and enhancers for RAB37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J074736 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 671 +67.3 67299 3.3 HDGF PKNOX1 FOXA2 SMAD1 MLX ARID4B SIN3A DMAP1 YY1 SLC30A9 RAB37 CD300A SLC9A3R1 DNAI2 CD300LF CD300LB
GH17J074671 Enhancer 1 ENCODE 650.7 +0.8 799 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 CBX5 ZNF213 RAB37 NAT9 LOC105371894
GH17J074746 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.6 +79.8 79812 8.6 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SLC9A3R1 LOC105371893 MIR3615 RAB37 NAT9 GC17P074757
GH17J074778 Enhancer 1.5 FANTOM5 ENCODE dbSUPER 18.8 +109.2 109226 3.5 PKNOX1 ARID4B SIN3A IRF4 ZNF48 TCF12 ZNF143 FOS ATF7 RUNX3 CD300LF RAB37 SLC9A3R1 GRIN2C CD300LB TMEM104 CD300A CD300C GGA3 SLC16A5
GH17J074639 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 17.5 -30.7 -30652 1.7 PKNOX1 CBFB HLF IRF5 CEBPB MEF2B DPF2 POLR2A IKZF1 EED CD300E CD300C CD300LB RAB37 TMEM104 CD300LF CD300LD CD300A ENSG00000236770 SLC9A3R1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB37 gene promoter:
  • NF-kappaB1
  • HNF-4alpha1
  • STAT5B
  • GATA-3
  • CBF-C
  • CBF-B
  • CBF-A
  • CBF(2)
  • NF-Y
  • CP1A

Genomic Locations for RAB37 Gene

Genomic Locations for RAB37 Gene
76,758 bases
Plus strand
76,758 bases
Plus strand

Genomic View for RAB37 Gene

Genes around RAB37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB37 Gene

Proteins for RAB37 Gene

  • Protein details for RAB37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-37
    Protein Accession:
    Secondary Accessions:
    • A8MXF5
    • A8MYT0
    • Q8IWA7

    Protein attributes for RAB37 Gene

    223 amino acids
    Molecular mass:
    24815 Da
    Quaternary structure:
    • Interacts with RIMS1.

    Alternative splice isoforms for RAB37 Gene


neXtProt entry for RAB37 Gene

Post-translational modifications for RAB37 Gene

  • Ubiquitination at posLast=189189 and Lys115
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB37 Gene

Domains & Families for RAB37 Gene

Gene Families for RAB37 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB37 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB37: view

Function for RAB37 Gene

Phenotypes From GWAS Catalog for RAB37 Gene

Gene Ontology (GO) - Molecular Function for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB37: view
genes like me logo Genes that share phenotypes with RAB37: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB37

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB37 Gene

Localization for RAB37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB37 Gene

Cytoplasmic vesicle. Note=Secretory granules. {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB37 gene
Compartment Confidence
plasma membrane 4
lysosome 4
cytosol 3
endosome 3
nucleus 2

Gene Ontology (GO) - Cellular Components for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IDA 15308636
GO:0005886 plasma membrane IBA,TAS --
GO:0008021 synaptic vesicle IBA --
GO:0012505 endomembrane system IBA --
genes like me logo Genes that share ontologies with RAB37: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB37 Gene

Pathways & Interactions for RAB37 Gene

genes like me logo Genes that share pathways with RAB37: view

Gene Ontology (GO) - Biological Process for RAB37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006904 vesicle docking involved in exocytosis IBA --
GO:0009306 protein secretion IBA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IBA --
genes like me logo Genes that share ontologies with RAB37: view

No data available for SIGNOR curated interactions for RAB37 Gene

Drugs & Compounds for RAB37 Gene

No Compound Related Data Available

Transcripts for RAB37 Gene

Unigene Clusters for RAB37 Gene

RAB37, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB37 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b · 12c · 12d · 12e ^ 13
SP1: - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - - - -
SP7: - - - - -
SP8: -
SP9: -
SP10: - -

Relevant External Links for RAB37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB37 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB37 Gene

This gene is overexpressed in Brain - Cerebellum (x11.0), Brain - Cerebellar Hemisphere (x10.7), and Whole Blood (x9.4).

Protein differential expression in normal tissues from HIPED for RAB37 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (39.3), Platelet (14.0), and Brain (6.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB37 Gene

Protein tissue co-expression partners for RAB37 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB37 Gene:


SOURCE GeneReport for Unigene cluster for RAB37 Gene:


Evidence on tissue expression from TISSUES for RAB37 Gene

  • Nervous system(4.6)
  • Blood(4.2)
genes like me logo Genes that share expression patterns with RAB37: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB37 Gene

Orthologs for RAB37 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB37 34 33
  • 96.71 (n)
(Canis familiaris)
Mammalia RAB37 34 33
  • 89.64 (n)
(Mus musculus)
Mammalia Rab37 16 34 33
  • 88.94 (n)
(Rattus norvegicus)
Mammalia LOC100364984 33
  • 88.89 (n)
(Monodelphis domestica)
Mammalia RAB37 34
  • 79 (a)
(Bos Taurus)
Mammalia RAB37 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia RAB37 34
  • 75 (a)
(Gallus gallus)
Aves RAB37 34
  • 64 (a)
(Anolis carolinensis)
Reptilia RAB37 34
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab37 33
  • 70.33 (n)
Str.14110 33
(Danio rerio)
Actinopterygii zgc:112183 33
  • 72.22 (n)
RAB37 34
  • 68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab26 34
  • 31 (a)
(Caenorhabditis elegans)
Secernentea rab-37 34 33
  • 57.8 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 52 (a)
Species where no ortholog for RAB37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB37 Gene

Gene Tree for RAB37 (if available)
Gene Tree for RAB37 (if available)
Evolutionary constrained regions (ECRs) for RAB37: view image

Paralogs for RAB37 Gene

genes like me logo Genes that share paralogs with RAB37: view

Variants for RAB37 Gene

Sequence variations from dbSNP and Humsavar for RAB37 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000080033 -- 74,745,241(+) G/C intron_variant
rs1000108071 -- 74,714,710(+) A/G genic_upstream_transcript_variant, intron_variant
rs1000124556 -- 74,691,526(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000193738 -- 74,735,877(+) C/A genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000201688 -- 74,730,115(+) C/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB37 Gene

Variant ID Type Subtype PubMed ID
dgv1815e59 CNV duplication 20981092
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2574609 CNV insertion 19546169
esv2716232 CNV deletion 23290073
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv3310549 CNV novel sequence insertion 20981092
esv3398562 CNV duplication 20981092
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
esv4044 CNV loss 18987735
esv8799 CNV loss 19470904
nsv1116238 CNV deletion 24896259
nsv1124759 CNV duplication 24896259
nsv2140 CNV deletion 18451855
nsv517569 CNV gain+loss 19592680

Variation tolerance for RAB37 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB37 Gene

Disorders for RAB37 Gene

Additional Disease Information for RAB37

No disorders were found for RAB37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB37 Gene

Publications for RAB37 Gene

  1. Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study. (PMID: 20031577) Danik JS … Ridker PM (Circulation. Cardiovascular genetics 2009) 3 44 58
  2. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. (PMID: 19148500) Dobashi S … Nakamura Y (Oncology reports 2009) 3 22 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PMID: 12665801) Gevaert K … Vandekerckhove J (Nature biotechnology 2003) 3 4 58

Products for RAB37 Gene

Sources for RAB37 Gene

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