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RAB35 (RAB35, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB35 include Familial Renal Oncocytoma and Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and TBC/RABGAPs. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IEA,IDA | 17562788 |
GO:0005515 | protein binding | IPI | 17562788 |
GO:0005525 | GTP binding | IEA,IDA | 20937701 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IDA | 16950109 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005768 | endosome | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IBA,IDA | 16950109 |
GO:0005905 | clathrin-coated pit | IEA,IDA | 16950109 |
GO:0010008 | endosome membrane | IBA,ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Metabolism of proteins | ||
3 | Cytoskeletal Signaling | ||
4 | Endocytosis | ||
5 | Autophagy Pathway |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000281 | mitotic cytokinesis | IMP | 16950109 |
GO:0006886 | intracellular protein transport | IBA | -- |
GO:0008104 | protein localization | IMP | 16950109 |
GO:0015031 | protein transport | IEA | -- |
GO:0016197 | endosomal transport | IMP | 16950109 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | RAB35 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | RAB35 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Rab35 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Rab35 30 |
|
||
Cow (Bos Taurus) |
Mammalia | RAB35 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | RAB35 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | RAB35 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | RAB35 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab35 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16236 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | RAB35 (3 of 3) 31 |
|
OneToMany | |
rab35b 30 31 |
|
OneToMany | |||
BX571714.2 31 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003028 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | Rab35 30 31 |
|
OneToOne | |
CG9575 32 |
|
|
|||
CG2885 32 |
|
|
|||
Worm (Caenorhabditis elegans) |
Secernentea | rab-35 30 31 |
|
OneToOne | |
4R79.2 32 |
|
|
|||
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC4 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.7112 31 |
|
OneToOne |
Disorder | Aliases | PubMed IDs |
---|---|---|
familial renal oncocytoma |
|
|
deafness, onychodystrophy, osteodystrophy, mental retardation, and seizures syndrome |
|
|
lowe oculocerebrorenal syndrome |
|
|
hypotrichosis 3 |
|
|
birt-hogg-dube syndrome |
|
|