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RAB35 (RAB35, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB35 include Hypotrichosis 3 and Charcot-Marie-Tooth Disease, Axonal, Type 2L. Among its related pathways are Vesicle-mediated transport and Cytoskeletal Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB1A.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000166 | nucleotide binding | IEA | -- |
GO:0003924 | GTPase activity | IDA,IEA | 17562788 |
GO:0005515 | protein binding | IPI | 17562788 |
GO:0005525 | GTP binding | IEA,IDA | 20937701 |
GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding | IDA | 16950109 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000139 | Golgi membrane | IBA | 21873635 |
GO:0005768 | endosome | IEA | -- |
GO:0005829 | cytosol | TAS | -- |
GO:0005886 | plasma membrane | IBA,IDA | 16950109 |
GO:0005905 | clathrin-coated pit | IDA,IEA | 16950109 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Vesicle-mediated transport | ||
2 | Metabolism of proteins | ||
3 | Cytoskeletal Signaling | ||
4 | Endocytosis | ||
5 | RAB GEFs exchange GTP for GDP on RABs |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000281 | mitotic cytokinesis | IMP | 16950109 |
GO:0006886 | intracellular protein transport | IBA | 21873635 |
GO:0008104 | protein localization | IMP | 16950109 |
GO:0015031 | protein transport | IEA | -- |
GO:0016197 | endosomal transport | IMP | 16950109 |
ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | · | 8c |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | |||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||
SP3: | - | - | - | - | |||||||||||||||||
SP4: | - | ||||||||||||||||||||
SP5: | - | - |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | RAB35 33 32 |
|
OneToOne | |
dog (Canis familiaris) |
Mammalia | RAB35 33 32 |
|
OneToOne | |
mouse (Mus musculus) |
Mammalia | Rab35 17 33 32 |
|
||
rat (Rattus norvegicus) |
Mammalia | Rab35 32 |
|
||
cow (Bos Taurus) |
Mammalia | RAB35 33 32 |
|
OneToOne | |
oppossum (Monodelphis domestica) |
Mammalia | RAB35 33 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | RAB35 33 32 |
|
OneToOne | |
lizard (Anolis carolinensis) |
Reptilia | RAB35 33 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | rab35 32 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.16236 32 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | RAB35 (3 of 3) 33 |
|
OneToMany | |
rab35b 33 32 |
|
OneToMany | |||
BX571714.2 33 |
|
OneToMany | |||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP003028 32 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | Rab35 33 32 |
|
OneToOne | |
CG9575 34 |
|
|
|||
CG2885 34 |
|
|
|||
worm (Caenorhabditis elegans) |
Secernentea | rab-35 33 32 |
|
OneToOne | |
4R79.2 34 |
|
|
|||
baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | SEC4 33 |
|
OneToMany | |
sea squirt (Ciona savignyi) |
Ascidiacea | CSA.7112 33 |
|
OneToOne |
SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000121048 | -- | 120,094,819(-) | G/A | downstream_transcript_variant | |
rs1000329592 | -- | 120,100,004(-) | G/A | intron_variant | |
rs1000473461 | -- | 120,105,259(-) | G/A/C | intron_variant | |
rs1000527192 | -- | 120,104,923(-) | C/A | intron_variant | |
rs1000692820 | -- | 120,116,818(-) | C/G | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant |
Disorder | Aliases | PubMed IDs |
---|---|---|
hypotrichosis 3 |
|
|
charcot-marie-tooth disease, axonal, type 2l |
|
|