Aliases for RAB35 Gene
External Ids for RAB35 Gene
Previous GeneCards Identifiers for RAB35 Gene
GeneCards Summary for RAB35 Gene
RAB35 (RAB35, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB35 include Familial Renal Oncocytoma and Deafness, Onychodystrophy, Osteodystrophy, Mental Retardation, And Seizures Syndrome. Among its related pathways are Cytoskeletal Signaling and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB1A.
UniProtKB/Swiss-Prot Summary for RAB35 Gene
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane. During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge. May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes.