Aliases for RAB34 Gene
External Ids for RAB34 Gene
Previous GeneCards Identifiers for RAB34 Gene
This gene encodes a protein belonging to the RAB family of proteins, which are small GTPases involved in protein transport. This family member is a Golgi-bound member of the secretory pathway that is involved in the repositioning of lysosomes and the activation of macropinocytosis. Alternative splicing of this gene results in multiple transcript variants. An alternatively spliced transcript variant produces the nine-amino acid residue-repeats (NARR) protein, which is a functionally distinct nucleolar protein resulting from a different reading frame. [provided by RefSeq, Dec 2016]
GeneCards Summary for RAB34 Gene
RAB34 (RAB34, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB34 include N Syndrome. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and guanyl nucleotide binding. An important paralog of this gene is RAB36.
UniProtKB/Swiss-Prot Summary for RAB34 Gene
Transport protein involved in the redistribution of lysosomes to the peri-Golgi region (PubMed:27113757). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays a role in the fusion of phagosomes with lysosomes (PubMed:21255211). Acts also as a positive regulator of hedgehog signaling and regulates ciliary function (By similarity).