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Aliases for RAB33A Gene

Aliases for RAB33A Gene

  • RAB33A, Member RAS Oncogene Family 2 3 5
  • Small GTP-Binding Protein S10 3 4
  • Ras-Related Protein Rab-33A 3
  • RabS10 3
  • RABS10 4

External Ids for RAB33A Gene

Previous GeneCards Identifiers for RAB33A Gene

  • GC0XP123951
  • GC0XP126151
  • GC0XP127250
  • GC0XP128011
  • GC0XP129031
  • GC0XP129133
  • GC0XP129305
  • GC0XP118701

Summaries for RAB33A Gene

Entrez Gene Summary for RAB33A Gene

  • The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is GTP-binding protein and may be involved in vesicle transport. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB33A Gene

RAB33A (RAB33A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB33A include Deafness, X-Linked 5 and Combined Oxidative Phosphorylation Deficiency 6. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB33B.

Gene Wiki entry for RAB33A Gene

Additional gene information for RAB33A Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB33A Gene

Genomics for RAB33A Gene

GeneHancer (GH) Regulatory Elements for RAB33A Gene

Promoters and enhancers for RAB33A Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH0XJ130170 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE 650.7 +1.0 1049 4.4 PKNOX1 ATF1 POLR2B ZNF766 ZFP91 ATF7 RUNX3 ZNF592 MEF2D ATF4 RAB33A ZNF280C RBMX2 BCORL1 UTP14A ELF4 GC0XP130201
GH0XJ130164 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.4 -5.9 -5858 3.2 HDGF PKNOX1 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A ZNF2 YY1 AIFM1 RAB33A BCORL1 UTP14A OCRL RBMX2 ELF4 ZNF280C
GH0XJ130108 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 650.2 -61.3 -61251 4.3 HDGF ATF1 ARNT SIN3A GLIS2 FOS ATF7 RUNX3 ZNF202 ZNF592 ELF4 RAB33A ZNF280C BCORL1 RBMX2 AIFM1 GC0XP130039
GH0XJ130117 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 13 -51.8 -51781 4.6 ATF1 SIN3A ZNF2 ZBTB7B POLR2B GLIS2 ARID2 ZNF143 ZFP91 FOS ZNF280C AIFM1 RAB33A ELF4 RBMX2 BCORL1 SASH3
GH0XJ130124 Enhancer 0.9 Ensembl ENCODE dbSUPER 12.7 -46.3 -46302 1.9 MEIS2 TEAD4 IKZF1 CREM AIFM1 RAB33A ELF4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB33A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB33A gene promoter:
  • ATF-2
  • c-Jun
  • Arnt
  • AhR
  • Evi-1
  • Pax-6

Genomic Locations for RAB33A Gene

Genomic Locations for RAB33A Gene
chrX:130,171,649-130,184,870
(GRCh38/hg38)
Size:
13,222 bases
Orientation:
Plus strand
chrX:129,305,623-129,318,844
(GRCh37/hg19)
Size:
13,222 bases
Orientation:
Plus strand

Genomic View for RAB33A Gene

Genes around RAB33A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB33A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB33A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB33A Gene

Proteins for RAB33A Gene

  • Protein details for RAB33A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14088-RB33A_HUMAN
    Recommended name:
    Ras-related protein Rab-33A
    Protein Accession:
    Q14088
    Secondary Accessions:
    • Q5JUZ6
    • Q92465

    Protein attributes for RAB33A Gene

    Size:
    237 amino acids
    Molecular mass:
    26593 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB33A Gene

Post-translational modifications for RAB33A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB33A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB33A Gene

Domains & Families for RAB33A Gene

Gene Families for RAB33A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB33A Gene

Suggested Antigen Peptide Sequences for RAB33A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q14088

UniProtKB/Swiss-Prot:

RB33A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB33A: view

Function for RAB33A Gene

Molecular function for RAB33A Gene

GENATLAS Biochemistry:
RAB33A,Ras oncogene superfamily member,expressed in brain

Phenotypes From GWAS Catalog for RAB33A Gene

Gene Ontology (GO) - Molecular Function for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity TAS,IBA --
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB33A: view
genes like me logo Genes that share phenotypes with RAB33A: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAB33A Gene

Localization for RAB33A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB33A Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB33A gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
cytosol 3
nucleus 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005886 plasma membrane IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB33A: view

Pathways & Interactions for RAB33A Gene

genes like me logo Genes that share pathways with RAB33A: view

Pathways by source for RAB33A Gene

Gene Ontology (GO) - Biological Process for RAB33A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0019882 antigen processing and presentation IMP 19717423
GO:0032482 Rab protein signal transduction IBA --
GO:2000785 regulation of autophagosome assembly IBA --
genes like me logo Genes that share ontologies with RAB33A: view

No data available for SIGNOR curated interactions for RAB33A Gene

Drugs & Compounds for RAB33A Gene

No Compound Related Data Available

Transcripts for RAB33A Gene

mRNA/cDNA for RAB33A Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(58) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB33A Gene

RAB33A, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB33A Gene

No ASD Table

Relevant External Links for RAB33A Gene

GeneLoc Exon Structure for
RAB33A
ECgene alternative splicing isoforms for
RAB33A

Expression for RAB33A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB33A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB33A Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.9).

Protein differential expression in normal tissues from HIPED for RAB33A Gene

This gene is overexpressed in Peripheral blood mononuclear cells (57.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB33A Gene



Protein tissue co-expression partners for RAB33A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB33A Gene:

RAB33A

SOURCE GeneReport for Unigene cluster for RAB33A Gene:

Hs.654356

mRNA Expression by UniProt/SwissProt for RAB33A Gene:

Q14088-RB33A_HUMAN
Tissue specificity: Expressed only in lymphoid cell lines.

Evidence on tissue expression from TISSUES for RAB33A Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with RAB33A: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB33A Gene

Orthologs for RAB33A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB33A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia RAB33A 34
  • 99 (a)
OneToOne
LOC784703 33
  • 95.5 (n)
chimpanzee
(Pan troglodytes)
Mammalia RAB33A 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB33A 34 33
  • 96.48 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab33a 33
  • 93.11 (n)
mouse
(Mus musculus)
Mammalia Rab33a 16 34 33
  • 92.26 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB33A 34
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB33A 34 33
  • 82.94 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB33A 34
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab33a 33
  • 65.89 (n)
zebrafish
(Danio rerio)
Actinopterygii rab33a 34 33
  • 72.12 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab9Fb 34
  • 32 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea rab-33 34
  • 36 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes SEC4 34
  • 36 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8759 34
  • 55 (a)
OneToMany
Species where no ortholog for RAB33A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB33A Gene

ENSEMBL:
Gene Tree for RAB33A (if available)
TreeFam:
Gene Tree for RAB33A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB33A: view image

Paralogs for RAB33A Gene

Variants for RAB33A Gene

Sequence variations from dbSNP and Humsavar for RAB33A Gene

SNP ID Clin Chr 0X pos Variation AA Info Type
rs1057515766 uncertain-significance, Combined oxidative phosphorylation deficiency 130,129,508(+) G/A genic_upstream_transcript_variant, intron_variant
rs1057515767 uncertain-significance, Combined oxidative phosphorylation deficiency 130,130,093(+) T/C genic_upstream_transcript_variant, intron_variant
rs1057516211 pathogenic, Combined oxidative phosphorylation deficiency 6 130,133,325(+) T/C genic_upstream_transcript_variant, intron_variant
rs1057518895 likely-pathogenic, Distal muscle weakness, Foot dorsiflexor weakness, Pes planus, Sensorineural hearing impairment 130,137,134(+) A/G genic_upstream_transcript_variant, intron_variant
rs1139851 benign, Combined oxidative phosphorylation deficiency 130,149,545(+) A/G/T genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB33A Gene

Variant ID Type Subtype PubMed ID
nsv528290 CNV gain 19592680

Variation tolerance for RAB33A Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.66; 31.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB33A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB33A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB33A Gene

Disorders for RAB33A Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAB33A Gene - From: GeneCards

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAB33A

genes like me logo Genes that share disorders with RAB33A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB33A Gene

Publications for RAB33A Gene

  1. Molecular cloning of a cDNA encoding a novel small GTP-binding protein. (PMID: 7688322) Koda T … Kakinuma M (FEBS letters 1993) 2 3 4 58
  2. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross MT … Bentley DR (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. A novel Rab GTPase, Rab33B, is ubiquitously expressed and localized to the medial Golgi cisternae. (PMID: 9512502) Zheng JY … Kakinuma M (Journal of cell science 1998) 2 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for RAB33A Gene

Sources for RAB33A Gene

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