Aliases for RAB32 Gene
External Ids for RAB32 Gene
Previous GeneCards Identifiers for RAB32 Gene
The protein encoded by this gene anchors the type II regulatory subunit of protein kinase A to the mitochondrion and aids in mitochondrial fission. The encoded protein also appears to be involved in autophagy and melanosome secretion. Variations in this gene may be linked to leprosy. [provided by RefSeq, Dec 2015]
GeneCards Summary for RAB32 Gene
RAB32 (RAB32, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB32 include Hermansky-Pudlak Syndrome and Warburg Micro Syndrome. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding. An important paralog of this gene is RAB38.
UniProtKB/Swiss-Prot Summary for RAB32 Gene
Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission (PubMed:12186851). Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis (PubMed:21255211). Plays an important role in the control of melanin production and melanosome biogenesis (PubMed:23084991). In concert with RAB38, regulates the proper trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes (By similarity).