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Aliases for RAB2B Gene

Aliases for RAB2B Gene

  • RAB2B, Member RAS Oncogene Family 2 3 5

External Ids for RAB2B Gene

Previous GeneCards Identifiers for RAB2B Gene

  • GC14M015714
  • GC14M019917
  • GC14M020997
  • GC14M021927
  • GC14M002046

Summaries for RAB2B Gene

Entrez Gene Summary for RAB2B Gene

  • Members of the Rab protein family are nontransforming monomeric GTP-binding proteins of the Ras superfamily that contain 4 highly conserved regions involved in GTP binding and hydrolysis. Rab proteins are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking; see MIM 179508.[supplied by OMIM, Apr 2006]

GeneCards Summary for RAB2B Gene

RAB2B (RAB2B, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB2A.

UniProtKB/Swiss-Prot for RAB2B Gene

  • Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Additional gene information for RAB2B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB2B Gene

Genomics for RAB2B Gene

GeneHancer (GH) Regulatory Elements for RAB2B Gene

Promoters and enhancers for RAB2B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I021475 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 560.2 -0.1 -93 2.9 HDGF PKNOX1 FOXA2 SMAD1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 TOX4 RAB2B METTL17 METTL3 SUPT16H CHD8 PIR42881
GH14I020657 Enhancer 1.2 Ensembl ENCODE 28.6 +819.2 819246 1.1 HDGF PKNOX1 SIN3A ZNF2 ZNF213 ZNF143 ZNF548 FOS KLF13 SP3 TRY-GTA4-1 METTL3 SUPT16H METTL17 ENSG00000258515 PARP2 TTC5 CHD8 RAB2B ENSG00000258768
GH14I020679 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +792.4 792440 9.8 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 ZNF213 E2F8 ZNF143 SP3 RNASE4 ANG ENSG00000259171 PIR55020 TRP-TGG3-2 TRY-GTA5-5 METTL3 ENSG00000258515 SUPT16H CHD8
GH14I021263 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 10.3 +209.9 209919 7.6 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 HNRNPC SUPT16H METTL3 CHD8 METTL17 ENSG00000258515 PIP4P1 RAB2B APEX1 TRAV8-5
GH14I020609 Promoter/Enhancer 1.6 Ensembl ENCODE 10.9 +867.1 867123 1.8 PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A ZNF2 IRF4 YY1 SLC30A9 ENSG00000259060 TRL-AAG2-3 TRP-AGG2-5 RNASE11 PARP2 SUPT16H METTL3 TTC5 ENSG00000258515 CHD8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB2B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB2B gene promoter:

Genomic Locations for RAB2B Gene

Genomic Locations for RAB2B Gene
17,954 bases
Minus strand

Genomic View for RAB2B Gene

Genes around RAB2B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB2B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB2B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB2B Gene

Proteins for RAB2B Gene

  • Protein details for RAB2B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-2B
    Protein Accession:
    Secondary Accessions:
    • B2RD03
    • D3DS24
    • Q6NZ33

    Protein attributes for RAB2B Gene

    216 amino acids
    Molecular mass:
    24214 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for RAB2B Gene

    Alternative splice isoforms for RAB2B Gene


neXtProt entry for RAB2B Gene

Post-translational modifications for RAB2B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB2B Gene

No data available for DME Specific Peptides for RAB2B Gene

Domains & Families for RAB2B Gene

Gene Families for RAB2B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB2B Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB2B: view

Function for RAB2B Gene

Molecular function for RAB2B Gene

UniProtKB/Swiss-Prot Function:
Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Phenotypes From GWAS Catalog for RAB2B Gene

Gene Ontology (GO) - Molecular Function for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB2B: view

Phenotypes for RAB2B Gene

genes like me logo Genes that share phenotypes with RAB2B: view

Animal Model Products

Clone Products

  • Addgene plasmids for RAB2B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB2B Gene

Localization for RAB2B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB2B Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Endoplasmic reticulum membrane. Golgi apparatus membrane.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB2B gene
Compartment Confidence
extracellular 5
plasma membrane 4
endoplasmic reticulum 4
golgi apparatus 4
cytosol 3
cytoskeleton 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IBA --
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0005886 plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB2B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB2B Gene

Pathways & Interactions for RAB2B Gene

genes like me logo Genes that share pathways with RAB2B: view

Pathways by source for RAB2B Gene

Gene Ontology (GO) - Biological Process for RAB2B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0045921 positive regulation of exocytosis IMP 19966785
genes like me logo Genes that share ontologies with RAB2B: view

No data available for SIGNOR curated interactions for RAB2B Gene

Drugs & Compounds for RAB2B Gene

No Compound Related Data Available

Transcripts for RAB2B Gene

Unigene Clusters for RAB2B Gene

RAB2B, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB2B

Alternative Splicing Database (ASD) splice patterns (SP) for RAB2B Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP1: - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: -

Relevant External Links for RAB2B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB2B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB2B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB2B Gene

This gene is overexpressed in Brain (23.5) and Fetal Brain (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB2B Gene

Protein tissue co-expression partners for RAB2B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB2B Gene:


SOURCE GeneReport for Unigene cluster for RAB2B Gene:


mRNA Expression by UniProt/SwissProt for RAB2B Gene:

Tissue specificity: Expressed in kidney, prostate, lung, liver, thymus, colon, pancreas, and skeletal muscle, and low levels in placenta. Not detected in heart, brain, spleen, testis, ovary, small intestine and leukocyte.

Evidence on tissue expression from TISSUES for RAB2B Gene

  • Nervous system(4.6)
  • Skin(4.2)
genes like me logo Genes that share expression patterns with RAB2B: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB2B Gene

Orthologs for RAB2B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB2B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB2B 33 34
  • 99.38 (n)
(Bos Taurus)
Mammalia RAB2B 33 34
  • 94.44 (n)
(Canis familiaris)
Mammalia RAB2B 33 34
  • 93.67 (n)
(Monodelphis domestica)
Mammalia RAB2B 34
  • 93 (a)
(Rattus norvegicus)
Mammalia Rab2b 33
  • 91.47 (n)
(Mus musculus)
Mammalia Rab2b 33 16 34
  • 91.2 (n)
(Ornithorhynchus anatinus)
Mammalia RAB2B 34
  • 74 (a)
(Gallus gallus)
Aves -- 34
  • 49 (a)
(Anolis carolinensis)
Reptilia RAB2B 34
  • 67 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab2b 33
  • 74.11 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.2749 33
(Danio rerio)
Actinopterygii rab11al 34
  • 46 (a)
fruit fly
(Drosophila melanogaster)
Insecta Rab2 34
  • 83 (a)
(Caenorhabditis elegans)
Secernentea unc-108 34
  • 86 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 34
  • 41 (a)
YPT32 34
  • 39 (a)
(Oryza sativa)
Liliopsida Os04g0470100 33
  • 68.28 (n)
(Hordeum vulgare)
Liliopsida Hv.5672 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 29 (a)
Species where no ortholog for RAB2B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB2B Gene

Gene Tree for RAB2B (if available)
Gene Tree for RAB2B (if available)

Paralogs for RAB2B Gene

genes like me logo Genes that share paralogs with RAB2B: view

Variants for RAB2B Gene

Sequence variations from dbSNP and Humsavar for RAB2B Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000014645 -- 21,467,467(-) A/T intron_variant
rs1000061699 -- 21,462,571(-) G/A intron_variant
rs1000075727 -- 21,473,419(-) C/T intron_variant
rs1000421889 -- 21,478,885(-) C/T upstream_transcript_variant
rs1000616826 -- 21,469,005(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB2B Gene

Variant ID Type Subtype PubMed ID
esv2422459 CNV duplication 17116639
esv3633716 CNV gain 21293372

Variation tolerance for RAB2B Gene

Residual Variation Intolerance Score: 25.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB2B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB2B Gene

Disorders for RAB2B Gene

Additional Disease Information for RAB2B

No disorders were found for RAB2B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB2B Gene

Publications for RAB2B Gene

  1. Molecular cloning and characterization of a novel human Rab ( Rab2B) gene. (PMID: 12376746) Ni X … Mao Y (Journal of human genetics 2002) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58

Products for RAB2B Gene

  • Addgene plasmids for RAB2B

Sources for RAB2B Gene

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