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Aliases for RAB2A Gene

Aliases for RAB2A Gene

  • RAB2A, Member RAS Oncogene Family 2 3 5
  • RAB2, Member RAS Oncogene Family 2 3
  • RAB2 3 4
  • Small GTP Binding Protein RAB2A 3
  • Ras-Related Protein Rab-2A 3
  • LHX 3

External Ids for RAB2A Gene

Previous HGNC Symbols for RAB2A Gene

  • RAB2

Previous GeneCards Identifiers for RAB2A Gene

  • GC08P061593
  • GC08P061429
  • GC08P056918

Summaries for RAB2A Gene

Entrez Gene Summary for RAB2A Gene

  • The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for RAB2A Gene

RAB2A (RAB2A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB2A include Sezary's Disease and Warburg Micro Syndrome 4. Among its related pathways are Cell Cycle, Mitotic and AMP-activated Protein Kinase (AMPK) Signaling. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB2B.

UniProtKB/Swiss-Prot for RAB2A Gene

  • Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Gene Wiki entry for RAB2A Gene

Additional gene information for RAB2A Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB2A Gene

Genomics for RAB2A Gene

GeneHancer (GH) Regulatory Elements for RAB2A Gene

Promoters and enhancers for RAB2A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH08J060515 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 677.6 +0.7 708 4 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 SP3 RAB2A PIR33286 LINC01301 ENSG00000255321 NPM1P6
GH08J060525 Enhancer 1 Ensembl ENCODE dbSUPER 27.2 +8.5 8453 1.1 TRIM22 JUNB IKZF1 TARDBP NBN ZNF143 MLLT1 ATF7 IKZF2 SPI1 RAB2A ENSG00000255321 PIR33286 GC08M060522
GH08J060576 Enhancer 1 ENCODE dbSUPER 27.2 +59.6 59639 0.9 HDAC1 PKNOX1 ARNT FEZF1 CHAMP1 TCF12 GATA2 ZSCAN5C NCOA1 ZEB2 GC08M060522 RAB2A ENSG00000255321 GC08P060601
GH08J060650 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 14.4 +135.7 135730 3.6 PKNOX1 CLOCK ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 ENSG00000254869 CHD7 RAB2A CLVS1 ENSG00000255321 CA8 ENSG00000228862
GH08J060541 Enhancer 0.8 ENCODE dbSUPER 27.2 +25.0 24987 1.4 HDGF ZNF687 NR2F1 JUNB RFX5 IKZF1 ATF7 CREM RUNX3 BCLAF1 RAB2A ENSG00000255321 PIR33286 GC08M060522
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB2A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB2A gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • Egr-2
  • RSRFC4
  • GATA-3
  • E47
  • Tal-1
  • Nkx3-1

Genomic Locations for RAB2A Gene

Genomic Locations for RAB2A Gene
106,788 bases
Plus strand
106,788 bases
Plus strand

Genomic View for RAB2A Gene

Genes around RAB2A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB2A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB2A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB2A Gene

Proteins for RAB2A Gene

  • Protein details for RAB2A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-2A
    Protein Accession:
    Secondary Accessions:
    • B2R5W8
    • B4DMQ5
    • P08886

    Protein attributes for RAB2A Gene

    212 amino acids
    Molecular mass:
    23546 Da
    Quaternary structure:
    • Interacts with PRKCI.

    Three dimensional structures from OCA and Proteopedia for RAB2A Gene

    Alternative splice isoforms for RAB2A Gene


neXtProt entry for RAB2A Gene

Post-translational modifications for RAB2A Gene

  • Ubiquitination at posLast=165165
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for RAB2A Gene

Domains & Families for RAB2A Gene

Gene Families for RAB2A Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB2A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB2A: view

Function for RAB2A Gene

Molecular function for RAB2A Gene

UniProtKB/Swiss-Prot Function:
Required for protein transport from the endoplasmic reticulum to the Golgi complex.

Phenotypes From GWAS Catalog for RAB2A Gene

Gene Ontology (GO) - Molecular Function for RAB2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IDA 16034420
GO:0005515 protein binding IPI 16189514
GO:0005525 GTP binding IDA,IEA 16034420
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB2A: view
genes like me logo Genes that share phenotypes with RAB2A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB2A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB2A Gene

Localization for RAB2A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB2A Gene

Endoplasmic reticulum-Golgi intermediate compartment membrane; Lipid-anchor. Melanosome. Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus membrane; Lipid-anchor. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB2A gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 5
golgi apparatus 5
endoplasmic reticulum 4
endosome 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for RAB2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005634 nucleus HDA 21630459
GO:0005765 lysosomal membrane HDA 17897319
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RAB2A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB2A Gene

Pathways & Interactions for RAB2A Gene

genes like me logo Genes that share pathways with RAB2A: view

Pathways by source for RAB2A Gene

1 Qiagen pathway for RAB2A Gene

Gene Ontology (GO) - Biological Process for RAB2A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP,TAS 17684057
GO:0007030 Golgi organization IMP 17684057
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
genes like me logo Genes that share ontologies with RAB2A: view

No data available for SIGNOR curated interactions for RAB2A Gene

Drugs & Compounds for RAB2A Gene

(2) Additional Compounds for RAB2A Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB2A: view

Transcripts for RAB2A Gene

mRNA/cDNA for RAB2A Gene

Unigene Clusters for RAB2A Gene

RAB2A, member RAS oncogene family:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB2A

Alternative Splicing Database (ASD) splice patterns (SP) for RAB2A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9
SP1: - - - -
SP2: - -
SP3: - - -
SP4: -

Relevant External Links for RAB2A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB2A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB2A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB2A Gene

Protein tissue co-expression partners for RAB2A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB2A Gene:


SOURCE GeneReport for Unigene cluster for RAB2A Gene:


Evidence on tissue expression from TISSUES for RAB2A Gene

  • Nervous system(5)
  • Skin(4.7)
  • Lung(4)
  • Kidney(3.1)
  • Pancreas(3)
  • Intestine(2.7)
  • Muscle(2.6)
  • Heart(2.5)
  • Liver(2.3)
  • Stomach(2.2)
  • Spleen(2.1)
  • Thyroid gland(2.1)
genes like me logo Genes that share expression patterns with RAB2A: view

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB2A Gene

Orthologs for RAB2A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB2A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB2A 34 33
  • 100 (n)
(Monodelphis domestica)
Mammalia RAB2A 34
  • 100 (a)
(Bos Taurus)
Mammalia RAB2A 34
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia RAB2A 34
  • 98 (a)
(Canis familiaris)
Mammalia RAB2A 34 33
  • 96.23 (n)
(Rattus norvegicus)
Mammalia Rab2a 33
  • 92.14 (n)
(Mus musculus)
Mammalia Rab2a 16 34 33
  • 91.98 (n)
(Gallus gallus)
Aves RAB2A 34 33
  • 87.42 (n)
(Anolis carolinensis)
Reptilia RAB2A 34
  • 99 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab2a 33
  • 83.16 (n)
(Danio rerio)
Actinopterygii rab2a 34 33
  • 81.76 (n)
Dr.20914 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.890 33
fruit fly
(Drosophila melanogaster)
Insecta Rab2 34 33
  • 73.94 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005393 33
  • 72.93 (n)
(Caenorhabditis elegans)
Secernentea unc-108 34 33
  • 74.49 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT31 34
  • 41 (a)
YPT32 34
  • 39 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons RABB1C 33
  • 74.29 (n)
(Glycine max)
eudicotyledons Gma.6653 33
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.232 33
(Oryza sativa)
Liliopsida Os02g0586400 33
  • 71.45 (n)
Os.8483 33
(Triticum aestivum)
Liliopsida Ta.5309 33
(Hordeum vulgare)
Liliopsida Hv.10692 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.388 34
  • 90 (a)
Cin.5043 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5043 33
Species where no ortholog for RAB2A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for RAB2A Gene

Gene Tree for RAB2A (if available)
Gene Tree for RAB2A (if available)
Evolutionary constrained regions (ECRs) for RAB2A: view image

Paralogs for RAB2A Gene Pseudogenes for RAB2A Gene

genes like me logo Genes that share paralogs with RAB2A: view

Variants for RAB2A Gene

Sequence variations from dbSNP and Humsavar for RAB2A Gene

SNP ID Clin Chr 08 pos Variation AA Info Type
rs1000005827 -- 60,572,713(+) G/A intron_variant
rs1000035478 -- 60,573,021(+) C/T intron_variant
rs1000076383 -- 60,518,411(+) C/T intron_variant
rs1000091175 -- 60,552,106(+) C/T intron_variant
rs1000107468 -- 60,559,882(+) AGAGA/AGA intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB2A Gene

Variant ID Type Subtype PubMed ID
esv1615811 CNV insertion 17803354
esv2737065 CNV deletion 23290073
esv2737066 CNV deletion 23290073
esv2737067 CNV deletion 23290073
esv2737068 CNV deletion 23290073
esv3305193 CNV mobile element insertion 20981092
esv3309463 CNV mobile element insertion 20981092
esv3395150 CNV insertion 20981092
esv3431404 CNV insertion 20981092
esv3572784 CNV loss 25503493
esv3617376 CNV loss 21293372
nsv472821 CNV novel sequence insertion 20440878
nsv6218 CNV deletion 18451855
nsv831335 CNV loss 17160897

Variation tolerance for RAB2A Gene

Residual Variation Intolerance Score: 56.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB2A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB2A Gene

Disorders for RAB2A Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAB2A Gene - From: HGMD, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
sezary's disease
  • sezary disease
warburg micro syndrome 4
  • warbm4
warburg micro syndrome
  • micro syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAB2A in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB2A

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAB2A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB2A Gene

Publications for RAB2A Gene

  1. Regulation of anterograde transport of adrenergic and angiotensin II receptors by Rab2 and Rab6 GTPases. (PMID: 17716866) Dong C … Wu G (Cellular signalling 2007) 3 22 58
  2. Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. (PMID: 17081065) Chi A … Hunt DF (Journal of proteome research 2006) 3 4 58
  3. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. (PMID: 14570876) Tisdale EJ (The Journal of biological chemistry 2003) 3 4 58

Products for RAB2A Gene

Sources for RAB2A Gene

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