RAB29 Gene (Protein Coding)

RAB29, Member RAS Oncogene Family

GC01M205768
GIFtS:
33

Aliases for RAB29 Gene

Aliases for RAB29 Gene

  • RAB29, Member RAS Oncogene Family 2 3 5
  • RAB7, Member RAS Oncogene Family-Like 1 2 3
  • Ras-Related Protein Rab-7L1 3 4
  • Ras-Related Protein Rab-29 3 4
  • Rab-7-Like Protein 1 3 4
  • RAB7L1 3 4
  • RAB7L 3

External Ids for RAB29 Gene

Previous HGNC Symbols for RAB29 Gene

  • RAB7L
  • RAB7L1

Summaries for RAB29 Gene

GeneCards Summary for RAB29 Gene

RAB29 (RAB29, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB29 include Frontotemporal Dementia and Kufor-Rakeb Syndrome. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB32.

UniProtKB/Swiss-Prot Summary for RAB29 Gene

  • The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847).

Additional gene information for RAB29 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB29 Gene

Genomics for RAB29 Gene

GeneHancer (GH) Regulatory Elements for RAB29 Gene

Promoters and enhancers for RAB29 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB29 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB29

Genomic Locations for RAB29 Gene

Genomic Locations for RAB29 Gene
chr1:205,767,986-205,775,487
(GRCh38/hg38)
Size:
7,502 bases
Orientation:
Minus strand
chr1:205,737,114-205,744,610
(GRCh37/hg19)
Size:
7,497 bases
Orientation:
Minus strand

Genomic View for RAB29 Gene

Genes around RAB29 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB29 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB29 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for RAB29 Gene

Proteins for RAB29 Gene

Products:

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  • Protein details for RAB29 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14966-RAB7L_HUMAN
    Recommended name:
    Ras-related protein Rab-7L1
    Protein Accession:
    O14966
    Secondary Accessions:
    • B4E1K3
    • C9JE77

    Protein attributes for RAB29 Gene

    Size:
    203 amino acids
    Molecular mass:
    23155 Da
    Quaternary structure:
    • Interacts with LRRK2.

    Three dimensional structures from OCA and Proteopedia for RAB29 Gene

    Alternative splice isoforms for RAB29 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB29 Gene

Protein Expression for RAB29 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for RAB29 Gene

  • In case of Salmonella enterica serovar Typhimurium (S.Typhimurium) infection, is proteolytically cleaved between Gly-41 and Val-42 by the GtgE viral protease encoded on the Gifsy-2 lysogen bacteriophage, which therefore prevents the recruitment of RAB29 to S.Typhimurium-containing vacuoles. In contrast, no proteolytically cleavage is detected in S.Typhi-infected cells (PubMed:22042847).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB29 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB29 Gene

Domains & Families for RAB29 Gene

Gene Families for RAB29 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB29 Gene

Blocks:
  • Transforming protein P21 RAS signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB29 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ51782, highly similar to Ras-related protein Rab-7L1 (B4E1K3_HUMAN)
  • RAB7L1 protein (Q6FGU7_HUMAN)
  • Rab-7-like protein 1 (RAB7L_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O14966

UniProtKB/Swiss-Prot:

RAB7L_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB29: view

Function for RAB29 Gene

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  2. CRISPR
  3. miRNA
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  6. Cell Line

Molecular function for RAB29 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators in vesicle trafficking (PubMed:24788816). Essential for maintaining the integrity of the endosome-trans-Golgi network structure (By similarity). Together with LRRK2, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner (PubMed:24788816). Recruits LRRK2 to the Golgi complex and stimulates LRRK2 kinase activity (PubMed:29212815). Regulates neuronal process morphology in the intact central nervous system (CNS) (By similarity). May play a role in the formation of typhoid toxin transport intermediates during Salmonella enterica serovar Typhi (S.Typhi) epithelial cell infection (PubMed:22042847).

Phenotypes From GWAS Catalog for RAB29 Gene

Gene Ontology (GO) - Molecular Function for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA,TAS 21873635
GO:0005515 protein binding IPI 24510904
GO:0005525 GTP binding IDA 24510904
GO:0017137 Rab GTPase binding IDA 26021297
GO:0019003 GDP binding IDA 24510904
genes like me logo Genes that share ontologies with RAB29: view
genes like me logo Genes that share phenotypes with RAB29: view

Animal Model Products

CRISPR Products

miRNA for RAB29 Gene

miRTarBase miRNAs that target RAB29

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB29

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB29 Gene

Localization for RAB29 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB29 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm. Cytoplasm, perinuclear region. Golgi apparatus. Golgi apparatus, trans-Golgi network. Vacuole. Cytoplasm, cytoskeleton. Note=Colocalizes with LRRK2 along tubular structures emerging from Golgi apparatus (PubMed:29212815). Colocalizes with GM130 at the Golgi apparatus (PubMed:22042847). Colocalizes with dynamic tubules emerging from and retracting to the Golgi apparatus (PubMed:22042847). Colocalizes with TGN46 at the trans-Golgi network (TGN) (PubMed:24788816). In Salmonella enterica serovar Typhi (S.Typhi) infected epithelial cells, is recruited and colocalized with both S.Typhi-containing vacuoles and dynamic tubules as well as those emerging from the vacuole toward the cell periphery (PubMed:22042847). {ECO:0000269 PubMed:22042847, ECO:0000269 PubMed:24788816, ECO:0000269 PubMed:29212815}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB29 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
extracellular 4
cytoskeleton 4
mitochondrion 4
endosome 4
cytosol 4
nucleus 3
lysosome 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IDA 24788816
GO:0005739 mitochondrion IDA 25767741
GO:0005769 early endosome IDA 26021297
GO:0005773 vacuole IEA --
GO:0005794 Golgi apparatus IDA 22042847
genes like me logo Genes that share ontologies with RAB29: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB29 Gene

Pathways & Interactions for RAB29 Gene

genes like me logo Genes that share pathways with RAB29: view

Pathways by source for RAB29 Gene

Gene Ontology (GO) - Biological Process for RAB29 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001921 positive regulation of receptor recycling IMP 26021297
GO:0006886 intracellular protein transport IBA 21873635
GO:0006888 NOT ER to Golgi vesicle-mediated transport IMP 24788816
GO:0007005 mitochondrion organization IMP 25767741
GO:0007030 Golgi organization IMP 24510904
genes like me logo Genes that share ontologies with RAB29: view

No data available for SIGNOR curated interactions for RAB29 Gene

Drugs & Compounds for RAB29 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for RAB29 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for RAB29 Gene

4 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB29

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB29 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f · 1g ^ 2a · 2b · 2c ^ 3 ^ 4a · 4b · 4c · 4d · 4e ^ 5a · 5b · 5c ^ 6a · 6b · 6c · 6d · 6e · 6f
SP1: - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - -
SP8: - - -
SP9: - - - - - - - -
SP10: - -
SP11: - -
SP12: - - - - - - - - - - -
SP13: -
SP14:

Relevant External Links for RAB29 Gene

GeneLoc Exon Structure for
RAB29

Expression for RAB29 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB29 Gene

mRNA expression in normal human tissues for RAB29 Gene
mRNA expression by GTEx for RAB29 Gene

Protein differential expression in normal tissues from HIPED for RAB29 Gene

This gene is overexpressed in Tlymphocyte (18.2) and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB29 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB29

mRNA Expression by UniProt/SwissProt for RAB29 Gene:

O14966-RAB7L_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for RAB29 Gene

  • Nervous system(2.8)
genes like me logo Genes that share expression patterns with RAB29: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB29 Gene

Orthologs for RAB29 Gene

This gene was present in the common ancestor of chordates.

Orthologs for RAB29 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia RAB7L1 31 30
  • 99.84 (n)
 OneToOne
cow
(Bos Taurus)
 Mammalia RAB7L1 31 30
  • 94.39 (n)
 OneToOne
dog
(Canis familiaris)
 Mammalia RAB7L1 31 30
  • 91.91 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia Rab7l1 31 30
  • 90.97 (n)
 OneToOne
Rab29 17
rat
(Rattus norvegicus)
 Mammalia Rab7l1 30
  • 89.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia RAB7L1 31
  • 88 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia RAB7L1 31
  • 87 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves RAB7L1 31 30
  • 75.53 (n)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia RAB7L1 31
  • 75 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia LOC100135159 30
  • 68.97 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.32195 30
zebrafish
(Danio rerio)
 Actinopterygii si:ch73-173m3.3 31
  • 46 (a)
 ManyToMany
Species where no ortholog for RAB29 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB29 Gene

ENSEMBL:
Gene Tree for RAB29 (if available)
TreeFam:
Gene Tree for RAB29 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB29: view image

Paralogs for RAB29 Gene

Variants for RAB29 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for RAB29 Gene

Variation tolerance for RAB29 Gene

Residual Variation Intolerance Score: 41.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.31; 26.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB29 Gene

Human Gene Mutation Database (HGMD)
RAB29
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB29

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RAB29 Gene

Disorders for RAB29 Gene

MalaCards: The human disease database

(4) MalaCards diseases for RAB29 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
frontotemporal dementia
  • ftd
kufor-rakeb syndrome
  • krs
juvenile-onset parkinson's disease
  • juvenile-onset parkinson disease
parkinson disease, late-onset
  • pd
- elite association - COSMIC cancer census association via MalaCards
Search RAB29 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB29

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAB29: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB29 Gene

Publications for RAB29 Gene

  1. Cloning and chromosome assignment to 1q32 of a human cDNA (RAB7L1) encoding a small GTP-binding protein, a member of the RAS superfamily. (PMID: 9284931) Shimizu F … Takahashi E (Cytogenetics and cell genetics 1997) 2 3 4 23 54
  2. A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor. (PMID: 24788816) Wang S … Wang T (PloS one 2014) 3 4 54
  3. Thousands of rab GTPases for the cell biologist. (PMID: 22022256) Diekmann Y … Pereira-Leal JB (PLoS computational biology 2011) 2 3 54
  4. Proteolytic targeting of Rab29 by an effector protein distinguishes the intracellular compartments of human-adapted and broad-host Salmonella. (PMID: 22042847) Spanò S … Galán JE (Proceedings of the National Academy of Sciences of the United States of America 2011) 3 4 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

ExternalLinks

View latest publications for RAB29 gene in Mastermind

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