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Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010] See more...
Aliases for RAB27B Gene
Aliases for RAB27B Gene
External Ids for RAB27B Gene
- HGNC: 9767
- Entrez Gene: 5874
- Ensembl: ENSG00000041353
- OMIM: 603869
- UniProtKB: O00194
Previous GeneCards Identifiers for RAB27B Gene
- GC18P052584
- GC18P052398
- GC18P052280
- GC18P050644
- GC18P050646
- GC18P052495
- GC18P049204
- GC18P052385
Summaries for RAB27B Gene
-
Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]
GeneCards Summary for RAB27B Gene
RAB27B (RAB27B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27B include Griscelli Syndrome and Piebald Trait. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB27A.
UniProtKB/Swiss-Prot Summary for RAB27B Gene
-
Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
Additional gene information for RAB27B Gene
- HGNC(9767)
- Entrez Gene(5874)
- Ensembl(ENSG00000041353)
- OMIM(603869)
- UniProtKB(O00194)
- Open Targets Platform(ENSG00000041353)
- Monarch Initiative
- Search for RAB27B at DataMed
- Search for RAB27B at HumanCyc
No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB27B Gene
Genomics for RAB27B Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for RAB27B Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH18J054827 | Promoter/Enhancer | 1.8 | EPDnew Ensembl ENCODE CraniofacialAtlas | 600.1 | +111.6 | 111640 | 3.5 | HNRNPL PRDM10 IKZF1 ZNF692 FOXA1 PRDM1 ZIC2 ZSCAN4 PATZ1 ZNF501 | RAB27B CCDC68 POLI piR-48325-079 lnc-DYNAP-2 | |
| GH18J054717 | Promoter/Enhancer | 1.3 | EPDnew Ensembl ENCODE dbSUPER | 600.7 | +0.2 | 230 | 0.9 | ZNF143 POLR2A RAD21 RUNX3 CTCF | RAB27B CCDC68 lnc-DYNAP-36 | |
| GH18J054716 | Enhancer | 0.2 | ENCODE | 600.7 | -1.1 | -1077 | 0.2 | RAB27B CCDC68 piR-46476 DYNAP | ||
| GH18J054822 | Enhancer | 1.1 | FANTOM5 Ensembl ENCODE | 19.7 | +105.8 | 105758 | 2.8 | JUND REST CEBPB SP1 HMBOX1 ATF3 NR3C1 CHD2 JUN RCOR1 | RAB27B POLI CCDC68 piR-48325-079 lnc-DYNAP-2 | |
| GH18J054873 | Enhancer | 0.9 | Ensembl ENCODE | 12.1 | +156.0 | 155968 | 1.2 | REST IKZF1 SP1 ETV6 TCF12 EP300 HMBOX1 FOXA2 YY1 ZBTB33 | RAB27B ENSG00000267311 piR-48325-079 CCDC68 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around RAB27B on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB27B
- Top Transcription factor binding sites by QIAGEN in the RAB27B gene promoter:
-
- Gfi-1
- Ik-3
- Oct-B1
- oct-B2
- oct-B3
- p53
- POU2F1
- POU2F1a
- POU6F1 (c2)
Genomic Locations for RAB27B Gene
Genomic Locations for RAB27B Gene
- chr18:54,717,842-54,895,516
- (GRCh38/hg38)
- Size:
- 177,675 bases
- Orientation:
- Plus strand
- chr18:52,385,091-52,562,747
- (GRCh37/hg19)
- Size:
- 177,657 bases
- Orientation:
- Plus strand
Genomic View for RAB27B Gene
Genes around RAB27B on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q21.2 by HGNC
- 18q21.2 by Entrez Gene
- 18q21.2 by Ensembl
RAB27B Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for RAB27B Gene
Proteins for RAB27B Gene
-
Protein details for RAB27B Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00194-RB27B_HUMAN
- Recommended name:
- Ras-related protein Rab-27B
- Protein Accession:
- O00194
- B2RAB0
- Q9BZB6
Protein attributes for RAB27B Gene
- Size:
- 218 amino acids
- Molecular mass:
- 24608 Da
- Quaternary structure:
-
- Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity). Interacts (GDP-bound form preferentially) with DENND10 (PubMed:30771381).
Protein Expression for RAB27B Gene
Post-translational modifications for RAB27B Gene
Other Protein References for RAB27B Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences RAB27B Antibody
- G Biosciences Immunotag™ RAB27B Antibody
- NSJ Bioreagents RAB27B Antibody
- HUABIO RAB27B antibody and RAB27B Antibody (ER2001-10)
- GeneTex Anti-RAB27B antibody
-
Custom Antibody ServicesOriGene Antibodies for RAB27B
- Novus Biologicals Antibodies for RAB27B
-
Abcam antibodies for RAB27B
- Invitrogen Antibodies for RAB27B (AFLGC-RAB27B)
-
Boster Bio Antibodies for RAB27B
-
Santa Cruz Biotechnology (SCBT) Antibodies for RAB27B
- Sino Biological Antibodies for RAB27B
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for RAB27B
- Origene Custom Protein Services for RAB27B
- Sino Biological Cell Lysates for RAB27B
- Sino Biological Recombinant Proteins for RAB27B
- ProSpec Recombinant Proteins for RAB27B
- antibodies-online: Show 12 available RAB27B Proteins ranked by validation data
- Compare Top RAB27B Proteins
-
Quality Products:
-
Signalway Proteins for RAB27B
-
Abcam proteins for RAB27B
Assay Products
- antibodies-online: Show 3 available RAB27B Elisa Kits ranked by validation data
- Compare Top RAB27B Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for RAB27B Gene
Domains & Families for RAB27B Gene
Gene Families for RAB27B Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Plasma proteins
- Predicted intracellular proteins
Protein Domains for RAB27B Gene
- InterPro:
- Blocks:
-
- Transforming protein P21 RAS signature
- ProtoNet:
Suggested Antigen Peptide Sequences for RAB27B Gene
- GenScript: Design optimal peptide antigens:
-
- C25KG (RB27B_HUMAN)
Graphical View of Domain Structure for InterPro Entry
O00194- Family:
-
- Belongs to the small GTPase superfamily. Rab family.
Function for RAB27B Gene
Molecular function for RAB27B Gene
- UniProtKB/Swiss-Prot Function:
- Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion (PubMed:30771381). Plays a role in NTRK2/TRKB axonal anterograde transport by facilitating the association of NTRK2/TRKB with KLC1 (PubMed:21775604). May be involved in targeting uroplakins to urothelial apical membranes (By similarity).
- UniProtKB/Swiss-Prot CatalyticActivity:
- Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565, ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2; Evidence={ECO:0000305|PubMed:30771381};.
- UniProtKB/Swiss-Prot EnzymeRegulation:
- Regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, GTPase activating proteins (GAPs) which increase the GTP hydrolysis activity, and GDP dissociation inhibitors which inhibit the dissociation of the nucleotide from the GTPase. Activated by GEFs such as DENND10.
Enzyme Numbers (IUBMB) for RAB27B Gene
Phenotypes From GWAS Catalog for RAB27B Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000166 | nucleotide binding | IEA | -- |
| GO:0003924 | GTPase activity | IEA,ISS | -- |
| GO:0005515 | protein binding | IPI | 15357836 |
| GO:0005525 | GTP binding | IEA,ISS | -- |
| GO:0016787 | hydrolase activity | IEA | -- |
Phenotypes for RAB27B Gene
- MGI mutant phenotypes for RAB27B:
- inferred from 5 alleles
- GenomeRNAi human phenotypes for RAB27B:
Animal Models for RAB27B Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAB27B - Select products 50% OFF >
- * RAB27B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAB27B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB27B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB27B
miRNA for RAB27B Gene
- miRTarBase miRNAs that target RAB27B
-
- hsa-miR-155-5p (MIRT001512)
- hsa-miR-30a-5p (MIRT005197)
- mmu-miR-181a-5p (MIRT014197)
- hsa-miR-1-3p (MIRT023764)
- mmu-miR-5125 (MIRT603503)
- mmu-miR-3110-5p (MIRT603504)
- mmu-miR-5127 (MIRT603505)
- mmu-miR-150-5p (MIRT603506)
- mmu-miR-292a-5p (MIRT605524)
- mmu-miR-290a-5p (MIRT605525)
- hsa-miR-193a-3p (MIRT731603)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB27B
- Browse OriGene Inhibitory RNA Products For RAB27B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB27B
Clone Products
- Applied Biological Materials (abm): Clones for RAB27B - Select products 50% OFF >
- * RAB27B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201117
- MG202445
- MR201117
- MR201117L3
- MR201117L4
- MR202445
- MR202445L3
- MR202445L4
- MR202450
- MR202450L3
- MR202450L4
- MR228161
- MR228573
- RC206519
- RC206519L3
- RC206519L4
- RG206519
- RR203341
- RR203341L3
- RR203341L4
- MR201117L3V
- MR201117L4V
- MR202445L3V
- MR202445L4V
- MR202450L3V
- MR202450L4V
- RC206519L3V
- RC206519L4V
- RR203341L3V
- RR203341L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAB27B
- Addgene plasmids for RAB27B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB27B
Cell Line Products
-
Horizon Cell Lines for RAB27B
No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB27B Gene
Localization for RAB27B Gene
Subcellular locations from UniProtKB/Swiss-Prot for RAB27B Gene
- Membrane. Lipid-anchor. Late endosome.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| endosome | 5 |
| golgi apparatus | 5 |
| extracellular | 4 |
| cytosol | 4 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| lysosome | 2 |
| endoplasmic reticulum | 1 |
- Golgi apparatus (3)
- Cytosol (2)
- Plasma membrane (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005623 | cell | IEA | -- |
| GO:0005768 | endosome | IEA | -- |
| GO:0005770 | late endosome | IEA,IDA | 30771381 |
| GO:0005794 | Golgi apparatus | IEA | -- |
| GO:0005795 | Golgi stack | IDA | 19966785 |
Pathways & Interactions for RAB27B Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Response to elevated platelet cytosolic Ca2+ |
.44
|
|
| 2 | Vesicle-mediated transport | ||
| 3 | Metabolism of proteins | ||
| 4 | Pancreatic secretion | ||
| 5 | Autophagy Pathway | ||
Pathways by source for RAB27B Gene
1 Sino Biological pathway for RAB27B Gene
1 BioSystems pathway for RAB27B Gene
10 Reactome pathways for RAB27B Gene
1 KEGG pathway for RAB27B Gene
1 Qiagen pathway for RAB27B Gene
- Epithelial Tight Junctions
Interacting Proteins for RAB27B Gene
Selected Interacting proteins:
O00194-RB27B_HUMAN
ENSP00000262094
for RAB27B Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for RAB27B
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002576 | platelet degranulation | TAS | -- |
| GO:0006886 | intracellular protein transport | IBA | -- |
| GO:0017157 | regulation of exocytosis | IEA | -- |
| GO:0032402 | melanosome transport | IBA | 21873635 |
| GO:0032482 | Rab protein signal transduction | IBA | -- |
No data available for SIGNOR curated interactions for RAB27B Gene
Transcripts for RAB27B Gene
mRNA/cDNA for RAB27B Gene
- 2 REFSEQ mRNAs :
- 6 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000262094 7003 nts (view in UCSC)
- ENST00000586570 432 nts (view in UCSC)
- ENST00000586594 597 nts (view in UCSC)
- ENST00000592334 423 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for RAB27B - Select products 50% OFF >
- * RAB27B CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for RAB27B
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for RAB27B
-
Santa Cruz Biotechnology (SCBT) CRISPR for RAB27B
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for RAB27B
- Browse OriGene Inhibitory RNA Products For RAB27B
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB27B
Clone Products
- Applied Biological Materials (abm): Clones for RAB27B - Select products 50% OFF >
- * RAB27B as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG201117
- MG202445
- MR201117
- MR201117L3
- MR201117L4
- MR202445
- MR202445L3
- MR202445L4
- MR202450
- MR202450L3
- MR202450L4
- MR228161
- MR228573
- RC206519
- RC206519L3
- RC206519L4
- RG206519
- RR203341
- RR203341L3
- RR203341L4
- MR201117L3V
- MR201117L4V
- MR202445L3V
- MR202445L4V
- MR202450L3V
- MR202450L4V
- RC206519L3V
- RC206519L4V
- RR203341L3V
- RR203341L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for RAB27B
- Addgene plasmids for RAB27B
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for RAB27B
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | |||||||||||
| SP2: | - |
Relevant External Links for RAB27B Gene
- GeneLoc Exon Structure for
- RAB27B
Expression for RAB27B Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Cardiovascular System)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Hematopoietic Bone Marrow
- Kidney (Urinary System)
-
Yolk Sac (Extraembryonic Tissues)
- Definitive Hematopoietic Stem Cells Definitive Yolk Sac
- Brain (Nervous System)
- Intestine (Gastrointestinal Tract)
- Eye (Sensory Organs)
- Lung (Respiratory System)
mRNA differential expression in normal tissues according to GTEx for RAB27B Gene
This gene is overexpressed in Esophagus - Mucosa (x5.2) and Brain - Anterior cingulate cortex (BA24) (x4.1).
This gene is overexpressed in Platelet (41.3) and Monocytes (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB27B Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB27B
SOURCE GeneReport for Unigene cluster for RAB27B Gene:
Hs.25318mRNA Expression by UniProt/SwissProt for RAB27B Gene:
O00194-RB27B_HUMAN
Tissue specificity:
Expressed primarily in testis.
Evidence on tissue expression from TISSUES for RAB27B Gene
- Nervous system(4.6)
- Blood(4.5)
- Skin(4.5)
- Kidney(2.3)
- Spleen(2.3)
- Stomach(2.1)
- Pancreas(2.1)
- Heart(2.1)
Primer Products
-
OriGene qPCR primer pairs for RAB27B
-
OriGene qPCR primer pairs and template standards for RAB27B
Gene Expression Assay Products
No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB27B Gene
Orthologs for RAB27B Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | RAB27B 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | RAB27B 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | RAB27B 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | RAB27B 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | RAB27B 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Rab27b 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Rab27b 30 |
|
||
| Chicken (Gallus gallus) |
Aves | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | RAB27B 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | rab27b 30 |
|
||
| Str.6764 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.16300 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | RAB27B 31 |
|
OneToOne | |
| si:ch1073-112i17.1 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | EG:80H7.4 32 |
|
|
|
| Rab27 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | aex-6 31 |
|
OneToMany | |
| 4R79.2 32 |
|
|
|||
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | YPT10 31 |
|
ManyToMany | |
| YPT52 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for RAB27B was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for RAB27B Gene
- ENSEMBL:
- Gene Tree for RAB27B (if available)
- TreeFam:
- Gene Tree for RAB27B (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for RAB27B: view image
Paralogs for RAB27B Gene
Paralogs for RAB27B Gene
- RAB27A 5
- RAB3D 5
- RAB26 5
- RAB8A 5
- RAB8B 5
- RAB10 5
- RAB3C 5
- RAB37 5
- RAB3B 5
- RAB3A 5
- RAB13 5
- ENSG00000285641 5
- RASEF 5
- RAB43 5
- RAB44 5
- RAB1A 5
- RAB35 5
- RAB1B 5
- RAB11A 5
- RAB11B 5
- RAB39B 5
- RAB30 5
- RAB25 5
- RAB19 5
- RAB12 5
- RAB42 5
- RAB15 5
- RAB39A 5
- RAB4B-EGLN2 5
- RAB4B 5
- RAB33A 5
- RAB18 5
- RAB9A 5
- RAB33B 5
- RAB2B 5
- RAB4A 5
- RAB6B 5
- RAB2A 5
- RAB9B 5
- RAB7A 5
- RAB5A 5
- RAB7B 5
- RAB41 5
- RAB6A 5
- RAB5B 5
- RAB22A 5
- RAB38 5
- RAB29 5
- RAB14 5
- RAB17 5
- RAB5C 5
- RAB31 5
- RAB40B 5
- RAB40C 5
- RAB6D 5
- RAB36 5
- RAB21 5
- RAB40AL 5
- RAB40A 5
- RAB23 5
- RAB20 5
- IFT27 5
- RAB6C 5
- RAB32 5
- RAB24 5
- RABL2A 5
- RAB28 5
- RABL2B 5
- ENSG00000267261 5
- RAB34 5
- DNAJC27 5
(79) SIMAP similar genes for RAB27B Gene using alignment to 3 proteins:
- RB27B_HUMAN
- K7EJ38_HUMAN
- K7ES41_HUMAN
- RAB27A
- RAB3A
- RAB8B
- RAB3B
- RAB7L1
- RAB3D
- RAB37
- RAB35
- RAB8A
- RAB3C
- RAB26
- RAB15
- RAB11A
- RAB7A
- RRAS2
- RAB17
- RAB4B
- RAB11B
- RAB6C
- RAB44
- RAB1C
- RAB13
- RAB10
- RAB30
- DKFZp686J07132
- RAB18
- RAB41
- RAB2A
- RAB12
- DKFZp313C1541
- RAB43
- RANP1
- RAP1B
- RAB39B
- RAB25
- TC4
- RABL2B
- RABL2A
- RAB39A
- RAB2B
- RAB21
- RAP2B
- RAP2A
- RAP2C
- RAB4A
- RAB22A
- RAB1B
- RAN
- RAB38
- RAB19
- RAB1A
- RAB7B
- RAB14
- RAB6A
- RAB6B
- RAB34
- RALB
- RAB32
- RASEF
- RAB9B
- RAB5B
- RAB33A
- KRAS
- RAB31
- RAP1A
- RAB5A
- HRAS
- NRAS
- MRAS
- RAB5C
- RALA
- RAB28
- RAB9A
- RAB36
- RAB33B
- RAB23
- RAB40C
- RAB40AL
- RAB40A
Variants for RAB27B Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB27B Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs9966265 | - | p.Ala92Thr |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2660892 | CNV | deletion | 23128226 |
| esv2717130 | CNV | deletion | 23290073 |
| esv3642588 | CNV | loss | 21293372 |
| nsv2314 | CNV | deletion | 18451855 |
| nsv510458 | OTHER | sequence alteration | 20534489 |
| nsv520160 | CNV | loss | 19592680 |
Residual Variation Intolerance Score:
66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.03;
21.13% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for RAB27B Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- RAB27B
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB27B Gene
Disorders for RAB27B Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| griscelli syndrome |
|
|
| piebald trait |
|
|
Search RAB27B in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for RAB27B
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for RAB27B Gene
Publications for RAB27B Gene
- Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PMID: 9066979) Chen D … Gahl WA (Biochemical and molecular medicine 1997) 2 3 4 23
- Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PMID: 11178108) Ramalho JS … Seabra MC (BMC genetics 2001) 3 4 23
- DENN domain-containing protein FAM45A regulates the homeostasis of late/multivesicular endosomes. (PMID: 30771381) Zhang J … Zhang Y (Biochimica et biophysica acta. Molecular cell research 2019) 3 4
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41
- Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PMID: 18478159) Hayasaka S … Okamura K (Asian journal of andrology 2008) 3 23
ExternalLinks
Products for RAB27B Gene
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Sources for RAB27B Gene
- (1) GeneCards
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- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
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- (27) ASD
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- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
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- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
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- (55) TGDB
- (56) Tocris
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- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
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- (77) ESI-BIO
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