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Aliases for RAB27B Gene

Aliases for RAB27B Gene

  • RAB27B, Member RAS Oncogene Family 2 3 5
  • C25KG 3 4
  • Ras-Related Protein Rab-27B 3

External Ids for RAB27B Gene

Previous GeneCards Identifiers for RAB27B Gene

  • GC18P052584
  • GC18P052398
  • GC18P052280
  • GC18P050644
  • GC18P050646
  • GC18P052495
  • GC18P049204
  • GC18P052385

Summaries for RAB27B Gene

Entrez Gene Summary for RAB27B Gene

  • Members of the Rab protein family, including RAB27B, are prenylated, membrane-bound proteins involved in vesicular fusion and trafficking (Chen et al., 1997 [PubMed 9066979]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB27B Gene

RAB27B (RAB27B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB27B include Griscelli Syndrome. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include GTP binding and protein domain specific binding. An important paralog of this gene is RAB27A.

UniProtKB/Swiss-Prot for RAB27B Gene

  • May be involved in targeting uroplakins to urothelial apical membranes.

Additional gene information for RAB27B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB27B Gene

Genomics for RAB27B Gene

GeneHancer (GH) Regulatory Elements for RAB27B Gene

Promoters and enhancers for RAB27B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18I054827 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.1 +111.6 111622 3.5 PKNOX1 ZSCAN4 SIN3A ZNF76 FEZF1 ZNF2 ZNF48 RAD21 ZNF335 ZNF766 RAB27B CCDC68 POLI ENSG00000267311 GC18P054745
GH18I054717 Enhancer 0.9 Ensembl ENCODE dbSUPER 550.8 +0.2 241 1 MXI1 POLR2A ZNF143 RUNX3 RAB27B CCDC68 GC18P054727
GH18I054716 Enhancer 0.2 ENCODE 550.8 -1.1 -1095 0.2 RAB27B CCDC68 ENSG00000267428
GH18I054822 Enhancer 1 FANTOM5 ENCODE 19.7 +105.4 105396 1.2 JUN MAX CEBPG RFX5 FOSL1 POLR2A SMC3 RCOR1 FOSL2 CHD2 RAB27B POLI ENSG00000267311 GC18P054745
GH18I054873 Enhancer 0.8 ENCODE 12.1 +155.9 155911 1.1 FOXA2 FEZF1 RAD21 YY1 TCF12 GATA2 ETV6 RXRA ELF1 REST RAB27B ENSG00000267311 GC18P054745
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB27B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB27B gene promoter:

Genomic Locations for RAB27B Gene

Genomic Locations for RAB27B Gene
177,657 bases
Plus strand

Genomic View for RAB27B Gene

Genes around RAB27B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB27B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB27B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB27B Gene

Proteins for RAB27B Gene

  • Protein details for RAB27B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-27B
    Protein Accession:
    Secondary Accessions:
    • B2RAB0
    • Q9BZB6

    Protein attributes for RAB27B Gene

    218 amino acids
    Molecular mass:
    24608 Da
    Quaternary structure:
    • Interacts with SYTL2, SYTL4, MYRIP and MLPH. Interacts with RPH3A and RPH3A (By similarity).

    Three dimensional structures from OCA and Proteopedia for RAB27B Gene

neXtProt entry for RAB27B Gene

Post-translational modifications for RAB27B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB27B Gene

No data available for DME Specific Peptides for RAB27B Gene

Domains & Families for RAB27B Gene

Gene Families for RAB27B Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB27B Gene

Suggested Antigen Peptide Sequences for RAB27B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB27B: view

Function for RAB27B Gene

Molecular function for RAB27B Gene

UniProtKB/Swiss-Prot Function:
May be involved in targeting uroplakins to urothelial apical membranes.

Phenotypes From GWAS Catalog for RAB27B Gene

Gene Ontology (GO) - Molecular Function for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,ISS --
GO:0005515 protein binding IPI 15357836
GO:0005525 GTP binding IEA,ISS --
GO:0019003 GDP binding IDA 20937701
GO:0019904 protein domain specific binding IPI 16880209
genes like me logo Genes that share ontologies with RAB27B: view
genes like me logo Genes that share phenotypes with RAB27B: view

Animal Models for RAB27B Gene

MGI Knock Outs for RAB27B:

Animal Model Products

miRNA for RAB27B Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB27B Gene

Localization for RAB27B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB27B Gene

Membrane; Lipid-anchor.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB27B gene
Compartment Confidence
plasma membrane 5
extracellular 5
golgi apparatus 5
endosome 5
cytosol 4
nucleus 2
lysosome 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005794 Golgi apparatus IEA --
GO:0005795 Golgi stack IDA 19966785
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016324 apical plasma membrane IEA --
genes like me logo Genes that share ontologies with RAB27B: view

Pathways & Interactions for RAB27B Gene

genes like me logo Genes that share pathways with RAB27B: view

Pathways by source for RAB27B Gene

Gene Ontology (GO) - Biological Process for RAB27B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002576 platelet degranulation TAS --
GO:0017157 regulation of exocytosis IEA --
GO:0032402 melanosome transport IBA --
GO:0045921 positive regulation of exocytosis IMP 19966785
GO:0071985 multivesicular body sorting pathway IMP 19966785
genes like me logo Genes that share ontologies with RAB27B: view

No data available for SIGNOR curated interactions for RAB27B Gene

Drugs & Compounds for RAB27B Gene

No Compound Related Data Available

Transcripts for RAB27B Gene

Unigene Clusters for RAB27B Gene

RAB27B, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB27B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP2: -

Relevant External Links for RAB27B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB27B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB27B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB27B Gene

This gene is overexpressed in Esophagus - Mucosa (x5.2) and Brain - Anterior cingulate cortex (BA24) (x4.1).

Protein differential expression in normal tissues from HIPED for RAB27B Gene

This gene is overexpressed in Platelet (41.3) and Monocytes (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB27B Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB27B Gene:


SOURCE GeneReport for Unigene cluster for RAB27B Gene:


mRNA Expression by UniProt/SwissProt for RAB27B Gene:

Tissue specificity: Expressed primarily in testis.

Evidence on tissue expression from TISSUES for RAB27B Gene

  • Blood(4.4)
  • Skin(4.4)
  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with RAB27B: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB27B Gene

Orthologs for RAB27B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB27B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB27B 33 34
  • 99.85 (n)
(Monodelphis domestica)
Mammalia RAB27B 34
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia RAB27B 34
  • 93 (a)
(Canis familiaris)
Mammalia RAB27B 33 34
  • 91.59 (n)
(Bos Taurus)
Mammalia RAB27B 33 34
  • 90.52 (n)
(Mus musculus)
Mammalia Rab27b 33 16 34
  • 88.99 (n)
(Rattus norvegicus)
Mammalia Rab27b 33
  • 88.07 (n)
(Gallus gallus)
Aves -- 34
  • 34 (a)
(Anolis carolinensis)
Reptilia RAB27B 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab27b 33
  • 78.9 (n)
Str.6764 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.16300 33
(Danio rerio)
Actinopterygii RAB27B 34
  • 80 (a)
si:ch1073-112i17.1 33
  • 72.04 (n)
fruit fly
(Drosophila melanogaster)
Insecta EG:80H7.4 35
  • 60 (a)
Rab27 34
  • 47 (a)
(Caenorhabditis elegans)
Secernentea aex-6 34
  • 61 (a)
4R79.2 35
  • 42 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT10 34
  • 31 (a)
YPT52 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
Species where no ortholog for RAB27B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB27B Gene

Gene Tree for RAB27B (if available)
Gene Tree for RAB27B (if available)

Paralogs for RAB27B Gene

Variants for RAB27B Gene

Sequence variations from dbSNP and Humsavar for RAB27B Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000006013 -- 54,799,690(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000045432 -- 54,888,325(+) T/G intron_variant
rs1000059189 -- 54,888,300(+) C/T intron_variant
rs1000070547 -- 54,825,317(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000071527 -- 54,759,123(+) G/A genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB27B Gene

Variant ID Type Subtype PubMed ID
esv2660892 CNV deletion 23128226
esv2717130 CNV deletion 23290073
esv3642588 CNV loss 21293372
nsv2314 CNV deletion 18451855
nsv510458 OTHER sequence alteration 20534489
nsv520160 CNV loss 19592680

Variation tolerance for RAB27B Gene

Residual Variation Intolerance Score: 66.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.13% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB27B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB27B Gene

Disorders for RAB27B Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB27B Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
griscelli syndrome
  • chédiak-higashi-like syndrome
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAB27B

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with RAB27B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB27B Gene

Publications for RAB27B Gene

  1. Molecular cloning and characterization of rab27a and rab27b, novel human rab proteins shared by melanocytes and platelets. (PMID: 9066979) Chen D … Gahl WA (Biochemical and molecular medicine 1997) 2 3 4 22 58
  2. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. (PMID: 11178108) Ramalho JS … Seabra MC (BMC genetics 2001) 3 4 22 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  4. Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PMID: 18478159) Hayasaka S … Okamura K (Asian journal of andrology 2008) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RAB27B Gene

Sources for RAB27B Gene

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