Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010] See more...

Aliases for RAB26 Gene

Aliases for RAB26 Gene

  • RAB26, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-26 3 4
  • Ras-Related Oncogene Protein 3
  • V46133 3
  • RAB26 5

External Ids for RAB26 Gene

Previous GeneCards Identifiers for RAB26 Gene

  • GC16P002215
  • GC16P002138
  • GC16P002198
  • GC16P002124
  • GC16P002190
  • GC16P002143
  • GC16P002144
  • GC16P002294
  • GC16P002324
  • GC16P002349
  • GC16P002391
  • GC16P002149
  • GC16P002151
  • GC16P002153
  • GC16P002160
  • GC16P002186
  • GC16P002216
  • GC16P002244
  • GC16P002256

Summaries for RAB26 Gene

Entrez Gene Summary for RAB26 Gene

  • Members of the RAB protein family, including RAB26, are important regulators of vesicular fusion and trafficking. The RAB family of small G proteins regulates intercellular vesicle trafficking, including exocytosis, endocytosis, and recycling (summary by Seki et al., 2000 [PubMed 11043516]).[supplied by OMIM, Nov 2010]

GeneCards Summary for RAB26 Gene

RAB26 (RAB26, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB26 include Warburg Micro Syndrome. Among its related pathways are Metabolism of proteins and Autophagy Pathway. Gene Ontology (GO) annotations related to this gene include GTP binding and GMP binding. An important paralog of this gene is RAB37.

UniProtKB/Swiss-Prot Summary for RAB26 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Gene Wiki entry for RAB26 Gene

Additional gene information for RAB26 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB26 Gene

Genomics for RAB26 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB26 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB26 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB26

Top Transcription factor binding sites by QIAGEN in the RAB26 gene promoter:
  • AP-1
  • CREB
  • deltaCREB

Genomic Locations for RAB26 Gene

Genomic Locations for RAB26 Gene
chr16:2,140,803-2,154,165
(GRCh38/hg38)
Size:
13,363 bases
Orientation:
Plus strand
chr16:2,190,804-2,204,166
(GRCh37/hg19)
Size:
13,363 bases
Orientation:
Plus strand

Genomic View for RAB26 Gene

Genes around RAB26 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB26 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB26 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB26 Gene

Proteins for RAB26 Gene

  • Protein details for RAB26 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9ULW5-RAB26_HUMAN
    Recommended name:
    Ras-related protein Rab-26
    Protein Accession:
    Q9ULW5
    Secondary Accessions:
    • B2RAA6
    • Q3L6K5
    • Q6NXS7

    Protein attributes for RAB26 Gene

    Size:
    256 amino acids
    Molecular mass:
    27900 Da
    Quaternary structure:
    • Interacts with RIMS1 (By similarity). Interacts with ADRA2B.
    SequenceCaution:
    • Sequence=BAA84707.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB26 Gene

    Alternative splice isoforms for RAB26 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB26 Gene

Post-translational modifications for RAB26 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB26 Gene

No data available for DME Specific Peptides for RAB26 Gene

Domains & Families for RAB26 Gene

Gene Families for RAB26 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB26 Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
ProtoNet:

Suggested Antigen Peptide Sequences for RAB26 Gene

GenScript: Design optimal peptide antigens:
  • cDNA, FLJ94800, Homo sapiens RAB26, member RAS oncogene family (RAB26), mRNA (B2RAA6_HUMAN)
  • Ras-related oncogene protein (Q3L6K5_HUMAN)
  • Ras-related protein Rab-26 (RAB26_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9ULW5

UniProtKB/Swiss-Prot:

RAB26_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB26: view

Function for RAB26 Gene

Molecular function for RAB26 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach. Plays a role in the secretion of amylase from acinar granules in the parotid gland.

Phenotypes From GWAS Catalog for RAB26 Gene

Gene Ontology (GO) - Molecular Function for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA --
GO:0005515 protein binding IPI 23105096
GO:0005525 GTP binding ISS --
GO:0019002 GMP binding IMP 23105096
genes like me logo Genes that share ontologies with RAB26: view
genes like me logo Genes that share phenotypes with RAB26: view

Animal Model Products

CRISPR Products

miRNA for RAB26 Gene

miRTarBase miRNAs that target RAB26

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB26

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB26 Gene

Localization for RAB26 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB26 Gene

Golgi apparatus membrane. Lipid-anchor. Cytoplasmic side. Cytoplasmic vesicle, secretory vesicle membrane. Lipid-anchor. Cytoplasmic side. Note=Not localized at the plasma membrane (By similarity). Inhibition of S-geranylgeranyl cysteine formation abolishes membrane location. {ECO:0000250 UniProtKB:P51156}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB26 gene
Compartment Confidence
golgi apparatus 5
plasma membrane 4
mitochondrion 3
cytosol 3
nucleus 2
endosome 2
lysosome 2
extracellular 1
cytoskeleton 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (1)
  • Plasma membrane (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA,IDA 23105096
GO:0005768 endosome IBA 21873635
GO:0005794 Golgi apparatus IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with RAB26: view

Pathways & Interactions for RAB26 Gene

genes like me logo Genes that share pathways with RAB26: view

Pathways by source for RAB26 Gene

1 Sino Biological pathway for RAB26 Gene
1 Qiagen pathway for RAB26 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB26 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IEA,ISS --
GO:0032482 Rab protein signal transduction IBA --
GO:0035272 exocrine system development IEA,ISS --
genes like me logo Genes that share ontologies with RAB26: view

No data available for SIGNOR curated interactions for RAB26 Gene

Drugs & Compounds for RAB26 Gene

No Compound Related Data Available

Transcripts for RAB26 Gene

mRNA/cDNA for RAB26 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB26

Alternative Splicing Database (ASD) splice patterns (SP) for RAB26 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b · 11c
SP1: -
SP2: -
SP3:
SP4: - -
SP5: -

Relevant External Links for RAB26 Gene

GeneLoc Exon Structure for
RAB26

Expression for RAB26 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB26 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB26 Gene

This gene is overexpressed in Brain - Cerebellum (x8.7) and Brain - Cerebellar Hemisphere (x8.5).

Protein differential expression in normal tissues from HIPED for RAB26 Gene

This gene is overexpressed in Breast (65.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for RAB26 Gene



Protein tissue co-expression partners for RAB26 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB26

SOURCE GeneReport for Unigene cluster for RAB26 Gene:

Hs.3797

mRNA Expression by UniProt/SwissProt for RAB26 Gene:

Q9ULW5-RAB26_HUMAN
Tissue specificity: Predominantly expressed in brain.

Evidence on tissue expression from TISSUES for RAB26 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RAB26: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB26 Gene

Orthologs for RAB26 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB26 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAB26 31
  • 100 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RAB26 30 31
  • 88.11 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB26 30 31
  • 87.11 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rab26 30
  • 86.95 (n)
Mouse
(Mus musculus)
Mammalia Rab26 30 17 31
  • 84.58 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RAB26 31
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RAB26 31
  • 75 (a)
OneToOne
Chicken
(Gallus gallus)
Aves RAB26 30 31
  • 79.15 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RAB26 31
  • 83 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rab15 31
  • 42 (a)
ManyToMany
Fruit Fly
(Drosophila melanogaster)
Insecta Rab26 30 31
  • 67.01 (n)
OneToMany
CG7605 32
  • 63 (a)
Worm
(Caenorhabditis elegans)
Secernentea rab-37 31
  • 49 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 58 (a)
OneToMany
Species where no ortholog for RAB26 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)

Evolution for RAB26 Gene

ENSEMBL:
Gene Tree for RAB26 (if available)
TreeFam:
Gene Tree for RAB26 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB26: view image

Paralogs for RAB26 Gene

genes like me logo Genes that share paralogs with RAB26: view

Variants for RAB26 Gene

Additional dbSNP identifiers (rs#s) for RAB26 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB26 Gene

Variant ID Type Subtype PubMed ID
dgv4859n54 CNV loss 21841781
dgv4861n54 CNV loss 21841781
dgv4863n54 CNV loss 21841781
esv2422427 CNV duplication 17116639
nsv1052260 CNV gain 25217958
nsv457349 CNV loss 19166990
nsv471072 CNV loss 18288195
nsv571190 CNV loss 21841781
nsv952902 CNV deletion 24416366

Variation tolerance for RAB26 Gene

Residual Variation Intolerance Score: 77.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.92; 19.08% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB26 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB26

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB26 Gene

Disorders for RAB26 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB26 Gene - From: DISEASES

Disorder Aliases PubMed IDs
warburg micro syndrome
  • micro syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAB26 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB26

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with RAB26: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB26 Gene

Publications for RAB26 Gene

  1. cDNA cloning of a human RAB26-related gene encoding a Ras-like GTP-binding protein on chromosome 16p13.3 region. (PMID: 11043516) Seki N … Saito T (Journal of human genetics 2000) 2 3 4
  2. Rab26 modulates the cell surface transport of α2-adrenergic receptors from the Golgi. (PMID: 23105096) Li C … Wu G (The Journal of biological chemistry 2012) 3 4
  3. RAB26 and RAB3D are direct transcriptional targets of MIST1 that regulate exocrine granule maturation. (PMID: 20038531) Tian X … Mills JC (Molecular and cellular biology 2010) 3 4
  4. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41
  5. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4

Products for RAB26 Gene

Sources for RAB26 Gene