The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015] See more...

Aliases for RAB25 Gene

Aliases for RAB25 Gene

  • RAB25, Member RAS Oncogene Family 2 3 5
  • CATX-8 2 3 4
  • Ras-Related Protein Rab-25 3 4
  • RAB11C 3
  • RAB25 5
  • CATX8 4

External Ids for RAB25 Gene

Previous GeneCards Identifiers for RAB25 Gene

  • GC01P153899
  • GC01P151796
  • GC01P152809
  • GC01P153247
  • GC01P152844
  • GC01P154297
  • GC01P156030
  • GC01P127393

Summaries for RAB25 Gene

Entrez Gene Summary for RAB25 Gene

  • The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]

GeneCards Summary for RAB25 Gene

RAB25 (RAB25, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB25 include Corneal Dystrophy, Posterior Polymorphous, 4 and Ovarian Cancer. Among its related pathways are Cytoskeletal Signaling and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB11A.

UniProtKB/Swiss-Prot Summary for RAB25 Gene

  • Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Gene Wiki entry for RAB25 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB25 Gene

Genomics for RAB25 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB25 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J156060 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 250.7 +0.4 376 2.7 ATF2 JUND POLR2A ETS1 SIN3A ZNF217 ELF1 SMARCE1 SCRT1 TAF1 DQ866751 RF00017-314 RAB25 GBA MEX3A
GH01J156059 Enhancer 0.2 Ensembl 250.7 -1.5 -1459 0.2 RF00017-314 RAB25 HSALNG0007545 LAMTOR2
GH01J156066 Enhancer 0.9 Ensembl ENCODE 0.7 +4.8 4841 1.6 ZNF207 ZNF654 NONO CTCF REST TRIM22 THAP11 FOXA2 RAD21 RFX5 piR-53544 KHDC4 RXFP4 TSACC CCT3 RAB25 lnc-UBQLN4-1 MEX3A
GH01J156063 Enhancer 0.8 Ensembl ENCODE 0.7 +2.5 2541 1 CEBPA ZIC2 CEBPB SMAD4 RARA PRDM6 BCL6 ZNF189 ZNF664 NR2F6 DQ866751 piR-53544 KHDC4 RXFP4 TSACC CCT3 RAB25 MEX3A
GH01J156074 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 0.4 +15.3 15274 4 SP1 ZNF207 IKZF1 ZNF341 NR2C1 SIN3A KLF9 RXRA RAD21 CTCF MEX3A lnc-UBQLN4-1 piR-53544 RAB25
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB25 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB25

Top Transcription factor binding sites by QIAGEN in the RAB25 gene promoter:
  • GATA-1
  • HEN1
  • ITF-2
  • MIF-1
  • NF-kappaB
  • NF-kappaB1
  • Pax-5
  • RelA
  • Sox9
  • Tal-1beta

Genomic Locations for RAB25 Gene

Latest Assembly
chr1:156,061,160-156,070,504
(GRCh38/hg38)
Size:
9,345 bases
Orientation:
Plus strand

Previous Assembly
chr1:156,030,951-156,040,295
(GRCh37/hg19 by Entrez Gene)
Size:
9,345 bases
Orientation:
Plus strand

chr1:156,030,951-156,040,295
(GRCh37/hg19 by Ensembl)
Size:
9,345 bases
Orientation:
Plus strand

Genomic View for RAB25 Gene

Genes around RAB25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB25 Gene

Proteins for RAB25 Gene

  • Protein details for RAB25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P57735-RAB25_HUMAN
    Recommended name:
    Ras-related protein Rab-25
    Protein Accession:
    P57735
    Secondary Accessions:
    • Q5VYA2
    • Q8NG24
    • Q96GB1
    • Q9BT12

    Protein attributes for RAB25 Gene

    Size:
    213 amino acids
    Molecular mass:
    23496 Da
    Quaternary structure:
    • Interacts with RAB11FIP1, RAB11FIP2, RAB11FIP3 and RAB11FIP4. Interacts (via the hypervariable C-terminal region) with ITGB1 (via the cytoplasmic region); the interaction is GTP-dependent. Interacts with ITGAV. Associates with the integrin alpha-V/beta-1 heterodimer.
    SequenceCaution:
    • Sequence=AAF98238.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAM69362.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB25 Gene

neXtProt entry for RAB25 Gene

Post-translational modifications for RAB25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB25 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB25 Gene

Domains & Families for RAB25 Gene

Gene Families for RAB25 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Protein Domains for RAB25 Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
  • GTP-binding nuclear protein Ran
  • Ras small GTPase, Ras type
  • Ras small GTPase, Rho type

Suggested Antigen Peptide Sequences for RAB25 Gene

GenScript: Design optimal peptide antigens:
  • CATX-8 (RAB25_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P57735

UniProtKB/Swiss-Prot:

RAB25_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB25: view

Function for RAB25 Gene

Molecular function for RAB25 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).

Phenotypes From GWAS Catalog for RAB25 Gene

Gene Ontology (GO) - Molecular Function for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 17925226
GO:0005525 GTP binding IEA --
GO:0031489 myosin V binding IPI 24006491
genes like me logo Genes that share ontologies with RAB25: view
genes like me logo Genes that share phenotypes with RAB25: view

Animal Models for RAB25 Gene

MGI Knock Outs for RAB25:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB25

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB25 Gene

Localization for RAB25 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB25 Gene

Cell membrane. Lipid-anchor. Cytoplasmic side. Cell projection, pseudopodium membrane. Cytoplasmic vesicle. Note=Colocalizes with integrin alpha-V/beta-1 in vesicles at the pseudopodial tips. {ECO:0000269 PubMed:17925226}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB25 gene
Compartment Confidence
plasma membrane 4
extracellular 4
endosome 4
cytosol 4
cytoskeleton 2
mitochondrion 2
nucleus 2
lysosome 2
golgi apparatus 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cell Junctions (1)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005886 plasma membrane IEA --
GO:0016020 membrane IEA --
GO:0031143 pseudopodium IDA 17925226
GO:0031260 pseudopodium membrane IEA --
genes like me logo Genes that share ontologies with RAB25: view

Pathways & Interactions for RAB25 Gene

genes like me logo Genes that share pathways with RAB25: view

Pathways by source for RAB25 Gene

1 Sino Biological pathway for RAB25 Gene
1 Qiagen pathway for RAB25 Gene
  • Epithelial Tight Junctions
1 Cell Signaling Technology pathway for RAB25 Gene

Gene Ontology (GO) - Biological Process for RAB25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003382 epithelial cell morphogenesis IEA,ISS --
GO:0006887 exocytosis IBA 21873635
GO:0008284 positive regulation of cell proliferation IDA 15502842
GO:0010634 positive regulation of epithelial cell migration IMP 22613965
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB25: view

No data available for SIGNOR curated interactions for RAB25 Gene

Drugs & Compounds for RAB25 Gene

(1) Additional Compounds for RAB25 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB25: view

Transcripts for RAB25 Gene

mRNA/cDNA for RAB25 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB25

Alternative Splicing Database (ASD) splice patterns (SP) for RAB25 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b
SP1: - - -
SP2: - - - - -
SP3: -
SP4: - - - -
SP5: - - -
SP6:

Relevant External Links for RAB25 Gene

GeneLoc Exon Structure for
RAB25

Expression for RAB25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB25 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB25 Gene

This gene is overexpressed in Esophagus - Mucosa (x13.4), Skin - Sun Exposed (Lower leg) (x6.2), Skin - Not Sun Exposed (Suprapubic) (x5.7), and Vagina (x4.1).

Protein differential expression in normal tissues from HIPED for RAB25 Gene

This gene is overexpressed in Nasal epithelium (21.1) and Cervix (16.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB25 Gene



Protein tissue co-expression partners for RAB25 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB25

SOURCE GeneReport for Unigene cluster for RAB25 Gene:

Hs.632469

mRNA Expression by UniProt/SwissProt for RAB25 Gene:

P57735-RAB25_HUMAN
Tissue specificity: Expressed in ovarian epithelium (NOE) and breast tissue. Expressed in ovarian cancer; expression is increased relative to NOE cells. Expression in ovarian cancer is stage dependent, with stage III and stage IV showing higher levels than early stage cancers. Expressed in breast cancer; expression is increased relative to normal breast tissue.

Evidence on tissue expression from TISSUES for RAB25 Gene

  • Intestine(4.6)
  • Skin(4.6)
  • Pancreas(4.4)
  • Stomach(2.5)
  • Kidney(2.5)
  • Lung(2.1)
  • Thyroid gland(2.1)
  • Blood(2)
genes like me logo Genes that share expression patterns with RAB25: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB25 Gene

Orthologs for RAB25 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB25 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAB25 29 30
  • 99.84 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RAB25 30
  • 92 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB25 29 30
  • 91.39 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rab25 29 16 30
  • 90.61 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rab25 29
  • 90.45 (n)
Dog
(Canis familiaris)
Mammalia RAB25 29 30
  • 88.58 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RAB25 29 30
  • 73.56 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rab25 29
  • 69.13 (n)
Str.10328 29
Zebrafish
(Danio rerio)
Actinopterygii rab25a 29 30
  • 66.83 (n)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta Rab11 30
  • 58 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea rab-11.1 30
  • 59 (a)
ManyToMany
rab-11.2 30
  • 56 (a)
ManyToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT32 30
  • 49 (a)
ManyToMany
YPT31 30
  • 49 (a)
ManyToMany
Species where no ortholog for RAB25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RAB25 Gene

ENSEMBL:
Gene Tree for RAB25 (if available)
TreeFam:
Gene Tree for RAB25 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB25: view image
Alliance of Genome Resources:
Additional Orthologs for RAB25

Paralogs for RAB25 Gene

genes like me logo Genes that share paralogs with RAB25: view

Variants for RAB25 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAB25 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAB25 Gene

Variant ID Type Subtype PubMed ID
nsv509513 CNV insertion 20534489

Variation tolerance for RAB25 Gene

Residual Variation Intolerance Score: 74.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.18; 39.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB25 Gene

Human Gene Mutation Database (HGMD)
RAB25
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB25
Leiden Open Variation Database (LOVD)
RAB25

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB25 Gene

Disorders for RAB25 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB25 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
corneal dystrophy, posterior polymorphous, 4
  • ppcd4
ovarian cancer
  • ovarian cancer, somatic
breast cancer
  • breast cancer, familial
- elite association - COSMIC cancer census association via MalaCards
Search RAB25 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB25

genes like me logo Genes that share disorders with RAB25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB25 Gene

Publications for RAB25 Gene

  1. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. (PMID: 17925226) Caswell PT … Norman JC (Developmental cell 2007) 3 4 22
  2. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) International Parkinson Disease Genomics Consortium … Wood NW (Lancet (London, England) 2011) 3 40
  3. Loss of Rab25 promotes the development of intestinal neoplasia in mice and is associated with human colorectal adenocarcinomas. (PMID: 20197623) Nam KT … Goldenring JR (The Journal of clinical investigation 2010) 3 22
  4. Tumor suppressor function of Rab25 in triple-negative breast cancer. (PMID: 19795443) Cheng JM … Rao KA (International journal of cancer 2010) 3 22
  5. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. (PMID: 15502842) Cheng KW … Mills GB (Nature medicine 2004) 3 4

Products for RAB25 Gene

Sources for RAB25 Gene