Aliases for RAB25 Gene
External Ids for RAB25 Gene
Previous GeneCards Identifiers for RAB25 Gene
The protein encoded by this gene is a member of the RAS superfamily of small GTPases. The encoded protein is involved in membrane trafficking and cell survival. This gene has been found to be a tumor suppressor and an oncogene, depending on the context. Two variants, one protein-coding and the other not, have been found for this gene. [provided by RefSeq, Nov 2015]
GeneCards Summary for RAB25 Gene
RAB25 (RAB25, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB25 include Corneal Dystrophy, Posterior Polymorphous, 4 and Ovarian Cancer. Among its related pathways are Cytoskeletal Signaling and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and myosin V binding. An important paralog of this gene is RAB11A.
UniProtKB/Swiss-Prot Summary for RAB25 Gene
Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia (PubMed:17925226). Involved in the regulation of epithelial morphogenesis through the control of CLDN4 expression and localization at tight junctions (By similarity). May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).