RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009] See more...

Aliases for RAB24 Gene

Aliases for RAB24 Gene

  • RAB24, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-24 3 4

External Ids for RAB24 Gene

Previous GeneCards Identifiers for RAB24 Gene

  • GC05M177101
  • GC05M177570
  • GC05M176663
  • GC05M176709
  • GC05M176660
  • GC05M176728
  • GC05M171648

Summaries for RAB24 Gene

Entrez Gene Summary for RAB24 Gene

  • RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB24 Gene

RAB24 (RAB24, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Innate Immune System and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot Summary for RAB24 Gene

Additional gene information for RAB24 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB24 Gene

Genomics for RAB24 Gene

GeneHancer (GH) Regulatory Elements for RAB24 Gene

Promoters and enhancers for RAB24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB24 gene promoter:
  • AML1a
  • ARP-1
  • Gfi-1
  • HEN1
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • STAT3

Genomic Locations for RAB24 Gene

Genomic Locations for RAB24 Gene
chr5:177,301,190-177,303,744
(GRCh38/hg38)
Size:
2,555 bases
Orientation:
Minus strand
chr5:176,728,199-176,730,745
(GRCh37/hg19)
Size:
2,547 bases
Orientation:
Minus strand

Genomic View for RAB24 Gene

Genes around RAB24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB24 Gene

Proteins for RAB24 Gene

  • Protein details for RAB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q5-RAB24_HUMAN
    Recommended name:
    Ras-related protein Rab-24
    Protein Accession:
    Q969Q5
    Secondary Accessions:
    • A0A024R7N9
    • Q7Z4Z7

    Protein attributes for RAB24 Gene

    Size:
    203 amino acids
    Molecular mass:
    23124 Da
    Quaternary structure:
    • Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
    Miscellaneous:
    • The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).

neXtProt entry for RAB24 Gene

Post-translational modifications for RAB24 Gene

  • Isoprenylation is inefficient compared to other Rab family members.
  • Ubiquitination at Lys104
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB24 Gene

No data available for DME Specific Peptides for RAB24 Gene

Domains & Families for RAB24 Gene

Gene Families for RAB24 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB24 Gene

Suggested Antigen Peptide Sequences for RAB24 Gene

GenScript: Design optimal peptide antigens:
  • RAB24, member RAS oncogene family, isoform CRA_d (Q8WY67_HUMAN)
  • cDNA FLJ11699 fis, clone HEMBA1005047, highly similar to RAS-RELATED PROTEIN RAB-24 (Q9HAG2_HUMAN)
  • Ras-related protein Rab-24 (RAB24_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q969Q5

UniProtKB/Swiss-Prot:

RAB24_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB24: view

Function for RAB24 Gene

Molecular function for RAB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in autophagy-related processes.
UniProtKB/Swiss-Prot Induction:
By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).

Phenotypes From GWAS Catalog for RAB24 Gene

Gene Ontology (GO) - Molecular Function for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IBA,IEA 21873635
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB24: view
genes like me logo Genes that share phenotypes with RAB24: view

Animal Models for RAB24 Gene

MGI Knock Outs for RAB24:
  • Rab24 Rab24<tm1.1(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RAB24 Gene

miRTarBase miRNAs that target RAB24

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB24 Gene

Localization for RAB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB24 Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269 PubMed:10660536}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB24 gene
Compartment Confidence
plasma membrane 4
cytosol 4
endosome 3
extracellular 1
nucleus 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA 21873635
GO:0005776 autophagosome IBA,IEA 21873635
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RAB24: view

Pathways & Interactions for RAB24 Gene

genes like me logo Genes that share pathways with RAB24: view

Pathways by source for RAB24 Gene

1 Qiagen pathway for RAB24 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0032482 Rab protein signal transduction IBA 21873635
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB24: view

No data available for SIGNOR curated interactions for RAB24 Gene

Drugs & Compounds for RAB24 Gene

No Compound Related Data Available

Transcripts for RAB24 Gene

mRNA/cDNA for RAB24 Gene

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB24

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP3:
SP4: -
SP5:

Relevant External Links for RAB24 Gene

GeneLoc Exon Structure for
RAB24
ECgene alternative splicing isoforms for
RAB24

Expression for RAB24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB24 Gene

mRNA differential expression in normal tissues according to GTEx for RAB24 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for RAB24 Gene

This gene is overexpressed in Brain (9.8), Peripheral blood mononuclear cells (9.1), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB24 Gene



Protein tissue co-expression partners for RAB24 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB24 Gene:

RAB24

SOURCE GeneReport for Unigene cluster for RAB24 Gene:

Hs.16258

Evidence on tissue expression from TISSUES for RAB24 Gene

  • Nervous system(4.7)
  • Pancreas(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with RAB24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB24 Gene

Orthologs for RAB24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB24 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB24 33 32
  • 99.84 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB24 33
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB24 33
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia RAB24 33 32
  • 93.92 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Rab24 17 33 32
  • 89 (n)
chicken
(Gallus gallus)
Aves RAB24 33 32
  • 79.8 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB24 33
  • 86 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab24 32
  • 72.25 (n)
Str.14066 32
African clawed frog
(Xenopus laevis)
Amphibia Xl.9937 32
zebrafish
(Danio rerio)
Actinopterygii rab24 33 32
  • 69.47 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11639 32
fruit fly
(Drosophila melanogaster)
Insecta chrw 33
  • 25 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 31 (a)
OneToMany
Species where no ortholog for RAB24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB24 Gene

ENSEMBL:
Gene Tree for RAB24 (if available)
TreeFam:
Gene Tree for RAB24 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB24: view image

Paralogs for RAB24 Gene

genes like me logo Genes that share paralogs with RAB24: view

Variants for RAB24 Gene

Sequence variations from dbSNP and Humsavar for RAB24 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000945330 -- 177,303,274(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1001397878 -- 177,302,923(-) G/C intron_variant
rs1001998859 -- 177,301,298(-) T/A/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1002825693 -- 177,304,318(-) G/A upstream_transcript_variant
rs1003185797 -- 177,304,838(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB24 Gene

Variant ID Type Subtype PubMed ID
esv2759396 CNV gain 17122850
nsv428132 CNV gain 18775914
nsv600364 CNV loss 21841781

Variation tolerance for RAB24 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB24

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB24 Gene

Disorders for RAB24 Gene

Additional Disease Information for RAB24

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB24 Gene

Publications for RAB24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 43 56
  2. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4 56
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  4. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PMID: 10660536) Erdman RA … Maltese WA (The Journal of biological chemistry 2000) 3 4 56
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56

Products for RAB24 Gene

Sources for RAB24 Gene