RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009] See more...

Aliases for RAB24 Gene

Aliases for RAB24 Gene

  • RAB24, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-24 3 4
  • RAB24 5

External Ids for RAB24 Gene

Previous GeneCards Identifiers for RAB24 Gene

  • GC05M177101
  • GC05M177570
  • GC05M176663
  • GC05M176709
  • GC05M176660
  • GC05M176728
  • GC05M171648

Summaries for RAB24 Gene

Entrez Gene Summary for RAB24 Gene

  • RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB24 Gene

RAB24 (RAB24, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB5A.

UniProtKB/Swiss-Prot Summary for RAB24 Gene

No data available for CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB24 Gene

Genomics for RAB24 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB24 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB24 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB24

Top Transcription factor binding sites by QIAGEN in the RAB24 gene promoter:
  • AML1a
  • ARP-1
  • Gfi-1
  • HEN1
  • IRF-7A
  • NF-kappaB
  • NF-kappaB1
  • RelA
  • STAT3

Genomic Locations for RAB24 Gene

Latest Assembly
2,547 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
2,522 bases
Minus strand

(GRCh37/hg19 by Ensembl)
2,547 bases
Minus strand

Genomic View for RAB24 Gene

Genes around RAB24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB24 Gene

Proteins for RAB24 Gene

  • Protein details for RAB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-24
    Protein Accession:
    Secondary Accessions:
    • A0A024R7N9
    • Q7Z4Z7

    Protein attributes for RAB24 Gene

    203 amino acids
    Molecular mass:
    23124 Da
    Quaternary structure:
    • Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
    • The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).

neXtProt entry for RAB24 Gene

Post-translational modifications for RAB24 Gene

  • Isoprenylation is inefficient compared to other Rab family members.
  • Ubiquitination at Lys104
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB24 Gene

Antibodies for research

  • Abcam antibodies for RAB24
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB24

No data available for DME Specific Peptides for RAB24 Gene

Domains & Families for RAB24 Gene

Gene Families for RAB24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB24 Gene

  • Transforming protein P21 RAS signature

Suggested Antigen Peptide Sequences for RAB24 Gene

GenScript: Design optimal peptide antigens:
  • RAB24, member RAS oncogene family, isoform CRA_d (Q8WY67_HUMAN)
  • cDNA FLJ11699 fis, clone HEMBA1005047, highly similar to RAS-RELATED PROTEIN RAB-24 (Q9HAG2_HUMAN)
  • Ras-related protein Rab-24 (RAB24_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB24: view

Function for RAB24 Gene

Molecular function for RAB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in autophagy-related processes.
UniProtKB/Swiss-Prot Induction:
By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).

Phenotypes From GWAS Catalog for RAB24 Gene

Gene Ontology (GO) - Molecular Function for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB24: view
genes like me logo Genes that share phenotypes with RAB24: view

Animal Models for RAB24 Gene

MGI Knock Outs for RAB24:
  • Rab24 Rab24<tm1.1(KOMP)Wtsi>

miRNA for RAB24 Gene

miRTarBase miRNAs that target RAB24

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB24

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB24 Gene

Localization for RAB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB24 Gene

Cytoplasm, cytosol. Membrane. Lipid-anchor. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269 PubMed:10660536}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB24 gene
Compartment Confidence
plasma membrane 4
endosome 4
cytosol 4
extracellular 2
nucleus 2
lysosome 2
golgi apparatus 2
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome IBA 21873635
GO:0005776 autophagosome IEA,IBA 21873635
GO:0005829 cytosol IEA --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with RAB24: view

Pathways & Interactions for RAB24 Gene

genes like me logo Genes that share pathways with RAB24: view

Pathways by source for RAB24 Gene

1 Qiagen pathway for RAB24 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB24: view

No data available for SIGNOR curated interactions for RAB24 Gene

Drugs & Compounds for RAB24 Gene

No Compound Related Data Available

Transcripts for RAB24 Gene

mRNA/cDNA for RAB24 Gene

13 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB24

Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP4: -

Relevant External Links for RAB24 Gene

GeneLoc Exon Structure for

Expression for RAB24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB24 Gene

mRNA differential expression in normal tissues according to GTEx for RAB24 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for RAB24 Gene

This gene is overexpressed in Brain (9.8), Peripheral blood mononuclear cells (9.1), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB24 Gene

Protein tissue co-expression partners for RAB24 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB24

SOURCE GeneReport for Unigene cluster for RAB24 Gene:


Evidence on tissue expression from TISSUES for RAB24 Gene

  • Nervous system(4.8)
  • Skin(4.5)
  • Pancreas(4.3)
  • Stomach(2.4)
genes like me logo Genes that share expression patterns with RAB24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB24 Gene

Orthologs for RAB24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB24 29 30
  • 99.84 (n)
(Bos Taurus)
Mammalia RAB24 30
  • 98 (a)
(Monodelphis domestica)
Mammalia RAB24 30
  • 97 (a)
(Canis familiaris)
Mammalia RAB24 29 30
  • 93.92 (n)
(Mus musculus)
Mammalia Rab24 29 16 30
  • 89 (n)
(Gallus gallus)
Aves RAB24 29 30
  • 79.8 (n)
(Anolis carolinensis)
Reptilia RAB24 30
  • 86 (a)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rab24 29
  • 72.25 (n)
Str.14066 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.9937 29
(Danio rerio)
Actinopterygii rab24 29 30
  • 69.47 (n)
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11639 29
Fruit Fly
(Drosophila melanogaster)
Insecta chrw 30
  • 25 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 31 (a)
Species where no ortholog for RAB24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RAB24 Gene

Gene Tree for RAB24 (if available)
Gene Tree for RAB24 (if available)
Evolutionary constrained regions (ECRs) for RAB24: view image
Alliance of Genome Resources:
Additional Orthologs for RAB24

Paralogs for RAB24 Gene

genes like me logo Genes that share paralogs with RAB24: view

Variants for RAB24 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAB24 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAB24 Gene

Variant ID Type Subtype PubMed ID
esv2759396 CNV gain 17122850
nsv428132 CNV gain 18775914
nsv600364 CNV loss 21841781

Variation tolerance for RAB24 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB24 Gene

Disorders for RAB24 Gene

Additional Disease Information for RAB24

Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for RAB24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB24 Gene

Publications for RAB24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 40
  2. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PMID: 10660536) Erdman RA … Maltese WA (The Journal of biological chemistry 2000) 3 4
  5. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3

Products for RAB24 Gene

Sources for RAB24 Gene