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Aliases for RAB24 Gene

Aliases for RAB24 Gene

  • RAB24, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-24 3

External Ids for RAB24 Gene

Previous GeneCards Identifiers for RAB24 Gene

  • GC05M177101
  • GC05M177570
  • GC05M176663
  • GC05M176709
  • GC05M176660
  • GC05M176728
  • GC05M171648

Summaries for RAB24 Gene

Entrez Gene Summary for RAB24 Gene

  • RAB24 is a small GTPase of the Rab subfamily of Ras-related proteins that regulate intracellular protein trafficking (Olkkonen et al., 1993 [PubMed 8126105]).[supplied by OMIM, Aug 2009]

GeneCards Summary for RAB24 Gene

RAB24 (RAB24, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity.

UniProtKB/Swiss-Prot for RAB24 Gene

  • May be involved in autophagy-related processes.

Additional gene information for RAB24 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB24 Gene

Genomics for RAB24 Gene

GeneHancer (GH) Regulatory Elements for RAB24 Gene

Promoters and enhancers for RAB24 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J177298 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 662.4 +0.6 574 10.3 HDGF PKNOX1 MLX ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B PRELID1 RAB24 PIR37443 PIR33608 RGS14 MXD3 UIMC1 NSD1 ZNF346 ENSG00000247679
GH05J177308 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 660.7 -7.3 -7250 4.9 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B E2F8 MXD3 RAB24 FAM193B RGS14 UIMC1 NSD1 PHYKPL HNRNPAB ENSG00000251414 ZNF346
GH05J177360 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 17.1 -58.7 -58686 3.3 HDGF PKNOX1 ATF1 ARNT SIN3A DMAP1 ZNF2 ZBTB7B ZNF48 GLIS2 RGS14 RAB24 MXD3 FAM193B FAF2 ZNF346-IT1 NSD1 ENSG00000247679 PFN3 GRK6
GH05J177425 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.1 -125.6 -125628 8.6 HDGF PKNOX1 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 GRK6 NSD1 FAF2 UIMC1 DOK3 ENSG00000247679 LOC202181 ZNF346-IT1 PFN3 FAM193B
GH05J177356 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 11 -54.7 -54746 3.7 HDGF RB1 STAT5A BMI1 ZBTB40 KLF5 IRF4 RAD21 YY1 ZNF207 RGS14 PRELID1 MXD3 HNRNPAB SLC34A1 UIMC1 RAB24 FAM193B FAF2 GC05P176931
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB24 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB24 gene promoter:
  • ARP-1
  • STAT3
  • RelA
  • NF-kappaB1
  • NF-kappaB
  • Gfi-1
  • HEN1
  • AML1a
  • IRF-7A

Genomic Locations for RAB24 Gene

Genomic Locations for RAB24 Gene
2,555 bases
Minus strand
2,547 bases
Minus strand

Genomic View for RAB24 Gene

Genes around RAB24 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB24 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB24 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB24 Gene

Proteins for RAB24 Gene

  • Protein details for RAB24 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Ras-related protein Rab-24
    Protein Accession:
    Secondary Accessions:
    • A0A024R7N9
    • Q7Z4Z7

    Protein attributes for RAB24 Gene

    203 amino acids
    Molecular mass:
    23124 Da
    Quaternary structure:
    • Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.
    • The unusual Ser-67, instead of a conserved Gln in other family members, is the cause of low GTPase activity. As a result, the predominant nucleotide associated with the protein is GTP (By similarity).

neXtProt entry for RAB24 Gene

Post-translational modifications for RAB24 Gene

  • Isoprenylation is inefficient compared to other Rab family members.
  • Ubiquitination at Lys104
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB24 Gene

No data available for DME Specific Peptides for RAB24 Gene

Domains & Families for RAB24 Gene

Gene Families for RAB24 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB24 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the small GTPase superfamily. Rab family.
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB24: view

Function for RAB24 Gene

Molecular function for RAB24 Gene

UniProtKB/Swiss-Prot Function:
May be involved in autophagy-related processes.
UniProtKB/Swiss-Prot Induction:
By extensive retinoic acid treatment, in Ntera-2 teratoma cell line induced to differentiate into post-mitotic neurons (NTN2) (at protein level).

Phenotypes From GWAS Catalog for RAB24 Gene

Gene Ontology (GO) - Molecular Function for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB24: view
genes like me logo Genes that share phenotypes with RAB24: view

Animal Models for RAB24 Gene

MGI Knock Outs for RAB24:
  • Rab24 Rab24<tm1.1(KOMP)Wtsi>

Animal Model Products

miRNA for RAB24 Gene

miRTarBase miRNAs that target RAB24

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB24 Gene

Localization for RAB24 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB24 Gene

Cytoplasm, cytosol. Membrane; Lipid-anchor. Note=Only about 20-25% is recovered in the particulate fraction. {ECO:0000269 PubMed:10660536}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB24 gene
Compartment Confidence
plasma membrane 5
cytosol 5
mitochondrion 2
extracellular 1
nucleus 1
lysosome 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005768 endosome IBA --
GO:0005776 autophagosome IBA,IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with RAB24: view

Pathways & Interactions for RAB24 Gene

genes like me logo Genes that share pathways with RAB24: view

Pathways by source for RAB24 Gene

Gene Ontology (GO) - Biological Process for RAB24 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA --
GO:0006914 autophagy IEA --
GO:0015031 protein transport IEA --
GO:0032482 Rab protein signal transduction IBA --
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with RAB24: view

No data available for SIGNOR curated interactions for RAB24 Gene

Drugs & Compounds for RAB24 Gene

No Compound Related Data Available

Transcripts for RAB24 Gene

mRNA/cDNA for RAB24 Gene

Unigene Clusters for RAB24 Gene

RAB24, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB24 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b
SP1: -
SP2: -
SP4: -

Relevant External Links for RAB24 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for RAB24 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB24 Gene

mRNA differential expression in normal tissues according to GTEx for RAB24 Gene

This gene is overexpressed in Whole Blood (x8.2).

Protein differential expression in normal tissues from HIPED for RAB24 Gene

This gene is overexpressed in Brain (9.8), Peripheral blood mononuclear cells (9.1), and Bone (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB24 Gene

Protein tissue co-expression partners for RAB24 Gene

NURSA nuclear receptor signaling pathways regulating expression of RAB24 Gene:


SOURCE GeneReport for Unigene cluster for RAB24 Gene:


Evidence on tissue expression from TISSUES for RAB24 Gene

  • Nervous system(4.7)
  • Pancreas(4.3)
  • Skin(4.3)
genes like me logo Genes that share expression patterns with RAB24: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB24 Gene

Orthologs for RAB24 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB24 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia RAB24 34 33
  • 99.84 (n)
(Bos Taurus)
Mammalia RAB24 34
  • 98 (a)
(Monodelphis domestica)
Mammalia RAB24 34
  • 97 (a)
(Canis familiaris)
Mammalia RAB24 34 33
  • 93.92 (n)
(Mus musculus)
Mammalia Rab24 16 34 33
  • 89 (n)
(Gallus gallus)
Aves RAB24 34 33
  • 79.8 (n)
(Anolis carolinensis)
Reptilia RAB24 34
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia rab24 33
  • 72.25 (n)
Str.14066 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.9937 33
(Danio rerio)
Actinopterygii rab24 34 33
  • 69.47 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11639 33
fruit fly
(Drosophila melanogaster)
Insecta chrw 34
  • 25 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 31 (a)
Species where no ortholog for RAB24 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB24 Gene

Gene Tree for RAB24 (if available)
Gene Tree for RAB24 (if available)
Evolutionary constrained regions (ECRs) for RAB24: view image

Paralogs for RAB24 Gene

genes like me logo Genes that share paralogs with RAB24: view

No data available for Paralogs for RAB24 Gene

Variants for RAB24 Gene

Sequence variations from dbSNP and Humsavar for RAB24 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000945330 -- 177,303,274(-) G/A coding_sequence_variant, non_coding_transcript_variant, synonymous_variant
rs1001397878 -- 177,302,923(-) G/C intron_variant
rs1001998859 -- 177,301,298(-) T/G 3_prime_UTR_variant, non_coding_transcript_variant
rs1002825693 -- 177,304,318(-) G/A upstream_transcript_variant
rs1003185797 -- 177,304,838(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB24 Gene

Variant ID Type Subtype PubMed ID
nsv600364 CNV loss 21841781
nsv428132 CNV gain 18775914
esv2759396 CNV gain 17122850

Variation tolerance for RAB24 Gene

Residual Variation Intolerance Score: 25.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.12; 2.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB24 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB24 Gene

Disorders for RAB24 Gene

Additional Disease Information for RAB24

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB24 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB24 Gene

Publications for RAB24 Gene

  1. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson SL … O'Brien SJ (PloS one 2010) 3 44 58
  2. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Rab24 is an atypical member of the Rab GTPase family. Deficient GTPase activity, GDP dissociation inhibitor interaction, and prenylation of Rab24 expressed in cultured cells. (PMID: 10660536) Erdman RA … Maltese WA (The Journal of biological chemistry 2000) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for RAB24 Gene

Sources for RAB24 Gene

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