The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008] See more...

Aliases for RAB22A Gene

Aliases for RAB22A Gene

  • RAB22A, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-22A 3 4
  • Rab-22 3 4
  • GTP-Binding Protein RAB22A 3
  • RAB22A 5
  • RAB22 4

External Ids for RAB22A Gene

Previous GeneCards Identifiers for RAB22A Gene

  • GC20P056613
  • GC20P057523
  • GC20P057570
  • GC20P056318
  • GC20P056884
  • GC20P053667

Summaries for RAB22A Gene

Entrez Gene Summary for RAB22A Gene

  • The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]

GeneCards Summary for RAB22A Gene

RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB22A include Pontiac Fever and Anterior Segment Dysgenesis 5. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.

UniProtKB/Swiss-Prot Summary for RAB22A Gene

  • Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).

Gene Wiki entry for RAB22A Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB22A Gene

Genomics for RAB22A Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB22A Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB22A on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB22A

Top Transcription factor binding sites by QIAGEN in the RAB22A gene promoter:
  • AP-1
  • c-Ets-1
  • CREB
  • deltaCREB
  • FOXO1
  • FOXO1a
  • Ik-3
  • Pax-4a
  • SRF
  • SRF (504 AA)

Genomic Locations for RAB22A Gene

Latest Assembly
chr20:58,309,715-58,367,507
(GRCh38/hg38)
Size:
57,793 bases
Orientation:
Plus strand

Previous Assembly
chr20:56,884,771-56,942,563
(GRCh37/hg19 by Entrez Gene)
Size:
57,793 bases
Orientation:
Plus strand

chr20:56,884,752-56,942,563
(GRCh37/hg19 by Ensembl)
Size:
57,812 bases
Orientation:
Plus strand

Genomic View for RAB22A Gene

Genes around RAB22A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB22A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB22A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB22A Gene

Proteins for RAB22A Gene

  • Protein details for RAB22A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL26-RB22A_HUMAN
    Recommended name:
    Ras-related protein Rab-22A
    Protein Accession:
    Q9UL26
    Secondary Accessions:
    • B3KR86
    • E1P605
    • Q8TF12
    • Q9H4E6

    Protein attributes for RAB22A Gene

    Size:
    194 amino acids
    Molecular mass:
    21855 Da
    Quaternary structure:
    • Interacts directly with ZFYVE20 (By similarity). Binds EEA1 (By similarity). Interacts (in its GTP-bound form) with RABGEF1 (PubMed:21849477). Interacts (in its GTP-bound form) with RINL (PubMed:21419809).

neXtProt entry for RAB22A Gene

Post-translational modifications for RAB22A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB22A Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for RAB22A
  • Boster Bio Antibodies for RAB22A
  • Santa Cruz Biotechnology (SCBT) Antibodies for RAB22A

No data available for DME Specific Peptides for RAB22A Gene

Domains & Families for RAB22A Gene

Gene Families for RAB22A Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB22A Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature

Suggested Antigen Peptide Sequences for RAB22A Gene

GenScript: Design optimal peptide antigens:
  • Ras-related protein Rab-22A (RB22A_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL26

UniProtKB/Swiss-Prot:

RB22A_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB22A: view

Function for RAB22A Gene

Molecular function for RAB22A Gene

UniProtKB/Swiss-Prot Function:
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).

Phenotypes From GWAS Catalog for RAB22A Gene

Gene Ontology (GO) - Molecular Function for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA,TAS 11870209
GO:0005515 protein binding IPI 11870209
GO:0005525 GTP binding IMP 24466322
GO:0019003 GDP binding IDA 20937701
genes like me logo Genes that share ontologies with RAB22A: view
genes like me logo Genes that share phenotypes with RAB22A: view

miRNA for RAB22A Gene

miRTarBase miRNAs that target RAB22A

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB22A

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB22A Gene

Localization for RAB22A Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB22A Gene

Endosome membrane. Lipid-anchor. Cell membrane. Lipid-anchor. Early endosome. Late endosome. Cell projection, ruffle. Cytoplasmic vesicle. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane. Lipid-anchor. Cytoplasmic side. Note=Recruited to phagosomes containing S.aureus or M.tuberculosis. {ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB22A gene
Compartment Confidence
plasma membrane 5
endosome 5
extracellular 4
cytoskeleton 4
cytosol 3
nucleus 2
endoplasmic reticulum 2
lysosome 2
golgi apparatus 2
mitochondrion 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001726 ruffle IEA --
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA,IDA 11870209
GO:0005770 late endosome IEA --
GO:0005886 plasma membrane IEA,IDA 11870209
genes like me logo Genes that share ontologies with RAB22A: view

Pathways & Interactions for RAB22A Gene

genes like me logo Genes that share pathways with RAB22A: view

Pathways by source for RAB22A Gene

1 Sino Biological pathway for RAB22A Gene
1 KEGG pathway for RAB22A Gene
1 Qiagen pathway for RAB22A Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB22A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006897 endocytosis IBA,IDA 11870209
GO:0007032 endosome organization IEP 11870209
GO:0015031 protein transport IEA --
GO:0097494 regulation of vesicle size IMP 24466322
genes like me logo Genes that share ontologies with RAB22A: view

No data available for SIGNOR curated interactions for RAB22A Gene

Drugs & Compounds for RAB22A Gene

No Compound Related Data Available

Transcripts for RAB22A Gene

mRNA/cDNA for RAB22A Gene

1 REFSEQ mRNAs :
12 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB22A

Alternative Splicing Database (ASD) splice patterns (SP) for RAB22A Gene

No ASD Table

Relevant External Links for RAB22A Gene

GeneLoc Exon Structure for
RAB22A

Expression for RAB22A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB22A Gene

Protein differential expression in normal tissues from HIPED for RAB22A Gene

This gene is overexpressed in Brain (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB22A Gene



Protein tissue co-expression partners for RAB22A Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB22A

SOURCE GeneReport for Unigene cluster for RAB22A Gene:

Hs.529044

Evidence on tissue expression from TISSUES for RAB22A Gene

  • Intestine(4.4)
  • Nervous system(3.8)
  • Kidney(2.5)
  • Skin(2.3)
genes like me logo Genes that share expression patterns with RAB22A: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB22A Gene

Orthologs for RAB22A Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB22A Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAB22A 29 30
  • 98.75 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RAB22A 30
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB22A 29 30
  • 93.3 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia RAB22A 30
  • 92 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RAB22A 29 30
  • 91.41 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rab22a 29 16 30
  • 90.03 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rab22a 29
  • 84.85 (n)
Chicken
(Gallus gallus)
Aves RAB22A 29 30
  • 86.08 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RAB22A 30
  • 96 (a)
OneToOne
Zebrafish
(Danio rerio)
Actinopterygii rab22a 29 30
  • 73.88 (n)
OneToOne
Dr.15361 29
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes VPS21 30
  • 39 (a)
ManyToMany
YPT53 30
  • 36 (a)
ManyToMany
TEM1 32
Species where no ortholog for RAB22A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for RAB22A Gene

ENSEMBL:
Gene Tree for RAB22A (if available)
TreeFam:
Gene Tree for RAB22A (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB22A: view image
Alliance of Genome Resources:
Additional Orthologs for RAB22A

Paralogs for RAB22A Gene

genes like me logo Genes that share paralogs with RAB22A: view

Variants for RAB22A Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAB22A Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAB22A Gene

Variant ID Type Subtype PubMed ID
nsv1055956 CNV gain 25217958
nsv476646 CNV novel sequence insertion 20440878
nsv828760 CNV loss 20364138

Variation tolerance for RAB22A Gene

Residual Variation Intolerance Score: 75.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.34; 7.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB22A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB22A
Leiden Open Variation Database (LOVD)
RAB22A

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB22A Gene

Disorders for RAB22A Gene

MalaCards: The human disease database

(2) MalaCards diseases for RAB22A Gene - From: COP

Disorder Aliases PubMed IDs
pontiac fever
anterior segment dysgenesis 5
  • asgd5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for RAB22A

genes like me logo Genes that share disorders with RAB22A: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB22A Gene

Publications for RAB22A Gene

  1. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4
  2. Rab22a regulates the sorting of transferrin to recycling endosomes. (PMID: 16537905) Magadán JG … Mayorga LS (Molecular and cellular biology 2006) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  5. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4

Products for RAB22A Gene

Sources for RAB22A Gene