Aliases for RAB22A Gene
External Ids for RAB22A Gene
Previous GeneCards Identifiers for RAB22A Gene
The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments. [provided by RefSeq, Jul 2008]
GeneCards Summary for RAB22A Gene
RAB22A (RAB22A, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB22A include Pontiac Fever and Anterior Segment Dysgenesis 5. Among its related pathways are Sertoli-Sertoli Cell Junction Dynamics and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.
UniProtKB/Swiss-Prot Summary for RAB22A Gene
Plays a role in endocytosis and intracellular protein transport. Mediates trafficking of TF from early endosomes to recycling endosomes (PubMed:16537905). Required for NGF-mediated endocytosis of NTRK1, and subsequent neurite outgrowth (PubMed:21849477). Binds GTP and GDP and has low GTPase activity. Alternates between a GTP-bound active form and a GDP-bound inactive form (PubMed:16537905).