This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated... See more...

Aliases for RAB21 Gene

Aliases for RAB21 Gene

  • RAB21, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-21 3 4
  • KIAA0118 2 4
  • GTP-Binding Protein RAB21 3
  • RAB21 5

External Ids for RAB21 Gene

Previous GeneCards Identifiers for RAB21 Gene

  • GC12P071929
  • GC12P072100
  • GC12P070434
  • GC12P069197

Summaries for RAB21 Gene

Entrez Gene Summary for RAB21 Gene

  • This gene belongs to the Rab family of monomeric GTPases, which are involved in the control of cellular membrane traffic. The encoded protein plays a role in the targeted trafficking of integrins via its association with integrin alpha tails. As a consequence, the encoded protein is involved in the regulation of cell adhesion and migration. Expression of this gene is associated with a poor prognosis for glioma patients. This gene is downregulated by the tumor suppressor miR-200b, and miRNA-200b is itself downregulated in glioma tissues. [provided by RefSeq, Nov 2015]

GeneCards Summary for RAB21 Gene

RAB21 (RAB21, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB21 include Charcot-Marie-Tooth Disease, Axonal, Type 2E and Carpenter Syndrome 1. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB31.

UniProtKB/Swiss-Prot Summary for RAB21 Gene

  • Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).

Gene Wiki entry for RAB21 Gene

Additional gene information for RAB21 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB21 Gene

Genomics for RAB21 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB21 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J071754 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 600.7 +0.8 838 3.4 SP1 HNRNPL CREB1 GATAD2A TEAD4 PRDM10 REST ZNF629 TFE3 LEF1 RAB21 ZFC3H1 RF00017-1185 TBC1D15
GH12J071753 Enhancer 0.9 FANTOM5 600.7 -1.7 -1731 0.1 LEF1 IKZF1 JUND MTA2 ZNF24 MTA1 BRD9 DPF2 HDAC1 SOX6 RAB21 ZFC3H1 TMEM19 THAP2 ENSG00000212461 piR-57133-123
GH12J071780 Enhancer 0.7 Ensembl ENCODE 12.1 +25.8 25841 1.1 CTCF TEAD4 REST RAD21 TRIM22 SMC3 TEAD1 ELF1 ZNF654 ARID4B TBC1D15 RAB21 TPH2 MN309579 NONHSAG011679.2
GH12J071782 Enhancer 0.6 Ensembl ENCODE 12.1 +27.1 27138 1.2 JUNB BATF IKZF1 TBC1D15 RAB21 TPH2 LGR5 MN309579 NONHSAG011679.2
GH12J071783 Enhancer 0.2 Ensembl 12.1 +28.9 28938 1.6 MN309579 TBC1D15 RAB21 TPH2 NONHSAG011679.2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB21 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB21

Top Transcription factor binding sites by QIAGEN in the RAB21 gene promoter:
  • C/EBPalpha
  • NF-kappaB
  • NF-kappaB1
  • NF-kappaB2
  • Nkx3-1 v1
  • Nkx3-1 v2
  • Pax-2
  • Pax-2a
  • XBP-1
  • YY1

Genomic Locations for RAB21 Gene

Genomic Locations for RAB21 Gene
chr12:71,754,863-71,800,286
(GRCh38/hg38)
Size:
45,424 bases
Orientation:
Plus strand
chr12:72,148,654-72,184,699
(GRCh37/hg19)
Size:
36,046 bases
Orientation:
Plus strand

Genomic View for RAB21 Gene

Genes around RAB21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB21 Gene

Proteins for RAB21 Gene

  • Protein details for RAB21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL25-RAB21_HUMAN
    Recommended name:
    Ras-related protein Rab-21
    Protein Accession:
    Q9UL25
    Secondary Accessions:
    • Q14466
    • Q569H3

    Protein attributes for RAB21 Gene

    Size:
    225 amino acids
    Molecular mass:
    24348 Da
    Quaternary structure:
    • Interacts with the cytoplasmic tail of integrins ITGA1, ITGA2, ITGA5, ITGA6, ITGA11 and ITGB1 (By similarity). Interacts with RABGEF1 (via VPS9 domain) (PubMed:17450153). Interacts with ANKRD27 (PubMed:16525121, PubMed:18477474). Interacts with VAMP7 (PubMed:25648148). Interacts (in GTP-bound form) with VAMP8 in response to starvation; the interaction probably regulates VAMP8 endolysosomal trafficking (PubMed:25648148).

    Three dimensional structures from OCA and Proteopedia for RAB21 Gene

neXtProt entry for RAB21 Gene

Post-translational modifications for RAB21 Gene

  • Ubiquitination at Lys157
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB21 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB21 Gene

Domains & Families for RAB21 Gene

Gene Families for RAB21 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB21 Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
ProtoNet:

Suggested Antigen Peptide Sequences for RAB21 Gene

GenScript: Design optimal peptide antigens:
  • Ras-related protein Rab-21 (RAB21_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9UL25

UniProtKB/Swiss-Prot:

RAB21_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB21: view

Function for RAB21 Gene

Molecular function for RAB21 Gene

UniProtKB/Swiss-Prot Function:
Regulates integrin internalization and recycling, but does not influence the traffic of endosomally translocated receptors in general (By similarity). As a result, may regulate cell adhesion and migration (By similarity). During the mitosis of adherent cells, controls the endosomal trafficking of integrins which is required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity). Following SBF2/MTMT13-mediated activation in response to starvation-induced autophagy, binds to and regulates SNARE protein VAMP8 endolysosomal transport required for SNARE-mediated autophagosome-lysosome fusion (PubMed:25648148).

Phenotypes From GWAS Catalog for RAB21 Gene

Gene Ontology (GO) - Molecular Function for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IBA,IDA 16034420
GO:0005515 protein binding IPI 16525121
GO:0005525 GTP binding IMP 15561770
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB21: view
genes like me logo Genes that share phenotypes with RAB21: view

Animal Models for RAB21 Gene

MGI Knock Outs for RAB21:
  • Rab21 Rab21<tm1b(KOMP)Wtsi>

Animal Model Products

CRISPR Products

miRNA for RAB21 Gene

miRTarBase miRNAs that target RAB21

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB21

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for RAB21 Gene

Localization for RAB21 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB21 Gene

Endoplasmic reticulum membrane. Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection. Note=Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the daughter cells, in vesicles at the base of lamellipodia formed by the separating daughter cells (PubMed:18804435). {ECO:0000250 UniProtKB:P35282, ECO:0000269 PubMed:10887961, ECO:0000269 PubMed:18804435}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB21 gene
Compartment Confidence
plasma membrane 5
endosome 5
cytosol 5
golgi apparatus 5
extracellular 4
endoplasmic reticulum 4
cytoskeleton 2
lysosome 2
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005768 endosome IDA --
GO:0005769 early endosome IBA 21873635
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with RAB21: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for RAB21 Gene

Pathways & Interactions for RAB21 Gene

genes like me logo Genes that share pathways with RAB21: view

Pathways by source for RAB21 Gene

1 Qiagen pathway for RAB21 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB21 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0007165 signal transduction IEA --
GO:0008089 anterograde axonal transport IMP 22705394
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IDA 22705394
genes like me logo Genes that share ontologies with RAB21: view

No data available for SIGNOR curated interactions for RAB21 Gene

Drugs & Compounds for RAB21 Gene

No Compound Related Data Available

Transcripts for RAB21 Gene

mRNA/cDNA for RAB21 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB21

Alternative Splicing Database (ASD) splice patterns (SP) for RAB21 Gene

No ASD Table

Relevant External Links for RAB21 Gene

GeneLoc Exon Structure for
RAB21

Expression for RAB21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB21 Gene

Protein differential expression in normal tissues from HIPED for RAB21 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB21 Gene



Protein tissue co-expression partners for RAB21 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB21

SOURCE GeneReport for Unigene cluster for RAB21 Gene:

Hs.524590

mRNA Expression by UniProt/SwissProt for RAB21 Gene:

Q9UL25-RAB21_HUMAN
Tissue specificity: Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.

Evidence on tissue expression from TISSUES for RAB21 Gene

  • Bone marrow(4.4)
  • Heart(2.8)
  • Nervous system(2.7)
  • Muscle(2.7)
  • Kidney(2.6)
  • Skin(2.5)
  • Lung(2.4)
  • Spleen(2.3)
  • Blood(2.1)
  • Pancreas(2.1)
  • Intestine(2.1)
  • Adrenal gland(2.1)
genes like me logo Genes that share expression patterns with RAB21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB21 Gene

Orthologs for RAB21 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB21 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAB21 30 31
  • 99.4 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB21 31
  • 97 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia RAB21 30 31
  • 96.87 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 92 (a)
OneToMany
-- 31
  • 85 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Rab21 30
  • 91.27 (n)
Mouse
(Mus musculus)
Mammalia Rab21 30 17 31
  • 90.59 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RAB21 30 31
  • 87.56 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RAB21 31
  • 85 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rab21 30
  • 83.57 (n)
Zebrafish
(Danio rerio)
Actinopterygii RAB21 31
  • 87 (a)
OneToOne
zgc:154045 30
  • 76.83 (n)
Fruit Fly
(Drosophila melanogaster)
Insecta CG17515 32
  • 64 (a)
Rab21 30 31
  • 62.2 (n)
OneToOne
chrw 32
  • 39 (a)
Worm
(Caenorhabditis elegans)
Secernentea rab-21 30 31
  • 55.39 (n)
OneToOne
Rice
(Oryza sativa)
Liliopsida Os05g0341600 30
  • 57.55 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.2167 31
  • 76 (a)
OneToOne
Species where no ortholog for RAB21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RAB21 Gene

ENSEMBL:
Gene Tree for RAB21 (if available)
TreeFam:
Gene Tree for RAB21 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB21: view image

Paralogs for RAB21 Gene

genes like me logo Genes that share paralogs with RAB21: view

Variants for RAB21 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB21 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
747920 Likely Benign: not provided 71,755,228(+) G/C SYNONYMOUS_VARIANT
786231 Benign: not provided 71,785,631(+) T/C SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for RAB21 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB21 Gene

Variant ID Type Subtype PubMed ID
esv2658849 CNV deletion 23128226
esv2759907 CNV gain 17122850
esv35030 CNV gain 17911159
esv3629915 CNV loss 21293372
esv3629916 CNV gain 21293372
esv3892218 CNV gain 25118596
nsv559329 CNV loss 21841781
nsv832451 CNV loss 17160897

Variation tolerance for RAB21 Gene

Residual Variation Intolerance Score: 55.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB21 Gene

Human Gene Mutation Database (HGMD)
RAB21
SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB21

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB21 Gene

Disorders for RAB21 Gene

MalaCards: The human disease database

(3) MalaCards diseases for RAB21 Gene - From: DISEASES

Disorder Aliases PubMed IDs
charcot-marie-tooth disease, axonal, type 2e
  • cmt2e
carpenter syndrome 1
  • crpt1
warburg micro syndrome
  • micro syndrome
- elite association - COSMIC cancer census association via MalaCards
Search RAB21 in MalaCards View complete list of genes associated with diseases
genes like me logo Genes that share disorders with RAB21: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB21 Gene

Publications for RAB21 Gene

  1. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. (PMID: 10887961) Opdam FJ … Fransen JA (European journal of cell biology 2000) 2 3 4
  2. Starvation-induced MTMR13 and RAB21 activity regulates VAMP8 to promote autophagosome-lysosome fusion. (PMID: 25648148) Jean S … Kiger AA (EMBO reports 2015) 3 4
  3. Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growth. (PMID: 19745841) Burgo A … Galli T (EMBO reports 2009) 3 4
  4. Integrin trafficking regulated by Rab21 is necessary for cytokinesis. (PMID: 18804435) Pellinen T … Ivaska J (Developmental cell 2008) 3 4
  5. Structural basis for Rab GTPase activation by VPS9 domain exchange factors. (PMID: 17450153) Delprato A … Lambright DG (Nature structural & molecular biology 2007) 3 4

Products for RAB21 Gene

Sources for RAB21 Gene