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Aliases for RAB20 Gene

Aliases for RAB20 Gene

  • RAB20, Member RAS Oncogene Family 2 3 5

External Ids for RAB20 Gene

Previous GeneCards Identifiers for RAB20 Gene

  • GC13M109535
  • GC13M105562
  • GC13M110012
  • GC13M108873
  • GC13M109973
  • GC13M111175
  • GC13M091774

Summaries for RAB20 Gene

GeneCards Summary for RAB20 Gene

RAB20 (RAB20, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and RAB geranylgeranylation. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB5C.

UniProtKB/Swiss-Prot for RAB20 Gene

  • Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Additional gene information for RAB20 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB20 Gene

Genomics for RAB20 Gene

GeneHancer (GH) Regulatory Elements for RAB20 Gene

Promoters and enhancers for RAB20 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13I110558 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 581.6 +0.4 388 4.9 FOXA2 MLX ARID4B ZNF48 YY1 GLIS2 GATA2 RUNX3 SP3 RXRA RAB20 COL4A2-AS2 COL4A2 ANKRD10 ING1 GC13P110514
GH13I110535 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 70.5 +24.5 24454 3.5 USF1 ETV1 MAX EBF1 YY1 ZFHX2 CTBP1 POLR2A EGR2 L3MBTL2 RAB20 COL4A2-AS2 COL4A2 ANKRD10 NAXD ING1 GC13P110514
GH13I110523 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 52.9 +33.6 33608 8.5 HDGF ATF1 NFIB KLF17 RAD21 YY1 RCOR1 BCLAF1 IKZF2 RUNX3 RAB20 COL4A2-AS2 COL4A2 ANKRD10 NAXD ING1 GC13P110514
GH13I110519 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 41.4 +40.5 40525 3.4 FOXA2 MAX RAD21 YY1 POLR2A HNF4G RUNX3 RXRA NFIA CEBPB RAB20 COL4A2-AS2 COL4A2 NAXD ANKRD10 ING1 GC13P110514
GH13I110540 Enhancer 1 Ensembl ENCODE dbSUPER 29 +20.0 20022 1.9 SOX5 SOX13 FOXA2 SOX6 MAX FOXA1 YY1 GATA3 HNF4A EZH2 RAB20 COL4A2-AS2 COL4A2 GC13P110514
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB20 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB20 gene promoter:

Genomic Locations for RAB20 Gene

Genomic Locations for RAB20 Gene
chr13:110,523,066-110,561,737
(GRCh38/hg38)
Size:
38,672 bases
Orientation:
Minus strand
chr13:111,175,413-111,214,080
(GRCh37/hg19)

Genomic View for RAB20 Gene

Genes around RAB20 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB20 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB20 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB20 Gene

Proteins for RAB20 Gene

  • Protein details for RAB20 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NX57-RAB20_HUMAN
    Recommended name:
    Ras-related protein Rab-20
    Protein Accession:
    Q9NX57
    Secondary Accessions:
    • Q5T9X5
    • Q9NX49

    Protein attributes for RAB20 Gene

    Size:
    234 amino acids
    Molecular mass:
    26277 Da
    Quaternary structure:
    No Data Available

neXtProt entry for RAB20 Gene

Post-translational modifications for RAB20 Gene

No Post-translational modifications

Other Protein References for RAB20 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB20 Gene

Domains & Families for RAB20 Gene

Gene Families for RAB20 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB20 Gene

Suggested Antigen Peptide Sequences for RAB20 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NX57

UniProtKB/Swiss-Prot:

RAB20_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB20: view

Function for RAB20 Gene

Molecular function for RAB20 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in apical endocytosis/recycling. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes.

Phenotypes From GWAS Catalog for RAB20 Gene

Gene Ontology (GO) - Molecular Function for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA --
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB20: view
genes like me logo Genes that share phenotypes with RAB20: view

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for RAB20 Gene

Localization for RAB20 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB20 Gene

Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side. Note=Highly enriched on apical endocytic structures in polarized epithelial cells of kidney proximal tubules (By similarity). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000250 UniProtKB:P35295, ECO:0000269 PubMed:21255211}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB20 gene
Compartment Confidence
golgi apparatus 5
endosome 4
plasma membrane 3
cytosol 3
nucleus 2
mitochondrion 1
peroxisome 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005769 early endosome IBA --
GO:0005794 Golgi apparatus IEA,IDA --
GO:0005886 plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0030670 phagocytic vesicle membrane IEA --
genes like me logo Genes that share ontologies with RAB20: view

Pathways & Interactions for RAB20 Gene

genes like me logo Genes that share pathways with RAB20: view

Pathways by source for RAB20 Gene

Gene Ontology (GO) - Biological Process for RAB20 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IEA --
GO:0015031 protein transport IEA --
GO:0030100 regulation of endocytosis IBA --
GO:0071346 cellular response to interferon-gamma IEA --
GO:0090383 phagosome acidification IMP 21255211
genes like me logo Genes that share ontologies with RAB20: view

No data available for SIGNOR curated interactions for RAB20 Gene

Drugs & Compounds for RAB20 Gene

No Compound Related Data Available

Transcripts for RAB20 Gene

mRNA/cDNA for RAB20 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(63) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB20 Gene

RAB20, member RAS oncogene family:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB20 Gene

No ASD Table

Relevant External Links for RAB20 Gene

GeneLoc Exon Structure for
RAB20
ECgene alternative splicing isoforms for
RAB20

Expression for RAB20 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB20 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for RAB20 Gene

This gene is overexpressed in Whole Blood (x7.2).

Protein differential expression in normal tissues from HIPED for RAB20 Gene

This gene is overexpressed in Pancreas (15.0), Platelet (10.5), Liver (9.6), Spleen (7.8), and Testis (6.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for RAB20 Gene



NURSA nuclear receptor signaling pathways regulating expression of RAB20 Gene:

RAB20

SOURCE GeneReport for Unigene cluster for RAB20 Gene:

Hs.743563

mRNA Expression by UniProt/SwissProt for RAB20 Gene:

Q9NX57-RAB20_HUMAN
Tissue specificity: Low or absent expression in normal pancreas and stronger expression in 15 of 18 exocrine pancreatic adenocarcinomas (at protein level).

Evidence on tissue expression from TISSUES for RAB20 Gene

  • Lung(4.2)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with RAB20: view

No data available for Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB20 Gene

Orthologs for RAB20 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB20 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB20 33 34
  • 98.86 (n)
dog
(Canis familiaris)
Mammalia RAB20 33 34
  • 83.9 (n)
mouse
(Mus musculus)
Mammalia Rab20 33 16 34
  • 81.97 (n)
rat
(Rattus norvegicus)
Mammalia Rab20 33
  • 81.9 (n)
cow
(Bos Taurus)
Mammalia RAB20 33 34
  • 80.52 (n)
oppossum
(Monodelphis domestica)
Mammalia RAB20 34
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia RAB20 34
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB20 33 34
  • 76.81 (n)
lizard
(Anolis carolinensis)
Reptilia RAB20 34
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab20 33
  • 67.42 (n)
zebrafish
(Danio rerio)
Actinopterygii rab20 33 34
  • 64.7 (n)
wufb01f02 33
fruit fly
(Drosophila melanogaster)
Insecta chrw 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
OneToMany
Species where no ortholog for RAB20 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for RAB20 Gene

ENSEMBL:
Gene Tree for RAB20 (if available)
TreeFam:
Gene Tree for RAB20 (if available)

Paralogs for RAB20 Gene

(3) SIMAP similar genes for RAB20 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with RAB20: view

Variants for RAB20 Gene

Sequence variations from dbSNP and Humsavar for RAB20 Gene

SNP ID Clin Chr 13 pos Variation AA Info Type
rs1000102567 -- 110,549,434(-) G/A intron_variant
rs1000259928 -- 110,546,102(-) A/C intron_variant
rs1000362361 -- 110,538,691(-) G/C intron_variant
rs1000392683 -- 110,556,167(-) A/C intron_variant
rs1000484134 -- 110,534,084(-) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB20 Gene

Variant ID Type Subtype PubMed ID
nsv832720 CNV loss 17160897
nsv509516 CNV insertion 20534489
nsv1134351 CNV deletion 24896259
nsv1070198 CNV deletion 25765185
nsv1046423 CNV gain 25217958
nsv1046291 CNV loss 25217958
nsv1044234 CNV gain 25217958
nsv1038914 CNV loss 25217958
esv3580901 CNV loss 25503493
esv3580900 CNV loss 25503493
esv1619657 CNV deletion 17803354

Variation tolerance for RAB20 Gene

Residual Variation Intolerance Score: 41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.10; 2.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB20 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB20

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB20 Gene

Disorders for RAB20 Gene

Additional Disease Information for RAB20

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB20 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB20 Gene

Publications for RAB20 Gene

  1. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 44 58
  3. Characterization of human Rab20 overexpressed in exocrine pancreatic carcinoma. (PMID: 16613320) Amillet JM … Goubin G (Human pathology 2006) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for RAB20 Gene

Sources for RAB20 Gene

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