Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).... See more...

Aliases for RAB1B Gene

Aliases for RAB1B Gene

  • RAB1B, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-1B 3 4
  • Small GTP-Binding Protein 3
  • RAB1B 5

External Ids for RAB1B Gene

Previous GeneCards Identifiers for RAB1B Gene

  • GC11P068570
  • GC11P067717
  • GC11P066285
  • GC11P065811
  • GC11P065792
  • GC11P065777
  • GC11P066036
  • GC11P062361

Summaries for RAB1B Gene

Entrez Gene Summary for RAB1B Gene

  • Members of the RAB protein family, such as RAB1B, are low molecular mass monomeric GTPases localized on the cytoplasmic surfaces of distinct membrane-bound organelles. RAB1B functions in the early secretory pathway and is essential for vesicle transport between the endoplasmic reticulum (ER) and Golgi (Chen et al., 1997 [PubMed 9030196]; Alvarez et al., 2003 [PubMed 12802079]).[supplied by OMIM, Jan 2009]

GeneCards Summary for RAB1B Gene

RAB1B (RAB1B, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB1B include Legionellosis and Hypotrichosis 3. Among its related pathways are RAB GEFs exchange GTP for GDP on RABs and Mitotic Prophase. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB1A.

UniProtKB/Swiss-Prot Summary for RAB1B Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).

Gene Wiki entry for RAB1B Gene

Additional gene information for RAB1B Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB1B Gene

Genomics for RAB1B Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB1B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB1B on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB1B

Top Transcription factor binding sites by QIAGEN in the RAB1B gene promoter:
  • AREB6
  • c-Ets-1
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • LCR-F1
  • MAZR

Genomic Locations for RAB1B Gene

Genomic Locations for RAB1B Gene
chr11:66,268,526-66,277,492
(GRCh38/hg38)
Size:
8,967 bases
Orientation:
Plus strand
chr11:66,036,004-66,044,963
(GRCh37/hg19)
Size:
8,960 bases
Orientation:
Plus strand

Genomic View for RAB1B Gene

Genes around RAB1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB1B Gene

Proteins for RAB1B Gene

  • Protein details for RAB1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H0U4-RAB1B_HUMAN
    Recommended name:
    Ras-related protein Rab-1B
    Protein Accession:
    Q9H0U4
    Secondary Accessions:
    • A8K7S1

    Protein attributes for RAB1B Gene

    Size:
    201 amino acids
    Molecular mass:
    22171 Da
    Quaternary structure:
    • Interacts with MICAL1 and MICAL2 (PubMed:15694364, PubMed:27552051). Interacts (in GTP-bound form) with MICALCL, MICAL1 and MILCAL3 (PubMed:15694364, PubMed:27552051). Interacts with GDI1; the interaction requires the GDP-bound state (PubMed:8836150, PubMed:11389151). Interacts with CHM/REP1; the interaction requires the GDP-bound form and is necessary for prenylation by GGTase II (PubMed:9437002, PubMed:11389151). Interacts with RabGAP TBC1D20 (PubMed:23236136). Interacts (in GDP-bound form) with lipid phosphatase MTMR6 (via GRAM domain); the interaction regulates MTMR6 recruitment to the endoplasmic reticulum-Golgi intermediate compartment (PubMed:23188820). Interacts (in GDP-bound form) with lipid phosphatase MTMR7 (By similarity).
    • (Microbial infection) Interacts with L.pneumophila AnkX (PubMed:21822290, PubMed:22307087). Interacts with L.pneumophila Lem3 (PubMed:22158903, PubMed:22307087). Interacts with L.pneumophila SidD (PubMed:21734656, PubMed:21680813). Interacts with L.pneumophila DrrA (PubMed:20064470, PubMed:20651120).
    Miscellaneous:
    • Rab-1B binds GTP and GDP and possesses low intrinsic GTPase activity.

    Three dimensional structures from OCA and Proteopedia for RAB1B Gene

neXtProt entry for RAB1B Gene

Post-translational modifications for RAB1B Gene

  • Prenylated; by GGTase II, only after interaction of the substrate with Rab escort protein 1 (REP1).
  • AMPylation at Tyr-77 by L.pneumophila DrrA occurs in the switch 2 region and leads to moderate inactivation of the GTPase activity. It appears to prolong the lifetime of the GTP state of RAB1B by restricting access of GTPase effectors to switch 2 and blocking effector-stimulated GTP hydrolysis, thereby rendering RAB1B constitutively active. It is later de-AMPylated by L.pneumophila SidD, releasing RAB1B from bacterial phagosomes.
  • Phosphocholinated at Ser-76 by L.pneumophila AnkX, leading to displace GDP dissociation inhibitors (GDI). Both GDP-bound and GTP-bound forms can be phosphocholinated. Dephosphocholinated by L.pneumophila Lem3, restoring accessibility to L.pneumophila GTPase effector LepB.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for RAB1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB1B Gene

Domains & Families for RAB1B Gene

Gene Families for RAB1B Gene

Protein Domains for RAB1B Gene

InterPro:
Blocks:
  • Transforming protein P21 RAS signature
ProtoNet:

Suggested Antigen Peptide Sequences for RAB1B Gene

GenScript: Design optimal peptide antigens:
  • RAB1B protein (Q6FIG4_HUMAN)
  • Small GTP-binding protein (Q92927_HUMAN)
  • Ras-related protein Rab-1B (RAB1B_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q9H0U4

UniProtKB/Swiss-Prot:

RAB1B_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB1B: view

Function for RAB1B Gene

Molecular function for RAB1B Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:9437002). Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum (PubMed:20545908). Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments (By similarity). Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment (By similarity).
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP).

Phenotypes From GWAS Catalog for RAB1B Gene

Gene Ontology (GO) - Molecular Function for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 15796781
GO:0005525 GTP binding IEA,IDA 20937701
genes like me logo Genes that share ontologies with RAB1B: view
genes like me logo Genes that share phenotypes with RAB1B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB1B

CRISPR Products

miRNA for RAB1B Gene

miRTarBase miRNAs that target RAB1B

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB1B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB1B Gene

Localization for RAB1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB1B Gene

Cytoplasm. Membrane. Lipid-anchor. Cytoplasmic side. Preautophagosomal structure membrane. Lipid-anchor. Cytoplasmic side. Cytoplasm, perinuclear region. Note=Targeted by REP1 to membranes of specific subcellular compartments including endoplasmic reticulum, Golgi apparatus, and intermediate vesicles between these two compartments (PubMed:11389151). In the GDP-form, colocalizes with GDI in the cytoplasm (PubMed:11389151). Co-localizes with MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment and to the peri-Golgi region (By similarity). {ECO:0000250 UniProtKB:P10536, ECO:0000269 PubMed:11389151}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB1B gene
Compartment Confidence
cytosol 5
golgi apparatus 5
extracellular 4
endoplasmic reticulum 4
plasma membrane 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
lysosome 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (3)
  • Golgi apparatus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0005737 cytoplasm IEA --
GO:0005789 endoplasmic reticulum membrane TAS --
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA --
GO:0005794 Golgi apparatus IDA --
genes like me logo Genes that share ontologies with RAB1B: view

Pathways & Interactions for RAB1B Gene

genes like me logo Genes that share pathways with RAB1B: view

Pathways by source for RAB1B Gene

1 KEGG pathway for RAB1B Gene
1 Qiagen pathway for RAB1B Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000045 autophagosome assembly IBA 21873635
GO:0006886 intracellular protein transport IBA 21873635
GO:0006888 ER to Golgi vesicle-mediated transport TAS --
GO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS --
GO:0006914 autophagy IEA --
genes like me logo Genes that share ontologies with RAB1B: view

No data available for SIGNOR curated interactions for RAB1B Gene

Drugs & Compounds for RAB1B Gene

(1) Drugs for RAB1B Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0

(2) Additional Compounds for RAB1B Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with RAB1B: view

Transcripts for RAB1B Gene

mRNA/cDNA for RAB1B Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB1B

Alternative Splicing Database (ASD) splice patterns (SP) for RAB1B Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b
SP1:
SP2: -

Relevant External Links for RAB1B Gene

GeneLoc Exon Structure for
RAB1B

Expression for RAB1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB1B Gene

This gene is overexpressed in Oral epithelium (7.6) and Nasal epithelium (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB1B Gene



Protein tissue co-expression partners for RAB1B Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB1B

SOURCE GeneReport for Unigene cluster for RAB1B Gene:

Hs.300816

Evidence on tissue expression from TISSUES for RAB1B Gene

  • Nervous system(4.8)
  • Pancreas(4.5)
  • Skin(3.5)
  • Lung(3.2)
  • Muscle(2.9)
  • Kidney(2.8)
  • Intestine(2.4)
  • Liver(2.3)
  • Blood(2.3)
  • Heart(2.3)
  • Thyroid gland(2.2)
  • Lymph node(2.1)
  • Eye(2.1)
  • Stomach(2)
genes like me logo Genes that share expression patterns with RAB1B: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB1B Gene

Orthologs for RAB1B Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for RAB1B Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia RAB1B 30 31
  • 99.83 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia -- 31
  • 99 (a)
OneToMany
RAB1B 30
  • 93.7 (n)
-- 31
  • 85 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia RAB1B 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB1B 30 31
  • 94.36 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Rab1b 30 17 31
  • 91.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rab1b 30
  • 90.38 (n)
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 75 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii rab1bb 31
  • 92 (a)
OneToMany
rab1ba 30 31
  • 80.93 (n)
OneToMany
zgc56049 30
Rainbow Trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2074 30
Fruit Fly
(Drosophila melanogaster)
Insecta Rab1 31 32
  • 82 (a)
OneToMany
Rab-RP3 32
  • 50 (a)
CG2885 32
  • 46 (a)
Worm
(Caenorhabditis elegans)
Secernentea rab-1 31 32
  • 80 (a)
OneToMany
K02E10.1 32
  • 40 (a)
C33D12.6 32
  • 38 (a)
4R79.2 32
  • 37 (a)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes YPT1 31
  • 68 (a)
OneToMany
Barley
(Hordeum vulgare)
Liliopsida Hv.3870 30
Rice
(Oryza sativa)
Liliopsida Os.7869 30
Wheat
(Triticum aestivum)
Liliopsida Ta.2042 30
Corn
(Zea mays)
Liliopsida Zm.5901 30
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.10592 31
  • 86 (a)
OneToMany
Species where no ortholog for RAB1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)

Evolution for RAB1B Gene

ENSEMBL:
Gene Tree for RAB1B (if available)
TreeFam:
Gene Tree for RAB1B (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB1B: view image

Paralogs for RAB1B Gene