Aliases for RAB15 Gene

Aliases for RAB15 Gene

  • RAB15, Member RAS Oncogene Family 2 3 5
  • Ras-Related Protein Rab-15 3 4
  • Ras-Related Protein Rab-15 Isoform AN1 3
  • Ras-Related Protein Rab-15 Isoform AN2 3
  • Ras-Related Protein Rab-15 Isoform AN3 3
  • RAB15, Member RAS Onocogene Family 3

External Ids for RAB15 Gene

Previous GeneCards Identifiers for RAB15 Gene

  • GC14M059207
  • GC14M063402
  • GC14M064482
  • GC14M065412
  • GC14M045582

Summaries for RAB15 Gene

GeneCards Summary for RAB15 Gene

RAB15 (RAB15, Member RAS Oncogene Family) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and GTPase activity. An important paralog of this gene is RAB8B.

UniProtKB/Swiss-Prot Summary for RAB15 Gene

  • May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Gene Wiki entry for RAB15 Gene

Additional gene information for RAB15 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB15 Gene

Genomics for RAB15 Gene

GeneHancer (GH) Regulatory Elements for RAB15 Gene

Promoters and enhancers for RAB15 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J064969 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 514.9 +1.5 1487 4.1 ZFX ZBTB26 EZH2 ZNF341 PCBP1 SRSF1 CTCF ZNF335 MAZ POLR2A RAB15 FNTB CHURC1 SPTB lnc-GPX2-2 CHURC1-FNTB
GH14J064976 Promoter/Enhancer 0.8 EPDnew Ensembl ENCODE 517.3 -3.8 -3775 1.6 RFX5 POU5F1 RAB15 piR-40163-034 CHURC1 GPX2 CHURC1-FNTB
GH14J064974 Enhancer 0.4 ENCODE 500.7 -1.6 -1575 0.5 TEAD4 HDAC2 NANOG RAB15 CHURC1 piR-40163-034 CHURC1-FNTB
GH14J064986 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 10.1 -14.1 -14075 2.2 RXRA EP300 FOXK2 ZBTB40 ZNF217 CTCF ZSCAN5C SIN3A NRF1 TCF12 FNTB HSALNG0101927 lnc-CHURC1-1 CHURC1 RAB15 SPTB piR-50443-117 CHURC1-FNTB
GH14J065100 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 8.4 -129.0 -128954 3.6 FOXK2 HNRNPK ZBTB40 ZNF217 CTCF SIN3A NRF1 MYC POLR2G USF1 MAX lnc-FNTB-6 lnc-RAB15-2 RAB15 FNTB LOC100506321
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB15 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB15

Top Transcription factor binding sites by QIAGEN in the RAB15 gene promoter:
  • Arnt
  • C/EBPbeta
  • FOXF2
  • Nkx2-2
  • Pax-4a
  • PPAR-gamma1
  • PPAR-gamma2
  • RFX1
  • USF-1
  • USF1

Genomic Locations for RAB15 Gene

Genomic Locations for RAB15 Gene
chr14:64,945,814-64,973,226
(GRCh38/hg38)
Size:
27,413 bases
Orientation:
Minus strand
chr14:65,412,532-65,439,494
(GRCh37/hg19)
Size:
26,963 bases
Orientation:
Minus strand

Genomic View for RAB15 Gene

Genes around RAB15 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB15 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB15 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB15 Gene

Proteins for RAB15 Gene

  • Protein details for RAB15 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59190-RAB15_HUMAN
    Recommended name:
    Ras-related protein Rab-15
    Protein Accession:
    P59190
    Secondary Accessions:
    • G5EMR7
    • Q86TX7
    • Q8IW89

    Protein attributes for RAB15 Gene

    Size:
    212 amino acids
    Molecular mass:
    24391 Da
    Quaternary structure:
    • The GTP bound form of RAB15 interacts with REP15. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1.

    Alternative splice isoforms for RAB15 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for RAB15 Gene

Post-translational modifications for RAB15 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for RAB15 Gene

Domains & Families for RAB15 Gene

Gene Families for RAB15 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB15 Gene

Blocks:
  • Ras small GTPase, Ras type
  • Transforming protein P21 RAS signature
  • Ras small GTPase, Rho type
  • GTP-binding nuclear protein Ran
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB15 Gene

GenScript: Design optimal peptide antigens:
  • Ras-related protein Rab-15 (RAB15_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P59190

UniProtKB/Swiss-Prot:

RAB15_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB15: view

Function for RAB15 Gene

Molecular function for RAB15 Gene

UniProtKB/Swiss-Prot Function:
May act in concert with RAB3A in regulating aspects of synaptic vesicle membrane flow within the nerve terminal.

Phenotypes From GWAS Catalog for RAB15 Gene

Gene Ontology (GO) - Molecular Function for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16195351
GO:0005525 GTP binding IEA --
genes like me logo Genes that share ontologies with RAB15: view
genes like me logo Genes that share phenotypes with RAB15: view

Animal Model Products

CRISPR Products

miRNA for RAB15 Gene

miRTarBase miRNAs that target RAB15

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB15 Gene

Localization for RAB15 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB15 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB15 gene
Compartment Confidence
endosome 5
plasma membrane 4
cytosol 4
cytoskeleton 2
nucleus 2
extracellular 1
mitochondrion 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centriolar satellite (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 16195351
GO:0005768 endosome IBA 21873635
GO:0005886 plasma membrane IBA 21873635
GO:0005929 cilium IDA 17646400
GO:0008021 synaptic vesicle IBA 21873635
genes like me logo Genes that share ontologies with RAB15: view

Pathways & Interactions for RAB15 Gene

PathCards logo

SuperPathways for RAB15 Gene

genes like me logo Genes that share pathways with RAB15: view

Pathways by source for RAB15 Gene

1 Qiagen pathway for RAB15 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB15 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006904 vesicle docking involved in exocytosis IBA 21873635
GO:0009306 protein secretion IBA 21873635
GO:0015031 protein transport IEA --
GO:0017157 regulation of exocytosis IBA 21873635
genes like me logo Genes that share ontologies with RAB15: view

No data available for SIGNOR curated interactions for RAB15 Gene

Drugs & Compounds for RAB15 Gene

(1) Drugs for RAB15 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with RAB15: view

Transcripts for RAB15 Gene

mRNA/cDNA for RAB15 Gene

3 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for RAB15 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c
SP1: - -
SP2: - - -
SP3: - -
SP4:

Relevant External Links for RAB15 Gene

GeneLoc Exon Structure for
RAB15

Expression for RAB15 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB15 Gene

mRNA differential expression in normal tissues according to GTEx for RAB15 Gene

This gene is overexpressed in Brain - Cerebellum (x5.2), Brain - Cerebellar Hemisphere (x5.0), and Brain - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for RAB15 Gene

This gene is overexpressed in Brain (34.4), Skin (19.4), and Pancreas (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB15 Gene



Protein tissue co-expression partners for RAB15 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB15

SOURCE GeneReport for Unigene cluster for RAB15 Gene:

Hs.512492

Evidence on tissue expression from TISSUES for RAB15 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with RAB15: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB15 Gene

Orthologs for RAB15 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for RAB15 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB15 31 30
  • 99.37 (n)
OneToOne
Species where no ortholog for RAB15 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for RAB15 Gene

ENSEMBL:
Gene Tree for RAB15 (if available)
TreeFam:
Gene Tree for RAB15 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB15: view image

Paralogs for RAB15 Gene

genes like me logo Genes that share paralogs with RAB15: view

Variants for RAB15 Gene

Additional dbSNP identifiers (rs#s) for RAB15 Gene

Structural Variations from Database of Genomic Variants (DGV) for RAB15 Gene

Variant ID Type Subtype PubMed ID
esv21993 CNV gain 19812545
esv2748779 CNV deletion 23290073
esv33119 CNV gain 17666407
esv3634758 CNV loss 21293372
nsv1071152 CNV deletion 25765185
nsv1121874 CNV deletion 24896259

Variation tolerance for RAB15 Gene

Residual Variation Intolerance Score: 65.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.08; 1.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB15 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB15

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB15 Gene

Disorders for RAB15 Gene

Additional Disease Information for RAB15

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for RAB15 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for RAB15 Gene

Publications for RAB15 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 41 54
  3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PMID: 19692168) Guey LT … EPICURO/Spanish Bladder Cancer Study investigators (European urology 2010) 3 41 54
  4. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PMID: 19625176) Hosgood HD … Lan Q (Respiratory medicine 2009) 3 41 54
  5. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PMID: 19170196) Shen M … Lan Q (Environmental and molecular mutagenesis 2009) 3 41 54

Products for RAB15 Gene

Sources for RAB15 Gene