Aliases for RAB14 Gene
External Ids for RAB14 Gene
Previous GeneCards Identifiers for RAB14 Gene
RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]
GeneCards Summary for RAB14 Gene
RAB14 (RAB14, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB14 include Non-Invasive Bladder Urothelial Carcinoma. Among its related pathways are Glycerophospholipid biosynthesis and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB4A.
UniProtKB/Swiss-Prot Summary for RAB14 Gene
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.