RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009] See more...

Aliases for RAB14 Gene

Aliases for RAB14 Gene

  • RAB14, Member RAS Oncogene Family 2 3 5
  • BA165P4.3 (Member RAS Oncogene Family) 2 3
  • Small GTP Binding Protein RAB14 2 3
  • F Protein-Binding Protein 1 2 3
  • Ras-Related Protein Rab-14 3 4
  • RAB-14 2 3
  • FBP 2 3
  • RAB14 5

External Ids for RAB14 Gene

Previous GeneCards Identifiers for RAB14 Gene

  • GC09M115045
  • GC09M115586
  • GC09M117394
  • GC09M119316
  • GC09M119299
  • GC09M121019
  • GC09M122980
  • GC09M123940
  • GC09M093558

Summaries for RAB14 Gene

Entrez Gene Summary for RAB14 Gene

  • RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB14 Gene

RAB14 (RAB14, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB14 include Non-Invasive Bladder Urothelial Carcinoma. Among its related pathways are Glycerophospholipid biosynthesis and Vesicle-mediated transport. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB4A.

UniProtKB/Swiss-Prot Summary for RAB14 Gene

  • Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Gene Wiki entry for RAB14 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB14 Gene

Genomics for RAB14 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for RAB14 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB14 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB14

Top Transcription factor binding sites by QIAGEN in the RAB14 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • HNF-3beta
  • NF-AT
  • NF-AT1
  • NF-AT2

Genomic Locations for RAB14 Gene

Latest Assembly
chr9:121,178,133-121,223,014
(GRCh38/hg38)
Size:
44,882 bases
Orientation:
Minus strand

Previous Assembly
chr9:123,940,411-123,964,147
(GRCh37/hg19 by Entrez Gene)
Size:
23,737 bases
Orientation:
Minus strand

chr9:123,940,415-123,985,292
(GRCh37/hg19 by Ensembl)
Size:
44,878 bases
Orientation:
Minus strand

Genomic View for RAB14 Gene

Genes around RAB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB14 Gene

Proteins for RAB14 Gene

  • Protein details for RAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61106-RAB14_HUMAN
    Recommended name:
    Ras-related protein Rab-14
    Protein Accession:
    P61106
    Secondary Accessions:
    • B3KR31
    • P35287
    • Q5JVD4
    • Q6Q7K5
    • Q969L0
    • Q9UI11

    Protein attributes for RAB14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23897 Da
    Quaternary structure:
    • Interacts with KIF16B (By similarity). Interacts with ZFYVE20.

    Three dimensional structures from OCA and Proteopedia for RAB14 Gene

neXtProt entry for RAB14 Gene

Post-translational modifications for RAB14 Gene

  • Ubiquitination at Lys35, Lys171, and Lys193
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB14 Gene

Domains & Families for RAB14 Gene

Gene Families for RAB14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for RAB14 Gene

InterPro:
Blocks:
  • GTP-binding nuclear protein Ran
  • Ras small GTPase, Ras type
  • Ras small GTPase, Rho type

Suggested Antigen Peptide Sequences for RAB14 Gene

GenScript: Design optimal peptide antigens:
  • Ras-related protein Rab-14 (RAB14_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P61106

UniProtKB/Swiss-Prot:

RAB14_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB14: view

Function for RAB14 Gene

Molecular function for RAB14 Gene

UniProtKB/Swiss-Prot Function:
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Phenotypes From GWAS Catalog for RAB14 Gene

Gene Ontology (GO) - Molecular Function for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,NAS 15004230
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA,IDA 16034420
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB14: view
genes like me logo Genes that share phenotypes with RAB14: view

Animal Models for research

  • Taconic Biosciences Mouse Models for RAB14

miRNA for RAB14 Gene

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB14 Gene

Localization for RAB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB14 Gene

Recycling endosome. Early endosome membrane. Lipid-anchor. Cytoplasmic side. Golgi apparatus membrane. Lipid-anchor. Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane. Lipid-anchor. Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:21255211, ECO:0000269 PubMed:22595670}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB14 gene
Compartment Confidence
plasma membrane 5
endosome 5
cytosol 5
extracellular 4
endoplasmic reticulum 4
lysosome 4
golgi apparatus 4
cytoskeleton 2
mitochondrion 2
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005764 lysosome ISS --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005768 endosome IEA --
GO:0005769 early endosome IBA,ISS --
genes like me logo Genes that share ontologies with RAB14: view

Pathways & Interactions for RAB14 Gene

genes like me logo Genes that share pathways with RAB14: view

Pathways by source for RAB14 Gene

1 Sino Biological pathway for RAB14 Gene
1 KEGG pathway for RAB14 Gene
1 Qiagen pathway for RAB14 Gene
  • Epithelial Tight Junctions

SIGNOR curated interactions for RAB14 Gene

Activates:

Gene Ontology (GO) - Biological Process for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006886 intracellular protein transport IBA 21873635
GO:0006895 Golgi to endosome transport IEA,TAS 15004230
GO:0008543 fibroblast growth factor receptor signaling pathway ISS --
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB14: view

Drugs & Compounds for RAB14 Gene

No Compound Related Data Available

Transcripts for RAB14 Gene

mRNA/cDNA for RAB14 Gene

1 REFSEQ mRNAs :
15 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for RAB14

Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for RAB14 Gene

GeneLoc Exon Structure for
RAB14

Expression for RAB14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB14 Gene

This gene is overexpressed in Nasal epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB14 Gene



Protein tissue co-expression partners for RAB14 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB14

SOURCE GeneReport for Unigene cluster for RAB14 Gene:

Hs.371563

Evidence on tissue expression from TISSUES for RAB14 Gene

  • Nervous system(5)
  • Liver(4.5)
  • Blood(4.5)
  • Adrenal gland(4.3)
  • Kidney(3.3)
  • Lung(3.2)
  • Pancreas(2.6)
  • Intestine(2.5)
  • Skin(2.5)
  • Muscle(2.3)
  • Lymph node(2.3)
  • Spleen(2.3)
  • Heart(2.3)
genes like me logo Genes that share expression patterns with RAB14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB14 Gene

Orthologs for RAB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB14 Gene

Organism Taxonomy Gene Similarity Type Details
Platypus
(Ornithorhynchus anatinus)
Mammalia RAB14 30
  • 100 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia RAB14 30
  • 100 (a)
OneToOne
Chimpanzee
(Pan troglodytes)
Mammalia RAB14 29 30
  • 99.84 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia RAB14 29 30
  • 95.5 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Rab14 29
  • 94.57 (n)
Mouse
(Mus musculus)
Mammalia Rab14 29 16 30
  • 94.42 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia RAB14 29 30
  • 91.16 (n)
OneToOne
Chicken
(Gallus gallus)
Aves RAB14 29 30
  • 89.46 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia RAB14 30
  • 100 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia rab14 29
  • 81.55 (n)
Str.5963 29
African clawed frog
(Xenopus laevis)
Amphibia Xl.8480 29
Zebrafish
(Danio rerio)
Actinopterygii rab14 30 30
  • 96 (a)
OneToMany
rab14l 29 30
  • 78.14 (n)
OneToMany
Dr.7872 29
Fruit Fly
(Drosophila melanogaster)
Insecta Rab14 30 31
  • 73 (a)
OneToOne
Worm
(Caenorhabditis elegans)
Secernentea rab-14 30
  • 85 (a)
OneToOne
F11A5.4 31
  • 55 (a)
F11A5.3 31
  • 51 (a)
Bread mold
(Neurospora crassa)
Ascomycetes NCU01647 29
  • 53.2 (n)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.2213 29
Species where no ortholog for RAB14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for RAB14 Gene

ENSEMBL:
Gene Tree for RAB14 (if available)
TreeFam:
Gene Tree for RAB14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB14: view image
Alliance of Genome Resources:
Additional Orthologs for RAB14

Paralogs for RAB14 Gene

genes like me logo Genes that share paralogs with RAB14: view

Variants for RAB14 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for RAB14 Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs140790437 Benign: not provided 121,182,941(-) C/T
NM_016322.4(RAB14):c.459G>A (p.Ala153=)
SYNONYMOUS
rs61757823 Benign: not provided 121,190,583(-) C/T
NM_016322.4(RAB14):c.255G>A (p.Ala85=)
SYNONYMOUS
VAR_012986 -- p.Ala4Thr

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for RAB14 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for RAB14 Gene

Variant ID Type Subtype PubMed ID
nsv820290 CNV loss 19587683
nsv950937 CNV duplication 24416366

Variation tolerance for RAB14 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB14
Leiden Open Variation Database (LOVD)
RAB14

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB14 Gene

Disorders for RAB14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB14 Gene - From: COP

Disorder Aliases PubMed IDs
non-invasive bladder urothelial carcinoma
  • stage 0 bladder urothelial carcinoma
- elite association - COSMIC cancer census association via MalaCards
Search RAB14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB14

genes like me logo Genes that share disorders with RAB14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB14 Gene

Publications for RAB14 Gene

  1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A … Barr FA (Developmental cell 2012) 3 4
  2. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4
  3. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PMID: 19702578) Kelly EE … McCaffrey MW (Biology of the cell 2009) 3 22
  4. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for RAB14 Gene

Sources for RAB14 Gene