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Aliases for RAB14 Gene

Aliases for RAB14 Gene

  • RAB14, Member RAS Oncogene Family 2 3 5
  • BA165P4.3 (Member RAS Oncogene Family) 2 3
  • Small GTP Binding Protein RAB14 2 3
  • F Protein-Binding Protein 1 2 3
  • Ras-Related Protein Rab-14 3
  • RAB-14 3
  • FBP 3

External Ids for RAB14 Gene

Previous GeneCards Identifiers for RAB14 Gene

  • GC09M115045
  • GC09M115586
  • GC09M117394
  • GC09M119316
  • GC09M119299
  • GC09M121019
  • GC09M122980
  • GC09M123940
  • GC09M093558

Summaries for RAB14 Gene

Entrez Gene Summary for RAB14 Gene

  • RAB14 belongs to the large RAB family of low molecular mass GTPases that are involved in intracellular membrane trafficking. These proteins act as molecular switches that flip between an inactive GDP-bound state and an active GTP-bound state in which they recruit downstream effector proteins onto membranes (Junutula et al., 2004 [PubMed 15004230]).[supplied by OMIM, Mar 2009]

GeneCards Summary for RAB14 Gene

RAB14 (RAB14, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB14 include Chlamydia. Among its related pathways are AMP-activated Protein Kinase (AMPK) Signaling and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and GDP binding. An important paralog of this gene is RAB4A.

UniProtKB/Swiss-Prot for RAB14 Gene

  • Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Gene Wiki entry for RAB14 Gene

Additional gene information for RAB14 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for RAB14 Gene

Genomics for RAB14 Gene

GeneHancer (GH) Regulatory Elements for RAB14 Gene

Promoters and enhancers for RAB14 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J121192 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 650.3 +25.4 25363 10.3 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 POLR2B ZNF207 ZNF143 RAB14 CUTALP FBXW2 CNTRL PSMD5 C5 GSN-AS1 ENSG00000239593 LOC102723324 STOM
GH09J121220 Enhancer 1.2 FANTOM5 Ensembl ENCODE dbSUPER 650.7 +1.6 1600 1.3 CTCF FOXA2 NANOG POU5F1 FOXA1 RAB14 CUTALP TRAF1 GSN
GH09J121222 Enhancer 0.7 Ensembl 650.7 +0.1 113 0.2 CTCF NFIB NFATC3 ZNF644 RFX5 ZSCAN5C ZNF444 ZBTB2 ZNF189 CAVIN1 RAB14 CNTRL CUTALP FBXW2 PSMD5 GSN
GH09J121223 Enhancer 0.7 ENCODE 650.7 +0.4 376 0.2 CTCF NFIB NFATC3 ZNF644 RAD21 RFX5 ZSCAN5C SMC3 ZNF444 SMARCA5 RAB14 CNTRL CUTALP FBXW2 PSMD5 GSN
GH09J121267 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.6 -47.4 -47428 6.1 HDAC1 CLOCK RB1 ARID4B NEUROD1 SIN3A ZBTB40 RAD21 ZNF335 EGR1 GSN PSMD5 CNTRL FBXW2 RAB14 CUTALP MRRF STOM LOC102723324 C5
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around RAB14 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the RAB14 gene promoter:
  • AP-1
  • c-Jun
  • ATF-2
  • HNF-3beta
  • NF-AT
  • NF-AT1
  • NF-AT2

Genomic Locations for RAB14 Gene

Genomic Locations for RAB14 Gene
chr9:121,178,137-121,223,014
(GRCh38/hg38)
Size:
44,878 bases
Orientation:
Minus strand
chr9:123,940,415-123,985,292
(GRCh37/hg19)
Size:
44,878 bases
Orientation:
Minus strand

Genomic View for RAB14 Gene

Genes around RAB14 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB14 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB14 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB14 Gene

Proteins for RAB14 Gene

  • Protein details for RAB14 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61106-RAB14_HUMAN
    Recommended name:
    Ras-related protein Rab-14
    Protein Accession:
    P61106
    Secondary Accessions:
    • B3KR31
    • P35287
    • Q5JVD4
    • Q6Q7K5
    • Q969L0
    • Q9UI11

    Protein attributes for RAB14 Gene

    Size:
    215 amino acids
    Molecular mass:
    23897 Da
    Quaternary structure:
    • Interacts with KIF16B (By similarity). Interacts with ZFYVE20.
    SequenceCaution:
    • Sequence=CAI12361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for RAB14 Gene

neXtProt entry for RAB14 Gene

Post-translational modifications for RAB14 Gene

  • Ubiquitination at Lys171 and Lys35
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB14 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for RAB14 Gene

Domains & Families for RAB14 Gene

Gene Families for RAB14 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for RAB14 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61106

UniProtKB/Swiss-Prot:

RAB14_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB14: view

Function for RAB14 Gene

Molecular function for RAB14 Gene

UniProtKB/Swiss-Prot Function:
Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity). Regulates, together with its guanine nucleotide exchange factor DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion.

Phenotypes From GWAS Catalog for RAB14 Gene

Gene Ontology (GO) - Molecular Function for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003924 GTPase activity IEA,NAS 15004230
GO:0005515 protein binding IPI 16034420
GO:0005525 GTP binding IEA,IDA 16034420
GO:0019003 GDP binding IDA 16034420
genes like me logo Genes that share ontologies with RAB14: view
genes like me logo Genes that share phenotypes with RAB14: view

Animal Model Products

  • Taconic Biosciences Mouse Models for RAB14

Clone Products

  • Addgene plasmids for RAB14

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB14 Gene

Localization for RAB14 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB14 Gene

Recycling endosome. Early endosome membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Golgi apparatus, trans-Golgi network membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle, phagosome. Note=Recruited to recycling endosomes by DENND6A (PubMed:22595670). Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). {ECO:0000269 PubMed:21255211, ECO:0000269 PubMed:22595670}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB14 gene
Compartment Confidence
plasma membrane 5
extracellular 5
endoplasmic reticulum 5
cytosol 5
lysosome 5
golgi apparatus 5
endosome 5
nucleus 2
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005622 intracellular IDA --
GO:0005764 lysosome ISS --
GO:0005765 lysosomal membrane HDA 17897319
GO:0005768 endosome IEA --
genes like me logo Genes that share ontologies with RAB14: view

Pathways & Interactions for RAB14 Gene

genes like me logo Genes that share pathways with RAB14: view

Pathways by source for RAB14 Gene

1 Qiagen pathway for RAB14 Gene

Gene Ontology (GO) - Biological Process for RAB14 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006661 phosphatidylinositol biosynthetic process TAS --
GO:0006886 intracellular protein transport IBA --
GO:0006895 Golgi to endosome transport IEA,TAS 15004230
GO:0008543 fibroblast growth factor receptor signaling pathway ISS --
GO:0009790 embryo development ISS --
genes like me logo Genes that share ontologies with RAB14: view

No data available for SIGNOR curated interactions for RAB14 Gene

Drugs & Compounds for RAB14 Gene

No Compound Related Data Available

Transcripts for RAB14 Gene

mRNA/cDNA for RAB14 Gene

(1) REFSEQ mRNAs :
(14) Additional mRNA sequences :
(540) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for RAB14 Gene

RAB14, member RAS oncogene family:
Representative Sequences:

Clone Products

  • Addgene plasmids for RAB14

Alternative Splicing Database (ASD) splice patterns (SP) for RAB14 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: - -
SP3:
SP4:
SP5: -
SP6: -

Relevant External Links for RAB14 Gene

GeneLoc Exon Structure for
RAB14
ECgene alternative splicing isoforms for
RAB14

Expression for RAB14 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for RAB14 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for RAB14 Gene

This gene is overexpressed in Nasal epithelium (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB14 Gene



Protein tissue co-expression partners for RAB14 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of RAB14 Gene:

RAB14

SOURCE GeneReport for Unigene cluster for RAB14 Gene:

Hs.371563

Evidence on tissue expression from TISSUES for RAB14 Gene

  • Nervous system(4.9)
  • Liver(4.4)
  • Adrenal gland(4.3)
  • Blood(4.3)
  • Kidney(3.1)
  • Lung(2.6)
  • Pancreas(2)
genes like me logo Genes that share expression patterns with RAB14: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB14 Gene

Orthologs for RAB14 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for RAB14 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia RAB14 34
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB14 34
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia RAB14 34 33
  • 99.84 (n)
OneToOne
dog
(Canis familiaris)
Mammalia RAB14 34 33
  • 95.5 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab14 33
  • 94.57 (n)
mouse
(Mus musculus)
Mammalia Rab14 16 34 33
  • 94.42 (n)
cow
(Bos Taurus)
Mammalia RAB14 34 33
  • 91.16 (n)
OneToOne
chicken
(Gallus gallus)
Aves RAB14 34 33
  • 89.46 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia RAB14 34
  • 100 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia rab14 33
  • 81.55 (n)
Str.5963 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.8480 33
zebrafish
(Danio rerio)
Actinopterygii rab14 34 34
  • 96 (a)
OneToMany
rab14l 34 33
  • 78.14 (n)
OneToMany
Dr.7872 33
fruit fly
(Drosophila melanogaster)
Insecta Rab14 34 35
  • 73 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rab-14 34
  • 85 (a)
OneToOne
F11A5.4 35
  • 55 (a)
F11A5.3 35
  • 51 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU01647 33
  • 53.2 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.2213 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2213 33
Species where no ortholog for RAB14 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB14 Gene

ENSEMBL:
Gene Tree for RAB14 (if available)
TreeFam:
Gene Tree for RAB14 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB14: view image

Paralogs for RAB14 Gene

Variants for RAB14 Gene

Sequence variations from dbSNP and Humsavar for RAB14 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000050717 -- 121,181,975(-) T/C intron_variant
rs1000147702 -- 121,194,564(-) C/T intron_variant
rs1000368914 -- 121,188,727(-) C/T intron_variant
rs1000384046 -- 121,188,520(-) T/A intron_variant
rs1000402065 -- 121,181,715(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for RAB14 Gene

Variant ID Type Subtype PubMed ID
nsv950937 CNV duplication 24416366
nsv820290 CNV loss 19587683

Variation tolerance for RAB14 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.43% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB14 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB14

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for RAB14 Gene

Disorders for RAB14 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB14 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
chlamydia
  • chlamydia trachomatis infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search RAB14 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB14

genes like me logo Genes that share disorders with RAB14: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB14 Gene

Publications for RAB14 Gene

  1. Rab14 and its exchange factor FAM116 link endocytic recycling and adherens junction stability in migrating cells. (PMID: 22595670) Linford A … Barr FA (Developmental cell 2012) 3 4 58
  2. Rab GTPases regulating phagosome maturation are differentially recruited to mycobacterial phagosomes. (PMID: 21255211) Seto S … Koide Y (Traffic (Copenhagen, Denmark) 2011) 3 4 58
  3. Class I Rab11-family interacting proteins are binding targets for the Rab14 GTPase. (PMID: 19702578) Kelly EE … McCaffrey MW (Biology of the cell 2009) 3 22 58
  4. Structural basis of family-wide Rab GTPase recognition by rabenosyn-5. (PMID: 16034420) Eathiraj S … Lambright DG (Nature 2005) 3 4 58
  5. Rab14 is involved in membrane trafficking between the Golgi complex and endosomes. (PMID: 15004230) Junutula JR … Scheller RH (Molecular biology of the cell 2004) 2 3 58

Products for RAB14 Gene

Sources for RAB14 Gene

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