This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between lumin... See more...

Aliases for RAB13 Gene

Aliases for RAB13 Gene

  • RAB13, Member RAS Oncogene Family 2 3 5
  • Cell Growth-Inhibiting Gene 4 Protein 3 4
  • Ras-Related Protein Rab-13 3 4
  • Growth-Inhibiting Gene 4 Protein 3
  • RAS-Associated Protein RAB13 3
  • GIG4 3

External Ids for RAB13 Gene

Previous GeneCards Identifiers for RAB13 Gene

  • GC01M151770
  • GC01M149685
  • GC01M150729
  • GC01M151170
  • GC01M150767
  • GC01M152220
  • GC01M153954
  • GC01M125316

Summaries for RAB13 Gene

Entrez Gene Summary for RAB13 Gene

  • This gene is a member of the Rab family of small G proteins and plays a role in regulating membrane trafficking between trans-Golgi network (TGN) and recycling endosomes (RE). The encoded protein is involved in the assembly of tight junctions, which are components of the apical junctional complex (AJC) of epithelial cells. The AJC plays a role in forming a barrier between luminal contents and the underlying tissue. Additional functions associated with the protein include endocytic recycling of occludin, regulation of epithelial cell scattering, neuronal regeneration and regulation of neurite outgrowth. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 12. [provided by RefSeq, Jan 2013]

GeneCards Summary for RAB13 Gene

RAB13 (RAB13, Member RAS Oncogene Family) is a Protein Coding gene. Diseases associated with RAB13 include Lymph Node Tuberculosis. Among its related pathways are Metabolism of proteins and Sertoli-Sertoli Cell Junction Dynamics. Gene Ontology (GO) annotations related to this gene include GTP binding and protein kinase A catalytic subunit binding. An important paralog of this gene is ENSG00000285641.

UniProtKB/Swiss-Prot Summary for RAB13 Gene

  • The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.

Gene Wiki entry for RAB13 Gene

Additional gene information for RAB13 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for RAB13 Gene

Genomics for RAB13 Gene

GeneHancer (GH) Regulatory Elements for RAB13 Gene

Promoters and enhancers for RAB13 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around RAB13 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for RAB13

Top Transcription factor binding sites by QIAGEN in the RAB13 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • AP-2beta
  • AP-2gamma
  • C/EBPalpha
  • GCNF-1
  • GCNF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • ZIC2

Genomic Locations for RAB13 Gene

Genomic Locations for RAB13 Gene
chr1:153,981,605-153,986,377
(GRCh38/hg38)
Size:
4,773 bases
Orientation:
Minus strand
chr1:153,954,127-153,958,834
(GRCh37/hg19)
Size:
4,708 bases
Orientation:
Minus strand

Genomic View for RAB13 Gene

Genes around RAB13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
RAB13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for RAB13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for RAB13 Gene

Proteins for RAB13 Gene

  • Protein details for RAB13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51153-RAB13_HUMAN
    Recommended name:
    Ras-related protein Rab-13
    Protein Accession:
    P51153
    Secondary Accessions:
    • A8K6B5
    • D3DV67
    • Q5U0A6
    • Q6GPG6
    • Q96GU4

    Protein attributes for RAB13 Gene

    Size:
    203 amino acids
    Molecular mass:
    22774 Da
    Quaternary structure:
    • Interacts (GTP-bound form) with MICALL2; competes with RAB8A and is involved in tight junctions assembly. Interacts (GTP-bound form) with MICALL1. Interacts (GTP-bound form) with MICAL1, MICAL3, MICALCL, EHBP1 and EHBP1L1; ternary complexes of RAB8A, RAB13 and either MICAL1 or EHBP1L1 are possible. Interacts with PRKACA; downstream effector of RAB13 involved in tight junction assembly. Interacts with GRB2; may recruit RAB13 to the leading edge of migrating endothelial cells where it can activate RHOA. Interacts (isoprenylated form) with PDE6D; dissociates RAB13 from membranes. Interacts with BICDL2/BICDR2. Interacts with LEPROT and LEPROTL1.

neXtProt entry for RAB13 Gene

Post-translational modifications for RAB13 Gene

  • Ubiquitination at Lys71
  • Modification sites at PhosphoSitePlus

Other Protein References for RAB13 Gene

Antibody Products

  • Abcam antibodies for RAB13
  • Boster Bio Antibodies for RAB13

No data available for DME Specific Peptides for RAB13 Gene

Domains & Families for RAB13 Gene

Gene Families for RAB13 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for RAB13 Gene

Blocks:
  • Transforming protein P21 RAS signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for RAB13 Gene

GenScript: Design optimal peptide antigens:
  • RAB13 protein (Q504R6_HUMAN)
  • Cell growth-inhibiting gene 4 protein (RAB13_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P51153

UniProtKB/Swiss-Prot:

RAB13_HUMAN :
  • Belongs to the small GTPase superfamily. Rab family.
Family:
  • Belongs to the small GTPase superfamily. Rab family.
genes like me logo Genes that share domains with RAB13: view

Function for RAB13 Gene

Molecular function for RAB13 Gene

UniProtKB/Swiss-Prot Function:
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab is involved in endocytic recycling and regulates the transport to the plasma membrane of transmembrane proteins like the tight junction protein OCLN/occludin. Thereby, it regulates the assembly and the activity of tight junctions. Moreover, it may also regulate tight junction assembly by activating the PKA signaling pathway and by reorganizing the actin cytoskeleton through the activation of the downstream effectors PRKACA and MICALL2 respectively. Through its role in tight junction assembly, may play a role in the establishment of Sertoli cell barrier. Plays also a role in angiogenesis through regulation of endothelial cells chemotaxis. Also involved in neurite outgrowth. Has also been proposed to play a role in post-Golgi membrane trafficking from the TGN to the recycling endosome. Finally, it has been involved in insulin-induced transport to the plasma membrane of the glucose transporter GLUT4 and therefore may play a role in glucose homeostasis.
UniProtKB/Swiss-Prot EnzymeRegulation:
Rab activation is generally mediated by a guanine exchange factor (GEF), while inactivation through hydrolysis of bound GTP is catalyzed by a GTPase activating protein (GAP). That Rab may be activated by DENND1C, a guanine exchange factor. Activated in response to insulin.
UniProtKB/Swiss-Prot Induction:
Up-regulated during osteoclast differentiation.
GENATLAS Biochemistry:
Ras-related small GTPase,component of the junctional complex of polarized epithelial cells,specific regulator of vesicular trafficking,cycling between cytosolic and membrane-bound forms under the control of PDE6B,expressed in skeletal muscle

Phenotypes From GWAS Catalog for RAB13 Gene

Gene Ontology (GO) - Molecular Function for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003924 GTPase activity IEA,IBA 21873635
GO:0005515 protein binding IPI 9712853
GO:0005525 GTP binding IEA,IDA 20937701
genes like me logo Genes that share ontologies with RAB13: view
genes like me logo Genes that share phenotypes with RAB13: view

Animal Model Products

CRISPR Products

miRNA for RAB13 Gene

miRTarBase miRNAs that target RAB13

Clone Products

  • Addgene plasmids for RAB13

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for RAB13 Gene

Localization for RAB13 Gene

Subcellular locations from UniProtKB/Swiss-Prot for RAB13 Gene

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasmic vesicle membrane; Lipid-anchor; Cytoplasmic side. Cell junction, tight junction. Golgi apparatus, trans-Golgi network membrane. Recycling endosome membrane. Cell projection, lamellipodium. Note=Tight junctions or associated with vesicles scattered throughout the cytoplasm in cells lacking tight junctions (PubMed:8294494). Relocalizes to the leading edge of lamellipodia in migrating endothelial cells (By similarity). {ECO:0000250 UniProtKB:Q9DD03, ECO:0000269 PubMed:8294494}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for RAB13 gene
Compartment Confidence
plasma membrane 5
endosome 5
cytosol 5
golgi apparatus 5
cytoskeleton 2
mitochondrion 2
lysosome 2
extracellular 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Plasma membrane (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005768 endosome IBA 21873635
GO:0005794 NOT Golgi apparatus IDA 18779367
GO:0005802 trans-Golgi network IDA 18779367
GO:0005829 cytosol TAS,IDA --
GO:0005886 plasma membrane IDA 15528189
genes like me logo Genes that share ontologies with RAB13: view

Pathways & Interactions for RAB13 Gene

genes like me logo Genes that share pathways with RAB13: view

Pathways by source for RAB13 Gene

1 Qiagen pathway for RAB13 Gene
  • Epithelial Tight Junctions

Gene Ontology (GO) - Biological Process for RAB13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IBA 21873635
GO:0006904 vesicle docking involved in exocytosis IBA 21873635
GO:0009306 protein secretion IBA 21873635
GO:0010737 protein kinase A signaling IMP 15096524
GO:0015031 protein transport IEA --
genes like me logo Genes that share ontologies with RAB13: view

No data available for SIGNOR curated interactions for RAB13 Gene

Drugs & Compounds for RAB13 Gene

No Compound Related Data Available

Transcripts for RAB13 Gene

mRNA/cDNA for RAB13 Gene

2 REFSEQ mRNAs :
14 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for RAB13

Alternative Splicing Database (ASD) splice patterns (SP) for RAB13 Gene

No ASD Table

Relevant External Links for RAB13 Gene

GeneLoc Exon Structure for
RAB13

Expression for RAB13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for RAB13 Gene

Protein differential expression in normal tissues from HIPED for RAB13 Gene

This gene is overexpressed in Nasal epithelium (22.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for RAB13 Gene



Protein tissue co-expression partners for RAB13 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for RAB13

SOURCE GeneReport for Unigene cluster for RAB13 Gene:

Hs.151536

mRNA Expression by UniProt/SwissProt for RAB13 Gene:

P51153-RAB13_HUMAN
Tissue specificity: Detected in several types of epithelia, including intestine, kidney, liver and in endothelial cells.

Evidence on tissue expression from TISSUES for RAB13 Gene

  • Nervous system(4.4)
  • Kidney(2.9)
  • Liver(2.4)
  • Spleen(2.4)
  • Heart(2.3)
  • Lung(2.3)
  • Muscle(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with RAB13: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for RAB13 Gene

Orthologs for RAB13 Gene

This gene was present in the common ancestor of animals.

Orthologs for RAB13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia RAB13 31 30
  • 99.67 (n)
OneToOne
cow
(Bos Taurus)
Mammalia RAB13 31 30
  • 93.92 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Rab13 30
  • 91.13 (n)
mouse
(Mus musculus)
Mammalia Rab13 17 31 30
  • 90.43 (n)
dog
(Canis familiaris)
Mammalia RAB13 31 30
  • 89.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia RAB13 31
  • 79 (a)
OneToOne
chicken
(Gallus gallus)
Aves RAB13 31
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia aca-mir-5405 31
  • 44 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC97787 30
  • 73.33 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.6108 30
zebrafish
(Danio rerio)
Actinopterygii rab13 31 30 30
  • 69.01 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Rab8 32
  • 64 (a)
Rab10 32
  • 63 (a)
CG2885 32
  • 50 (a)
Rab-RP3 32
  • 47 (a)
RabX4 31
  • 44 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea rab-8 32
  • 64 (a)
4R79.2 32
  • 40 (a)
C33D12.6 32
  • 38 (a)
Species where no ortholog for RAB13 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for RAB13 Gene

ENSEMBL:
Gene Tree for RAB13 (if available)
TreeFam:
Gene Tree for RAB13 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for RAB13: view image

Paralogs for RAB13 Gene

genes like me logo Genes that share paralogs with RAB13: view

Variants for RAB13 Gene

Additional dbSNP identifiers (rs#s) for RAB13 Gene

Variation tolerance for RAB13 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.24; 40.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for RAB13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
RAB13

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Structural Variations from Database of Genomic Variants (DGV) for RAB13 Gene

Disorders for RAB13 Gene

MalaCards: The human disease database

(1) MalaCards diseases for RAB13 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lymph node tuberculosis
  • king's evil
- elite association - COSMIC cancer census association via MalaCards
Search RAB13 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for RAB13

genes like me logo Genes that share disorders with RAB13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for RAB13 Gene

Publications for RAB13 Gene

  1. A small rab GTPase is distributed in cytoplasmic vesicles in non polarized cells but colocalizes with the tight junction marker ZO-1 in polarized epithelial cells. (PMID: 8294494) Zahraoui A … Louvard D (The Journal of cell biology 1994) 2 3 4 23 54
  2. Rab13 is upregulated during osteoclast differentiation and associates with small vesicles revealing polarized distribution in resorbing cells. (PMID: 22562557) Hirvonen MJ … Väänänen HK (The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2012) 3 4 54
  3. MICAL-like1 mediates epidermal growth factor receptor endocytosis. (PMID: 21795389) Abou-Zeid N … Zahraoui A (Molecular biology of the cell 2011) 3 4 54
  4. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. (PMID: 20937701) Yoshimura S … Barr FA (The Journal of cell biology 2010) 3 4 54
  5. Rab13 regulates neurite outgrowth in PC12 cells through its effector protein, JRAB/MICAL-L2. (PMID: 20008558) Sakane A … Sasaki T (Molecular and cellular biology 2010) 3 4 54

Products for RAB13 Gene

Sources for RAB13 Gene